In an unconventional, but promising approach to treat neurological conditions like Parkinson, researchers use nanoscale magnetic pull to rebuild lost conncections between brain cells.
Molecular markers in saliva could reveal the risk of a person developing major diseases such as cancer, cardiovascular diseases, diabetes and neurodegenerative diseases, new research finds.
In a world first, researchers have identified a set of biomarkers that could someday make it easy to spot Parkinson's disease in a patient’s blood sample.
Movement disorders often show overlapping symptoms, making it difficult for doctors to make the correct diagnosis. A new AI tool could help distinguish between different disorders, such as tremor and myoclonus.
Researchers from Université Laval discovered that the retina of people with Parkinson's disease responds differently to light than that of healthy people. This offers new diagnostic options.
Using vibrations to help people living with Parkinson's disease regain motor control: Engineering students have created a special glove that aims to reduce the symptoms of the condition.
A new study found that a significant proportion of Parkinson's disease diagnoses are later corrected. The results demonstrate the need for improved diagnostic processes.
Using the COX-2 enzyme, a new PET imaging approach offers a never-before-seen view of inflammation in the brain, opening the door for clinical and research settings for various brain disorders.
To suppress tremors, such as those from Parkinson's disease, scientists equipped a biorobotic arm with artificial muscles, which compensate for the back-and-forth movement of the tremor.
Playing video games to recover hand and wrist mobility? A new system of exergames demonstrates the potential for rehabilitation while providing therapists with data to analyse patients’ progress.
Promising insights into amyotrophic lateral sclerosis (ALS): New research links characteristic symptoms of the disease, such as motor impairment and respiratory issues, to sleep disorders.
New insights on the degradation of implantable chips in the body could lead to enhanced longevity of the chips and better treatments for patients with Parkinson's or clinical depression.
More than just a sports injury: A new study shows that head trauma may activate latent viruses, leading to neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease.
Researchers uncovered a surprising link between Alzheimer’s disease and herpes simplex virus-1 (HSV-1), suggesting that viral infections may play a role in the disease.
Skills shortages and digitalization, trends in cardiology and oncology, future prospects in laboratory medicine, and healthy aging – these pressing topics are at the forefront of discussions at this year’s Medica Labmed Forum.
New research suggests that transcranial ultrasound stimulation (TUS) could be used to help people with pain, alcoholism, OCD, and Parkinson’s disease, without drugs or surgery.
Acute kidney injury not only affects the kidneys, but can also impact brain health, leading to an increased risk for developing dementia. This is according to a new study from Sweden.
Researchers discovered a gene that might be a key factor in the progression of Huntington’s disease in organoids. The gene may contribute to brain abnormalities much earlier than previously thought.
Toxoplasma gondii is a parasite with the ability to infect the brain, causing life-threatening diseases. Researchers now want to harness its properties to advance treatment of cognitive disorders.
A novel blood test shows promise to predict Parkinson's disease in risk patients up to seven years before the typical motor symptoms appear.
Researchers have developed a technology for targeted stimulation of the brain with ultrasound. This could be used to treat diseases and conditions such as epilepsy, Parkinson’s disease, depression, addiction, and even the aftereffects of stroke.
New robotic technology could pave the way for more precise MRI-guided stereotactic surgery, for example by assisting with cannula/needle targeting during deep brain stimulation (DBS) interventions.
Structural differences in male and female brains might explain why women are more prone to concussions and experience longer recovery from the injury than men, according to a new preclinical study.
With a field strength of 11.7 T, the Iseult MRI machine currently is the most powerful scanner of its kind. Now, the first images of a living human brain showcase impressive resolution.
Researchers have now shown that a noninvasive treatment that stimulates gamma frequency brain waves may hold promise for treating memory impairment and other cognitive effects of chemotherapy.
Researchers have found a surprising method to reduce blood glucose levels in a person: Shining red light on their back. This could help control diabetes without medication.
Three disease subtypes, based on causes rather than symptoms: A new classification model for Parkinson's disease aims to pave the way for better diagnostics and therapies.
A team of researchers has developed a handheld, non-invasive device that can detect biomarkers for Alzheimer’s and Parkinson’s Diseases. The biosensor can also transmit the results wirelessly.
Could a single biomarker detect all types of diseases related to dopamine deficiency in the brain? According to a Swedish research group, such a marker may have just been found.
It had long been recognized that the brain was made up of two types of cells, neurons and glial cells. Now, neuroscientists discovered an additional type - with huge implications for brain disorders.
Japanese researchers have found that natural language processing might be an effective tool to analyze specific speech changes of patients with Parkinson's disease, allowing for better diagnosis.
Researchers at the University of Helsinki have demonstrated that certain strains of Desulfovibrio bacteria are the likely cause of Parkinson’s disease in most cases.
For decades, researchers have marveled at the ability of glioblastoma, a particularly aggressive brain cancer, to turn off a patient's cancer-fighting immune cells, thereby allowing tumors to grow freely.
Researchers at the University of Campinas and the Federal University of São Carlos in Brazil have developed an electrochemical sensor that detects Parkinson's disease at different stages.
The newly founded UK Focused Ultrasound Foundation is dedicated to advancing the development and adoption of the technology, which can be used to non-invasively treat tissue deep in the body.
Are climate change and air pollution making neurologic diseases like headaches, dementia and multiple sclerosis (MS) worse? A scoping review of research explores the connection.
Treatment of central nervous system diseases and tumors is often hindered by the blood-brain barrier. A new method aims to overcome this obstacle using focused ultrasound intranasal delivery (FUSIN).
Swiss researchers have demonstrated how sensors could help detect health problems in the elderly at an early stage. This could help seniors to live a self-determined life at home for longer.
A device with the appearance of a Wi-Fi router uses a neural network to discern the presence and severity of one of the fastest-growing neurological diseases in the world: Parkinson's.
A new understanding of the 'swallow-tail', an anatomical landmark in the brain, could pave the way for earlier detection of Parkinson's disease.
Striving to improve the patient’s quality of life after laryngectomy, researchers conducted a study, during which they searched for pathologies in patients’ voices using artificial intelligence (AI).
A sensor identifies misfolded protein biomarkers in the blood. This offers a chance to detect Alzheimer's disease before any symptoms occur. Researchers intend to bring it to market maturity.
Copper exposure in the environment and the protein alpha-synuclein in the human brain could play an important role in the pathogenesis of Parkinson's disease, researchers found.
Researchers visualize brain inflammation using diffusion-weighted MRI. This detailed "X-ray" of inflammation cannot be obtained with conventional MRI, but requires data acquisition sequences and special mathematical models.
A research team in Spain and the US has created 3D-printed acoustic holograms to improve the treatment of diseases like Alzheimer's and Parkinson's, among others.
Ultra-powerful 7T MRI scanners could be used to help identify patients with Parkinson’s disease and similar conditions who are most likely to benefit from new treatments, say scientists.
A significant number of Covid-19 neurological complications – such as fatigue, headache, and cognitive impairment – are ultimately reversible, according to new research.
An anti-inflammatory drug incorporated into the coating around an implantable electronic medical device – such as a pacemaker – can reduce the body’s "foreign body" reaction.
Researchers pinpoint a sound-sensitive mammalian protein that lets them activate brain, heart or other cells with ultrasound.
Cleveland Clinic has launched a landmark study to better understand why millions of people around the world suffer from brain diseases, with the goal of pinpointing disease biomarkers early, well before clinical symptoms present themselves.
Connecting the brain with a machine has been a powerful dream of mankind. What used to be science fiction, from the Borg in Star Trek to the Matrix, has become mainstream thanks to Elon Musk and Mark Zuckerberg who have put their entrepreneurial commitments into the area of neurotechnology. Recently, Professor Surjo R. Soekadar outlined current and upcoming applications of brain-computer…
The joint research team of Prof. Hongsoo Choi (DGIST) & Prof. Sung Won Kim (Seoul St. Mary’s Hospital), developed an hNTSC-based microrobot for minimally invasive delivery into the brain tissue via the intranasal pathway.
Since Compamed could only be held digitally last year, due to the pandemic, the event now takes place publicly again. Almost 500 registrations from exhibitors prove that there is a high level of interest from medical technology suppliers – a huge step towards reaching normality again.
Treating diseases such as Alzheimer’s or Parkinson’s is a challenge because drugs have to be able to cross the blood–brain barrier. As a result, the doses administered must be high and only a small fraction reaches the brain, which can lead to significant systemic side effects.
For the first time, researchers have used human data to quantify the speed of different processes that lead to Alzheimer’s disease and found that it develops in a very different way than previously thought. Their results could have important implications for the development of potential treatments.
Researchers at Durham University are working on a new infrared light therapy that might have the potential to help people with dementia. In the approach, people wear a specially adapted helmet which delivers infrared light deep into the brain for six-minutes per treatment. This stimulates mitochondria that generate most of the chemical energy needed to power the biochemical reaction in the…
Researchers at Lund University in Sweden have developed a completely new stimulation method, using ultra-thin microelectrodes, to combat severe pain. This provides effective and personalised pain relief without the common side effects from pain relief drugs. The study, which was conducted on rats, has been published in the research journal Science Advances.
According to new research, vaccinated people are at greatest risk from severe Covid-19 leading to hospitalisation or death from 14 days post the second dose vaccination, when substantial immunity should be expected.
A novel method of gene therapy is helping children born with a rare genetic disorder called AADC deficiency that causes severe physical and developmental disabilities. The study, led by researchers at The Ohio State University Wexner Medical Center and The Ohio State University College of Medicine, offers new hope to those living with incurable genetic and neurodegenerative diseases.
A team of engineers and clinicians has developed an ultra-thin, inflatable device that can be used to treat the most severe forms of pain without the need for invasive surgery. The device, developed by researchers at the University of Cambridge, uses a combination of soft robotic fabrication techniques, ultra-thin electronics and microfluidics.
Neurological disorders such as Parkinson’s disease and epilepsy have had some treatment success with deep brain stimulation, but those require surgical device implantation. A multidisciplinary team at Washington University in St. Louis has developed a new brain stimulation technique using focused ultrasound that is able to turn specific types of neurons in the brain on and off and precisely…
Brown University researchers have developed a technique that could allow deep brain stimulation devices to sense activity in the brain and adjust stimulation accordingly.
Researchers from ETH Zurich and University of Zurich have developed a new microscopy technique that lights up the brain with high resolution imagery. This allows neuroscientists to study brain functions and ailments more closely and non-invasively.
A new idea for treating Alzheimer’s disease could eradicate the toxic proteins most closely linked to cognitive decline in the places where they do the most damage, a study from researchers at Columbia University Vagelos College of Physicians and Surgeons suggests. The study was published online in Science Translational Medicine.
A new low-cost method targeting genetic mutations often missed by existing diagnostic approaches has been developed. Researchers at Virginia Commonwealth University (VCU) in the United States noted that most rearrangement mutations implicated in cancer and neurological diseases fall between what can be detected by DNA sequence reads and optical microscopy methods. The new technique combines…
Kobe University Hospital’s Dr. Makoto Nishimori and Project Assistant Professor Kunihiko Kiuchi et al. (of the Division of Cardiovascular Medicine, Department of Internal Medicine) have developed an AI that uses multiple kinds of test data to predict the location of surplus pathways in the heart called ‘accessory pathways’, which cause the heart to beat irregularly. In this study, the…
At a cost of $38 billion a year, an estimated 5.3 million people are living with a permanent disability related to traumatic brain injury (TBI) in the United States today, according to the Centers for Disease Control and Prevention. The physical, mental and financial toll of a TBI can be enormous, but new research from the University of Georgia provides promise. In a new study, researchers at…
Skin swab samples analysed using mass spectrometry could be used to detect Covid-19 in patients, according to research conducted at the University of Surrey in the UK. Current Covid-19 testing is via a polymerase chain reaction (PCR) test, which involves taking a swab of the back of the throat and inside the nose, but the team from Surrey - working with Frimley NHS Trust and the Universities of…
Parkinson’s disease (PD) usually causes facial abnormalities that affect a person’s self-esteem and relationships. However, these abnormalities are difficult to analyze quantitatively with current methods. To address this issue, scientists from Okayama University, Japan, explored whether commercial AI-based facial analysis software could be useful in this context. Their results show that…
The German Center for Neurodegenerative Diseases (DZNE) and Eisai Co., Ltd. announced that both parties have entered into a research collaboration agreement aiming to create potential novel treatments for neurodegenerative disorders including Alzheimer’s disease (AD) which modulate immune competence in neurons and glia cells.
It is possible to identify Parkinson’s Disease based on compounds found on the surface of skin, according to new research. The findings offer hope that a pioneering new test could be developed to diagnose the degenerative condition through a simple and painless skin swab. Scientists at The University of Manchester have developed a technique which works by analysing compounds found in sebum -…
Grafting neurons grown from monkeys’ own cells into their brains relieved the debilitating movement and depression symptoms associated with Parkinson’s disease, researchers at the University of Wisconsin–Madison report. In a study published in the journal Nature Medicine, the team describes its success with neurons made from induced pluripotent stem cells from the monkeys’ own bodies.…
In many ways, our brain and our digestive tract are deeply connected. Feeling nervous may lead to physical pain in the stomach, while hunger signals from the gut make us feel irritable. Recent studies have even suggested that the bacteria living in our gut can influence some neurological diseases. Modeling these complex interactions in animals such as mice is difficult to do, because their…
A scalpel-free alternative to brain surgery has the potential to benefit people with Parkinson’s disease symptoms that are much more severe on one side of the body, new research suggests. More testing is needed, but the approach, which uses a technology called focused ultrasound, could offer a new option for patients whose symptoms are poorly controlled by medications and those who cannot or do…
In the past few decades, researchers have identified biological pathways leading to neurodegenerative diseases and developed promising molecular agents to target them. However, the translation of these findings into clinically approved treatments has progressed at a much slower rate, in part because of the challenges scientists face in delivering therapeutics across the blood-brain barrier (BBB)…
To target ionised radiation as precisely as possible, imaging a tumour is vital in radiotherapy planning. ‘Today, imaging is used increasingly during the therapy itself,’ explained Professor Mark Ladd during the 51st annual meeting of the German Society for Medical Physics (DGMP).
Italian neurosurgeon Professor Francesco Di Meco, explored the current and potential role of intra-operative ultrasound in neurosurgical oncology during the annual meeting of the European Association of Neurosurgical Societies (EANS) this October. The extent of resection is considered a prognostic factor in operative neuro oncology surgery and image-guided surgery is being regarded as one of the…
MEDICA in Düsseldorf is a world-leading platform for the medical technology business and the healthcare industry and has always been one of the places to be for the entire sector as it covers current digital health trends, innovative products and services for linking all of the major stakeholders in medical care. Consequently, digital health is a mainstay of virtual.MEDICA, which, due to the…
The Focused Ultrasound Foundation (FUS) has published its 2020 State of the Field Report, a 63-page annual update detailing new potential indications, laboratory research, clinical trials, treatments and growth in worldwide procedures performed in 2019.
Scientists have unearthed a possible link between the severity of COVID-19 and air quality. The preliminary study – looking at whether areas with higher levels of air pollutants in England are associated with a larger number of cases/deaths from COVID-19 – was conducted by a team from the University of Cambridge. Aware of the effects that air pollutants have on human health – and that…
Although the name may suggest otherwise, Parkinson's disease is not one but two diseases, starting either in the brain or in the intestines. Which explains why patients with Parkinson’s describe widely differing symptoms, and points towards personalised medicine as the way forward for people with Parkinson's disease. This is the conclusion of a study which has just been published in the leading…
Pupil size predicts death and hospital readmission in patients with heart failure, according to new research. “Our results suggest that pupil area is a novel way to identify heart patients at elevated risk of death or hospital readmission,” said study author Dr. Kohei Nozaki of Kitasato University Hospital, Kanagawa, Japan. “This provides an opportunity to intervene and improve outlook.”
Recently developed MRI techniques used to more precisely target a small area in the brain linked to Parkinson's disease and essential tremor may lead to better outcomes without surgery and with less risk of negative effects, a new study led by UT Southwestern researchers suggests.
New imaging technique combines two technologies to spot early warning signs of Alzehimer's disease in mice.
Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury—a first-ever “biomarker” for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve…
Diabetes is called an incurable disease because once it develops, it does not disappear regardless of treatment in modern medicine. Having diabetes means a life-long obligation of insulin shots and monitoring of blood glucose levels. Recently, a research team at Pohang University of Science and Technology developed a wirelessly driven ‘smart contact lens’ technology that can detect diabetes…
Researchers at Karolinska Institutet and the University of North Carolina have mapped out the cell types behind various brain disorders. The findings are published in Nature Genetics and offer a roadmap for the development of new therapies to target neurological and psychiatric disorders.
Researchers in The University of Texas at El Paso’s (UTEP) Department of Chemistry and Biochemistry have developed a nanohybrid vehicle that can be used to optimally deliver drugs into the human body. The research was published in ACS Applied Materials & Interfaces. Leading the study are Mahesh Narayan, Ph.D., professor, and Sreeprasad Sreenivasan, Ph.D., assistant professor, both from the…
University of Liverpool researchers have used a newly developed eye movement test to improve the understanding of how parts of the brain work. Healthy, older adults are widely reported to experience cognitive decline, including impairments in inhibitory control (the ability to stop ourselves thinking or doing things). However, because ageing effects on inhibitory control are highly variable…
The body can recover from many things, but the damage caused by Parkinson’s disease isn’t one of them. No cure exists for Parkinson’s, which 1 million people in the U.S. are expected to be living with by 2020. But an outright cure isn’t the primary objective of research by Chongli Yuan, a Purdue University chemical engineering professor and leader of Purdue’s section of a…
Parkinson’s and multisystem atrophy (MSA) – both of them neurodegenerative diseases – are associated with the accumulation of alpha-synuclein proteins in the brain. Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the Max Planck Institute for Biophysical Chemistry (MPI-BPC) have investigated the molecular makeup of these protein deposits finding structural…
A protein newly discovered by scientists in China is aiding in the dramatic reversal of stroke-like damage in laboratory animals and may one day rescue humans from neurological injury, the research team is predicting.
Researchers have created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer’s and Parkinson’s diseases and other neurological disorders.
For the first time, scientists have found a way that can effectively transport medication into the brain - which could lead to improved treatments for neurological and neurodegenerative diseases. In a study, scientists from Newcastle University have led an international team in a major breakthrough in unlocking the secrets of how medications can infiltrate the brain.
We all know someone affected by the battle against cancer. And we know that treatments can be quite efficient at shrinking the tumor but too often, they can’t kill all the cells, and so it may come back. With some aggressive types of cancer, the problem is so great that there is very little that can be done for the patients.
Neonatal exposure to nicotine alters the reward circuity in the brains of newborn mice, increasing their preference for the drug in later adulthood, report researchers at University of California San Diego School of Medicine in a study published in Biological Psychiatry. A UC San Diego School of Medicine team of scientists, headed by senior author Davide Dulcis, PhD, associate professor in the…
A new study provides critical insight into a little-known, yet relatively common, inherited neurological condition called Charcot-Marie-Tooth disease (CMT). The findings point to a pathway to possible treatments for this disease and better understanding of other neurodegenerative disorders, including Alzheimer's disease, that affect millions. The study focused on two related proteins, MFN2 and…
A study has identified chemicals in the skin responsible for a unique scent in people with Parkinson’s disease. The chemicals can be detected in an oily substance secreted from the skin called sebum, the researchers found. The findings suggest Parkinson’s disease could one day be diagnosed from skin swabs, potentially leading to new tests. There are no tests for Parkinson’s disease at…
According to the Swedish Knee Arthroplasty Register, knee arthroplasty – with a revision rate of five percent after ten years – is one of the most successful surgical interventions of the post-World War II decades. The most frequent reasons for revision are loosening or infections, whereas patient dissatisfaction is often caused by mobility impairment and pain. Since many adverse events are…
Poor sleep has long been linked with Alzheimer’s disease, but researchers have understood little about how sleep disruptions drive the disease. Now, studying mice and people, researchers at Washington University School of Medicine in St. Louis have found that sleep deprivation increases levels of the key Alzheimer’s protein tau. And, in follow-up studies in the mice, the research team has…
A new neurostimulator developed by engineers at the University of California, Berkeley, can listen to and stimulate electric current in the brain at the same time, potentially delivering fine-tuned treatments to patients with diseases like epilepsy and Parkinson's. The device, named the WAND, works like a "pacemaker for the brain," monitoring the brain's electrical activity and…
Siemens Healthineers and Insightec announce the CE clearance of Exablate Neuro compatible with Magnetom Skyra, Prisma and Prisma Fit scanners from Siemens Healthineers. Exablate Neuro uses focused ultrasound for treatments deep within the brain with no surgical incisions. MR imaging provides a complete anatomical survey of the treatment area, patient-specific planning and real-time outcome…
One in two women and one in three men will likely be diagnosed with dementia, Parkinson's disease, or stroke in their lifetime, estimate Dutch researchers in an observational study
A drug which has been used to treat liver disease for decades could help to restore cells damaged by Alzheimer's, a new study from the University of Sheffield has found. The pioneering study discovered the drug ursodeoxycholic acid (UDCA) improves mitochondrial dysfunction – which is known to be a causative factor for both sporadic and familial Alzheimer's disease.
A team of neurobiologists has identified a novel neuronal circuit in the midbrain that gates fear learning. They think that associative learning of fear is mediated by a novel dopamine circui.
The way you walk can reveal current and future health problems. New research from Halmstad University suggests the use of wearable sensors for analysing your movement. This can potentially result in early detection of for example Parkinson’s disease, dementia, multiple sclerosis and other neuro-physiological disorders. Many of our body systems, such as the cardio-vascular system and the…
The first patient in a multicenter pivotal trial using focused ultrasound to address the major motor symptoms of Parkinson’s disease has been treated at Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center in New York. This randomized, double-blind clinical trial is evaluating the safety and efficacy of using Insightec’s Exablate Neuro device in more than 100 patients…
Gadolinium-containing/gadolinium-based contrast agents (GCCAs/GBCAs) and their usage was a major topic at ECR 2018. Fuelled by the current debate a number of presentations focused on possible impact, risks and necessities. Some were highly specific, others took a broader view. The only consensus, however, seems to be the need for more research and the focus on safety. Three ECR speakers, Joseph…
Alzheimer’s, Parkinson’s and Huntington’s disease may have more in common than their effects on the functions of the brain and spinal cord. And finding that common thread could lead to a treatment that could work for all three. A recent study by David Smith, associate professor of biochemistry in the West Virginia University School of Medicine, suggests that at the heart of all three…
Until very recently, Parkinson’s had been thought a disease that starts in the brain, destroying motion centers and resulting in tremors and loss of movement. New research published this week, shows the most common Parkinson’s gene mutation may change how immune cells react to generic infections like colds, which in turn trigger the inflammatory reaction in the brain that causes…
Tears may hold clues to whether someone has Parkinson’s disease, according to a preliminary study released that will be presented at the American Academy of Neurology’s 70th Annual Meeting in Los Angeles, April 21 to 27, 2018. “We believe our research is the first to show that tears may be a reliable, inexpensive and noninvasive biological marker of Parkinson’s disease,” said study…
Mutations in the p63 protein lead to a number of disorders, but none is as severe as the AEC syndrome. Scientists at Goethe University Frankfurt in collaboration with a research group from the University of Naples Federico II have now discovered that this syndrome resembles diseases such as Alzheimer’s, Parkinson’s or ALS more closely than it does other p63-based syndromes. Their results,…
What if one of the prime suspects behind Alzheimer’s disease was a case of mistaken identity? Amyloid plaques, sticky buildup that accumulates in and around neurons in the brain, have long been believed to be an indicator of neurodegenerative disease. Most clinical drug trials for Alzheimer’s disease treatment have failed, presumably because they target these plaques. But according to Raymond…
Testing the level of caffeine in the blood may provide a simple way to aid the diagnosis of Parkinson’s disease, according to a study published in the online issue of Neurology, the medical journal of the American Academy of Neurology. The study found that people with Parkinson’s disease had significantly lower levels of caffeine in their blood than people without the disease, even if they…
Cancer surgeons perform an estimated 1.7 breast biopsies each year, according to the American Association of Preferred Provider Organizations. This makes the procedure a significant proportion of cases referred to anatomic pathologists. This surgery, however, is time-consuming and not always accurate due to shortcomings in existing surgical technology and to human error. Now, a 3D-printed…
The chemical compound “anle138b” eases cognitive deficits and normalizes gene expression in a mouse model of Alzheimer’s disease. Furthermore, the drug seems to close harmful openings in the membrane of nerve cells. An international collaboration reports these findings in the journal “EMBO Molecular Medicine”. The scientists suggest that anle138b should be validated in clinical trials…
Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a peptide that could lead to the early detection of Alzheimer’s disease (AD). The discovery, published in Nature Communications, may also provide a means of homing drugs to diseased areas of the brain to treat AD, Parkinson’s disease, as well as glioblastoma, brain injuries and stroke. “Our goal was to…
Nanosensors are incredible information-gathering tools for myriad applications, including molecular targets such as the brain. Neurotransmitter molecules govern brain function through chemistry found deep within the brain, so University of California, Berkeley researchers are developing nanosensors to gain a better understanding of exactly how this all plays out. During the AVS 64th…
A common feature of neurodegenerative diseases are deposits of aggregated proteins in the patient's cells that cause damage to cellular functions. Scientists report that, even in normal cells, aberrant aggregation-prone proteins are continually produced due to partial failure of the respiratory system. Unless they are removed by degradation, aggregates accumulate preferentially in the…
Blood-thinning drugs not only reduce the risk of stroke in patients with atrial fibrillation (AF) but are also associated with a significant reduction in the risk of dementia, according to new research published today in the European Heart Journal.
G protein-coupled receptors (GPCRs) are among the "hottest” targets for the therapy of diseases such as hypertension, asthma or Parkinson's. These receptors are the site of action of many hormones and neurotransmitters and allow them to regulate the activity of our cells. How and where this happens has long been the subject of numerous hypotheses. An international team of scientists from…
In old age a variety of cellular processes decline and the risk to develop age-related diseases such as Alzheimer’s, Parkinson’s or Diabetes increases dramatically. But does ageing affect all organs and tissues in the body in the same way? And should drugs that are developed to improve health in old age have the same effect on every organ? Now scientists from the Max Planck Institute for…
A long-term study of nearly 3,000 adults, aged 57 to 85, found that those who could not identify at least four out of five common odors were more than twice as likely as those with a normal sense of smell to develop dementia within five years. Although 78 percent of those tested were normal – correctly identifying at least four out of five scents – about 14 percent could name just three out…
Scientists have helped provide a way to better understand how to enable drugs to enter the brain and how cancer cells make it past the blood brain barrier.
Researchers have developed an automated and affordable system to diagnose early-stage Parkinson’s disease through a simple drawing task.
A largely aged population is already a reality in some countries, and this will become a worldwide problem by 2047, when the number of the Earth’s old people is likely to surpass the number of young people.
People with the movement disorder Parkinson’s disease have a much higher risk of the skin cancer melanoma, and vice versa, a Mayo Clinic study finds. Yet the results of the study argue against the Parkinson's drug levodopa as the cause.
The Congress of the European Academy of Neurology (EAN) in Amsterdam received a royal visit: H.M. Queen Máxima of the Netherlands attended the major scientific event at RAI Amsterdam, in which over 6,000 people are participating.
A simple eye test could help solve the biggest global cause of irreversible blindness, glaucoma. In clinical trials, the pioneering diagnostic test - developed by researchers at UCL Institute of Ophthalmology and the Western Eye Hospital - allowed doctors to see individual nerve cell death in the back of the eye.
A new app measuring the biomechanics of the voice could impact the market of ENT and speech pathology products.
Scientists are hoping that a single drug can treat two devastating brain diseases: Parkinson's and Alzheimer's. The drug is nilotinib, which is approved to treat a form of leukemia.
The Technion breathalyzer would give pathology groups and medical laboratories unprecedented ability to support physicians in diagnosing and treating cancers, chronic diseases, and other illnesses.
Penn Medicine today launched its first Apple ResearchKit app, focused on patients with sarcoidosis, an inflammatory condition that can affect the lungs, skin, eyes, heart, brain, and other organs. The effort marks Penn’s first time using modules from Apple’s ResearchKit framework, as part of the institution’s focus on mobile health and innovative research strategies.
Type and intensity of stimuli control the activity of nerve cells that release the neurotransmitter dopamine
Moderate-to-severe traumatic brain injury is a known risk factor for diseases that gradually destroy the brain - such as late-onset Alzheimer's disease. Now, a new study links mild traumatic brain injury, or concussion, in people at genetic risk for Alzheimer's to accelerated brain deterioration and mental decline associated with the disease.
Genetics stepping ahead as Spain-based researchers develop biomedical robots that can help in the study of rare diseases, neurodegenerative disorders and cancer, as well as the creation of orphan drugs.
An international team of 56 researchers in five countries has confirmed a hypothesis first proposed by the ancient Greeks – that different diseases are characterized by different “chemical signatures” identifiable in breath samples. The findings by the team led by Professor Hossam Haick of the Technion-Israel Institute of Technology Department of Chemical Engineering and Russell Berrie…
Scientists at Washington University School of Medicine in St. Louis have detailed the structure of a molecule that has been implicated in Alzheimer’s disease. Knowing the shape of the molecule — and how that shape may be disrupted by certain genetic mutations — can help in understanding how Alzheimer’s and other neurodegenerative diseases develop and how to prevent and treat them.
Despite their different triggers, the same molecular chain of events appears to be responsible for brain cell death from strokes, injuries and even such neurodegenerative diseases as Alzheimer's. Now, researchers at Johns Hopkins say they have pinpointed the protein at the end of that chain of events, one that delivers the fatal strike by carving up a cell's DNA. The find, they say, potentially…
Tufts University researchers have discovered a new technique for generating rapidly-differentiating human neural stem cells for use in a variety of tissue engineering applications, including a three-dimensional model of the human brain, according to a paper published in Stem Cell Reports. The work could pave the way for experiments that engineer other innervated tissues, such as the skin and…
Stroke patients will first undergo a CT scan as they enter the hospital. Before any further imaging scan is carried out, the medical team must decide whether they need to intervene intra or extra cranially. ‘Imaging enables you to see which pathology you are dealing with and helps you select patients for either recanalisation or revascularisation or, in some cases, occlusion by embolisation,’…
People with high levels of four biomarkers in the blood may be more likely to develop a stroke than people with low levels of the biomarkers, according to a study published in the August 24, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The cause of Alzheimer’s disease remains unknown. Early diagnosis is currently not possible as clinical symptoms only occur once a large number of neurones in the brain have already been destroyed. There is no treatment available either.
The mechanism by which drug-resistant bacteria maintain a defensive barrier has been identified by researchers at England’s University of East Anglia (UEA) and their findings could result in a new wave of drugs that can bring down those defensive walls rather than attack the bacteria – thus they may not develop drug-resistance at all.
Studying a new type of pinhead-size, lab-grown brain made with technology first suggested by three high school students, Johns Hopkins researchers have confirmed a key way in which Zika virus causes microcephaly and other damage in fetal brains: by infecting specialized stem cells that build its outer layer, the cortex.
Accurate diagnosis of Parkinson's disease, and the related disease "dementia with Lewy bodies," can be difficult in the early stages of both conditions. While brain biopsies can be more accurate, the risk of complications has been considered too high.
When there is an accident or a house fire, we call the police or the fire services. A control room quickly coordinates emergency operations. The cells in our bodies also have helpers in a crisis; the heat-shock proteins. These are triggered in response to cellular stress, such as high temperature, UV radiation or cancer. Heat-shock proteins help other proteins maintain their functional structure…
An international public-private research consortium has identified and validated a cellular role of a primary Parkinson’s disease drug target, the LRRK2 kinase. This important finding illuminates a novel route for therapeutic development and intervention testing for Parkinson’s, the second most common neurodegenerative disease after Alzheimer’s.
École polytechnique fédérale de Lausanne (EPFL) scientists have developed a new method that turns cells into stem cells by "squeezing" them. The method paves the way for large-scale production of stem cells for medical purposes.
Proteins are like a body’s in-house Lego set. These large, complex molecules are made up of building blocks called amino acids. Most of the time, proteins fold correctly, but sometimes they can misfold. This misfolding causes the proteins to get sticky, and that can promote clumping, or aggregation, which is the hallmark of several neurodegenerative diseases such as ALS, Alzheimer’s and…
By implanting electrodes in the brain tissue one can stimulate or capture signals from different areas of the brain. These types of brain implants, or neuro-prostheses as they are sometimes called, are used to treat Parkinson's disease and other neurological diseases.
People with Parkinson’s disease (PD) tend to slow down and decrease the intensity of their movements even though many retain the ability to move more quickly and forcefully. Now, in proof-of-concept experiments with “joysticks” that measure force, a team of Johns Hopkins scientists report evidence that the slowdown likely arises from the brain’s “cost/benefit analysis,” which gets…
Researchers at the University of Maryland and the University of Virginia have performed the first focused ultrasound treatments in the United States for dyskinesia associated with Parkinson’s disease.
There may be two new ways to fight AIDS -- using a heat shock protein or a small molecule – to attack fibrils in semen associated with the human immunodeficiency virus (HIV) during the initial phases of infection, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
Stony Brook researchers publish experimental findings in the Journal of Neuroscience that show the lateral position more efficiently rids the brain of solutes that may contribute to disease.
By providing tools to allow users to be more productive in working with healthcare big data, several Silicon Valley giants hope to increase their presence in medical services. The latest company to enter the field is Apple Computers. In March it announced the availability of ResearchKit, an open-source software framework that turns the iPhone into a research tool.
“I am very concerned about the impact that Angelina Jolie has on the media,” Walter Rocca, professor of epidemiology and neurology at the Mayo Clinic in Rochester, Minnesota, stated. He wasn’t hinting to Jolie’s acting choices or waifish silhouette, but to the confusion surrounding her decision to remove her ovaries to prevent ovarian cancer. By Mélisande Rouger
A multi-year study led by researchers from the Simons Center for Data Analysis (SCDA) and major universities and medical schools has broken substantial new ground, establishing how genes work together within 144 different human tissues and cell types in carrying out those tissues' functions.
Radiology will be in the spotlight on November 8, as radiologists celebrate the International Day of Radiology (IDoR) through a series of events and information campaigns to help the public better understand the role of medical imaging in healthcare.
The numbers of ‘suicide tourists’ going to Switzerland to take their own lives has doubled within the space of four years, reports a study published online in the Journal of Medical Ethics.
There is a global shortage of doctors that is getting worse every year. With the demographic shift in many countries from a predominantly young to an increasing aging population, a steep increase in chronic disease is occurring.
A joint meeting combining the Euroson and Three Countries congresses creates a veritable European summit on the state-of-the-art in ultrasound
The Alliance for MRI welcomes the European Parliament's approval of a derogation for Magnetic Resonance Imaging (MRI) in its draft report on the revised Directive on Protecting Workers from Exposure to Electromagnetic Fields.
Israel - Researchers are using breath-test technology to detect volatile organic compounds to tell whether a patient has stomach cancer.
In the meantime, the Compamed Spring forum has become as much a part of the furniture as the Compamed in Düsseldorf - the leading international specialist trade fair for suppliers to the medical technology industry which has been held every year in November since 1992.
There are too many loopholes that allow bad or fraudulent physicians to beat the system.
For the first time, a EU agency recommends a gene therapy drug for commercial release in Europe. The European Medicine's Agency announced in late July 2012 that its Committee for Medicinal Products for Human Use (CHMP) recommends Glybera for commercial release in the European Union
Uncontrollable convulsions, tremor or spasms can considerably impair the lives of neurodegenerative disease patients. Deep brain stimulation (DBS) – for which tiny electrodes are implanted in the brain to stimulate the target areas continuously with electrical impulses – can significantly reduce the movement disorder.
Neural networks are emblematic of complex systems, so it's no surprise that the field of neurology is eclectic and intricate, too. Main challenges for neurologists are therapies of and research on stroke, seizures, movement disorders such as Parkinson's disease, autoimmune disorders such as multiple sclerosis and dementias such as Alzheimer's disease.