The ingestible sensor is equipped with bacteria programmed to sense...
The ingestible sensor is equipped with bacteria programmed to sense environmental conditions and relay the information to an electronic circuit.

Source: Lillie Paquette/MIT School of Engineering

Smart pill

Swallowed sensor sends signal if you’re sick

Researcher have created an ingestible sensor to non-invasively monitor indicators of disease in the stomach and intestines.

NIBIB-funded researchers at the Massachusetts Institute of Technology (MIT) have created an ingestible sensor to non-invasively monitor indicators of disease in the stomach and intestines. The capsule carries genetically engineered bacteria that sense specific substances in the gut. The other components built into the one-and-a-half-inch capsule include phototransistors, a custom integrated circuit, a small battery, and a radio transmitter.

This is the first demonstration of the technology,  and it uses bacteria that were genetically engineered to sense blood in the gut. If there is blood present, the bacteria will glow. The phototransistor detects the glow, triggering the radio transmitter to send a signal to a computer or smartphone, reporting that blood has been detected.

The test was done in pigs, which were first fed a dilute solution containing traces of blood. The sensor successfully sensed and reported, by radio signal, that there was blood in the stomach of the pig. The test simulated a bleeding ulcer in humans. Currently, if a patient is suspected of having a bleeding ulcer they must undergo an uncomfortable endoscopy procedure that often requires sedation. “This first test for sensing bleeding from an ulcer shows the potential for this type of device to be used to avoid invasive procedures, such as endoscopy,” said senor author Timothy K. Lu, M.D., Ph.D., Associate Professor of Biological Engineering and Electrical Engineering and Computer Science at MIT. “Following ingestion of the capsule, physicians would know within minutes if there was bleeding and could initiate treatment.”

One goal of the research is to reduce the size of the device, so it can be more easily swallowed. In addition, the research team is expanding this platform to use bacteria that have been genetically engineered to sense a sulfur compound, an indicator of Crohn’s disease, and a molecule called AHL, which would indicate the presence of gastrointestinal infections.

Source: National Institute of Biomedical Imaging and Bioengineering

Source: Massachusetts Institute of Technology

09.07.2018

Read all latest stories

Related articles

Photo

Infectious disease

Sensor technology could detect Dengue fever earlier

Researchers from the University of Bath are developing a new tool for detecting the presence of Dengue fever early on, helping prevent people from suffering potential life-threatening complications.

Photo

Experimental therapy

CRP apheresis: First successful treatment of Covid-19 patient

Apheresis, a procedure that separates removes particular blood constituents, has so far been primarily used with myocardial infarction patients. Now, however, it seems to be a promising approach for…

Photo

Solving a mystery

How the TB bacterium develops rapid resistance to antibiotics

For a slow-growing microbe that multiplies infrequently, Mycobacterium tuberculosis, the pathogen that causes tuberculosis (TB) has long puzzled researchers as to how it develops resistance to…

Related products

Greiner – VACUETTE FC Mix tube

Blood Glucose

Greiner – VACUETTE FC Mix tube

Greiner Bio-One
Analyticon Biotechnologies AG - Urilyzer 100 Pro

Urinalysis

Analyticon Biotechnologies AG - Urilyzer 100 Pro

Analyticon Biotechnologies AG
Analyticon Biotechnologogies – Hemolyzer 3 NG / Hemolyzer 5 NG

Blood Cell Counter

Analyticon Biotechnologogies – Hemolyzer 3 NG / Hemolyzer 5 NG

Analyticon Biotechnologies AG
Beckman Coulter – Early Sepsis Indicator

Blood Cell Counter

Beckman Coulter – Early Sepsis Indicator

Beckman Coulter, Inc.
Greiner – Vacuette EDTA Tube

Blood Cell Counter

Greiner – Vacuette EDTA Tube

Greiner Bio-One
Subscribe to Newsletter