Images of macrophages (red) in which the active substance (green) is...
Images of macrophages (red) in which the active substance (green) is distributed. On the left, the active substance heparin is shown, on the right hyaluronic acid.

Photo: Hala Al Khoury

News • Anti-inflammation

Can special coatings reduce complications after implant surgery?

New coatings on implants could help make them more compatible.

Researchers at the Martin Luther University Halle-Wittenberg (MLU) have developed a new method of applying anti-inflammatory substances to implants in order to inhibit undesirable inflammatory reactions in the body. Their study was recently published in the "International Journal of Molecular Sciences".

This is kind of tricky, because we obviously do not want to completely turn off the immune system as its processes are vital for healing wounds and killing pathogens

Thomas Groth

Implants, such as pacemakers or insulin pumps, can in some cases cause complications after implantation. The immune system identifies the implant as a foreign body and attempts to remove it. "This is actually a completely natural and useful reaction by the immune system," says Professor Thomas Groth, a biophysicist at MLU. It helps to heal wounds and kills harmful pathogens. If this reaction does not subside on its own after a few weeks, it can lead to chronic inflammation and more serious complications. "The immune system attracts various cells that try to isolate or remove the foreign entity. These include macrophages, a type of phagocyte, and other types of white blood cells and connective tissue cells," explains Groth. Implants can become encapsulated by connective tissue, which can be very painful for those affected. In addition, the implant is no longer able to function properly. Drugs that suppress the immune response in a systemic manner are often used to treat chronic inflammation, but may have undesired side effects.

Thomas Groth’s team was looking for a simple way to modify the immune system’s response to an implant in advance. "This is kind of tricky, because we obviously do not want to completely turn off the immune system as its processes are vital for healing wounds and killing pathogens. So, in fact we only wanted to modulate it," says the researcher. To do this, his team developed a new coating for implants that contains anti-inflammatory substances. For their new study, the team used two substances that are already known to have an anti-inflammatory effect: heparin and hyaluronic acid.

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Sponsored • The Heraeus Symposium at DKOU

Challenges of periprosthetic infection

Periprosthetic joint infection (PJI) is on the increase internationally. In Germany, for example, around 14,500 cases of PJI in hip and knee replacements occur annually. 5,100 of those are caused by multidrug resistant pathogens. ‘Eighty-seven percent of those affected die within five years,’ orthopaedic surgeon Professor Rudolf Ascherl MD pointed out during the Heraeus Symposium held at the…

In the laboratory, the scientists treated a surface with the two substances by applying a layer that was only a few nanometres thick. "The layer is so thin that it does not affect how the implant functions. However, it must contain enough active substance to control the reaction of the immune system until the inflammatory reaction has subsided," adds Groth. In cell experiments, the researchers observed how the two substances were absorbed by the macrophages, thereby reducing inflammation in the cell cultures. The untreated cells showed clear signs of a pronounced inflammatory reaction. This is because the active substances inside the macrophages interfere with a specific signalling pathway that is crucial for the immune response and cell death. "Both heparin and hyaluronic acid prevent the release of certain pro-inflammatory messenger substances. Heparin is even more effective because it can be absorbed by macrophage cells," Groth concludes.

So far, the researchers have only tested the method on model surfaces and in cell cultures. Further studies on real implants and in model organisms are to follow.


Source: Martin-Luther-University Halle-Wittenberg (MLU)

01.07.2020

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