Search for: "SARS-Cov-2" - 250 articles found

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Saliva Collection

COVID-19 virus diagnostics products

Highlights:Validated containers for saliva collection for virus diagnostics: Monovette® VD, V-Monovette® VD and Salivette® VD.Saliva testing has become particularly important and is ideal for screening for SARS-CoV-2. Saliva collection using gargling and/or the Salivette® offers the key advantage that the user can collect the saliva themselves under supervision.Both the gargling…

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Reagents

PurePrep TL+

Highlights:Offering the combination of the safe transfer of viruses and lysis in one tube, the PurePrep TL+ buffer optimizes research.Compatible with most liquid handling systemsDecreases prep timeImproves workflows as it breaks down viscous samples within the tubeThe PurePrep TL+ buffer is suitable for diagnostic tests and molecular biology techniques, facilitating processes like nucleic acid…

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Article • Knowledge gaps in gender medicine

Covid-19 and sex: higher mortality of male patients

The Covid-19 pandemic has affected scientific research in numerous ways – for example by highlighting knowledge gaps in gender medicine. In many studies differences in morbidity and mortality between women and men surfaced incidentally. While the extent and causes of these differences remain largely unexplored, the preliminary insights confirm the need for further research.

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News • Based on image-based flow cytometry

Rapid test to predict severe Covid-19 infections

Researchers have developed a method for assessing the number and structure of aggregated blood platelets (or thrombocytes) that can potentially help quantify the risk of a severe Covid-19 infection. As a result, they have identified a predictive biomarker for the seriousness of a Covid-19 infection. This will allow physicians to adjust treatment at an early stage. The researchers used a method…

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Immunoassays

EXI1800 Chemiluminescence Immunoassay Analyzer

Dimensions: 650 × 790 × 650 mm (w × d × h)Weight: 110 kgSample throughput: up to 180 tests/hAssays: Comprehensive test menu covers SARS-CoV-2, thyroid, fertility, inflammation, cardiac markers, diabetes, tumor markers and moreHighlights:EXI 1800 is a desktop automatic chemiluminescence immunoassay analyzer with compact design which only needs 0.52 m2. With its patented…

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Sponsored • Disease management

Multiplex Testing: A Solution to Manage Surge in Respiratory Illnesses as Concerns over “Multi-demic” Rise

Eunsin Bae, M.D. specializes in laboratory medicine and leads the Institute of Clinical Research at Seegene Inc. Her research focuses on microbiology, molecular biology, and hematology. Dr. Bae is currently working toward implementing a global clinical study and establishing an international network of clinical investigations.

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Lab-on-a-chip

Multiplexed lab-on-a-chip bioassays for testing antibodies against SARS-CoV 2 and its variants in multiple individuals

The coronavirus pandemic caused by SARS-CoV-2 and its variants is still a major public safety issue worldwide. The “alpha” variant B.1.1.7, the “gamma” variant P.1, the “beta” variant B.1.351, and the “delta” variant B.1.617 are of particular concern because of their high prevalence. Large-scale vaccination and sensitive detection are vital for preventing the spread of Covid-19.

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Sponsored • Covid-19 management

Rapid and robust PCR testing for infectious diseases at Innklinikum Altötting and Mühldorf

The Covid-19 pandemic has highlighted the importance of the fast and accurate diagnosis of infectious diseases in clinical settings. Harald Maier discusses the implementation of rapid molecular diagnostics in the central clinical diagnostics laboratory at Innklinikum Altötting and Mühldorf, highlighting how the use of PCR testing has benefitted the hospital during the Covid-19 pandemic.

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Article • Super-resolution miscroscopy

PEAR: setting nano-imaging in motion

Ever since the Abbe diffraction limit of conventional microscopy has been surpassed, super-resolution techniques have been diving ever deeper into the most miniscule details of molecular structures. We spoke with Prof. Dominic Zerulla, whose company PEARlabs is developing an imaging technique that sets out to push the boundaries once more – by looking at in-vivo nano-scale processes in motion.

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Sponsored • DNA extraction chemistry

Providing innovative molecular workflows to empower future diagnostics

Founded in 2018 as a DNA extraction chemistry company, Dutch company MolGen entered the market operating within the agricultural sector. At first, the company’s founders, Maarten de Groot, Wim van Haeringen and Niels Kruize, focused solely on this one industry, mainly developing and marketing advanced bulk chemistry kits for DNA/RNA extraction. These testing products and solutions successfully…

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Sponsored • Coronavirus antigen detection

An innovative test for the early diagnosis of Covid-19

Compared to previous SARS and MERS, SARS-CoV-2 became a pandemic due to the high infectivity and different mode of contagion. SARS-CoV-2 spreads more because it is contagious also before symptoms, during incubation phase. No tests to date have been able to find the virus during the pre-symptomatic stage. Stark has developed a new, rapid, non-invasive method "Stark Portable Covid-19 Antigen…

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News • 'CRyPTIC' research

Global tuberculosis study identifies genetic causes of drug resistance

Using cutting-edge genomic sequencing techniques, researchers at the University of Oxford have identified almost all the genomic variation that gives people resistance to 13 of the most common tuberculosis (TB) drug treatments. The Comprehensive Resistance Prediction for Tuberculosis International Consortium (CRyPTIC) research project has collected the largest ever global dataset of clinical M.…

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News • Coronavirus inhibition

Highly potent antibody against SARS-CoV-2 discovered

Scientists at Lausanne University Hospital (CHUV) and École polytechnique fédérale de Lausanne (EPFL) have discovered a highly potent monoclonal antibody that targets the SARS-CoV-2 spike protein and is effective at neutralizing all variants of concern identified to date, including the delta variant. Their findings are published in the journal Cell Reports.

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News • Rapid detection

Molecular diagnostic test for Covid-19, Flu, RSV receives CE mark

A new rapid molecular diagnostic test from Cepheid has received the CE mark for distribution in the European market. The test, called Xpert Xpress CoV-2/Flu/RSV plus, is designed for qualitative detection of the viruses causing Covid-19, Flu A, Flu B, and respiratory syncytial virus (RSV) infections from a single patient sample. The new plus version of the test provides a third gene target for…

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News • microRNAs hint at cognitive decline

Researchers find warning signs for dementia in the blood

Researchers at the DZNE and the University Medical Center Göttingen (UMG) have identified molecules in the blood that can indicate impending dementia. Their findings, which are presented in the scientific journal “EMBO Molecular Medicine”, are based on human studies and laboratory experiments. Various university hospitals across Germany were also involved in the investigations.

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News • Immune response study

Is a "natural" Covid-19 infection better than vaccination? It's complicated

Hope for a future without fear of Covid-19 comes down to circulating antibodies and memory B cells. Unlike circulating antibodies, which peak soon after vaccination or infection only to fade a few months later, memory B cells can stick around to prevent severe disease for decades. And they evolve over time, learning to produce successively more potent “memory antibodies” that are better at…

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News • Immunological memory

How our lungs 'remember' a Covid-19 infection

After infection with SARS-CoV-2, where does the immune system store the memory to provide long-term protection against reinfection? Though numerous studies have examined blood to track immune responses to SARS-CoV-2, a new study of Covid survivors shows that the memory of the infection is primarily stored in T and B cells within the lung and the lymph nodes surrounding the lung.

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Article • Covid-19 and pathology

Lung cancer care across Europe affected by coronavirus pandemic

The impact of the coronavirus pandemic on lung cancer patient care across Europe, and the contribution lung pathologists, have led to a better understanding of Covid-19, as outlined during the 33rd European Congress of Pathology, Within ‘The lung pathologist in the Covid-19 pandemic’ session, speakers detailed how the pandemic has affected patients, diagnosis and clinical trials, yet also…

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News • SARS-CoV-2 in the media

Does 'beautifying' the Coronavirus make us underestimate its danger?

Colourful, 3D rendered scientific images are fascinating - but can they deceive viewers? New research from Spain suggests this might be the case. According to the study by the Instituto de Radio Televisión Española and the Universitat Autònoma de Barcelona conducted during the Covid-19 lockdown, black and white images of SARS-CoV-2 make the virus seem more infectious. The results, published on…

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News • Respiratory research

Covid-19 infection does not affect lung function in kids, young adults

Covid-19 infection does not appear to affect the lung function of young adults, according to new research presented at the ‘virtual’ European Respiratory Society International Congress. In the first study to investigate the impact of Covid-19 infection on lung function, researchers led by Dr Ida Mogensen, a post-doctoral fellow at the Karolinska Institute, Stockholm, Sweden, found that even…

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News • SARS CoV-2 B.1.621

WHO classifies Coronavirus "Mu" as new 'Variant of Interest'

The World Health Organization (WHO) has taken a closer look at coronavirus variant B.1.621. The strain, first encountered in January 2021 in Colombia, shows traits that could enable the virus to circumvent immune response to vaccination. As a result, the variant, named "Mu", has been classified as "Variant of Interest" (VOI). Despite its prominence in Colombian new infection,…

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Video • Coronavirus medication research

Lab-grown beating heart cells could identify Covid drugs

Scientists have grown beating heart cells to attempt to identify drugs to prevent Covid-19-related heart damage. Concerns over the extent of cardiac damage among Covid patients emerged during the coronavirus pandemic and there are also suggestions that the impact on cardiomyocytes could contribute to the symptoms of long Covid. To explore these issues, a research team at the University of…

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News • Public health worldwide

Sharing Covid-19 vaccines between nations: a mathematical approach

New research from the University of Oxford and the UK Centre for Ecology & Hydrology uses mathematical modelling to determine the most equitable way to share vaccines between nations. Vaccines provide a route to achieving high levels of immunity against SARS-CoV-2 across populations, and provide a route to reopening economies, tourism, and livelihoods. However, vaccine resources amongst…

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News • Infection research

Understanding lung damage in Covid-19 patients

Covid-19 disease severity is determined by the individual patient’s immune response. The precise mechanisms taking place inside the lungs and blood during the early phase of the disease, however, remain unclear. Researchers from Charité – Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC) and Freie Universität Berlin have now studied the cellular mechanisms…

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News • Potential for pan-variant therapies

SARS-CoV-2 might have a 'sugar coated' weak spot

Researchers identify two sugar-binding proteins that impede the viral entry of circulating SARS-CoV-2 variants. The team, spearheaded by researchers at IMBA – Institute of Molecular Biotechnology of the Austrian Academy of Sciences – may have found the “Achilles’ heel” of the virus, with potential for pan-variant therapeutic interventions. The findings are now published in the EMBO…

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News • Genome editing

Using CRISPR to speed up Covid-19 testing

A research team led by scientists in the labs of Jennifer Doudna, David Savage and Patrick Hsu at the University of California, Berkeley, is aiming to develop a rapid Covid-19 diagnostic test that is much faster and easier to deploy than qRT-PCR. It has now combined two different types of CRISPR enzymes to create an assay that can detect small amounts of viral RNA in less than an hour. Doudna…

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News • Coronavirus research

Contagious cash? The role of banknotes and coins in Covid-19 infections

How long do coronaviruses remain infectious on banknotes and coins? Is it possible to become infected through contact with cash? Experts at the European Central Bank, in collaboration with the Department of Medical and Molecular Virology at Ruhr-Universität Bochum, wanted to clarify this question. The researchers led by Professor Eike Steinmann and Dr. Daniel Todt developed a method specifically…

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News • Immune response determined

How Covid-19 vaccines prepare our immune system for the virus

In view of the continuing high numbers of infections, vaccination offers important protection against severe Covid-19 disease. Scientists from the Faculty of Medicine – University of Freiburg have now been able to determine in detail at what time point initial immune protection is established after vaccination with an mRNA-based vaccine and how the reactions of the various components of the…

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News • Search for signatures

‘Long Covid’ biomarkers in blood could lead to diagnostic test

Markers in our blood – ‘fingerprints’ of infection – could help identify individuals who have been infected by SARS-CoV-2, the coronavirus that causes Covid-19, several months after infection even if the individual had only mild symptoms or showed no symptoms at all, say Cambridge researchers. The team has received funding from the National Institute for Health Research to develop a test…

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News • Covid-19 detection

New blood test measures immunity against SARS-CoV-2 and its variants

The Lausanne University Hospital (CHUV) and EPFL teamed up to develop a new test that’s sensitive enough to measure the amount of SARS-CoV-2 neutralizing antibodies present in the bloodstream. The scientists’ discovery, published in Science Translational Medicine, opens promising new avenues for tracking immunity acquired by infection or vaccination.

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News • Early detection of coronavirus presence

Covid-19 wastewater testing: new quantification kit launched

Life science research and clinical diagnostics company Bio-Rad Laboratories announced the launch of its PREvalence ddPCR SARS-CoV-2 Wastewater Quantification Kit, a tool to detect the virus that causes Covid-19 in a community’s wastewater. "With wastewater testing becoming more widely adopted, this assay provides the ability for a community to determine if the virus is present days to…

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News • Sample-to-answer workflow

Partnership for Covid-19 test solution

SpeeDx Pty, Ltd. and MolGen announced the signing of an agreement to collaborate on supply and distribution of clinical diagnostics products and instrumentation across Europe and Asia Pacific. The partnership links specimen handling, nucleic acid extraction, assay set-up, amplification, and results reporting in a seamless integration of the companies technologies. “This partnership capitalises…

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News • Aerosol propagation study

Covid-19: is it safe to play the trumpet and other wind instruments?

Aerosol generated by playing woodwind and brass instruments is less than that produced when vocalising (speaking and singing) and is no different than a person breathing, new research has found. The findings could be crucial to developing a roadmap for lifting Covid-19 restrictions in the performing arts, which have been significantly restricted since the start of the pandemic.

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News • Coronavirus epidemiology

A cloud-based software for the surveillance of SARS-CoV-2 variants

In-vitro-diagnostics company bioMérieux has launched Episeq SARS-CoV-2, a genomic software solution to support microbiology labs in identification and reporting from raw sequencing data related to SARS-CoV-2 variants. Viral mutation is a naturally occurring phenomenon leading to the emergence of variants that can have different characteristics. Today, a number of SARS-CoV-2 variants are…

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News • Corona and EBV

Long Covid symptoms likely caused by Epstein-Barr virus reactivation

Epstein-Barr virus (EBV) reactivation resulting from the inflammatory response to coronavirus infection may be the cause of previously unexplained long Covid symptoms—such as fatigue, brain fog, and rashes—that occur in approximately 30% of patients after recovery from initial Covid-19 infection. The first evidence linking EBV reactivation to long Covid, as well as an analysis of long Covid…

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News • Unexpected find

Anti-tapeworm drug shows promise against Covid-19

Researchers from the German Center for Infection Research (DZIF) at Charité – Universitätsmedizin Berlin and the University of Bonn have examined the way in which SARS-CoV-2 reprograms the metabolism of the host cell in order to gain an overall advantage. According to their report in Nature Communications, the researchers were able to identify four substances which inhibit SARS-CoV-2…

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News • Corona and the brain

PET imaging measures cognitive impairment in Covid-19 patients

The effects of Covid-19 on the brain can be accurately measured with positron emission tomography (PET), according to research presented at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2021 Annual Meeting. In the study, newly diagnosed Covid-19 patients, who required inpatient treatment and underwent PET brain scans, were found to have deficits in neuronal function and…

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News • Severe effects

How COVID-19 wreaks havoc on human lungs

Scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory have published the first detailed atomic-level model of the SARS-CoV-2 "envelope" protein bound to a human protein essential for maintaining the lining of the lungs.

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News • Fighting the pandemic

90 drugs against Covid-19

Mining the world's most comprehensive drug repurposing collection for Covid-19 therapies, scientists have identified 90 existing drugs or drug candidates with antiviral activity against the coronavirus that's driving the ongoing global pandemic.

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News • Good news

Mild COVID-19 induces lasting antibody protection

Months after recovering from mild cases of COVID-19, people still have immune cells in their body pumping out antibodies against the virus that causes COVID-19, according to a study from researchers at Washington University School of Medicine in St. Louis. Such cells could persist for a lifetime, churning out antibodies all the while.

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News • Coronavirus complications

Post-acute Covid: study explores risk of developing long term conditions

One in 7 (14%) adults with coronavirus infection developed at least one new condition that required medical care during the post-acute phase of illness, which is 5% higher than adults with no coronavirus infection in 2020, finds a US study published by The BMJ. The post-acute phase in this study started 21 days (or 3 weeks) after initial infection.

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News • Coronavirus disease biomarkers

New Covid-19 testing method gives results within one second

The Covid-19 pandemic made it clear technological innovations were urgently needed to detect, treat, and prevent the SARS-CoV-2 virus. A year and a half into this epidemic, waves of successive outbreaks and the dire need for new medical solutions — especially testing — continue to exist. In the Journal of Vacuum Science & Technology B, researchers from the University of Florida and…

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News • Coronavirus diagnostics

Rapid Covid-19 test delivers results within 4 minutes with 90 percent accuracy

A low-cost, rapid diagnostic test for Covid-19 developed by Penn Medicine provides Covid-19 results within four minutes with 90 percent accuracy. A paper published this week in Matter details the fast and inexpensive diagnostic test, called RAPID 1.0 (Real-time Accurate Portable Impedimetric Detection prototype 1.0). Compared to existing methods for Covid-19 detection, RAPID is inexpensive and…

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News • SARS-CoV-2 medication

Remdesivir: additional mechanism against Covid-19 discovered

When a cell is infected, SARS-CoV-2 not only causes the host cell to produce new virus particles. The virus also suppresses host cell defence mechanisms. The virus protein nsP3 plays a central role in this. Using structural analyses, researchers at Goethe University in cooperation with the Swiss Paul Scherrer Institute have now discovered that a decomposition product of the virostatic agent…

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News • Labs processing 2,000 to 5,000 tests a day

Workflow automation solutions for mid-volume laboratories

Clinical diagnostics company Beckman Coulter announced the European launch of the DxA 5000 Fit, a workflow-automation solution designed to fit into medium-sized labs that run fewer than 5,000 tests a day. The clinical laboratory has gone through trial by fire in 2020, where total testing was 245% of baseline volumes, with ~55% being SARS-CoV-2 molecular tests. Despite vaccines, many industry…

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News • Medication testing

'Airway-on-a-chip' to find new Covid-19 drugs

A collaboration spanning four research labs and hundreds of miles has used the organ-on-a-chip (Organ Chip) technology from the Wyss institute at Harvard Univesity to identify the antimalarial drug amodiaquine as a potent inhibitor of infection with SARS-CoV-2, the virus that causes Covid-19. The Organ Chip-based drug testing ecosystem established by the collaboration greatly streamlines the…

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News • Vigorous ventilation

Covid-19: Why faster air exchange in buildings is not always beneficial

Vigorous and rapid air exchanges might not always be a good thing when it comes to addressing levels of coronavirus particles in a multiroom building, according to a new modeling study. The study suggests that, in a multiroom building, rapid air exchanges can spread the virus rapidly from the source room into other rooms at high concentrations. Particle levels spike in adjacent rooms within 30…

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News • Building a coronavirus factory

How SARS-CoV-2 reprograms human cells to their own benefit

Coronavirus researchers under Prof. Rolf Hilgenfeld of the University of Lübeck and Dr. Albrecht von Brunn of the Ludwig-Maximilians University of Munich discovered how SARS viruses enhance the production of viral proteins in infected cells, so that many new copies of the virus can be generated. Other coronaviruses apart from SARS-CoV and SARS-CoV-2 do not use this mechanism, thereby providing a…

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News • Lipid research

Solving the sub-zero challenge of Covid-19 vaccines

New research by University of Texas at Dallas scientists could help solve a major challenge in the deployment of certain Covid-19 vaccines worldwide — the need for the vaccines to be kept at below-freezing temperatures during transport and storage. In a study published online in Nature Communications, the researchers demonstrate a new, inexpensive technique that generates crystalline…

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News • Coronavirus transmission

Experts: Covid-19 prevention efforts should focus on airborne transmission

Any future attempts to reduce the spread of Covid-19 should be focused on tackling close airborne transmission of the virus which is considered to be the primary route for its circulation, according to experts. Respiratory experts argue that it is now clear that SARS-CoV-2 is most likely to transmit between people at close range through inhalation rather than through contact with surfaces or…

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News • After overcoming a Corona infection

Covid-19: Study on long-term antibody protection

Does overcoming a SARS-CoV-2 infection protect against reinfection? The “Rhineland Study”, a population-based study conducted by DZNE in the Bonn area, is now providing new findings in this regard. Blood samples taken last year indicate that an important component of immunity – the levels of specific neutralizing antibodies against the coronavirus - had dropped in most of the study…

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News • Reverse genetics system

SARS-CoV-2: An easier and quicker way to analyse mutations

SARS-CoV-2 is the virus responsible for the Covid-19 pandemic. We know that mutations in the genome of SARS-CoV-2 have occurred and spread, but what effect do those mutations have? Current methods for studying mutations in the SARS-CoV-2 genome are very complicated and time-consuming because coronaviruses have large genomes, but now a team from Osaka University and Hokkaido University have…

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News • Protection from bacteria, fungi, viruses

Antimicrobial technologies – how do they work?

Antimicrobial technologies such as coatings and textiles containing silver and copper are helping people during the Covid-19 pandemic by ensuring that whatever they touch, whether that is a door handle or their own mask, is free from live SARS-CoV-2 particles. But how exactly do these antimicrobial technologies work? How can a silver, copper or even polymeric coating kill microorganisms such as…

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News • SARS-CoV-2 detection and sequencing

'Nirvana': Fast, portable test diagnoses Covid-19, tracks variants

Clinicians using a new viral screening test can not only diagnose Covid-19 in a matter of minutes with a portable, pocket-sized machine, but can also simultaneously test for other viruses—like influenza—that might be mistaken for the coronavirus. At the same time, they can sequence the virus, providing valuable information on the spread of Covid-19 mutations and variants. The new test, dubbed…

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News • Proof of concept

Surveillance system tracks Covid infection hotspots in hospital

A University of Manchester team has applied new techniques to detect and track the transmission of Covid-19 in hospital. The proof of concept system combines the movement and interaction of staff and patients with genomic sequencing of the virus, helping to signpost how best to improve patient pathways, staff movement and reduce risk. They identified hotspots within hospitals where patients and…

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News • Immune response in pregnant and lactating women

Mothers pass on Covid-19 protection to their babies after vaccination

In the largest study of its kind to date, researchers at Massachusetts General Hospital, Brigham and Women’s Hospital and the Ragon Institute of MGH, MIT and Harvard have found the new mRNA Covid-19 vaccines to be highly effective in producing antibodies against the SARS-CoV-2 virus in pregnant and lactating women. They also demonstrated the vaccines confer protective immunity to newborns…

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News • A much-needed update

New 'double antibody' delivers dual strike SARS-CoV-2 and its variants

The Institute for Research in Biomedicine (IRB) in Switzerland developed a second-generation ‘double antibody’ that protects from SARS-CoV-2, the virus causing Covid-19, and all its tested variants. It also prevents the virus from mutating to resist the therapy. Antibody-based immunotherapy was already shown to be effective against Covid-19 but faces two main obstacles: it needs to work…

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News • SARS-CoV-2 neutralising antibodies

Covid-19 immunity may last from days to decades

Scientists from Singapore found that antibodies against SARS-CoV-2 wane at different rates, lasting for mere days in some individuals, while remaining present in others for decades. The study, published in The Lancet Microbe, shows that the severity of the infection could be a deciding factor in having longer-lasting antibodies. Individuals with low levels of neutralising antibodies may still be…

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News • Asymptomatic disease spread

Why vaccines alone may not be enough to end the Covid-19 pandemic

Even as vaccines are becoming more readily available, protecting against the asymptomatic and pre-symptomatic spread of the virus (SARS-CoV-2) that causes Covid-19 is key to ending the pandemic, say two infectious disease experts at the Georgetown University Medical Center. In their Perspective, “SARS-CoV-2 Transmission Without Symptoms,” published in the journal Science, they make the case…

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News • Coronavirus demographics analysis

Does living with children increase Covid-19 risk? Probably not

A study published by The BMJ sheds light on the risk of infection with SARS-CoV-2 and covid-19 outcomes among adults living with and without children during the first two waves of the UK pandemic. It finds no evidence of any increased risk in wave 1 (Feb to Aug 2020). Small increased risks of infection and hospital admission were seen in wave 2 (Sept to Dec 2020), but this did not translate into…

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News • New study confirms

Covid-19 vaccines highly effective in nursing homes

In what is believed to be the first published study of Covid-19 vaccine effectiveness in long-term care facilities such as nursing homes, a research team co-led by the Yale School of Public Health found a widely used vaccine is highly successful in preventing infections. Residents of such facilities, particularly those in skilled nursing facilities (SNFs), have experienced disproportionately high…

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News • Model analysis

Machine learning for Covid-19 diagnosis: promising, but still too flawed

Systematic review finds that machine learning models for detecting and diagnosing Covid-19 from medical images have major flaws and biases, making them unsuitable for use in patients. However, researchers have suggested ways to remedy the problem. Researchers have found that out of the more than 300 Covid-19 machine learning models described in scientific papers in 2020, none of them is suitable…

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News • Epidemilogical study shows

Covid variant B.1.1.7.: A lot more dangerous than the original form

The highly infectious variant of Covid-19 discovered in Kent, which swept across the UK last year before spreading worldwide, is between 30 and 100 per cent more deadly than previous strains, new analysis has shown. A pivotal study, by epidemiologists from the Universities of Exeter and Bristol, has shown that the SARS-CoV-2 variant, B.1.1.7, is associated with a significantly higher mortality…

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Article • Laboratory management

Covid-19: Overcoming unprecedented challenges

During a pandemic, the demands for laboratory testing challenge routines in an efficiently run clinical laboratory. Gold standard procedures may need modification, or to be discarded, and the more nimble, resilient and receptive a lab is to change, the better off it could be. Senior managers at ARUP Laboratories in Salt Lake City, Utah, a large clinical reference laboratory that offers over 3,000…

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News • Airborne attack

Pollen increase Covid-19 risk

When airborne pollen levels are higher, increased SARS-CoV-2 infection rates can be observed. These results were determined by a large-scale study conducted by an international team headed by researchers at the Technical University of Munich (TUM) and the Helmholtz Zentrum München. Members of high-risk groups could protect themselves by watching pollen forecasts and wearing dust filter masks.

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News • Improved Coronavirus detection

Low-cost and fast Covid-19 test uses pool of gargle lavage samples

In order to monitor and contain the spread of SARS-CoV-2 it is necessary to test large numbers of people on a regular basis in decentralized settings. Researchers of the Max Planck Institute for Evolutionary Anthropology and the Hospital St. Georg in Leipzig, Germany, have developed improved protocols for the detection of SARS-CoV-2. The method can detect a positive sample in a pool with 25…

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News • Mutations of SARS-CoV-2 & Co.

Tracking virus variants faster with sequencing

A global group of researchers is calling for better integration of viral genetics, bioinformatics, and public health to enable better pandemic response now and better pandemic preparedness in the future. In a comment piece in the journal Nature, an international collaboration of specialists in viral and genetic analysis, led by Swiss scientists Dr. Emma Hodcroft at the University of Bern and…

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News • Coronavirus research

Promising SARS-CoV-2 inhibitors discovered

A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease. The study is based on laboratory experiments. Extensive clinical trials are still required for their further development as…

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News • Peptide research

A 'fake handshake' to trick the coronavirus

Scientists have developed peptides that fit snugly into a groove on the SARS-CoV-2 Spike protein that it would normally use to access a host cell. These protein fragments effectively trick the virus into “shaking hands” with a replica rather than with the actual protein on a cell’s surface that lets the virus in. revious research has determined that the novel coronavirus binds to a receptor…

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Article • Healthcare facilities analysed

Cutting Coronavirus air contamination in hospitals

Preventing air contamination in healthcare facilities is crucial to minimise the airborne spread of Covid-19 and its new strains. Universal masking, rigorous use of and safe disposal of PPE, plus building ventilation are vital. Twenty-four studies reporting hospital SARS-CoV-2 air contamination are summarised in a meta-analysis by a multi-institutional team of French researchers. These show that,…

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News • Study from Zambia shows many more deaths

Experts: Impact of Covid-19 in Africa “vastly underestimated”

The impact of Covid-19 in Africa has been vastly underestimated, warn researchers in a new study. Outside of South Africa, this is the first study to provide systematic surveillance data capturing the impact of Covid-19 in Africa. Their findings are based on polymerase chain reaction (PCR) test results for 364 deceased people of all ages at the University Teaching Hospital morgue in Lusaka,…

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Article • MHH SARS-CoV-2 Antigen Rapid Test Kit

First Covid-19 test 'made in Poland'

To date, testing for SARS-CoV-2 infection mostly has relied on RT-PCR performed on a nasopharyngeal specimen. This testing method is very unpleasant for a patient: the professional tester has to tilt the patient’s head back slightly about 45°-70° to straighten the passage from the front of the nose, insert the swab through the nostril parallel to the palate, and the swab should reach a depth…

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News • Spotting viral differences

Finding a better way to search for Covid-19 drugs

Is there a better approach to Covid drug research? Research from the University of Kent, Goethe-University in Frankfurt am Main, and the Philipps-University in Marburg has provided crucial insights into the biological composition of SARS-CoV-2, the cause of Covid-19, revealing vital clues for the discovery of antiviral drugs. Researchers compared SARS-CoV-2 and the closely related virus SARS-CoV,…

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Video • Portable testing solution

A corona lab that fits in a suitcase

The PCR test is the most accurate tool to identify SARS-CoV-2. However, valid results are often available only after days. Moreover, the laboratory must be well equipped, have trained personnel and sufficient financial resources. All of this is usually a problem in Africa. A portable suitcase could help. In cooperation with several African universities, scientists at Leipzig University have found…

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News • Target cells, medication effects, evasion methods

4 new facts about early Covid-19 infections

University of Minnesota Medical School researchers studied SARS-CoV-2 infections at individual cellular levels and made four major discoveries about the virus, including one that validates the effectiveness of remdesivir – an FDA-approved antiviral drug – as a form of treatment for severe Covid-19 disease. “Since the start of the Covid-19 pandemic, the way that each individual responds…

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News • Lessons learned from Covid-19

A 'blueprint' for preventing the next pandemic

Scientific and public health experts have been raising the alarm for decades, imploring public officials to prepare for the inevitability of a viral pandemic. Infectious epidemics seemingly as benign as "the flu" and as deadly as the Ebola virus provided ample warning, yet government officials seemed caught off guard and ill prepared for dealing with Covid-19.

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News • Environmental connections

Has climate change driven the emergence of SARS-CoV-2?

Global greenhouse gas emissions over the last century have made southern China a hotspot for bat-borne coronaviruses, by driving growth of forest habitat favoured by bats. A new study published in the journal Science of the Total Environment provides the first evidence of a mechanism by which climate change could have played a direct role in the emergence of SARS-CoV-2, the virus that caused the…

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News • A closer look at thapsigargin

Potential antiviral treatment for Covid-19 found

Researchers from the University of Nottingham have discovered a novel antiviral property of a drug that could have major implications in how future epidemics/pandemics – including Covid-19 – are managed. The study, published in Viruses, shows that thapsigargin is a promising broad‑spectrum antiviral, highly effective against SARS-CoV-2, a common cold coronavirus, respiratory syncytial virus…

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News • Image-based diagnosis of Covid-19

AI detects coronavirus on CT scans

In order to detect the Corona virus SARS-CoV-2, there are further methods of diagnosis apart from the globally used PCR tests (Polymerase chain reaction): The infection can also be recognised on CT scans – for which Artificial Intelligence (AI) can be used as well. An AI system can not only filter CT scan of Covid-19 patients from a data set, but also estimate, which areas of the image are of…

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News • Promising agents

The effect of vitamins, steroids and potential antivirals on SARS-CoV-2

Evidence is emerging that vitamin D – and possibly vitamins K and A – might help combat Covid-19. A new study from the University of Bristol published in the journal of the German Chemical Society Angewandte Chemie has shown how they – and other antiviral drugs – might work. The research indicates that these dietary supplements and compounds could bind to the viral spike protein and so…

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News • Viral sequencing

How SARS-CoV-2 spreads and evolves

The emergence of SARS-CoV-2 virus variants that are adding twists in the battle against COVID-19 highlight the need for better genomic monitoring of the virus, says Katia Koelle, associate professor of biology at Emory University.

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News • Microneedles

No more needles for bloodtests?

Blood draws are no fun. They hurt. Veins can burst, or even roll — like they’re trying to avoid the needle, too. Oftentimes, doctors use blood samples to check for biomarkers of disease: antibodies that signal a viral or bacterial infection, such as SARS-CoV-2, the virus responsible for COVID-19, or cytokines indicative of inflammation seen in conditions such as rheumatoid arthritis and…

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News • Coronavirus infection response

SARS-CoV-2 IgG II antibody test launched in CE Mark countries

Clinical diagnostics company Beckman Coulter launched its Access SARS-CoV-2 IgG II assay in countries accepting the CE Mark. The new Access SARS-CoV-2 IgG II assay quantitatively measures a patient’s level of antibodies in response to a previous SARS-CoV-2 infection. The ability to establish a quantitative baseline to evaluate an individual’s immune response to the SARS-CoV-2 virus allows…

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News • TB test shows promise

New method to assist fast-tracking of vaccines

With Covid-19 dominating medical science and human concern, chemists at the University of Sydney have developed a method to quickly and safely synthesise protein vaccines for respiratory diseases for pre-clinical tests. Their approach can be used to test vaccine strategies against novel pandemic pathogens such as SARS-CoV-2, the virus that causes Covid-19.

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News • "Faces" of the disease

Covid-19: researchers identify at least 5 variants

According to current studies, the Covid-19 disease which is caused by the SARS-CoV-2 coronavirus comprises at least five different variants. These differ in how the immune system responds to the infection. Researchers from the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, together with other experts from Germany, Greece and the Netherlands, present these findings…

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News • Variant COH.20G/501Y

New Coronavirus strain discovered

Scientists at The Ohio State University have discovered a new variant of SARS-Cov-2, the virus that causes Covid-19. The new variant carries a mutation identical to the U.K. strain, but it likely arose in a virus strain already present in the United States. The College of Medicine researchers also report the evolution of another U.S. strain that acquired three other gene mutations not previously…

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News • 'Nanobodies'

Small antibodies show promise against Covid-19

Researchers at Karolinska Institutet have developed, in collaboration with researchers in Germany and the U.S., new small antibodies, also known as nanobodies, which prevent the SARS-CoV-2 coronavirus from entering human cells. The research study, published in Science, shows that a combined nanobody had a particularly good effect – even if the virus mutated. According to the researchers, the…

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News • Lasts longer, causes more damage

Covid-19 pneumonia: not your typical garden-variety pneumonia

Bacteria or viruses like influenza that cause pneumonia can spread across large regions of the lung within hours. In the modern intensive care unit, these bacteria or viruses are usually controlled either by antibiotics or by the body’s immune system within the first few days of the illness. But in a study published in Nature, investigators at Northwestern Medicine show Covid-19 pneumonia is…

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News • Virion recreated

First computational model of entire SARS-CoV-2 virus

Researchers at the University of Chicago have created the first usable computational model of the entire virus responsible for Covid-19—and they are making this model widely available to help advance research during the pandemic. “If you can understand how a virus works, that’s the first step towards stopping it,” said Prof. Gregory Voth, whose team created the model published in…

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News • Influence of gut bacteria

How our gut microbiome affects Covid-19 severity

The variety and volume of bacteria in the gut, known as the microbiome, may influence the severity of Covid-19 as well as the magnitude of the immune system response to the infection, suggests research published online in the journal Gut. Imbalances in the make-up of the microbiome may also be implicated in persisting inflammatory symptoms, dubbed ‘long Covid’, the findings suggest. Covid-19…

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News • Dangerous immune response

New insight on severe virus attacks on the lungs

In some cases, immune cells in the lungs can contribute to worsening a virus attack. In a new study, researchers at Karolinska Institutet describe how different kinds of immune cells, called macrophages, develop in the lungs and which of them may be behind severe lung diseases. The study, which was published in Immunity, may contribute to future treatments for Covid-19, among other diseases.

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News • Promising candidate

Single-dose nanoparticle vaccine for Covid-19 in development

Before the pandemic, the lab of Stanford University biochemist Peter S. Kim focused on developing vaccines for HIV, Ebola and pandemic influenza. But, within days of closing their campus lab space as part of Covid-19 precautions, they turned their attention to a vaccine for SARS-CoV-2, the virus that causes Covid-19. Although the coronavirus was outside the lab’s specific area of expertise,…

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News • Enzyme Linked Immunosorbent Assay

Startup develops breakthrough IgG antibody test for Covid-19

ZTA Biotech, a Budapest-based biotech startup, has developed a Covid-19 antibody (IgG) test using the ELISA protocol. This new detection method represents a great step forward in determining if patients have had a coronavirus infection and if they might still have immunity to the disease. Early results have proven 100% in specificity after testing 280 samples, and 100% sensitivity by testing 260…

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Video • Computer model vs. Covid-19

Discovering new weaknesses of SARS-CoV-2 through bioinformatics

The search for antiviral agents against the new coronavirus is in full swing. Using a novel approach, Bioinformaticians have now discovered a weakness in the virus that could be exploited for drug development. In a computer model, the scientists discovered a human enzyme that is crucial for the virus. When it was switched off in the model, the virus could no longer multiply.

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News • Measuring aerosol travel while talking and singing

Imaging exhaled breath to provide new insights into Covid-19 transmission

A new method for visualizing breath that is exhaled while someone is speaking or singing could provide important new insights into how diseases such as Covid-19 spread and the effectiveness of face masks. “Scientists believe the SARS-CoV-2 virus is primarily spread through respiratory droplets that can be carried in the breath or expelled through coughing or sneezing,” said Thomas Moore from…

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News • SARS-CoV-2 vs the proteome

Researchers explore coronavirus interactions with cells

Scientists from Würzburg and the US have charted the first global atlas of direct interactions between SARS-CoV-2 RNA and human host cells. This may provide a starting point for novel treatments. SARS-CoV-2 infections pose a global threat to human health and a formidable research challenge. One of the most urgent tasks is to gain a detailed understanding of the molecular interactions between the…

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News • Rapid antigen testing at point of care

AI-assisted SARS-CoV-2 testing: Cooperation for first live project in Munich

Medicus AI announces the successful launch of its first live project under SafePlay, the digital platform supporting rapid antigen testing, which went live in partnership with Roche Diagnostics Germany and 21Dx in Munich this month. Medicus provides operators with a tech-enabled end-to-end solution that supports the logistical aspects of testing, managing the administrative workflow from…

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News • Natural variation impacts virus-relevant proteins

How SARS-CoV-2 benefits from helpers within the human body

Like all viruses, the novel coronavirus is dependent on help from the human host cell. Proteins are the functional units of the cell and enable the virus to enter the host cell or help the virus to replicate. Scientists from Charité – Universitätsmedizin Berlin and from the Berlin Institute of Health (BIH), along with colleagues from the United Kingdom, Germany and the United States, have…

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News • Digital health

AI test rules out Covid-19 diagnosis within one hour

An Artificial Intelligence test has been shown to be able to rapidly screen patients arriving in Emergency Departments for Covid-19, using clinical information routinely available within the first hour of coming to hospital. Results of the CURIAL study, published in The Lancet Digital Health, show that the AI test correctly predicted the Covid-19 status of 92.3% of patients coming to Emergency…

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News • Pandemic problems

Covid-19: risk increased sevenfold for healthcare workers

Healthcare workers are 7 times as likely to have severe Covid-19 infection as those with other types of ‘non-essential’ jobs, finds research focusing on the first UK-wide lockdown. And those with jobs in the social care and transport sectors are twice as likely to do so, emphasising the need to ensure that essential (key) workers are adequately protected against the infection, say the…

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Article • Diagnosing SARS-CoV-2

The arsenal: Molecular (PCR), antigen and antibody testing

Germany’s lack of diagnostic ability led to significantly underestimation of its own as well as global Covid-19 infection levels during the first wave. Now, however, improved testing and diagnosis of the condition more realistically reveal nearer 20,000 new cases a day across the country, according to Professor Hendrik Streeck, one of the country’s leading virologists. Speaking at a virtual…

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News • Success in Düsseldorf

virtual.Medica receives international resonance

For the first time in the history of MEDICA, the world-leading medical trade fair, and the industry’s number one platform for the suppliers of the medical technology industry, COMPAMED, held from 16 to 19 November 2020, took place entirely online due to the pandemic - but still won over their audiences due to their high degree of international resonance in this format too, as virtual.MEDICA and…

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News • Coronavirus assay receives CE Mark

Quantitative Covid-19 test to measure neutralizing antibodies

Siemens Healthineers announced its SARS-CoV-2 IgG Antibody Test (sCOVG) has proven to measure neutralizing antibodies and has achieved CE Mark. The test is an enhanced version of the assay which became available globally this summer. It demonstrates the ability to detect neutralizing antibodies and reports quantitative results measuring the amount of neutralizing antibodies present in a patient's…

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News • New gargle test

Mass spectrometry to improve Covid testing

A UK biotech laboratory has used mass spectrometry in a new approach to coronavirus testing. MAP Sciences developed a gargle test, which collects samples from the back of the throat, and avoids the unpleasant sensation of the current PCR (polymerase chain reaction) swab tests. From there, the sample is tested for coronavirus using mass spectrometry (MS) with high levels of accuracy.

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News • Interview

Disinfection: let mist do the work

Healthcare settings require sharp weapons to fight both hospital-acquired infections and pathogens like SARS-CoV-2. Besides protective equipment, regular room disinfection is one of them. So, why not fog the room? Read more in the MEDICA magazine.

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Article • Profiling the coronavirus

Experts unlock Covid-19 secrets

Experts have identified two distinct immunological and cellular profiles in the lungs of Covid-19 patients which they believe could help define treatment pathways. From some of the earliest Covid-19 autopsies conducted in Europe, Swiss-based researchers have performed integrative digital pathology and transcriptomic analyses of lung tissues of 16 coronavirus patients who died from respiratory…

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News • The countdown is on

virtual.MEDICA starts off with full programme and innovations

For the first time in their history, the world-leading medical trade fair MEDICA and the international number one event for the medical manufacturing supply market, COMPAMED, will be held entirely online as virtual.MEDICA and virtual.COMPAMED from Monday, with around 1,400 exhibitors hailing from 56 countries. Throughout the four days of the trade fair (16 – 19 November 2020), international…

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News • In countries accepting CE Mark

Beckman Coulter launches SARS-CoV-2 IgM antibody test

Beckman Coulter announced the launch of its Access SARS-CoV-2 Immunoglobulin M (IgM) assay in countries accepting the CE Mark. The new IgM antibody test demonstrated 99.9% specificity with 1,400 negative samples and 100% sensitivity at >18 days post symptom onset and post positive PCR. Beckman Coulter’s IgM assay is part of a full suite of testing solutions the company is developing to…

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News • False positive results

Accuracy of rapid covid test may be lower than previously suggested

The accuracy of a rapid finger-prick antibody test for SARS-CoV-2, the virus responsible for covid-19 infection, may be considerably lower than previously suggested, finds a study published by The BMJ. The results suggest that if 10% of people given the test had previously been infected, around 1 in 5 positive test results would be incorrect (false positive results). These conclusions contrast…

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News • Preclinical data

COVID-19 vaccine candidate designed via computer

An innovative nanoparticle vaccine candidate for the pandemic coronavirus produces virus-neutralizing antibodies in mice at levels ten-times greater than is seen in people who have recovered from COVID-19 infections. Designed by scientists at the University of Washington School of Medicine in Seattle, the vaccine candidate has been transferred to two companies for clinical development.

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News • Block of erythrocytes formation

SARS-CoV-2 might attack red marrow

Specialists from the Department of Fundamental Medicine of Far Eastern Federal University (FEFU) with Russian and Japanese colleagues have probed into mechanisms of COVID-19 inside-the-body distribution linked to erythrocytes damaging.

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News • Autopsy study

Myocarditis linked to COVID-19 not as common as believed

A study conducted by Richard Vander Heide, MD, PhD, Professor and Director of Pathology Research at LSU Health New Orleans School of Medicine, and Marc Halushka, MD, PhD, Professor of Pathology at Johns Hopkins University School of Medicine, suggests myocarditis caused by COVID-19 may be a relatively rare occurrence.

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