Early detection is crucial for effective treatment of colorectal cancer, but the initial stages are easily missed during endoscopy screenings. With GI Genius, Medtronic presents an AI-powered tool to help detect precancerous lesions in real-time. In an upcoming large-scale trial, the intelligent endoscopy module will demonstrate its benefit in the clinical context.
In a move to promote greater sustainability in research, organizations and experts from nine European countries have published the Heidelberg Agreement as a framework for research funding.
Early detection and management of asthma and COPD is critical. US researchers have developed a deep learning model paired with a wearable sensor patch to automatically detect wheezing sounds.
Using a melt electrowriting (MEW) technique, bioengineers have developed a hybrid structure to address the clinical need for small-diameter vascular grafts and help combat cardiovascular disease.
A band-aid for the heart? US researchers have developed a new way to 3D print material that is at once elastic, tough, and shapable enough to fit a patient’s unique heart or joint defects.
Researchers have created a mucus-based bioink which can be used for 3D printing lung tissue. This advance could one day help study and treat chronic lung conditions.
A new heart valve comprised of biological material obtained from human cells, opens up new therapeutic avenues for patients with paediatric heart diseases, such as tetralogy of Fallot.
Enzyme-driven nanorobots could be used in the treatment of joint diseases such as arthritis. A new research project explores the potential of this technology.
A new research project focuses on creating a 3D printed device to grow a human spinal cord organoid for the study of spinal cord injury and subsequent drug testing.
Researchers were able to produce sub-millimetre resolution images of cardiac micro-vessels. This non-invasive new technique could allow scientists to study the physiology of the heart in more detail.
Artificial cells to combat cancer: Research groups are working to create synthetic micro-organisms capable of detecting the presence of the disease and delivering anti-cancer therapies.
A newly-developed material made of proteins shows promise for targeted cancer therapies: Like secretory granules in the endocrine system, it delivers nanoparticles which attack specific cancer cells.
A research team created a computational model that simulates the invasion of cancer cells in breast tumors on a biomechanical level. This could help predict the evolution of breast cancer in patients.
Using 3D bioprinting to accurately replicate the biological environment surrounding gastric cancer cells, researchers predicted a patient’s response to anticancer drugs during the preclinical stage.
A novel AI-based, non-invasive diagnostic tool enables accurate brain tumor diagnosis, outperforming current classification methods. The tool leverages MRI information to aid clinical decision making.
In a breakthrough for personalised oncology, scientists have developed and demonstrated a novel platform that can significantly reduce the time needed to determine the efficacy of anti-cancer drugs.
New research demonstrates how tiny nanomachines could greatly reduce bladder cancer by precisely targeting the tumour and attacking it with a radioisotope carried on their surface.
A research team has developed a nanoparticle-based contrast agent with the properties necessary to successfully use MRI for targeted diagnosis of liver fibrosis.
When your stomach is full after a large meal, certain receptors are activated to tell the brain. A newly developed capsule could provoke this fullness signal early, potentially helping with treating obesity.
Using AI and optoacoustic imaging, researchers have developed a new method to assess microvascular changes in the skin – and thus the severity of diabetes in the patient.
A team of researchers has developed a handheld, non-invasive device that can detect biomarkers for Alzheimer’s and Parkinson’s Diseases. The biosensor can also transmit the results wirelessly.
The field of lab-on-a-chip needs to meet important challenges around sustainability. This includes not only the development of smart analytical systems that are able to sense the changes that are occurring within the environment but also, more generally, the mitigation of single-use plastics in analysis and the use of low-power, recyclable microsystem technologies.
Faster, more accurate and cost-effective testing: Experts outline the beginnings and evolution of “lab-on-a-chip” technology, and its benefits for advanced and next-gen operational platforms.
Inspired by the enhanced visual system of butterflies, researchers have developed an imaging sensor to “see” into the UV range for differentiating between cancer and normal cells.
Researchers in Spain have developed a system using patient cells which represents the first 3D muscle model capable of replicating the damage caused by Duchenne muscular dystrophy (DMD).
Researchers at the University of Michigan have zeroed in on Candida auris – a fungus with the uncanny ability to stick to everything from skin to catheters – and made a startling discovery.
A research team led by the Institute for Bioengineering of Catalonia (IBEC) and Hospital del Mar has conducted a study to analyze cough sounds recorded by smartphones in patients with Covid-19.
Half as thick as a human hair: Researchers at TU Munich have developed the world's first microrobot capable of navigating within groups of cells and stimulating individual cells.
A new approach to treating kidney failure could one day free people from needing dialysis or having to take harsh drugs to suppress their immune system after a transplant.
Scientists from the University of California San Diego and their colleagues in Australia have engineered bacteria that can detect the presence of tumor DNA in a live organism.
Missing crucial doses of medicines and vaccines could become a thing of the past thanks to Rice University bioengineers’ technology for making time-released drugs.
One day, the ultrasound equipment that health care professionals use for diagnostic imaging may no longer be confined to the clinic, instead operated by patients in the comfort of their homes.
A new method for cheaply producing heart valves in the span of minutes shows great promise. The scientists describe the method as "a cotton-candy machine with a hair dryer behind it."
Researchers have succeeded in introducing a vascular system into tiny living and beating model human heart muscles, an achievement which it's hoped will accelerate progress toward the ultimate goal of repairing damage from heart disease.
During the Covid-19 pandemic, the use of these single-use diagnostics, or point-of-care tests has exploded. This is having major environmental consequences, experts point out.
New research has found variable voltages in the membranes of breast cancer cells, revealing clues about how they grow and spread.
Bowel cancer patients could in future benefit from a new 3D bioprinting technology which would use their own cells to replicate the complex cellular environment of solid tumours in 3D models.
In the future, many types of open surgeries will be replaced with minimally invasive interventions, predicts Kevin Cleary, PhD, engineering lead at the Sheikh Zayed Institute for Pediatric Surgical Innovation at Children’s National Hospital, and Professor of Pediatrics and Radiology at George Washington University, both in Washington, D.C. Surgeons and interventional radiologists will be able…
How can rapid antigen tests be adjusted to reliably detect future variants of SARS-CoV-2? A research team funded by the National Institutes of Health is currently working on finding an answer.
By recreating the helical structure of heart muscles, bioengineers improve understanding of how the heart beats.
A new type of vaccine provides protection against a variety of SARS-like betacoronaviruses, including SARS-CoV-2 variants, in mice and monkeys, according to a new study.
A wireless sensor could offer doctors a way to monitor changes in brain chemistry without requiring a second operation to remove the implant.
Bioengineers have shown they can eradicate advanced-stage ovarian and colorectal cancer in mice in as little as six days with a treatment that could be ready for human clinical trials later this year.
Researchers have identified a previously unrecognized key player in cancer evolution: clusters of mutations occurring at certain regions of the genome.
Artificial intelligence (AI) models that evaluate medical images have potential to speed up and improve accuracy of cancer diagnoses, but they may also be vulnerable to cyberattacks.
Combining knowledge of chemistry, physics, biology, and engineering, scientists from McGill University develop a biomaterial tough enough to repair the heart, muscles, and vocal cords, representing a major advance in regenerative medicine.
A team led by the University of Washington has developed a new, non-destructive method that images entire 3D biopsies instead of a slice. The 3D images provided more information than a 2D image — specifically, details about the tree-like structure of the glands throughout the tissue.
Ion-mobility spectrometry (IMS) offers opportunities for rapid diagnosis and clinical decision-making due to breath analysis. As a rapid separation tool, it has clinical value in the identification and analysis of proteins, peptides, lipids, and glycans. The tool is already used as an exhaled drug monitor for anaesthetised patients. It is flexible, portable and has use for point-of-care testing,…
Wearables are a trend in respiratory care and many products are being developed to monitor patients remotely. But how much can these tools really help clinicians? An Italian expert discussed current solutions and challenges to their development.
A 'new technology shows promise by analyzing images of suspicious-looking lesions and quickly producing a detailed, microscopic image of the skin, bypassing several standard steps typically used for diagnosis - including skin biopsy, tissue fixation, processing, sectioning and histochemical staining.
Blood transfusions save lives, yet the precious fluid is in desperately short supply around the globe. But what if transfusions don’t always require blood? A new mathematical model of the body’s interacting physiological and biochemical processes – including blood vessel expansion, blood thickening and flow-rate changes in response to the transfusion of red blood cells – shows that…
In the fight against diseases like amyotrophic lateral sclerosis (ALS), biomedical engineering researchers at the University of Southern California have created a powerful lab model to better see how our muscles and neurons connect.
Researchers identify two sugar-binding proteins that impede the viral entry of circulating SARS-CoV-2 variants. The team, spearheaded by researchers at IMBA – Institute of Molecular Biotechnology of the Austrian Academy of Sciences – may have found the “Achilles’ heel” of the virus, with potential for pan-variant therapeutic interventions. The findings are now published in the EMBO…
Magnetic fields can be used to stimulate blood vessel growth, according to a new study. The findings, published in the journal Science and Technology of Advanced Materials by researchers at the Técnico Lisboa and NOVA School of Science and Technology in Portugal, could lead to new treatments for cancers and help regenerate tissues that have lost their blood supply.
Cancer care and the treatment clinicians can offer patients is being increasingly enhanced by Artificial Intelligence (AI). The technology has a role in diagnosis, with algorithms trained to design and deliver patient care, can match patients to clinical trials they may benefit from, and even help predict outcomes and those at greatest risk.
Brown University researchers have developed a technique that could allow deep brain stimulation devices to sense activity in the brain and adjust stimulation accordingly.
Thin-film electrodes developed at Lawrence Livermore National Laboratory (LLNL) have been used in human patients at the University of California, San Francisco, generating never-before-seen recordings of brain activity in the hippocampus, a region responsible for memory and other cognitive functions. In a study published in the journal Nature Communications, surgeons at UCSF placed the flexible…
A low-cost, rapid diagnostic test for Covid-19 developed by Penn Medicine provides Covid-19 results within four minutes with 90 percent accuracy. A paper published this week in Matter details the fast and inexpensive diagnostic test, called RAPID 1.0 (Real-time Accurate Portable Impedimetric Detection prototype 1.0). Compared to existing methods for Covid-19 detection, RAPID is inexpensive and…
Researchers used AI to identify which daily changing clinical parameters best predict intervention responses in critically ill Covid-19 patients. The investigators used machine learning to predict which patients might get worse and not respond positively to being turned onto their front in intensive care units (ICUs) - a technique known as proning that is commonly used in this setting to improve…
A collaboration spanning four research labs and hundreds of miles has used the organ-on-a-chip (Organ Chip) technology from the Wyss institute at Harvard Univesity to identify the antimalarial drug amodiaquine as a potent inhibitor of infection with SARS-CoV-2, the virus that causes Covid-19. The Organ Chip-based drug testing ecosystem established by the collaboration greatly streamlines the…
New research by University of Texas at Dallas scientists could help solve a major challenge in the deployment of certain Covid-19 vaccines worldwide — the need for the vaccines to be kept at below-freezing temperatures during transport and storage. In a study published online in Nature Communications, the researchers demonstrate a new, inexpensive technique that generates crystalline…
Researchers at the Human Genome and Stem Cell Research Center (HUG-CELL), hosted by the University of São Paulo’s Institute of Biosciences (IB-USP) in Brazil, have developed a technique to reconstruct and produce livers in the laboratory. The proof-of-concept study was conducted with rat livers. In the next stage of their research, the scientists will adapt the technique for the production of…
Healthy and cancer cells can look similar under a microscope. One way of differentiating them is by examining the level of acidity, or pH level, inside the cells. Tapping on this distinguishing characteristic, a research team from the National University of Singapore (NUS) has developed a technique that uses artificial intelligence (AI) to determine whether a single cell is healthy or cancerous…
Research into 3D bioprinting has grown rapidly in recent years as scientists seek to re-create the structure and function of complex biological systems from human tissues to entire organs. The most popular 3D printing approach uses a solution of biological material or bioink that is loaded into a syringe pump extruder and deposited in a layer-by-layer fashion to build the 3D object. Gravity,…
Wearable devices can identify Covid-19 cases earlier than traditional diagnostic methods and can help track and improve management of the disease, Mount Sinai researchers report in one of the first studies on the topic. The findings were published in the Journal of Medical Internet Research. The Warrior Watch Study found that subtle changes in a participant’s heart rate variability (HRV)…
In the past few decades, researchers have identified biological pathways leading to neurodegenerative diseases and developed promising molecular agents to target them. However, the translation of these findings into clinically approved treatments has progressed at a much slower rate, in part because of the challenges scientists face in delivering therapeutics across the blood-brain barrier (BBB)…
A smart ring that generates continuous temperature data may foreshadow Covid-19, even in cases when infection is not suspected. The device, which may be a better illness indicator than a thermometer, could lead to earlier isolation and testing, curbing the spread of infectious diseases, according to a preliminary study led by UC San Francisco and UC San Diego.
Scientists at UC Berkeley and Gladstone Institutes have developed a new CRISPR-based COVID-19 diagnostic test that, with the help of a smartphone camera, can provide a positive or negative result in 15 to 30 minutes.
As COVID-19 continues to spread, bottlenecks in supplies and laboratory personnel have led to long waiting times for results in some areas. In a new study, University of Illinois, Urbana-Champaign researchers have demonstrated a prototype of a rapid COVID-19 molecular test and a simple-to-use, portable instrument for reading the results with a smartphone in 30 minutes, which could enable…
Scientists combined induced pluripotent stem cells (iPSC) and their deep knowledge in the bioengineering of human organoids to for the first time bioengineer the human brain at the macroscale level with comprehensive network function
Michigan State University researchers have created for the first time a miniature human heart model in the laboratory, complete with all primary heart cell types and a functioning structure of chambers and vascular tissue.
Scientists at Nanyang Technological University, Singapore (NTU Singapore) have developed a synthetic peptide that can make multidrug-resistant bacteria sensitive to antibiotics again when used together with traditional antibiotics, offering hope for the prospect of a combination treatment strategy to tackle certain antibiotic-tolerant infections.
A new technique could enable vascular surgeons to reach even the more difficult body regions. Instead of pushing catheters into minute veins, the system, devised in Canada by Professor Sylvain Martel and team at the Polytechnique Montréal Nanorobotics Laboratory, uses magnetic forces to pull a guidewire, or catheter, into remote physical locations, guiding medical instruments into narrow and…
Benchtop tools for studying the respiratory system misrepresent the interdependence between the diaphragm, abdomen and lungs. Meanwhile, computational models often hide the mechanisms in a black box computation, without a clear picture of what transpires in the process. This means students form a poor understanding of respiratory mechanisms and makes it hard to train clinicians for real scenarios…
A new machine learning approach classifies a common type of brain tumour into low or high grades with almost 98% accuracy, researchers report in the journal IEEE Access. Scientists in India and Japan, including from Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS), developed the method to help clinicians choose the most effective treatment strategy for individual…
An international team led by University of British Columbia (UBC) researcher Dr. Josef Penninger has found a trial drug that effectively blocks the cellular door SARS-CoV-2 uses to infect its hosts. The findings, published in Cell, hold promise as a treatment capable of stopping early infection of the novel coronavirus that, as of April 2, has affected more than 981,000 people and claimed the…
Glioblastomas are complex, fast-growing malignant brain tumors that are made up of various types of cells. Even with aggressive treatment — which often includes surgery, radiation, and chemotherapy — glioblastomas are difficult to treat, leading to an average survival of 11-15 months. In research published in Science Advances, Xavier Intes, a professor of biomedical engineering at Rensselaer,…
Layering minute amounts of Manuka honey between layers of surgical mesh acts as a natural antibiotic that could prevent infection following an operation, new research has shown. Meshes are used to help promote soft tissue healing inside the body following surgery and are common in operations such as hernia repair. However, they carry with them an increased risk of infection as the bacteria are…
For almost any conceivable protein, corresponding antibodies can be developed to block it from binding or changing shape, which ultimately prevents it from carrying out its normal function. As such, scientists have looked to antibodies as a way of shutting down proteins inside cells for decades, but there is still no consistent way to get them past the cell membrane in meaningful numbers. Now,…
Inhalation therapy is widely used for the treatment of lung diseases. Targeting of drugs to the site of disease is a major goal to improve drug efficacy and minimize side effects. Scientists at the Helmholtz Zentrum München and the Technical University of Munich have now shown that combined insight from various imaging methods allows for real-time monitoring of the dynamic process of drug…
Researchers at the University of Helsinki in collaboration with researchers from Åbo Akademi University (Finland) and Huazhong University of Science and Technology (China) have developed a new anti-cancer nanomedicine for targeted cancer chemotherapy. This new nano-tool provides a new approach to use cell-based nanomedicines for efficient cancer chemotherapy. Exosomes contain various molecular…
Twenty people die every day waiting for an organ transplant in the U.S., and while more than 30,000 patients now receive transplants annually, another 113,000 are currently on organ waitlists. Many people see artificially grown human organs as the Holy Grail for resolving the organ shortage, and advances in 3D printing have led to a boom in using that technique to build living tissue constructs…
Scientists in the UK have developed tiny patches of engineered heart tissue that have the potential to be implanted to help people recover from a heart attack. Measuring approximately 3cm x 2cm, the patches contain up to 50 million human-induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM). Yet, these are programmed to turn into working heart muscle that can beat and gradually be…
Help for patients with sickle cell disease may soon come from gene editing to fix the mutation that causes the disease and boost the patient's own protective fetal hemoglobin.
The future of medicine is biological – and scientists hope we will soon be using 3D-printed biologically functional tissue to replace irreparably damaged tissue in the body. A team of researchers from the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB has been working with the University of Stuttgart for a number of years on a project to develop and optimize suitable…
The first total-body positron emission tomography/computed tomography (PET/CT) that can acquire a 3D image of the human body in a single position received 510(k) clearance from the U.S. Food and Drug Administration (FDA) in January 2019. Its forthcoming commercial availability for clinical use in the United States later this year is the milestone achievement of a multi-institutional consortium…
New medical software which overlays tumour information from MRI scans onto ultrasound images is helping to improve detection of prostate cancer by guiding surgeons as they conduct biopsies. Developed at University College London (UCL), the software is deployed via a system called SmartTarget and embraces artificial intelligence (AI) to use both systems in tandem to enable surgeons to pick up…
It is still a mystery why a blow to the chest can kill people by inducing cardiac arrest yet save others that are in cardiac arrest. We may be one step closer to an answer, however, thanks to a device developed by researchers of the University of Bern and the EPFL that can replicate the experience in the laboratory. A hefty blow to the chest can have entirely opposite outcomes. While, for…
A study provides new insight into how the stiffening of breast tissue plays a role in breast cancer development. By examining how mammary cells respond in a stiffness-changing hydrogel, bioengineers at the University of California San Diego discovered that several pathways work together to promote the transformation of breast cells into cancer cells. The work could inspire new approaches to…
UC San Francisco researchers have for the first time transformed human stem cells into mature insulin-producing cells, a major breakthrough in the effort to develop a cure for type 1 (T1) diabetes. Replacing these cells, which are lost in patients with T1 diabetes, has long been a dream of regenerative medicine, but until now scientists had not been able to figure out how to produce cells in a…
You’re sweating and feverish and have no idea why. Fortunately, Sandia National Laboratories scientists have built a device that can pinpoint what’s wrong in less than an hour. Unlike most medical diagnostic devices which can perform only one type of test — either protein or nucleic acid tests — Sandia’s SpinDx can now perform both. This allows it to identify nearly any cause of…
A team of University of Illinois at Urbana-Champaign researchers led by Bioengineering Professor Stephen Boppart has successfully visualized the tumor microenvironment of human breast tissue shortly after it was surgically removed from a patient in the operating room. The researchers achieved this using a new portable optical imaging system developed in Boppart's lab.
Researchers funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) are literally breaking barriers using ultrasound waves emitted from a flexible patch to accurately measure central blood pressure and help detect cardiovascular problems earlier. For a while now, smart, wearable devices have had the ability to capture how many steps we take in a day or measure our heart…
Many people who are diagnosed with cancer will undergo some type of surgery to treat their disease — almost 95 percent of people with early-diagnosed breast cancer will require surgery and it’s often the first line of treatment for people with brain tumors, for example. But despite improvements in surgical techniques over the past decade, the cancer often comes back after the procedure. Now,…
A material based on a natural product of bones and citrus fruits, called citrate, provides the extra energy stem cells need to form new bone tissue, according to a team of Penn State bioengineers. The new understanding of the mechanism that allows citrate to aid in bone regeneration will help the researchers develop slow-release, biodegradable citrate-releasing scaffolds to act as bone-growth…
Whilst acknowledging that state-of-the-art bioengineering approaches are being applied in preventing Medical Device Related Pressure Ulcers (MDRPUs), Professor Amit Gefen, from the Department of Biomedical Engineering at Tel Aviv University, believes there are gaps in knowledge and technology in this area and therefore more must be done to improve patient care and avoid additional healthcare…
The selection of a first-line chemotherapy drug to treat many types of cancer is often a clear-cut decision governed by standard-of-care protocols, but what drug should be used next if the first one fails? That’s where Georgia Institute of Technology researchers believe their new open source decision support tool could come in. Using machine learning to analyze RNA expression tied to…
Researchers have developed laser-activated nanomaterials that integrate with wounded tissues to form seals that are superior to sutures for containing body fluids and preventing bacterial infection. Tissue repair following injury or during surgery is conventionally performed with sutures and staples, which can cause tissue damage and complications, including infection. Glues and adhesives have…
Scientists working to bioengineer the entire human gastrointestinal system in a laboratory now report using pluripotent stem cells to grow human esophageal organoids.
Scientists have developed a new bone engineering technique called Segmental Additive Tissue Engineering (SATE). The technique allows researchers to combine segments of bone engineered from stem cells to create large scale, personalized grafts that will enhance treatment for those suffering from bone disease or injury through regenerative medicine.
A team led by the University of California San Diego has developed a chip that can detect a type of genetic mutation known as a single nucleotide polymorphism (SNP) and send the results in real time to a smartphone, computer, or other electronic device. The chip is at least 1,000 times more sensitive at detecting an SNP than current technology. The advance could lead to cheaper, faster and…
Researcher have created an ingestible sensor to non-invasively monitor indicators of disease in the stomach and intestines.
Measuring RNA fragments in a pregnant woman’s blood gives a reliable estimate of the baby’s due date and can predict if the baby will arrive prematurely, a Stanford-led team has shown.
To date, examining patient tissue samples has meant cutting them into thin slices for histological analysis. This might now be set to change – thanks to a new staining method devised by an interdisciplinary team from the Technical University of Munich (TUM). This allows specialists to investigate three-dimensional tissue samples using the Nano-CT system also recently developed at TUM. Tissue…
NIH-supported researchers at Massachusetts General Hospital (MGH) are studying an alternative to the contrast agents currently used for magnetic resonance imaging. In a recent study, they showed that the experimental alternative, a manganese-based compound, performs as well as approved contrast agents. Their study appeared online in Radiology. Magnetic resonance (MR) images are taken so that a…
For centuries, hands, eyes and ears were the physicians’ most important instruments when it came to detecting and diagnosing disease. Today, one of the traditional techniques, percussion, is being revived, supported by state-of-the-art technology and dressed in a new name: optoacoustics. In one of the most exciting visionary ideas in modern healthcare short laser pulses (optics) are transmitted…
Bacteria are stealthy organisms. They can multiply in minutes and evolve to survive what we throw at them—including antibiotics. The World Health Organization calls antibiotic resistance “one of the biggest threats to global health, food security, and development today.” Each year, about 2 million people in the United States become infected with antibiotic-resistant bacteria, according to…
T cells play a key role in the body’s immune response against pathogens. As a new class of therapeutic approaches, T cells are being harnessed to fight cancer, promising more precise, longer-lasting mitigation than traditional, chemical-based approaches. These “living drugs” are poised to transform medicine, with a growing number of cellular therapies receiving FDA-approval. A current…
Sutures and staples are the traditional methods for closing surgical incisions and wounds in emergency situations. However, these methods can be inadequate in complex surgeries and cannot make an air-tight or liquid-tight seal on a lung or artery wound or incision. Now researchers funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have created a surgical glue that…
The chemical compound “anle138b” eases cognitive deficits and normalizes gene expression in a mouse model of Alzheimer’s disease. Furthermore, the drug seems to close harmful openings in the membrane of nerve cells. An international collaboration reports these findings in the journal “EMBO Molecular Medicine”. The scientists suggest that anle138b should be validated in clinical trials…
Scientists are using their increasing knowledge of the complex interaction between cancer and the immune system to engineer increasingly potent anti-cancer vaccines. Now researchers at the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have developed a synergistic nanovaccine packing DNA and RNA sequences that modulate the immune response, along with anti-tumor antigens, into…
In a spectacular development, Spanish researchers demonstrate for the first time that 3-D printing can be used to produce human skin deemed appropriate for transplants and testing applications.
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of…
Researchers at the Institute of Bioengineering and Nanotechnology (IBN) of A*STAR have engineered a three-dimensional heart tissue from human stem cells to test the safety and efficacy of new drugs on the heart.
A tiny robot that gets into the human body through the simple medical injection and, passing healthy organs, finds and treats directly the goal – a non-operable tumor… Doesn’t it sound at least like science-fiction? To make it real, a growing number of researchers are now working towards this direction with the prospect of transforming many aspects of healthcare and bioengineering in the…
Bill Kochevar is the first recipient of implanted brain-recording and muscle-stimulating systems reanimates limb that had been stilled for eight years.
A team of UCLA bioengineers has demonstrated that its technology may go a long way toward overcoming the challenges of treatment for acute lymphoblastic leukemia, among the most common types of cancer in children, and has the potential to help doctors personalize drug doses.
3-D printed tumour-like constructs will be used by a research team at Scotland’s Heriot-Watt University in Edinburgh, to raise research to a new level and successfully lead to new treatment options.
NIBIB-funded researchers at the University of Washington have pioneered an approach to image functional activity in the brains of individual fetuses, allowing a better look at how functional networks within the brain develop. The work addresses a common problem of functional MRI; if the subject moves during the scanning, the images get distorted.
In a groundbreaking new study led by University of Minnesota biomedical engineers, artificial blood vessels bioengineered in the lab and implanted in young lambs are capable of growth within the recipient. If confirmed in humans, these new vessel grafts would prevent the need for repeated surgeries in some children with congenital heart defects.
Researchers funded in part by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have recently shown that magnetic bacteria are a promising vehicle for more efficiently delivering tumor-fighting drugs.
NIBIB researchers have created a nanovaccine that could make a current approach to cancer immunotherapy more effective while also reducing side effects. The nanovaccine helps to efficiently deliver a unique DNA sequence to immune cells – a sequence derived from bacterial DNA and used to trigger an immune reaction. The nanovaccine also protects the DNA from being destroyed inside the body, where…
Multidrug resistance (MDR) is the mechanism by which many cancers develop resistance to chemotherapy drugs, resulting in minimal cell death and the expansion of drug-resistant tumors. To address the problem of resistance, researchers at the National Institute of Biomedical Imaging and Bioengineering (NIBIB) at the National Institutes of Health (NIH) have developed nanoparticles that…
A new technique developed by Gordana Vunjak-Novakovic, the Mikati Foundation Professor of Biomedical Engineering at Columbia Engineering and professor of medical sciences (in Medicine) at Columbia University, repairs large bone defects in the head and face by using lab-grown living bone, tailored to the patient and the defect being treated. This is the first time researchers have grown living…
New, screen-printed, flexible MRI coils may be able to reduce the amount of time it takes to get an MRI scan. Researchers funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the National Institutes of Health (NIH), have developed light and flexible MRI coils that produce high quality MRI images and in the future could lead to shorter MRI scan time periods.
As one of medicine’s largest challenges, viral infections often escape vaccines due to their natural ability to mutate rapidly and develop drug resistance easily. Many viruses, such as Zika, Ebola and dengue fever, have grown into major global health epidemics with great human and economic toll. IBM Research and Singapore’s Institute of Bioengineering, Nanotechnology (IBN) announced they have…
On top of the meaning and mystery that humans heap on the heart, it is first and foremost, a muscle. And one that beats about once a second for a person’s entire life, with no rest. Given its vital importance, it’s ironic researchers have only recently made direct observations of its subcellular parts in motion.
Bioengineers and physicians at the University of California, San Diego have developed a potential new therapy for critical limb ischemia, a condition that causes extremely poor circulation in the limbs and leads to an estimated 230,000 amputations every year in North America and Europe alone to prevent the spread of infection and tissue death. The new therapy could prevent or limit amputations…
Radiology is going beyond assessing body fat, bringing a notable contribution in weight loss therapy. Clifford Weiss from Johns Hopkins University is one of the pioneers of a new procedure, bariatric arterial embolisation, details of which he will unveil at the ECR 2016.
Bioengineers and cognitive scientists have developed the first portable, 64-channel wearable brain activity monitoring system that’s comparable to state-of-the-art equipment found in research laboratories.
Taking clear pictures of megaenzymes isn’t easy. But it’s definitely worth it. These proteins play an active role in creating many common antibiotics. They are in constant motion, with sections that flip around acrobatically to carry out necessary tasks. Now, for the first time, McGill researchers have been able to take a series of 3D images of a large section from one of these…
École polytechnique fédérale de Lausanne (EPFL) scientists have developed a new method that turns cells into stem cells by "squeezing" them. The method paves the way for large-scale production of stem cells for medical purposes.
Fibrocartilage tissue in the knee is comprised of a more varied molecular structure than researchers previously appreciated, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania and the University of Delaware.
Brain tumor tissue can be hard to distinguish from normal brain during surgery. Neurosurgeons use their best judgment in the operating room but often must guess exactly where the edges of the tumor are while removing it.
Researchers funded by the National Institute of Biomedical Imaging and Bioengineering at Tufts University and their collaborators have successfully developed a 3-dimensional (3D) tissue-engineered model of bone marrow that can produce functional human platelets outside the body (ex vivo).
When surgical residents need to practice a complicated procedure to fashion a new ear for children without one, they typically get a bar of soap, carrot or an apple. To treat children with a missing or under-developed ear, experienced surgeons harvest pieces of rib cartilage from the child and carve them into the framework of a new ear. They take only as much of that precious cartilage as they…
Vaccination remains one of the most efficient strategies against infectious diseases, often being the best protection against infections such as hepatitis B, or influenza. European Hospital reports on expert reviews of vaccines in the pipeline and the potential of nanomedicine given during the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) annual meeting in…
Researchers at the University of Alberta have found that spinal manipulation--applying force to move joints to treat pain, a technique most often used by chiropractors and physical therapists--does indeed have immediate benefits for some patients with low-back pain but does not work for others with low-back pain.
Researchers at Rice University and University of Texas MD Anderson Cancer Center have developed a way to mimic the conditions under which cancer tumors grow in bones.
Researchers at the University of California, San Diego School of Medicine and Moores Cancer Center have discovered a molecular mechanism that connects breast tissue stiffness to tumor metastasis and poor prognosis. The study may inspire new approaches to predicting patient outcomes and halting tumor metastasis.
The mechanical basis of mitosis has only been understood in fragments so far. Scientists at Technische Universität Dresden have now been able to add another piece to the puzzle of cell biological mechanisms, as they report in the latest issue of the renowned scientific journal “Cell” .
Gideon Ho, CEO and co-founder of Singapore-based HistoIndex is confident: ‘After a biopsy a patient waits in a hospital bed, but now, instead of waiting a couple days until doctors know how to treat this patient, we can deliver results while the patient is still in the hospital.’ Report: John Brosky
Artificial vascular trees, the growing of heart tissue, nerve regeneration: The World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) held in Vienna this October offered an impressive display of current developments in tissue reconstruction and regeneration, Michael Krassnitzer reports
In a paper published in ”Nature Biotechnology” on the 22nd of July of 2012 Harvard researchers explain how making a jellyfish from rat DNA can help to solve cardiac problems.
Findings from the landmark National Lung screening Trial (NLST) continue to make waves in the United States, and increasingly around the world. The principal investigator for the component of the NLST sponsored by the American College of Radiology Imaging Network (ACRIN), Denise Aberle, MD, said the NLST can provide a road map for public policy regarding lung cancer screening, though she cautions…
Often a life-saving intervention, mechanical ventilation also has some serious drawbacks: the need for sedation, the risk of ventilator associated pneumonia, intubation or tracheostomy related complications. In 1972, Donald Hill from Pacific Medical Centre, Los Angeles, reported the first successful long-term mechanical lung assist device with extracorporeal membrane oxygenation (ECMO).
On 4 October, the waste reservoir of an aluminium factory in Hungary burst. Red sludge, which is the waste resulting from the production of aluminium, flooded nearby villages. In the second week of October, researchers were granted access to the area. Doctoral student Stefan Ruyters and postdoctoral researcher Jelle Mertens of the Division of Soil and Water Management (Faculty of Bioengineering)…
Professor Roger Tsien, Nobel Laureate in Chemistry 2008 for the ‘Discovery and Development of Green Fluorescent Proteins’, was one three* Keynote Speakers at the opening ceremony of the Medical Physics and Bioengineering World Congress 2009, held in Munich this September.
In recent years, stem cells have become a hot topic of investigation with studies suggesting revolutionary medical benefits due to their ability to be converted into selected types of newly generated cells. Scientists have now come up with a way to help accelerate bone growth through the use of nanotubes and stem cells. This could lead to quicker and better recovery, for example after orthopedic…
Information in patients' records could benefit biomedical research in terms of understanding diseases and their treatments. The drawback is that those records contain confidential information that could identify patients. If that data has to be removed manually, the task is not only painstaking and therefore expensive, but also not foolproof.
Stroke treatment is a question of time. The faster the cerebral infarct can be diagnosed, the less the brain will be damaged. But unfortunately it is not always easy to get the patient to a brain scanner within the required three-hour window. Real-time 3D ultrasound might bring the solution, according to researchers from the Duke University in Durham, NC.
By Professor Robert D Speller, Head of the Radiation Physics Group, University College London, and Dr Alessandro Olivo, of the Medical Physics & Bioengineering Dept. University College London
The Virtual Physiological Human By Hans-Ulrich Kauczor MD PhD, Director and Chairman of Radiology at Heidleburg University Clinic, and radiologists Frederik Giesel MD MBA and Hendrik von Tengg-Kobligk MD of the German Cancer Research Centre in Heidleburg, Germany.
Urinary tract infections caused by catheterisation are a common and nasty affliction for the disabled, elderly and hospital patients.
By Shahram Vaezy, Associate Professor of Bioengineering at the University of Washington, Washington, Seattle, and Vesna Zderic, Assistant Professor at Electronic and Computer Engineering Department at George Washington University, Washington DC.
General information concerning the country's healthcare is held at the Instituto Nacional de Estadística (INE).