Women with type 1 or type 2 diabetes often have difficulty getting pregnant, due to complications from the disease, being obese or seriously underweight, or having conditions like polycystic ovary syndrome. Once pregnant, they face challenges of having a safe pregnancy and delivering a healthy baby. Recent advances in diabetes technology, including continuous glucose monitoring (CGM) and most…
Insulinomas are benign tumors in the pancreas, but can still cause problems for patients. A new imaging technique reliably detects these previously hard-to-find tumors, according to recent research.
A new study reveals that cardiometabolic risk factors and subclinical atherosclerosis impair the function of the microvessels that irrigate the heart, potentially increasing atherosclerosis risk.
Many medicines require cold storage, which is a challenge for infrastructure and sustainability. Now, researchers designed a hydrogel protecting therapeutics at temperatures as high as 50°C.
‘Computer, why did the doctor take that MRI scan of my leg? And what did it show?’: Popularized by OpenAI’s ChatGPT, generative artificial intelligence (AI) is already beginning to see practical applications in medical settings. The technology holds immense potential, with benefits for patients, clinicians, and even hospital administration, according to Shez Partovi, MD.
New research could revolutionize noninvasive monitoring of blood glucose levels (BGLs): a Japanese team developed a novel methodology to estimate BGLs from near-infrared light (NIR) measurements.
When your stomach is full after a large meal, certain receptors are activated to tell the brain. A newly developed capsule could provoke this fullness signal early, potentially helping with treating obesity.
Engineers from MIT are developing a device containing insulin-producing cells and a tiny oxygen-producing factory to keep the cells of diabetes patients healthy.
Brain tumour progression to a malignant state is believed to be the result of an intricate interplay between cancer cells and the tumour microenvironment. Greek researchers shed new light on the mechanisms.
A new AI model finds that x-ray images collected during routine medical care can provide warning signs for diabetes, even in patients who don’t meet the guidelines for elevated risk.
60 percent of all administered drugs do not have the desired therapeutic effect. Even worse: in Germany alone about 60,000 deaths per year are caused by medication. With these shocking statistics Professor Dr Christian Franken started his presentation on “Pills from the 3D printer” at last year’s Medica in Düsseldorf. He hopes that his vision of personalized medication based on 2D and 3D…
Not just uncomfortable, but hard on the heart: Accumulating research suggests a link between hot flashes during the menopause and cardiovascular disease risk in women.
A newly developed capsule that tunnels through mucus in the GI tract could be used to orally administer large protein drugs such as insulin.
A device using next-gen technology to automatically deliver insulin was found to be more effective at maintaining blood glucose levels than standard-of-care management for type 1 diabetes.
Overweight increases the risk of an imbalance in sugar metabolism and even diabetes – but the opposite is also true: insulin production deficits contribute to overweight, a new study shows.
A new device, which doesn’t rely on immunosuppressing drugs, may assist efforts to develop an artificial pancreas to treat diabetes.
This overview introduces connected and continuous glucose sensing technologies, smart insulin delivery systems and more innovations that help patients and doctors monitor and manage glucose levels and guide decision-making in diabetes care.
More than 15 billion batteries are sent to landfill sites every year – technology that converts glucose and oxygen into electricity has the potential to reduce this waste and serve as a sustainable alternative power source for medical devices.
Researchers pinpoint a sound-sensitive mammalian protein that lets them activate brain, heart or other cells with ultrasound.
Scientists have found that fat can help the pancreas adapt to excess sugar, thereby slowing the onset of diabetes.
The number of gamified mobile applications is rising rapidly—especially in healthcare. Gamified apps or devices are used in many fields, from mental health therapy to stroke rehab to managing metabolic conditions. This article illustrates how gamification is employed in diabetes care.
Drug delivery, blood extraction, contrast agent injection – many procedures in modern medicine would be utterly impossible without needles. Despite the benefits, inserting pointy metal tubes into a patient also comes with several drawbacks. By downscaling the to micrometer-size, Japanese researchers open even more areas of application for needles, while bypassing some of the most important…
Heart failure with preserved ejection fraction was previously considered largely untreatable. A research team at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) led by Professor Michael Gotthardt has now succeeded for the first time in improving cardiac function with the help of a synthetic nucleic acid, as the researchers report in the journal Science…
Professor Dina Tiniakos, from the National and Kapodistrian University of Athens, predicts that NASH (Non-alcohol related steatohepatitis) cases will soar worldwide by 2030, with 800,000 liver deaths, costing health economies billions of dollars.
Researchers at Umeå University now demonstrate a method by which specific cell types in human organs can be studied with micrometer precision. The method can be used to reveal previously unrecognised alterations in the pancreas, but it can also be used to study other human organs and diseases.
A study by an international research group identified 15 novel biomarkers that are linked to late-onset dementias. These biomarkers are proteins, which predict cognitive decline and subsequent increased risk of dementia already 20 years before the disease onset. The proteins are related to immune system dysfunction, blood-brain-barrier dysfunction, vascular pathologies, and central insulin…
Researchers have shown that the life expectancy of mices can be increased by an average of 30% in both males and females. For humans, that would means that a 90-year-old could live until nearly 120.
First you see it as a transparent shape on a computer screen – a small electronic replica of the human pancreas. Then just 30 seconds later the tissue is printed out on a bioprinter, blood vessels and all, from a sample of human stem cells. This amazing feat is possible thanks to new technology created at EPFL’s Laboratory of Applied Photonics Devices (LAPD) and further developed by…
Body composition information derived from routine chest CTs can provide important information on the overall health of people with chronic obstructive pulmonary disease (COPD), including their risk of all-cause mortality. This is the result of a new study, published in Radiology. COPD is a group of chronic, progressive lung diseases that affect about 30 million people in the United States alone.…
From swallowing pills to injecting insulin, patients frequently administer their own medication. But they don’t always get it right. Improper adherence to doctors’ orders is commonplace, accounting for thousands of deaths and billions of dollars in medical costs annually. Researchers at the Massachusetts Institute of Technology (MIT) have developed a system to reduce those numbers for some…
The length of the female reproductive period (the time from the onset of menses to the final menstrual period) has important health implications. A new study compared the length of reproductive periods for women with type 1 diabetes with women without diabetes to confirm the effect diabetes has on the female reproductive system. Study results are published online in Menopause, the journal of The…
Researchers from Helmholtz Zentrum Muenchen, the Technical University of Munich and the German Center for Diabetes have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes…
For the first time, scientists have come up with a precise atomic level explanation for why glulisine - a commonly used medication to treat diabetes - is faster acting than insulin. The findings, published in Scientific Reports, could have benefits for diabetes patients in ensuring that a more improved insulin can be developed for future treatment. The study was carried out by experts from the…
All prediabetes is not the same: in people in the preliminary stages of type 2 diabetes, there are six clearly distinguishable subtypes, which differ in the development of the disease, diabetes risk, and the development of secondary diseases. This is shown in a study by the Institute for Diabetes Research and Metabolic Diseases (IDM) of Helmholtz Zentrum München at the University of Tübingen,…
A study of almost 400,000 British participants has identified a new link between raised levels of the growth factor IGF-1 and increased thyroid cancer risk and has confirmed associations with breast, prostate and colorectal cancer. This could lead to new preventative strategies, including diet and lifestyle interventions.
Scientists from Nanyang Technological University, Singapore (NTU Singapore) and the Agency for Science, Technology and Research (A*STAR) have showed that applying “temporal pressure” to the skin of mice can create a new way to deliver drugs. In a paper published in Science Advances, the researchers showed that bringing together two magnets so that they pinch and apply pressure to a fold of…
New coatings on implants could help make them more compatible. Researchers at the Martin Luther University Halle-Wittenberg (MLU) have developed a new method of applying anti-inflammatory substances to implants in order to inhibit undesirable inflammatory reactions in the body. Their study was recently published in the "International Journal of Molecular Sciences".
Diabetes is called an incurable disease because once it develops, it does not disappear regardless of treatment in modern medicine. Having diabetes means a life-long obligation of insulin shots and monitoring of blood glucose levels. Recently, a research team at Pohang University of Science and Technology developed a wirelessly driven ‘smart contact lens’ technology that can detect diabetes…
The production of highly sensitive sensors is a complex process: it requires many different steps and the almost dust-free environment of special cleanrooms. A research team from Materials Science at Kiel University (CAU) and from Biomedical Engineering at the Technical University of Moldova has now developed a procedure to produce extremely sensitive and energy-efficient sensors using 3D…
The world’s first licensed, downloadable artificial pancreas app for people with type 1 diabetes now launched, based on over a decade of research by Professor Roman Hovorka at the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust. The CamAPS FX app works with an insulin pump and a glucose monitor to automatically deliver insulin to people living with the condition…
A growth hormone called insulin-like growth factor-1 (IGF-1) is likely to play a role in the development of breast cancer, according to new research published in the leading cancer journal Annals of Oncology. IGF-1 is already known to encourage the growth and proliferation of cancer cells. Now, two analyses of information from several hundred thousand women enrolled in the UK Biobank study have…
An organic compound produced by the gut flora – the metabolite 4-Cresol – is considered to have protective effects against both type 1 and 2 diabetes, notably by stimulating the growth of the insulin-producing pancreatic beta cells. This is according to a new study led by Inserm researcher Dominique Gauguier at the Environmental Toxicology, Therapeutic Targets, Cell Signaling and Biomarkers…
A surprising discovery about a rare form of childhood brain cancer suggests a new treatment approach for that cancer – and potentially many others. Researchers at the University of Virginia School of Medicine have determined that the supposedly simple cancer, called medulloblastoma, forms an unexpectedly intricate network to drive its growth. Some tumor cells actually turn into another type of…
A protein newly identified as important in type 1 diabetes can delay onset of the disease in diabetic mice, providing a new target for prevention and treatment in people, according to research led by scientists at the Department of Energy’s (DOE) Pacific Northwest National Laboratory and Indiana University School of Medicine. Because type 1 diabetes is incurable and has serious lifelong health…
Due to the scientific and technical developments in recombinant DNA technology and protein engineering since the early 1980s, therapeutic proteins have emerged as one of the most important classes of new pharmaceuticals. Currently, more than 200 protein and peptide based drugs have gained approval by the USA’s Food and Drug Administration (FDA) and many more are under preclinical or clinical…
Non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver disorder in developed countries. Histological analysis of liver tissue is the only widely accepted test for diagnosing and distinguishing different stages of NAFLD. However, this technique provides only two-dimensional images of the liver tissue in low resolution and overlooks potentially important 3D structural…
A protein newly discovered by scientists in China is aiding in the dramatic reversal of stroke-like damage in laboratory animals and may one day rescue humans from neurological injury, the research team is predicting.
Viscosity sensors are used by scientists fighting various diseases, such as Alzheimer's and Diabetes. Vilnius-based chemist Aurimas Vyšniauskas has enhanced their measuring capabilities. This breakthrough will equip researchers with additional tools to study living cells and how they change in a sick organism.
Researchers at ETH Zurich have refined the famous CRISPR-Cas method. Now, for the very first time, it is possible to modify dozens, if not hundreds, of genes in a cell simultaneously. The biotechnological method CRISPR-Cas offers a relatively quick and easy way to manipulate single genes in cells, meaning they can be precisely deleted, replaced or modified. Furthermore, in recent years,…
The traditional classification of diabetes, mainly in type 1 and type 2 diabetes, has been challenged by studies from Scandinavia. In the current issue of The Lancet Diabetes & Endocrinology, researchers from DDZ together with colleagues from DZD and University of Lund published a cluster analysis of diabetes allowing for phenotyping into subgroups, which extended the findings by showing that…
For patients with Type 1 diabetes who don’t respond well to insulin or have other serious medical complications caused by their disease, pancreas transplantation offers hope for a cure. But obese candidates who need a pancreas transplant often are denied the procedure because of poor outcomes, including high rates of incision infections, which are linked to an increased risk for failure and…
In the most comprehensive study of its kind, researchers from the Department of Nutritional Sciences at the University of Surrey investigated if protein intake can impact bone health of adults and children. Examining 127 previous studies published over a 40 year period, which scrutinised the link between protein and bone density, bone mineral content and relative risk of osteoporotic fractures,…
Eating too much fat and sugar makes you overweight and unhealthy – even young children know that. But why is that, and is there anything we can do about it? In a study published in the journal Cell, Prof. Jens Brüning's research group at the Max Planck Institute for Metabolism Research in Cologne has shown how altering fat metabolism in the liver can make obese mice thinner, despite eating an…
More than a third of people with Type 2 diabetes who took part in a weight management programme delivered by the NHS through GP surgeries remain free of diabetes two years later. These latest findings of the Diabetes Remission Clinical Trial (DiRECT), funded by Diabetes UK and led by experts at Newcastle University and the University of Glasgow, were announced today at Diabetes UK’s…
UC San Francisco researchers have for the first time transformed human stem cells into mature insulin-producing cells, a major breakthrough in the effort to develop a cure for type 1 (T1) diabetes. Replacing these cells, which are lost in patients with T1 diabetes, has long been a dream of regenerative medicine, but until now scientists had not been able to figure out how to produce cells in a…
New research by the University of Bristol in collaboration with Medical Detection Dogs has found that the best trained alert dogs have the potential to vastly improve the quality of life of people living with Type 1 diabetes. As reported in PLOS One, on average trained dogs alerted their owners to 83 per cent of hypoglycaemic episodes in over 4,000 hypo- and hyper-glycaemic episodes that were…
More than 100 million Americans have potentially deadly fatty liver disease and most do not even know it. Overeating and drinking excessive amounts of alcohol this holiday season could put someone with the disease on the fast track to liver failure. “There are no symptoms associated with fatty liver disease and no pain, so most people never get checked or treated for it and, over time, if it is…
Researchers recently evaluated the accuracy of a technology to monitor blood glucose levels without needles or a finger prick. Early results show that the noninvasive technology measures blood glucose levels as effectively as a finger prick test — without drawing blood.
A scientist has discovered a gene-editing technology that could efficiently and accurately correct the genetic defects that underlie certain diseases, positioning the new tool as the basis for the next generation of genetic therapies.
Another piece in the puzzle that is non-alcoholic fatty liver disease has been solved by a University of Queensland researcher in a step towards developing treatments for a disease that affects about one in every five Australians. PhD student Laurence Britton has discovered a pivotal mechanism by which iron is able to make the liver more vulnerable to the injury and metabolic dysfunction that…
The Endocrine Society expressed continued concerns today that the European Union’s (EU’s) criteria for regulating endocrine-disrupting chemicals (EDCs) in pesticides and biocides do not go far enough to protect public health.
Aging is a major risk factor for physical frailty and the development of age-related diseases such as cancer, cardiovascular diseases, type II diabetes and Alzheimer's disease. Numerous studies have already shown that a calorie-restricted diet can significantly delay age-related conditions in several organisms like flies, worms, fish and mice, and that it even improves fitness at old age. But who…
According to new research, obese women with polycystic ovary syndrome (PCOS) may be able to improve their health outlook with a particularly enjoyable form of therapy: regular sessions in a hot tub. The research found that soaking in a hot tub several times per week for two months results in improved measures of cardiovascular health, beneficial changes in fat tissue and other improvements…
A completely new classification of diabetes which also predicts the risk of serious complications and provides treatment suggestions. The major difference from today’s classification is that type 2 diabetes actually consists of several subgroups, the results indicate. “This is the first step towards personalised treatment of diabetes”, says physician and diabetes expert Leif Groop.
Type 2 diabetes, which affects >0.5 billion people worldwide, results from the inability of beta cells in the pancreatic islets to provide the body with enough insulin to maintain blood glucose levels within the range for a healthy life. A collaborative study led by Prof. Michele Solimena at the Technische Universität in Dresden as well as the Helmholtz Zentrum München, Dr. Anke M Schulte at…
Treating type 1 diabetes and some cases of type 2 diabetes has long required painful and frequent insulin injections or a mechanical insulin pump for insulin infusion. But researchers from the University of North Carolina and NC State have now developed what could be a much more patient-friendly option: artificial cells that automatically release insulin into the bloodstream when glucose levels…
In old age a variety of cellular processes decline and the risk to develop age-related diseases such as Alzheimer’s, Parkinson’s or Diabetes increases dramatically. But does ageing affect all organs and tissues in the body in the same way? And should drugs that are developed to improve health in old age have the same effect on every organ? Now scientists from the Max Planck Institute for…
German researches have linked the increased production of a certain enzyme in the liver to fatty liver and insulin resistance.
Surgeons at Johns Hopkins Medicine report that their first series of a minimally invasive procedure to treat chronic pancreas disease, known as severe pancreatitis, resulted in shorter hospital stays, less need for opioids and fewer complications, compared with standard surgical approaches.
Many diabetes patients must inject themselves with insulin, sometimes several times a day, while others take medications orally to control blood sugar. The injections, as well as the side effects from both regimens, can be painful. Now, one team reports in the Journal of the American Chemical Society progress toward an insulin-free diabetes treatment that requires fewer injections.
New research further illuminates the surprising relationship between blood sugar and brain tumors and could begin to shed light on how certain cancers develop. While many cancers are more common among those with diabetes, cancerous brain tumors called gliomas are less common among those with elevated blood sugar and diabetes, a study from The Ohio State University has found. The discovery builds…
Approximately 30,000 organ transplants occur in the United States each year. However, between 20 and 50 percent—depending on the organ type—of the transplanted organs fail within five years, most often because the recipient’s immune system attacks, or “rejects,” the donated organ.
ETH Researchers have used the simplest approach yet to produce artificial beta cells from human kidney cells. Like their natural model, the artificial cells act as both sugar sensors and insulin producers.
n type 1 diabetes, the body attacks its own insulin-producing cells. Scientists at Helmholtz Zentrum München, partner in the German Center for Diabetes Research, and their colleagues at Technical University of Munich have now reported in the journal ‘PNAS’ about a mechanism used by the immune system to prepare for this attack. They were able to inhibit this process through targeted…
It’s well known that cardiovascular disease (CVD) is the leading cause of death in the UK and worldwide. In the UK it is responsible for more than 73,000 deaths annually, affecting 1 in 6 men and 1 in 10 women. With the emergence of such startling statistics, this begs the question, why do routine cholesterol tests still rely on the basic biomarkers high density lipoprotein (HDL), low density…
Including a small amount of chocolate each day could help prevent diabetes type 2 and insulin resistance. That’s one of the research findings from the Luxembourg Institute of Health (LIH), the University of Warwick Medical School, the University of South Australia and the University of Maine.
Insulin deficiency and hyperglycemia are two well-known culprits behind diabetes, both of which are reflected in blood glucose concentrations. Now, researchers are working to create ultrasensitive lab-on-a-chip devices to quickly measure glucose concentrations with the goal of developing device for early diagnosis and prevent of diabetes.
A team of scientists at Helmholtz Zentrum München, in collaboration with Technische Universität München and the German Center for Diabetes Research (DZD), have shown in a preclinical model that specifically modified insulin mimetopes may lead to an immune tolerance. The results, published in ‘Nature Communications’, may be a step to improved prevention of type 1 diabetes.
In patients suffering from Type 1 diabetes, the immune system attacks the pancreas, eventually leaving patients without the ability to naturally control blood sugar. These patients must carefully monitor the amount of sugar in their blood, measuring it several times a day and then injecting themselves with insulin to keep their blood sugar levels within a healthy range. However, precise control…
Researchers have identified a mechanism that allows cancer cells to respond and grow rapidly when levels of sugar in the blood rise. This may help to explain why people who develop conditions in which they have chronically high sugar levels in their blood, such as obesity, also have an increased risk of developing certain types of cancer.
In addition to physical examinations, medical history laboratory test results are critical in almost all medical decisions made in the hospital. The demand for adequate, fast measurements has increased exponentially over at least the last 50 years and may have increased 100-fold, or more, since the 1950s. This could not have been achieved without the introduction of partial or full automation, of…
Findings demonstrate that testosterone is a metabolic hormone as well as a sex hormone, University at Buffalo researchers say.
Every year, worldwide, over a million patients have a pacemaker or defibrillator implanted. Home monitoring systems can significantly improve the safety and quality of life for these patients, says Professor Gerhard Hindricks, head physician in the rhythmology department at Leipzig’s Heart Centre. Report: Sascha Keutel
The University of Hawai'i Cancer Center discovery could warn patients years in advance allowing for a lifestyle change.
Scientists have evidence that Popeye was right: Spinach makes you stronger. But it’s the high nitrate content in the leafy greens — not the iron — that creates the effect.
A gap in scientific knowledge about a family of drugs that are used to treat Type 2 diabetes has been highlighted in a new study.
Researchers at Rice University and University of Texas MD Anderson Cancer Center have developed a way to mimic the conditions under which cancer tumors grow in bones.
Looking at measurements of the vertebrae – the series of small bones that make up the spinal column – in newborn children, investigators at Children’s Hospital Los Angeles found that differences between the sexes are present at birth. Results of the study in the August issue of the Journal of Pediatrics, suggest that this difference is evolutionary, allowing the female spine to adapt to the…
Fructose not only results in a lower level of satiety, it also stimulates the reward system in the brain to a lesser degree than glucose. This may cause excessive consumption accompanied by effects that are a risk to health, report researchers from the University of Basel in a study published in the scientific journal PLOS ONE. Various diseases have been attributed to industrial fructose in…
‘Health insurers should keep a tighter rein on the quality of endoscopic interventions because, mostly, they represent a gentler alternative to surgery,’ asserts international expert Horst Neuhaus, during an EH interview. Report: Daniela Zimmermann/Juliane Dannert
Painful insulin injections could become a thing of the past for the millions of Americans who suffer from diabetes, thanks to a new invention from researchers at the University of North Carolina and NC State, who have created a “smart insulin patch” that can detect increases in blood sugar levels and secrete doses of insulin into the bloodstream whenever needed.
This year’s German medical diagnostics manufacturers association (Verband der deutschen Diagnostica-Hersteller = VDGH) congress, focused on diabetes. The panel discussion that closed the evening session revealed unanimous support for the adoption of a German national diabetes plan. Report: Bettina Döbereiner
The focus of the 2015 Diabetes Congress held in Berlin this May was ‘Personalised diabetes treatment: innovative – individual – sustained’. EH reports on points aired during the supporting press briefing. Report: Bettina Döbereiner
Is your network safe? This loaded question made delegates shiver during Inforsalud 2015, the annual meeting of the Spanish Health Informatics Society, which was held Feb 17 - 18 in Madrid. Report: Mélisande Rouger
Research published in the open access journal Microbiome offers new evidence for the success of fecal microbial transplantation (FMT) in treating severe Clostridium difficile infection (CDI), a growing problem worldwide that leads to thousands of fatalities every year.
Despite a slight drop in sales in 2013 compared to the previous year, for 2014 the German medical diagnostics manufacturers anticipate a positive business development, according to the trend indicator presented by the business association Verband der Diagnostika-Industrie (VDGH) in Berlin.
Poor growth in the first three months of pregnancy is associated with a range of cardiovascular risk factors in childhood, finds a study published on bmj.com.
According to Molly Polen, at the AACC, great opportunities lie ahead for laboratory medicine and, to seize them, ‘meeting with colleagues and learning about new technologies is a critical first step. The 2013 AACC will provide these and other opportunities, such as informative sessions and live demonstrations of new technology.’
Bayer HealthCare supports local projects under the "Excellence across Borders" program in order to improve care of people with diabetes. Among the projects is a Diabetic School Awareness Program in the Kingdom of Saudi Arabia, which is planned to start in autumn this year.
The 2013 turnover expected by German in vitro diagnostics producers are significantly lower compared to last year, according to a survey of members carried out by the German Diagnostics Industry Association (VDGH) presented in January at the Diagnostica Forum in Berlin.
‘We aim to develop an understanding of which novel research activities could bring benefits for patients,’ explained Professor Christof von Kalle, Director of the Department of Translational Oncology, NCT (German National Centre for Tumour Diseases) and the German Cancer Research Centre (DKFZ), speaking on translational activities during the New Cancer Targets gathering in Heidelberg this…
Swedish researchers from the Karolinska Institutet managed to prevent onset of Type 1 diabetes in mice genetically susceptible to the disease by injecting them with specifically prepared cells.
Ensuring the safety of hospitalised patients is vital – and brought under a particularly strong focus in anaesthesiology. Launched in 2010, the Helsinki Declaration provided a further boost. Report: Holger Zorn
Anja Behringer reports on a neglected risk factor. With an aging population multimorbidity is increasingly a major challenge for hospital care. Diabetes is one of the medical conditions frequently encountered in multimorbid patients since cardiac and vascular diseases are often accompanied by dysfunctions of the blood sugar metabolism.
Meeting with EH editor Brigitte Dinkloh, Congress Secretary Professor Alexis Ulrich MD (left), Assistant Medical Director at the Clinic for General, Visceral and Transplant Surgery at the University of Heidelberg, outlined the scientific programme, discussed some impressive advances in surgical procedures, and explained why the gathering bears the slogan Surgery in Partnership.
Obesity is physically debilitating – and costly for healthcare. Losing excess weight has positive effects on the entire metabolism and improves life expectancy. However, for patients who cannot lose their morbid, excess weight through diet, today’s surgical interventions can help towards permanent weight loss – and reduction in insulin dependency for diabetics.
Dysglycaemia is a new term in critical care that recognises the vital importance for glucose monitoring of patients in the intensive care unit (ICU). Beyond the clinical consensus over this word for grouping critically ill patients with hyperglycaemia, hypoglycaemia or high blood sugar, there is no broad agreement on how best to manage these patients. Report: John Brosky.
September saw the international crème de la crème of bariatric surgery descend on Hamburg for the 16th World Congress of the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO 2011). Among their discussions: new minimally invasive procedures, the importance of aftercare and the lack of recognition of the importance of surgical treatment of the severely obese in…
High levels of chocolate consumption might be associated with a one third reduction in the risk of developing heart disease, finds a study published on bmj.com. The findings confirm results of existing studies that generally agree on a potential beneficial link between chocolate consumption and heart health. However, the authors stress that further studies are needed to test whether chocolate…
Professor Ulf Ahlgren and associates at Umeå University in Sweden are a leading research team in the world in the development of optical projection tomography. With the aid of this imaging technology, they have now described aspects of how the pancreas develops during embryonic development and how the so-called islets of Langerhans are distributed in the adult organ. The findings are important…
UHB is leading the way in creating key networks with other European centres of excellence to share knowledge between renowned specialists. The project is already enhancing the Trust’s profile as a focus of translational research in Service Delivery, Haematology, Liver Disease, Diabetes and e-Prescribing.
A modern-day childhood totally differs from what was common just a few decades ago. It is mostly spent sitting -- at school desks, in front of TV screens or before computer monitors – all combined with the sweet temptations of the kid’s food industry. According to a WHO worldwide estimate, an estimated 10% of school-age children between five and 17 years old are overweight or obese. The…
For three years the SWEET project, funded by the EU and the International Society for Paediatric and Adolescent Diabetes (ISPAD), has been preparing the establishment of centres of reference (CORs) for childhood diabetes. Now, the first 12 European CORs that are certified by SWEET have joined forces to promote improved cross-border cooperation in the treatment of young Type 1 and Type 2 diabetics.
Too much unhealthy food, too little exercise – the risk factors for the development of non-alcoholic fatty liver disease and Type 2 diabetes are not only similar but also form a life-threatening alliance.
France – Re-opening clogged arteries with metal stents has proved a life-saver for a majority of patients with coronary disease. Yet the high rates of complications and mortality for patients with diabetes following a percutaneous coronary intervention (PCI) continue to baffle cardiologists. Report: John Brosky
Since the German Federal Ministry of Health did not oppose the Federal Joint Committee (G-BA) decision to eliminate reimbursement for urine and blood sugar test strips for Type 2 diabetics not dependent on insulin from the services provided by statutory medical insurers, from this October test strips will only be prescribed in exceptional cases.
Morbid obesity is a chronic, lifelong, multifactorial, constitutional disease with negative medical, psychological, physical, social and economic side-effects. Obesity-related secondary diseases are Type 2 diabetes mellitus (T2DM), cardiovascular diseases such as hypertension or sleep apnoea. Report: Holger Zorn
Two small randomised trials published on bmj.com suggest that closed loop insulin delivery (also referred to as an artificial pancreas) may improve overnight blood glucose control and reduce the risk of nocturnal hypoglycaemia in adults with type 1 diabetes.
The International Diabetes Federation* (IDF) today launched the first ever Charter setting out the fundamental rights of more than 300 million people living with diabetes.
Metabolic syndrome, diabetes and vascular disease: What do we need to know? During ECR session this important question is addressed by vascular specialist Professor Erich Minar, Assistant Head of the Department of Angiology at the Vienna General Hospital (AKH), President of the Austrian Society of Angiology, and scientific researcher working closely with research centres in the USA.
To face the national and worldwide increase in diabetes mellitus cases, the German Federal Ministry of Education and Research initiated the foundation of the German Centre for Diabetes Research (DZD), aiming to improve basic research, prevention, diagnostic and therapy of diabetes. Inaugurated in Berlin a few months ago, the centre has five strategic partners.
Over the last 25 years overweight and obesity have become a global epidemic. According to WHO figures, at least 400 million adults are obese worldwide. Part of this phenomenon relates to lifestyle changes - lack of exercise, wrong eating habits - whereas genetic factors also play a role (according to twin studies, the determination of obesity is 70% nature and 30% nurture).
During intensive care, hyperglycaemia and insulin resistance are widespread in diabetics as well as non-diabetics. However, whether the normalisation of blood glucose levels with insulin therapy improves the prognosis of such patients is still debated. Karoline Laarmann reports
Although there is still disagreement as to ‘how’, when it comes to the question of whether the glucose level affects the prognosis for intensive care patients, the answer is a definite ‘yes’. ‘
Innumerable studies (e.g. Ceriello A., et. al. 2006) have shown that postprandial hyperglycaemia is an independent risk factor for cardiovascular disease (CVD) in all populations. In diabetics, according to IDF figures, CVD is even the major cause of death (some 50 % of all diabetes fatalities) and much disability. ‘Therefore, the primary goal in diabetes treatment should be not only lowering…
In November, European diabetologists converged on Leverkusen, Germany, to discuss current practices in diabetic management of Type 1 and Type 2 in adults, as well as new technologies, procedures and the need for patients’ education.
7,000 people from 120 countries met in Stockholm this September to hear international experts discuss the progress, solutions and challenges of one of our greatest healthcare burdens. Prevention, self-monitoring, surgery, guidelines, economic problems, drug-safety, and co-morbidities – these are just a few of the problems associated with the care of about 55 million diabetics in Europe.
Muscular diseases belong to a heterogeneous group with various causes like neurogenic, metabolic, dystrophic, or inflammatory mechanisms as well as channelopathies leading to disorders of the muscle cell membrane potential. In most progressive disease cases the result is a focal or general muscle weakness that, unfortunately, is a very unspecific symptom. Standard neuromuscular literature…
A nurse-initiated, nurse-led, and nurse-implemented study shows that nurses taking charge of diabetes care in hospital results in more patients hitting their target glucose levels. The study was led by Esther Boteach, Soroka University Medical Center Beer-Sheva, Israel, and co-workers.
Researchers have identified 12 new genes associated with Type 2 diabetes (T2D) that look set to improve the understanding of the processes underpinning the condition. The findings could also offer new biological pathways that can be explored as targets for new therapies to tackle T2D.
Drug company Novo Nordisk’s decision to pull its Mixtard 30 insulin drug from the UK could add almost €11 million to the NHS drugs bill in England alone, according to an editorial in the Drug and Therapeutics Bulletin (DTB). This decision could also leave thousands of patients dependent on others to help them take their insulin, said DTB, as it launched its Don’t Drop Mixtard 30 campaign in…
Does diabetes further increase the risk of death in patients diagnosed with cancer? A team at the Johns Hopkins School of Medicine in Baltimore, Maryland, has discovered something very sobering: Cancer patients are 51% to 85% more likely to die after surgical resection if they had pre-existing diabetes.
Dr Susan S Braithwaite, a visiting clinical professor in endocrinology at the Department of Medicine, University of Illinois, Chicago, specialises in the management of hyperglycaemia among hospitalised patients. Hyperglycaemia, the presence of an abnormally high concentration of glucose in the blood, is a common occurrence in adults who are hospital in-patients, especially among diabetic…
A team led by UK-based researchers has found that having diabetes doubles the risk of developing a wide range of blood vessel diseases, including heart attacks and different types of stroke. The consortium, headed by Dr Nadeem Sarwar and Professor John Danesh of the University of Cambridge, analysed data from the individual records on 700,000 people, each of whom was monitored for about a decade…
The daily management of diabetes mellitus is a complex interaction between blood glucose measuring, lifestyle aspects and drug therapy. Large epidemiological trials such as UKPDS (United Kingdom Diabetes Prospective Study) have shown that an optimal blood glucose adjustment has beneficial long-term effects on type-2 diabetics’ risk of micro- and macrovascular secondary complications.
Diabetes mellitus is a lingering disease – for a long time it causes subjectively few complaints or no complaints at all. Despite this, it is life-threatening – especially if undiagnosed, or diagnosed too late. However, although diabetes is the most widespread disease it is often only discovered by accident in a hospital, where many hospital doctors feel that diabetology is the responsibility…
An adequate blood glucose level (4–7 mmol/l) is important not only for a diabetic’s daily well-being but also to prevent diabetes-related illnesses. HbA1c is the central marker to evaluate the success of diabetes management. But HbA1c measurement has a crucial limitation: current blood glucose fluctuations are not taken into consideration. However, the recognition of steep post-prandial blood…
In 2009, the continuous glucose monitoring (CGM) market earned manufacturers $23.5; this is forecast to reach $52.0 million in 2016, according to a new analysis from Frost and Sullivan (F&S). For the study the markets covered by region are Benelux, Germany, France, Italy, Scandinavia, Spain and the United Kingdom.
Since February 2008, the Federal Joint Committee (G-BA) has been trying to exclude short acting insulin analogues completely from reimbursement by the statutory medical insurers. Why? Insulin analogues are 30% more expensive than human insulin.
Around 75% of adult type 1 and type 2 diabetics say they believe they know what their blood sugar levels are, without testing, according to data presented at the American Diabetes Association 70th Scientific Sessions. These results are important to consider because self-monitoring with a blood glucose meter is essential for people with diabetes to obtain accurate blood glucose results that guide…
A new method to produce insulin cheaply has been developed by researchers at the Helmholtz-Centre for Infection Research (HZI) in Braunschweig, in a German-Indo collaboration. The group’s results are published in the open access online research magazine Microbial Cell Factories. The data is freely accessible by anyone and is not subject to patent law.
Type 2 diabetics run an elevated risk of developing cancer, according to the world’s largest study on the combined risk of diabetes and cancer, conducted by scientists at the German Cancer Research Centre (DKFZ). The study focused on 24 types of cancer. The effect is most evident for liver cancer and pancreatic cancer. However, by contrast, diabetics have a significantly lower rate of prostate…
In type 2 diabetes, which is occurring at alarming rates, the hormone insulin does not work effectively to lower blood sugars and patients also do not make enough insulin. These two processes have been widely considered as separate. However, a surprising discovery was made by Joslin Diabetes Center researchers in animal models of diabetes: insulin is important in regulating its own production.…
According to estimates up to 450 million patients will suffer from diabetes in the year 2025 (currently 250 million). In view of this, glucose monitoring is of utmost importance. Scientific studies and practical experiences with glucose monitoring at the point of care (POC) were evaluated recently during a meeting of experts in Vienna.
A child's blood pressure, body mass index, blood glucose level and other laboratory tests and simple office measures may predict the risk of developing type 2 diabetes nine and 26 years later, according to a report in the January issue of Archives of Pediatrics & Adolescent Medicine, one of, one of the JAMA/Archives journals.
Western societies are struggling to pay for their ever increasing medical budgets. In the US up to 393 billion US-$ were spent in 2005 for cardiovascular diseases alone. Based on epidemiologic studies in primary prevention it is reasonable to estimate that 30% of coronary heart disease and stroke could be prevented by 2.5 hours of brisk walking per week.
Four different population-based studies, recently published in Diabetelogia, the journal of the European Association for the Study of Diabetes (EASD), examine a possible link between insulin glargine (brand name, Lantus) and cancer.
The fact that child diabetics (type I) in Russia do not receive necessary and qualitative therapy was again highlighted during the 7th Russian conference 'The priority national project - Health - and the tasks of children's endocrinologists' held in Saint-Petersburg this June.
Type 1 diabetes is a life-long autoimmune disease with onset in early childhood. The diagnosis will initially turn the everyday life of children and their families topsy-turvy due to blood glucose testing, insulin injections, thorough calculation of meals, etc. It takes time before all these new and often frightening procedures become part of the daily routine of small diabetics.
Common European guidelines for self-monitoring of blood glucose (SMBG) designed to improve glucose management in diabetics
HIV/AIDS has reached pandemic proportions. 35 million people are infected. Given the situation of hard pressed general practitioners (GPs) today, as well as geographical and other difficulties (as in Africa, for example), a new device that will enable HIV patients to monitor their own health and the effectiveness of treatments, without visiting their doctors so often, is indeed promising.
A telemedicine programme, run through Leicester University Hospitals since last November, allows parents and young patients with Type 1 diabetes to use their mobile phone to record blood sugar levels.
Professor Rudolf A Weiner, head of the surgical department at Sachsenhausen Hospital, Germany, reports that some developing procedures result not only result in weight loss but also in the systematic elimination of metabolic disorders, and that many new developments in the field promise hope for both the obese and their doctors
Allein in Deutschland müssen jährlich schätzungsweise vier Millionen Patienten mit chronischen Wunden versorgt werden. Eine Wundauflage, die von den Hohenstein Instituten in Bönnigheim im Rahmen eines Forschungsprojektes in Zusammenarbeit mit der Gesellschaft zur Förderung von Medizin-, Bio- und Umwelttechnologien e.V. (GMBU) in Dresden entwickelt wurde, eröffnet…
A wound compress is being developed at the Hohenstein Institute in Boennigheim, Germany, that could pave the way for new treatment opportunities. The new wound compress would integrate and continually deliver effective ingredients on the basis of nanosol technology. The technique speeds up healing, simplifies treatment and reduces the amount of time required for care.
In a strategic move intended to enhance the global launch of its 'groundbreaking' diabetes monitoring device, set to help combat the 'worldwide epidemic', the US company Sensys Medical has chosen to relocate its world headquarters to the United Kingdom (UK).
A panel of experts, convened by the American Diabetes Association and the European Association for the Study of Diabetes, has issued updated treatment recommendations for type 2 diabetes, in a consensus statement published online in two journals: Diabetes Care and Diabetologia*.
Diabetes presents a special challenge for the young. Here we see how a young Swiss girl has successfully come to terms with her metabolic disorder. A true life story from Bayer HealthCare Diabetes Care (BayNews)
Die erste am Universitätsklinikum Carl Gustav Carus vorgenommene Transplantation von Inselzellen aus einer Bauchspeicheldrüse verlief erfolgreich: Zwei Wochen nach dem Eingriff bildet die seit 51 Jahren an Diabetes Typ 1 erkrankte Patientin wieder körpereigenes Insulin. Die Transplantation ist Ergebnis einer über zwei Jahre dauernden, aufwendigen Aufbauarbeit an Uniklinikum und Medizinischer…
Researchers have discovered a potential new treatment for diabetes by isolating and killing defective cells which prevent the natural production of insulin. The investigation opens the door to a potential therapy for patients with type 1 diabetes.
ESC speaker John Cleland from the University of Hull, UK, sumed up the latest treatment available for patients with diabetes mellitus and expressed his worries about side-effects and efficacy of available anti-diabetic drugs. If you want to read his ESC abstract, just click the “read more” button.
Approximately 31 million people in the European Union are suffering from diabetes, a devastating disease with severe consequences for patients and their families, but also for the society at large and the economic prosperity of Europe. This week EH Online will focus on innovative strategies in diabetes care and on new management systems to support physicians and patients alike. Moreover, we will…
Bayer HealthCare Diabetes Care unveiled the new CONTOUR® blood glucose meter with enhanced testing features at the 44th Annual Meeting of the European Association for the Study of Diabetes in Rome, Italy.
Researchers at Linköping University and Uppsala University in Sweden can show that accumulation of protein aggregatess, amyloid, in the transplanted cells may be causing their death. With the aid of their results, physicians can enhance survival of islets transplants and improve treatment of type 1 diabetes.
According to a study conducted by researchers at the University of Zurich and the Zurich University Hospital the answer is: Yes. They demonstrated that one injection per month sufficed to improve blood sugar levels significantly. Even more: The insulin production of the patients improved.
French findings support the notion that gastric bypass can rapidly reverse diabetes symptoms' a side-effect that lap-band surgery does not show. The benefit results from a new-found element of glucose production by the intestine which also increases insulin sensitivity and lowers blood sugar.
The inverse epidemiological association between serum levels of HDL-C and risk of coronary artery disease (CAD) is graded and has been validated in multiple studies. However, there is remaining controversy whether a low HDL-C should not predominantly be considered a marker of poor lifestyle (obesity, lack of exercise, hypertriglyceridemia, diet, etc.), rather than a primary causal agent for…
Lifestyle and risk factor results show that recommended scientific guidelines form a contrast to what is achieved in daily practice in high risk individuals in primary prevention of CVD. Together with its partners the ESC demands a comprehensive and multisdicplinary primary prevention programme involving the high-risk population, their GP's and other health professionals, a health insurance…
The new Contour blood glucose meter from Bayer HealthCare Diabetes Care promises enhanced testing features that can be personalised to meet diabetics individual treatments. The firm has also redesigned the Microlet 2 lancing system.
Unlike regular laboratory analyses, which is performed by clinical pathologists and technicians in the clinical laboratory, Point of Care Testing (POCT) are devices to perform laboratory analyses in the vicinity of the patient by the attending physician or nurses.
This week not only one but rather two studies report about a new and independent marker that is associated with type 2 diabetes. The protein that is called fetuin-A is produced in the liver and secreted to the blood stream also indicates a higher risk of developing diabetes disease.
Bayer loves sports. Therefore it developes medical devices to work under extremes. Recently extrem-athlete and diabetic Geri Winkler conquered the Seven Summits - a group of mountains comprising the highest peaks on each of the seven continents. The blood glucose monitoring system from Bayer HealthCare is always with him.
Despite Hurricane Amma storming over Prague, hundreds of medical specialists paid little attention when they attended the 1st International Conference on Advanced Technologists and Treatments for Diabetes (ATTD), observed our Russian correspondent Olga Ostrovskaya, reporting on the International Conference on Advanced Technologies & Treatments for Diabetes (ATTD) in Prague (ATTD) held in…
By Professor Jean-Charles Preiser MD PhD, of the Department of General Intensive Care, University Hospital Centre, University of Liege, Belgium
Presented during a symposium at Langenbeck-Virchow-Haus, in Berlin, the European CLINICIP research project aims to develop a method to improve glycaemic control during intensive care and provide a low-risk monitoring and control system that can control the metabolism of the critically ill
Heidelberger-Medical-Marketing GmbH (HMM) presented the first CE-Certified and EU-Registered blood glucose meter for self-monitoring with Bluetooth technology, the smartLABgenie at Medica on Wednesday.
The Hamburg-based company seca has specialized in the manufacture of weighing and height measuring scales for over 165 years. Today, the firm has locations in Switzerland, the UK, France, Japan, China, Mexico and the USA, and manufactures products in Germany, the Czech Republic and China, and exports its range of products - which include infant, column and flat scales, with height measuring…
Omega-3 may protect children at high risk of developing type 1 diabetes, according to a study published in the Journal of the American Medical Association.
Born in 1891, Canadian Sir Frederick Banting was destined to become a medical scientist and Nobel Prize winner for work that led to the discovery of insulin. World Diabetes Day, held on his birthday, aims to sensitise the public - including potential patients - to this condition. Worldwide, around 245 million people suffer Diabetes mellitus. With 5.3 million of them in Germany, the country's…
Professor Oliver Schnell, of the Diabetes Research Institute, Munich, reports on discussions and findings of a panel of diabetes experts who met this summer in Switzerland
In Europe, more than ten million people suffer from diabetes mellitus, 90 percent of whom have diabetes type II.
Researchers from the Robert Gordon University in Aberdeen, UK, presented a study at The British Pharmaceutical Conference, held from 10th to 12th September, 2007, at Manchester Central, showing that a chemical coating is able to encapsulate and protect insulin against enzymes that usually break down the hormone in the gastrointestinal tract.
Phosphagenics' TPM uses natural dermal transport mechanisms to deliver a dose of medication through the skin into the bloodstream. Now a Phase 1b transdermal insulin trial was completed successfully.
Already in 1993, the world market for contrast media was thought to be worth $ 3 billion. In 2001, an astonishing 12.2 million contrast medium-supported CT studies were carried out in Europe alone. Currently, the overall sales of contrast media are estimated to rise to $ 915 million in Europe in 2008.
A convenient technology to quantify three-dimensional (3D) morphological features would have widespread applications in biomedical research. Now, researchers from Umea University in Sweden presented a new method for 3D imaging and quantification of biological preparations ten times larger than the limit for traditional confocal microscopes.
Obesity is a burgeoning nightmare for everyone involved in healthcare delivery. New treatment possibilities can help to solve this probelm.
An application report by assistant plastic surgeon Thomas Aigner, and F Weyer, of the Department of Plastic, Aesthetic and Reconstructive Surgery, at St. Polten Hospital, Austria
It occupies approximately the same space as one to three atoms.
Recent advances in percutaneous coronary intervention (PCI) may offer a new approach to treating this complex group of patients.
25,000 visitors and medical professionals from 47 National Cardiac Societies across central and greater Europe, will attend the 2004 ESC Congress, where 'Diabetes and heart disease' will be the main theme. Lars Ryden, ESC Past-President, team member for the Euro-Heart Survey on Diabetes, and Chairman of the 'Guidelines for Diabetes & the Heart', and William Wijns, co-chair and Chairman of the…
UK - A hand-sized, electronic peak flow meter, which measures lung capacity and can be connected to a PDA mobile handset is being tested for use by asthma sufferers.