Unique detection

'Super smeller' could lead to parkinson skin swab test

A study has identified chemicals in the skin responsible for a unique scent in people with Parkinson’s disease. The chemicals can be detected in an oily substance secreted from the skin called sebum, the researchers found.

The findings suggest Parkinson’s disease could one day be diagnosed from skin swabs, potentially leading to new tests. There are no tests for Parkinson’s disease at present. Patients are diagnosed from observation of symptoms, a process that can take several years. Scientists at The University of Edinburgh first had the idea that Parkinson’s might be diagnosed from chemicals in the skin when they met Joy Milne, the widow of a former patient. Her acute sense of smell had noticed that people with the disease have a unique scent.

Did you know? Persons afflicted with Parkinson's disease have a unique smell. This could lead to the development of a new kind of test.

Source: Unsplash/Erik Odiin

In a pilot study, Joy accurately differentiated Parkinson’s patients from healthy people by smelling T-shirts they had worn for 24 hours. Using a specialised technique that mimics the human nose, researchers at The University of Manchester analysed sebum samples of patients with Parkinson’s Disease. They identified three molecules in sebum linked to the odour caused by Parkinson’s Disease. Researchers say this could lead to new tests. The research was published in the journal ACS Central Science.

"This is a really exciting step towards a test for Parkinson’s that could cut short the time it currently takes to reach a diagnosis. Having a conclusive test would have a huge impact, not only for patients, but could also aid research for new treatments", says Dr Tilo Kunath from the Medical Research Council Centre for Regenerative Medicine, University of Edinburgh.

Parkinson’s is caused by a loss of nerve cells in the part of the brain that controls body movement. There currently is no cure, but researchers hope that spotting affected people sooner could help them in the search for treatments.


Source: University of Edinburgh

21.03.2019

Read all latest stories

Related articles

Photo

New test

Tears don't lie – they may even help diagnose Parkinson’s

Tears may hold clues to whether someone has Parkinson’s disease, according to a preliminary study released that will be presented at the American Academy of Neurology’s 70th Annual Meeting in Los…

Photo

CMT, Alzheimer's, Parkinson's

Study links key protein to Charcot-Marie-Tooth and other nerve diseases

A new study provides critical insight into a little-known, yet relatively common, inherited neurological condition called Charcot-Marie-Tooth disease (CMT). The findings point to a pathway to…

Photo

Neurodegeneration

Study sheds new light on microglia

Inside the body, disease and injury can leave behind quite the mess — a scattering of cellular debris, like bits of broken glass, rubber and steel left behind in a car accident. Inside the central…

Related products

Agena Bioscience - MassARRAY Colon Panel

Amplification/Detection

Agena Bioscience - MassARRAY Colon Panel

Agena Bioscience GmbH
Beckman Coulter -  phi (Prostate Health Index)

Immunochemistry

Beckman Coulter - phi (Prostate Health Index)

Beckman Coulter, Inc.
Eppendorf - Mastercycler nexus X2

Research use only (RUO)

Eppendorf - Mastercycler nexus X2

Eppendorf AG
SARSTEDT - Low DNA Binding Micro Tubes

Research use only (RUO)

SARSTEDT - Low DNA Binding Micro Tubes

SARSTEDT AG & CO. KG
Shimadzu - CLAM-2000

Research use only (RUO)

Shimadzu - CLAM-2000

Shimadzu Europa GmbH