Search for: "SARS-Cov-2" - 422 articles found

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Reagents

PurePrep TL+

Highlights:Offering the combination of the safe transfer of viruses and lysis in one tube, the PurePrep TL+ buffer optimizes research.Compatible with most liquid handling systemsDecreases prep timeImproves workflows as it breaks down viscous samples within the tubeThe PurePrep TL+ buffer is suitable for diagnostic tests and molecular biology techniques, facilitating processes like nucleic acid…

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Saliva Collection

COVID-19 virus diagnostics products

Highlights:Validated containers for saliva collection for virus diagnostics: Monovette® VD, V-Monovette® VD and Salivette® VD.Saliva testing has become particularly important and is ideal for screening for SARS-CoV-2. Saliva collection using gargling and/or the Salivette® offers the key advantage that the user can collect the saliva themselves under supervision.Both the gargling…

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Article • Knowledge gaps in gender medicine

Covid-19 and sex: higher mortality of male patients

The Covid-19 pandemic has affected scientific research in numerous ways – for example by highlighting knowledge gaps in gender medicine. In many studies differences in morbidity and mortality between women and men surfaced incidentally. While the extent and causes of these differences remain largely unexplored, the preliminary insights confirm the need for further research.

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News • Based on image-based flow cytometry

Rapid test to predict severe Covid-19 infections

Researchers have developed a method for assessing the number and structure of aggregated blood platelets (or thrombocytes) that can potentially help quantify the risk of a severe Covid-19 infection. As a result, they have identified a predictive biomarker for the seriousness of a Covid-19 infection. This will allow physicians to adjust treatment at an early stage. The researchers used a method…

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Article • Sustainability

The challenge of "greening" medical technologies

Under the impulse of the European Commission, the in vitro diagnostic industry is developing emerging technologies to implement sustainable practices in medical laboratories. As sustainability has been a growing priority of the European Union (EU) in the last decade, ‘the medical technology sector, particularly the IVD sector, must comply with European legislation in this field like all other…

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Immunoassays

EXI1800 Chemiluminescence Immunoassay Analyzer

Dimensions: 650 × 790 × 650 mm (w × d × h)Weight: 110 kgSample throughput: up to 180 tests/hAssays: Comprehensive test menu covers SARS-CoV-2, thyroid, fertility, inflammation, cardiac markers, diabetes, tumor markers and moreHighlights:EXI 1800 is a desktop automatic chemiluminescence immunoassay analyzer with compact design which only needs 0.52 m2. With its patented…

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Sponsored • Disease management

Multiplex Testing: A Solution to Manage Surge in Respiratory Illnesses as Concerns over “Multi-demic” Rise

Eunsin Bae, M.D. specializes in laboratory medicine and leads the Institute of Clinical Research at Seegene Inc. Her research focuses on microbiology, molecular biology, and hematology. Dr. Bae is currently working toward implementing a global clinical study and establishing an international network of clinical investigations.

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Lab-on-a-chip

Multiplexed lab-on-a-chip bioassays for testing antibodies against SARS-CoV 2 and its variants in multiple individuals

The coronavirus pandemic caused by SARS-CoV-2 and its variants is still a major public safety issue worldwide. The “alpha” variant B.1.1.7, the “gamma” variant P.1, the “beta” variant B.1.351, and the “delta” variant B.1.617 are of particular concern because of their high prevalence. Large-scale vaccination and sensitive detection are vital for preventing the spread of Covid-19.

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Article • Infection prevention

Vaccination: why ‘positive consensus’ is crucial

Vaccination projects across the world are at a pivotal post-Covid moment, according to one of the leading experts in the field. Speaking to Healthcare in Europe ahead of the World Innovation Summit for Health (WISH) congress in Qatar – where vaccination will be a central topic – Dr Jerome Kim said there is an urgent need to regain a ‘positive consensus’ around the value of vaccines. He…

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Article • Imaging biomarkers, AI support and beyond

New tools for Covid-19 assessment

As knowledge about Covid-19 advances, so does the arsenal of techniques to predict, diagnose and follow up on the disease. At ECR, researchers presented a range of promising imaging modalities to keep track of Covid-19 symptoms, severity, and mortality, often including AI support to enhance or accelerate diagnostics.

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Sponsored • Covid-19 management

Rapid and robust PCR testing for infectious diseases at Innklinikum Altötting and Mühldorf

The Covid-19 pandemic has highlighted the importance of the fast and accurate diagnosis of infectious diseases in clinical settings. Harald Maier discusses the implementation of rapid molecular diagnostics in the central clinical diagnostics laboratory at Innklinikum Altötting and Mühldorf, highlighting how the use of PCR testing has benefitted the hospital during the Covid-19 pandemic.

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Article • Super-resolution miscroscopy

PEAR: setting nano-imaging in motion

Ever since the Abbe diffraction limit of conventional microscopy has been surpassed, super-resolution techniques have been diving ever deeper into the most miniscule details of molecular structures. We spoke with Prof. Dominic Zerulla, whose company PEARlabs is developing an imaging technique that sets out to push the boundaries once more – by looking at in-vivo nano-scale processes in motion.

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Sponsored • DNA extraction chemistry

Providing innovative molecular workflows to empower future diagnostics

Founded in 2018 as a DNA extraction chemistry company, Dutch company MolGen entered the market operating within the agricultural sector. At first, the company’s founders, Maarten de Groot, Wim van Haeringen and Niels Kruize, focused solely on this one industry, mainly developing and marketing advanced bulk chemistry kits for DNA/RNA extraction. These testing products and solutions successfully…

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Sponsored • Coronavirus antigen detection

An innovative test for the early diagnosis of Covid-19

Compared to previous SARS and MERS, SARS-CoV-2 became a pandemic due to the high infectivity and different mode of contagion. SARS-CoV-2 spreads more because it is contagious also before symptoms, during incubation phase. No tests to date have been able to find the virus during the pre-symptomatic stage. Stark has developed a new, rapid, non-invasive method "Stark Portable Covid-19 Antigen…

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News • 'CRyPTIC' research

Global tuberculosis study identifies genetic causes of drug resistance

Using cutting-edge genomic sequencing techniques, researchers at the University of Oxford have identified almost all the genomic variation that gives people resistance to 13 of the most common tuberculosis (TB) drug treatments. The Comprehensive Resistance Prediction for Tuberculosis International Consortium (CRyPTIC) research project has collected the largest ever global dataset of clinical M.…

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News • Coronavirus inhibition

Highly potent antibody against SARS-CoV-2 discovered

Scientists at Lausanne University Hospital (CHUV) and École polytechnique fédérale de Lausanne (EPFL) have discovered a highly potent monoclonal antibody that targets the SARS-CoV-2 spike protein and is effective at neutralizing all variants of concern identified to date, including the delta variant. Their findings are published in the journal Cell Reports.

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News • Rapid detection

Molecular diagnostic test for Covid-19, Flu, RSV receives CE mark

A new rapid molecular diagnostic test from Cepheid has received the CE mark for distribution in the European market. The test, called Xpert Xpress CoV-2/Flu/RSV plus, is designed for qualitative detection of the viruses causing Covid-19, Flu A, Flu B, and respiratory syncytial virus (RSV) infections from a single patient sample. The new plus version of the test provides a third gene target for…

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News • microRNAs hint at cognitive decline

Researchers find warning signs for dementia in the blood

Researchers at the DZNE and the University Medical Center Göttingen (UMG) have identified molecules in the blood that can indicate impending dementia. Their findings, which are presented in the scientific journal “EMBO Molecular Medicine”, are based on human studies and laboratory experiments. Various university hospitals across Germany were also involved in the investigations.

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News • Immune response study

Is a "natural" Covid-19 infection better than vaccination? It's complicated

Hope for a future without fear of Covid-19 comes down to circulating antibodies and memory B cells. Unlike circulating antibodies, which peak soon after vaccination or infection only to fade a few months later, memory B cells can stick around to prevent severe disease for decades. And they evolve over time, learning to produce successively more potent “memory antibodies” that are better at…

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News • Immunological memory

How our lungs 'remember' a Covid-19 infection

After infection with SARS-CoV-2, where does the immune system store the memory to provide long-term protection against reinfection? Though numerous studies have examined blood to track immune responses to SARS-CoV-2, a new study of Covid survivors shows that the memory of the infection is primarily stored in T and B cells within the lung and the lymph nodes surrounding the lung.

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Article • Covid-19 and pathology

Lung cancer care across Europe affected by coronavirus pandemic

The impact of the coronavirus pandemic on lung cancer patient care across Europe, and the contribution lung pathologists, have led to a better understanding of Covid-19, as outlined during the 33rd European Congress of Pathology, Within ‘The lung pathologist in the Covid-19 pandemic’ session, speakers detailed how the pandemic has affected patients, diagnosis and clinical trials, yet also…

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News • SARS-CoV-2 in the media

Does 'beautifying' the Coronavirus make us underestimate its danger?

Colourful, 3D rendered scientific images are fascinating - but can they deceive viewers? New research from Spain suggests this might be the case. According to the study by the Instituto de Radio Televisión Española and the Universitat Autònoma de Barcelona conducted during the Covid-19 lockdown, black and white images of SARS-CoV-2 make the virus seem more infectious. The results, published on…

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News • Respiratory research

Covid-19 infection does not affect lung function in kids, young adults

Covid-19 infection does not appear to affect the lung function of young adults, according to new research presented at the ‘virtual’ European Respiratory Society International Congress. In the first study to investigate the impact of Covid-19 infection on lung function, researchers led by Dr Ida Mogensen, a post-doctoral fellow at the Karolinska Institute, Stockholm, Sweden, found that even…

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News • Resource management

Automated filling machine could stave off Covid-19 vaccine shortage

Researchers in Thailand have developed a device to get the most out of vaccine supplies: The automated vaccine filling machine from the Faculty of Engineering at Chulalongkorn University can fill AstraZeneca vaccine into syringes with precision, speed, and safety, helping to increase the number of vaccinated people by 20 percent. The prototype is now operating at Chula Vaccination Center and more…

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News • SARS CoV-2 B.1.621

WHO classifies Coronavirus "Mu" as new 'Variant of Interest'

The World Health Organization (WHO) has taken a closer look at coronavirus variant B.1.621. The strain, first encountered in January 2021 in Colombia, shows traits that could enable the virus to circumvent immune response to vaccination. As a result, the variant, named "Mu", has been classified as "Variant of Interest" (VOI). Despite its prominence in Colombian new infection,…

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Video • Coronavirus medication research

Lab-grown beating heart cells could identify Covid drugs

Scientists have grown beating heart cells to attempt to identify drugs to prevent Covid-19-related heart damage. Concerns over the extent of cardiac damage among Covid patients emerged during the coronavirus pandemic and there are also suggestions that the impact on cardiomyocytes could contribute to the symptoms of long Covid. To explore these issues, a research team at the University of…

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News • Variants of concern

Are Covid-19 vaccines still effective against Delta variant? New study says yes

Obtaining two vaccine doses remains the most effective way to ensure protection against the Covid-19 Delta variant of concern dominant in the UK today, according to a study from the University of Oxford. Conducted in partnership with the Office of National Statistics (ONS) and the Department for Health and Social Care (DHSC), the study found that with Delta, Pfizer-BioNTech and Oxford-AstraZeneca…

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News • Public health worldwide

Sharing Covid-19 vaccines between nations: a mathematical approach

New research from the University of Oxford and the UK Centre for Ecology & Hydrology uses mathematical modelling to determine the most equitable way to share vaccines between nations. Vaccines provide a route to achieving high levels of immunity against SARS-CoV-2 across populations, and provide a route to reopening economies, tourism, and livelihoods. However, vaccine resources amongst…

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News • Infection research

Understanding lung damage in Covid-19 patients

Covid-19 disease severity is determined by the individual patient’s immune response. The precise mechanisms taking place inside the lungs and blood during the early phase of the disease, however, remain unclear. Researchers from Charité – Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC) and Freie Universität Berlin have now studied the cellular mechanisms…

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News • Potential for pan-variant therapies

SARS-CoV-2 might have a 'sugar coated' weak spot

Researchers identify two sugar-binding proteins that impede the viral entry of circulating SARS-CoV-2 variants. The team, spearheaded by researchers at IMBA – Institute of Molecular Biotechnology of the Austrian Academy of Sciences – may have found the “Achilles’ heel” of the virus, with potential for pan-variant therapeutic interventions. The findings are now published in the EMBO…

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News • Genome editing

Using CRISPR to speed up Covid-19 testing

A research team led by scientists in the labs of Jennifer Doudna, David Savage and Patrick Hsu at the University of California, Berkeley, is aiming to develop a rapid Covid-19 diagnostic test that is much faster and easier to deploy than qRT-PCR. It has now combined two different types of CRISPR enzymes to create an assay that can detect small amounts of viral RNA in less than an hour. Doudna…

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News • Coronavirus research

Contagious cash? The role of banknotes and coins in Covid-19 infections

How long do coronaviruses remain infectious on banknotes and coins? Is it possible to become infected through contact with cash? Experts at the European Central Bank, in collaboration with the Department of Medical and Molecular Virology at Ruhr-Universität Bochum, wanted to clarify this question. The researchers led by Professor Eike Steinmann and Dr. Daniel Todt developed a method specifically…

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News • Immune response determined

How Covid-19 vaccines prepare our immune system for the virus

In view of the continuing high numbers of infections, vaccination offers important protection against severe Covid-19 disease. Scientists from the Faculty of Medicine – University of Freiburg have now been able to determine in detail at what time point initial immune protection is established after vaccination with an mRNA-based vaccine and how the reactions of the various components of the…

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News • Search for signatures

‘Long Covid’ biomarkers in blood could lead to diagnostic test

Markers in our blood – ‘fingerprints’ of infection – could help identify individuals who have been infected by SARS-CoV-2, the coronavirus that causes Covid-19, several months after infection even if the individual had only mild symptoms or showed no symptoms at all, say Cambridge researchers. The team has received funding from the National Institute for Health Research to develop a test…

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News • Covid-19 detection

New blood test measures immunity against SARS-CoV-2 and its variants

The Lausanne University Hospital (CHUV) and EPFL teamed up to develop a new test that’s sensitive enough to measure the amount of SARS-CoV-2 neutralizing antibodies present in the bloodstream. The scientists’ discovery, published in Science Translational Medicine, opens promising new avenues for tracking immunity acquired by infection or vaccination.

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News • Early detection of coronavirus presence

Covid-19 wastewater testing: new quantification kit launched

Life science research and clinical diagnostics company Bio-Rad Laboratories announced the launch of its PREvalence ddPCR SARS-CoV-2 Wastewater Quantification Kit, a tool to detect the virus that causes Covid-19 in a community’s wastewater. "With wastewater testing becoming more widely adopted, this assay provides the ability for a community to determine if the virus is present days to…

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News • Sample-to-answer workflow

Partnership for Covid-19 test solution

SpeeDx Pty, Ltd. and MolGen announced the signing of an agreement to collaborate on supply and distribution of clinical diagnostics products and instrumentation across Europe and Asia Pacific. The partnership links specimen handling, nucleic acid extraction, assay set-up, amplification, and results reporting in a seamless integration of the companies technologies. “This partnership capitalises…

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News • Aerosol propagation study

Covid-19: is it safe to play the trumpet and other wind instruments?

Aerosol generated by playing woodwind and brass instruments is less than that produced when vocalising (speaking and singing) and is no different than a person breathing, new research has found. The findings could be crucial to developing a roadmap for lifting Covid-19 restrictions in the performing arts, which have been significantly restricted since the start of the pandemic.

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News • Coronavirus epidemiology

A cloud-based software for the surveillance of SARS-CoV-2 variants

In-vitro-diagnostics company bioMérieux has launched Episeq SARS-CoV-2, a genomic software solution to support microbiology labs in identification and reporting from raw sequencing data related to SARS-CoV-2 variants. Viral mutation is a naturally occurring phenomenon leading to the emergence of variants that can have different characteristics. Today, a number of SARS-CoV-2 variants are…

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News • Corona and EBV

Long Covid symptoms likely caused by Epstein-Barr virus reactivation

Epstein-Barr virus (EBV) reactivation resulting from the inflammatory response to coronavirus infection may be the cause of previously unexplained long Covid symptoms—such as fatigue, brain fog, and rashes—that occur in approximately 30% of patients after recovery from initial Covid-19 infection. The first evidence linking EBV reactivation to long Covid, as well as an analysis of long Covid…

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News • Unexpected find

Anti-tapeworm drug shows promise against Covid-19

Researchers from the German Center for Infection Research (DZIF) at Charité – Universitätsmedizin Berlin and the University of Bonn have examined the way in which SARS-CoV-2 reprograms the metabolism of the host cell in order to gain an overall advantage. According to their report in Nature Communications, the researchers were able to identify four substances which inhibit SARS-CoV-2…

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News • Corona and the brain

PET imaging measures cognitive impairment in Covid-19 patients

The effects of Covid-19 on the brain can be accurately measured with positron emission tomography (PET), according to research presented at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2021 Annual Meeting. In the study, newly diagnosed Covid-19 patients, who required inpatient treatment and underwent PET brain scans, were found to have deficits in neuronal function and…

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News • Severe effects

How COVID-19 wreaks havoc on human lungs

Scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory have published the first detailed atomic-level model of the SARS-CoV-2 "envelope" protein bound to a human protein essential for maintaining the lining of the lungs.

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News • Fighting the pandemic

90 drugs against Covid-19

Mining the world's most comprehensive drug repurposing collection for Covid-19 therapies, scientists have identified 90 existing drugs or drug candidates with antiviral activity against the coronavirus that's driving the ongoing global pandemic.

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News • Good news

Mild COVID-19 induces lasting antibody protection

Months after recovering from mild cases of COVID-19, people still have immune cells in their body pumping out antibodies against the virus that causes COVID-19, according to a study from researchers at Washington University School of Medicine in St. Louis. Such cells could persist for a lifetime, churning out antibodies all the while.

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News • Coronavirus complications

Post-acute Covid: study explores risk of developing long term conditions

One in 7 (14%) adults with coronavirus infection developed at least one new condition that required medical care during the post-acute phase of illness, which is 5% higher than adults with no coronavirus infection in 2020, finds a US study published by The BMJ. The post-acute phase in this study started 21 days (or 3 weeks) after initial infection.

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News • Coronavirus disease biomarkers

New Covid-19 testing method gives results within one second

The Covid-19 pandemic made it clear technological innovations were urgently needed to detect, treat, and prevent the SARS-CoV-2 virus. A year and a half into this epidemic, waves of successive outbreaks and the dire need for new medical solutions — especially testing — continue to exist. In the Journal of Vacuum Science & Technology B, researchers from the University of Florida and…

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News • Coronavirus diagnostics

Rapid Covid-19 test delivers results within 4 minutes with 90 percent accuracy

A low-cost, rapid diagnostic test for Covid-19 developed by Penn Medicine provides Covid-19 results within four minutes with 90 percent accuracy. A paper published this week in Matter details the fast and inexpensive diagnostic test, called RAPID 1.0 (Real-time Accurate Portable Impedimetric Detection prototype 1.0). Compared to existing methods for Covid-19 detection, RAPID is inexpensive and…

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News • SARS-CoV-2 medication

Remdesivir: additional mechanism against Covid-19 discovered

When a cell is infected, SARS-CoV-2 not only causes the host cell to produce new virus particles. The virus also suppresses host cell defence mechanisms. The virus protein nsP3 plays a central role in this. Using structural analyses, researchers at Goethe University in cooperation with the Swiss Paul Scherrer Institute have now discovered that a decomposition product of the virostatic agent…

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News • Covid-19 prevention side effects

Rare blood clots after Oxford-AstraZeneca vaccine: study sheds more light

A large study from Denmark and Norway published by The BMJ sheds more light on the risk of rare blood clots in adults receiving their first dose of the Oxford-AstraZeneca Covid-19 vaccine. The findings show slightly increased rates of vein blood clots including clots in the veins of the brain, compared with expected rates in the general population. However, the researchers stress that the risk of…

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News • Post-traumatic stress disorder

Is PTSD on the rise - or just overdiagnosed?

Some clinicians are concerned that post-traumatic stress disorder (PTSD) diagnosis has risen throughout Western society since the late 1980s. Is this correct? And if so, has the true incidence of PTSD really spiralled out of control, or has it simply become overdiagnosed? Experts debate the issue in The BMJ this week. PTSD is a serious and uncommon condition resulting from severe trauma, but it…

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News • Labs processing 2,000 to 5,000 tests a day

Workflow automation solutions for mid-volume laboratories

Clinical diagnostics company Beckman Coulter announced the European launch of the DxA 5000 Fit, a workflow-automation solution designed to fit into medium-sized labs that run fewer than 5,000 tests a day. The clinical laboratory has gone through trial by fire in 2020, where total testing was 245% of baseline volumes, with ~55% being SARS-CoV-2 molecular tests. Despite vaccines, many industry…

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News • Medication testing

'Airway-on-a-chip' to find new Covid-19 drugs

A collaboration spanning four research labs and hundreds of miles has used the organ-on-a-chip (Organ Chip) technology from the Wyss institute at Harvard Univesity to identify the antimalarial drug amodiaquine as a potent inhibitor of infection with SARS-CoV-2, the virus that causes Covid-19. The Organ Chip-based drug testing ecosystem established by the collaboration greatly streamlines the…

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News • Vigorous ventilation

Covid-19: Why faster air exchange in buildings is not always beneficial

Vigorous and rapid air exchanges might not always be a good thing when it comes to addressing levels of coronavirus particles in a multiroom building, according to a new modeling study. The study suggests that, in a multiroom building, rapid air exchanges can spread the virus rapidly from the source room into other rooms at high concentrations. Particle levels spike in adjacent rooms within 30…

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News • Coronavirus research

'Covid-19 atlas' uncovers differing immune responses in asymptomatic versus severe cases

The largest study of its kind in the UK has identified differences in the immune response to Covid-19 between people with no symptoms, compared to those suffering a more serious reaction to the virus. The research by Newcastle University and collaborators within the Human Cell Atlas initiative found raised levels of specific immune cells in asymptomatic people. They also showed people with more…

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News • Building a coronavirus factory

How SARS-CoV-2 reprograms human cells to their own benefit

Coronavirus researchers under Prof. Rolf Hilgenfeld of the University of Lübeck and Dr. Albrecht von Brunn of the Ludwig-Maximilians University of Munich discovered how SARS viruses enhance the production of viral proteins in infected cells, so that many new copies of the virus can be generated. Other coronaviruses apart from SARS-CoV and SARS-CoV-2 do not use this mechanism, thereby providing a…

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News • Lipid research

Solving the sub-zero challenge of Covid-19 vaccines

New research by University of Texas at Dallas scientists could help solve a major challenge in the deployment of certain Covid-19 vaccines worldwide — the need for the vaccines to be kept at below-freezing temperatures during transport and storage. In a study published online in Nature Communications, the researchers demonstrate a new, inexpensive technique that generates crystalline…

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News • Coronavirus transmission

Experts: Covid-19 prevention efforts should focus on airborne transmission

Any future attempts to reduce the spread of Covid-19 should be focused on tackling close airborne transmission of the virus which is considered to be the primary route for its circulation, according to experts. Respiratory experts argue that it is now clear that SARS-CoV-2 is most likely to transmit between people at close range through inhalation rather than through contact with surfaces or…

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News • After overcoming a Corona infection

Covid-19: Study on long-term antibody protection

Does overcoming a SARS-CoV-2 infection protect against reinfection? The “Rhineland Study”, a population-based study conducted by DZNE in the Bonn area, is now providing new findings in this regard. Blood samples taken last year indicate that an important component of immunity – the levels of specific neutralizing antibodies against the coronavirus - had dropped in most of the study…

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News • Shepherding medical data

Machine learning platform turns healthcare data into insights

Over the past decade, hospitals and other healthcare providers have put massive amounts of time and energy into adopting electronic healthcare records, turning hastily scribbled doctors' notes into durable sources of information. But collecting these data is less than half the battle. It can take even more time and effort to turn these records into actual insights — ones that use the learnings…

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News • Reverse genetics system

SARS-CoV-2: An easier and quicker way to analyse mutations

SARS-CoV-2 is the virus responsible for the Covid-19 pandemic. We know that mutations in the genome of SARS-CoV-2 have occurred and spread, but what effect do those mutations have? Current methods for studying mutations in the SARS-CoV-2 genome are very complicated and time-consuming because coronaviruses have large genomes, but now a team from Osaka University and Hokkaido University have…

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News • Protection from bacteria, fungi, viruses

Antimicrobial technologies – how do they work?

Antimicrobial technologies such as coatings and textiles containing silver and copper are helping people during the Covid-19 pandemic by ensuring that whatever they touch, whether that is a door handle or their own mask, is free from live SARS-CoV-2 particles. But how exactly do these antimicrobial technologies work? How can a silver, copper or even polymeric coating kill microorganisms such as…

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News • SARS-CoV-2 detection and sequencing

'Nirvana': Fast, portable test diagnoses Covid-19, tracks variants

Clinicians using a new viral screening test can not only diagnose Covid-19 in a matter of minutes with a portable, pocket-sized machine, but can also simultaneously test for other viruses—like influenza—that might be mistaken for the coronavirus. At the same time, they can sequence the virus, providing valuable information on the spread of Covid-19 mutations and variants. The new test, dubbed…

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News • Proof of concept

Surveillance system tracks Covid infection hotspots in hospital

A University of Manchester team has applied new techniques to detect and track the transmission of Covid-19 in hospital. The proof of concept system combines the movement and interaction of staff and patients with genomic sequencing of the virus, helping to signpost how best to improve patient pathways, staff movement and reduce risk. They identified hotspots within hospitals where patients and…

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News • Immune response in pregnant and lactating women

Mothers pass on Covid-19 protection to their babies after vaccination

In the largest study of its kind to date, researchers at Massachusetts General Hospital, Brigham and Women’s Hospital and the Ragon Institute of MGH, MIT and Harvard have found the new mRNA Covid-19 vaccines to be highly effective in producing antibodies against the SARS-CoV-2 virus in pregnant and lactating women. They also demonstrated the vaccines confer protective immunity to newborns…

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News • A much-needed update

New 'double antibody' delivers dual strike SARS-CoV-2 and its variants

The Institute for Research in Biomedicine (IRB) in Switzerland developed a second-generation ‘double antibody’ that protects from SARS-CoV-2, the virus causing Covid-19, and all its tested variants. It also prevents the virus from mutating to resist the therapy. Antibody-based immunotherapy was already shown to be effective against Covid-19 but faces two main obstacles: it needs to work…

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News • SARS-CoV-2 neutralising antibodies

Covid-19 immunity may last from days to decades

Scientists from Singapore found that antibodies against SARS-CoV-2 wane at different rates, lasting for mere days in some individuals, while remaining present in others for decades. The study, published in The Lancet Microbe, shows that the severity of the infection could be a deciding factor in having longer-lasting antibodies. Individuals with low levels of neutralising antibodies may still be…

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News • Asymptomatic disease spread

Why vaccines alone may not be enough to end the Covid-19 pandemic

Even as vaccines are becoming more readily available, protecting against the asymptomatic and pre-symptomatic spread of the virus (SARS-CoV-2) that causes Covid-19 is key to ending the pandemic, say two infectious disease experts at the Georgetown University Medical Center. In their Perspective, “SARS-CoV-2 Transmission Without Symptoms,” published in the journal Science, they make the case…

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News • Coronavirus demographics analysis

Does living with children increase Covid-19 risk? Probably not

A study published by The BMJ sheds light on the risk of infection with SARS-CoV-2 and covid-19 outcomes among adults living with and without children during the first two waves of the UK pandemic. It finds no evidence of any increased risk in wave 1 (Feb to Aug 2020). Small increased risks of infection and hospital admission were seen in wave 2 (Sept to Dec 2020), but this did not translate into…

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News • New study confirms

Covid-19 vaccines highly effective in nursing homes

In what is believed to be the first published study of Covid-19 vaccine effectiveness in long-term care facilities such as nursing homes, a research team co-led by the Yale School of Public Health found a widely used vaccine is highly successful in preventing infections. Residents of such facilities, particularly those in skilled nursing facilities (SNFs), have experienced disproportionately high…

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News • Model analysis

Machine learning for Covid-19 diagnosis: promising, but still too flawed

Systematic review finds that machine learning models for detecting and diagnosing Covid-19 from medical images have major flaws and biases, making them unsuitable for use in patients. However, researchers have suggested ways to remedy the problem. Researchers have found that out of the more than 300 Covid-19 machine learning models described in scientific papers in 2020, none of them is suitable…

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News • Epidemilogical study shows

Covid variant B.1.1.7.: A lot more dangerous than the original form

The highly infectious variant of Covid-19 discovered in Kent, which swept across the UK last year before spreading worldwide, is between 30 and 100 per cent more deadly than previous strains, new analysis has shown. A pivotal study, by epidemiologists from the Universities of Exeter and Bristol, has shown that the SARS-CoV-2 variant, B.1.1.7, is associated with a significantly higher mortality…

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Article • Laboratory management

Covid-19: Overcoming unprecedented challenges

During a pandemic, the demands for laboratory testing challenge routines in an efficiently run clinical laboratory. Gold standard procedures may need modification, or to be discarded, and the more nimble, resilient and receptive a lab is to change, the better off it could be. Senior managers at ARUP Laboratories in Salt Lake City, Utah, a large clinical reference laboratory that offers over 3,000…

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News • Airborne attack

Pollen increase Covid-19 risk

When airborne pollen levels are higher, increased SARS-CoV-2 infection rates can be observed. These results were determined by a large-scale study conducted by an international team headed by researchers at the Technical University of Munich (TUM) and the Helmholtz Zentrum München. Members of high-risk groups could protect themselves by watching pollen forecasts and wearing dust filter masks.

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News • Improved Coronavirus detection

Low-cost and fast Covid-19 test uses pool of gargle lavage samples

In order to monitor and contain the spread of SARS-CoV-2 it is necessary to test large numbers of people on a regular basis in decentralized settings. Researchers of the Max Planck Institute for Evolutionary Anthropology and the Hospital St. Georg in Leipzig, Germany, have developed improved protocols for the detection of SARS-CoV-2. The method can detect a positive sample in a pool with 25…

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News • Mutations of SARS-CoV-2 & Co.

Tracking virus variants faster with sequencing

A global group of researchers is calling for better integration of viral genetics, bioinformatics, and public health to enable better pandemic response now and better pandemic preparedness in the future. In a comment piece in the journal Nature, an international collaboration of specialists in viral and genetic analysis, led by Swiss scientists Dr. Emma Hodcroft at the University of Bern and…

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News • Coronavirus research

Promising SARS-CoV-2 inhibitors discovered

A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease. The study is based on laboratory experiments. Extensive clinical trials are still required for their further development as…

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News • Peptide research

A 'fake handshake' to trick the coronavirus

Scientists have developed peptides that fit snugly into a groove on the SARS-CoV-2 Spike protein that it would normally use to access a host cell. These protein fragments effectively trick the virus into “shaking hands” with a replica rather than with the actual protein on a cell’s surface that lets the virus in. revious research has determined that the novel coronavirus binds to a receptor…

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Article • Healthcare facilities analysed

Cutting Coronavirus air contamination in hospitals

Preventing air contamination in healthcare facilities is crucial to minimise the airborne spread of Covid-19 and its new strains. Universal masking, rigorous use of and safe disposal of PPE, plus building ventilation are vital. Twenty-four studies reporting hospital SARS-CoV-2 air contamination are summarised in a meta-analysis by a multi-institutional team of French researchers. These show that,…

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News • Study from Zambia shows many more deaths

Experts: Impact of Covid-19 in Africa “vastly underestimated”

The impact of Covid-19 in Africa has been vastly underestimated, warn researchers in a new study. Outside of South Africa, this is the first study to provide systematic surveillance data capturing the impact of Covid-19 in Africa. Their findings are based on polymerase chain reaction (PCR) test results for 364 deceased people of all ages at the University Teaching Hospital morgue in Lusaka,…

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Article • MHH SARS-CoV-2 Antigen Rapid Test Kit

First Covid-19 test 'made in Poland'

To date, testing for SARS-CoV-2 infection mostly has relied on RT-PCR performed on a nasopharyngeal specimen. This testing method is very unpleasant for a patient: the professional tester has to tilt the patient’s head back slightly about 45°-70° to straighten the passage from the front of the nose, insert the swab through the nostril parallel to the palate, and the swab should reach a depth…

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News • Spotting viral differences

Finding a better way to search for Covid-19 drugs

Is there a better approach to Covid drug research? Research from the University of Kent, Goethe-University in Frankfurt am Main, and the Philipps-University in Marburg has provided crucial insights into the biological composition of SARS-CoV-2, the cause of Covid-19, revealing vital clues for the discovery of antiviral drugs. Researchers compared SARS-CoV-2 and the closely related virus SARS-CoV,…

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Video • Portable testing solution

A corona lab that fits in a suitcase

The PCR test is the most accurate tool to identify SARS-CoV-2. However, valid results are often available only after days. Moreover, the laboratory must be well equipped, have trained personnel and sufficient financial resources. All of this is usually a problem in Africa. A portable suitcase could help. In cooperation with several African universities, scientists at Leipzig University have found…

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News • Target cells, medication effects, evasion methods

4 new facts about early Covid-19 infections

University of Minnesota Medical School researchers studied SARS-CoV-2 infections at individual cellular levels and made four major discoveries about the virus, including one that validates the effectiveness of remdesivir – an FDA-approved antiviral drug – as a form of treatment for severe Covid-19 disease. “Since the start of the Covid-19 pandemic, the way that each individual responds…

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News • Lessons learned from Covid-19

A 'blueprint' for preventing the next pandemic

Scientific and public health experts have been raising the alarm for decades, imploring public officials to prepare for the inevitability of a viral pandemic. Infectious epidemics seemingly as benign as "the flu" and as deadly as the Ebola virus provided ample warning, yet government officials seemed caught off guard and ill prepared for dealing with Covid-19.

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News • Environmental connections

Has climate change driven the emergence of SARS-CoV-2?

Global greenhouse gas emissions over the last century have made southern China a hotspot for bat-borne coronaviruses, by driving growth of forest habitat favoured by bats. A new study published in the journal Science of the Total Environment provides the first evidence of a mechanism by which climate change could have played a direct role in the emergence of SARS-CoV-2, the virus that caused the…

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News • A closer look at thapsigargin

Potential antiviral treatment for Covid-19 found

Researchers from the University of Nottingham have discovered a novel antiviral property of a drug that could have major implications in how future epidemics/pandemics – including Covid-19 – are managed. The study, published in Viruses, shows that thapsigargin is a promising broad‑spectrum antiviral, highly effective against SARS-CoV-2, a common cold coronavirus, respiratory syncytial virus…

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News • Image-based diagnosis of Covid-19

AI detects coronavirus on CT scans

In order to detect the Corona virus SARS-CoV-2, there are further methods of diagnosis apart from the globally used PCR tests (Polymerase chain reaction): The infection can also be recognised on CT scans – for which Artificial Intelligence (AI) can be used as well. An AI system can not only filter CT scan of Covid-19 patients from a data set, but also estimate, which areas of the image are of…

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News • Promising agents

The effect of vitamins, steroids and potential antivirals on SARS-CoV-2

Evidence is emerging that vitamin D – and possibly vitamins K and A – might help combat Covid-19. A new study from the University of Bristol published in the journal of the German Chemical Society Angewandte Chemie has shown how they – and other antiviral drugs – might work. The research indicates that these dietary supplements and compounds could bind to the viral spike protein and so…

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News • Viral sequencing

How SARS-CoV-2 spreads and evolves

The emergence of SARS-CoV-2 virus variants that are adding twists in the battle against COVID-19 highlight the need for better genomic monitoring of the virus, says Katia Koelle, associate professor of biology at Emory University.

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News • Microneedles

No more needles for bloodtests?

Blood draws are no fun. They hurt. Veins can burst, or even roll — like they’re trying to avoid the needle, too. Oftentimes, doctors use blood samples to check for biomarkers of disease: antibodies that signal a viral or bacterial infection, such as SARS-CoV-2, the virus responsible for COVID-19, or cytokines indicative of inflammation seen in conditions such as rheumatoid arthritis and…

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News • Coronavirus infection response

SARS-CoV-2 IgG II antibody test launched in CE Mark countries

Clinical diagnostics company Beckman Coulter launched its Access SARS-CoV-2 IgG II assay in countries accepting the CE Mark. The new Access SARS-CoV-2 IgG II assay quantitatively measures a patient’s level of antibodies in response to a previous SARS-CoV-2 infection. The ability to establish a quantitative baseline to evaluate an individual’s immune response to the SARS-CoV-2 virus allows…

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News • TB test shows promise

New method to assist fast-tracking of vaccines

With Covid-19 dominating medical science and human concern, chemists at the University of Sydney have developed a method to quickly and safely synthesise protein vaccines for respiratory diseases for pre-clinical tests. Their approach can be used to test vaccine strategies against novel pandemic pathogens such as SARS-CoV-2, the virus that causes Covid-19.

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News • "Faces" of the disease

Covid-19: researchers identify at least 5 variants

According to current studies, the Covid-19 disease which is caused by the SARS-CoV-2 coronavirus comprises at least five different variants. These differ in how the immune system responds to the infection. Researchers from the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, together with other experts from Germany, Greece and the Netherlands, present these findings…

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News • Variant COH.20G/501Y

New Coronavirus strain discovered

Scientists at The Ohio State University have discovered a new variant of SARS-Cov-2, the virus that causes Covid-19. The new variant carries a mutation identical to the U.K. strain, but it likely arose in a virus strain already present in the United States. The College of Medicine researchers also report the evolution of another U.S. strain that acquired three other gene mutations not previously…

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News • 'Nanobodies'

Small antibodies show promise against Covid-19

Researchers at Karolinska Institutet have developed, in collaboration with researchers in Germany and the U.S., new small antibodies, also known as nanobodies, which prevent the SARS-CoV-2 coronavirus from entering human cells. The research study, published in Science, shows that a combined nanobody had a particularly good effect – even if the virus mutated. According to the researchers, the…

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News • Lasts longer, causes more damage

Covid-19 pneumonia: not your typical garden-variety pneumonia

Bacteria or viruses like influenza that cause pneumonia can spread across large regions of the lung within hours. In the modern intensive care unit, these bacteria or viruses are usually controlled either by antibiotics or by the body’s immune system within the first few days of the illness. But in a study published in Nature, investigators at Northwestern Medicine show Covid-19 pneumonia is…

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News • Virion recreated

First computational model of entire SARS-CoV-2 virus

Researchers at the University of Chicago have created the first usable computational model of the entire virus responsible for Covid-19—and they are making this model widely available to help advance research during the pandemic. “If you can understand how a virus works, that’s the first step towards stopping it,” said Prof. Gregory Voth, whose team created the model published in…

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News • Influence of gut bacteria

How our gut microbiome affects Covid-19 severity

The variety and volume of bacteria in the gut, known as the microbiome, may influence the severity of Covid-19 as well as the magnitude of the immune system response to the infection, suggests research published online in the journal Gut. Imbalances in the make-up of the microbiome may also be implicated in persisting inflammatory symptoms, dubbed ‘long Covid’, the findings suggest. Covid-19…

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News • Dangerous immune response

New insight on severe virus attacks on the lungs

In some cases, immune cells in the lungs can contribute to worsening a virus attack. In a new study, researchers at Karolinska Institutet describe how different kinds of immune cells, called macrophages, develop in the lungs and which of them may be behind severe lung diseases. The study, which was published in Immunity, may contribute to future treatments for Covid-19, among other diseases.

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News • Promising candidate

Single-dose nanoparticle vaccine for Covid-19 in development

Before the pandemic, the lab of Stanford University biochemist Peter S. Kim focused on developing vaccines for HIV, Ebola and pandemic influenza. But, within days of closing their campus lab space as part of Covid-19 precautions, they turned their attention to a vaccine for SARS-CoV-2, the virus that causes Covid-19. Although the coronavirus was outside the lab’s specific area of expertise,…

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News • Enzyme Linked Immunosorbent Assay

Startup develops breakthrough IgG antibody test for Covid-19

ZTA Biotech, a Budapest-based biotech startup, has developed a Covid-19 antibody (IgG) test using the ELISA protocol. This new detection method represents a great step forward in determining if patients have had a coronavirus infection and if they might still have immunity to the disease. Early results have proven 100% in specificity after testing 280 samples, and 100% sensitivity by testing 260…

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Video • Computer model vs. Covid-19

Discovering new weaknesses of SARS-CoV-2 through bioinformatics

The search for antiviral agents against the new coronavirus is in full swing. Using a novel approach, Bioinformaticians have now discovered a weakness in the virus that could be exploited for drug development. In a computer model, the scientists discovered a human enzyme that is crucial for the virus. When it was switched off in the model, the virus could no longer multiply.

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News • Measuring aerosol travel while talking and singing

Imaging exhaled breath to provide new insights into Covid-19 transmission

A new method for visualizing breath that is exhaled while someone is speaking or singing could provide important new insights into how diseases such as Covid-19 spread and the effectiveness of face masks. “Scientists believe the SARS-CoV-2 virus is primarily spread through respiratory droplets that can be carried in the breath or expelled through coughing or sneezing,” said Thomas Moore from…

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News • SARS-CoV-2 vs the proteome

Researchers explore coronavirus interactions with cells

Scientists from Würzburg and the US have charted the first global atlas of direct interactions between SARS-CoV-2 RNA and human host cells. This may provide a starting point for novel treatments. SARS-CoV-2 infections pose a global threat to human health and a formidable research challenge. One of the most urgent tasks is to gain a detailed understanding of the molecular interactions between the…

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News • Rapid antigen testing at point of care

AI-assisted SARS-CoV-2 testing: Cooperation for first live project in Munich

Medicus AI announces the successful launch of its first live project under SafePlay, the digital platform supporting rapid antigen testing, which went live in partnership with Roche Diagnostics Germany and 21Dx in Munich this month. Medicus provides operators with a tech-enabled end-to-end solution that supports the logistical aspects of testing, managing the administrative workflow from…

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News • Natural variation impacts virus-relevant proteins

How SARS-CoV-2 benefits from helpers within the human body

Like all viruses, the novel coronavirus is dependent on help from the human host cell. Proteins are the functional units of the cell and enable the virus to enter the host cell or help the virus to replicate. Scientists from Charité – Universitätsmedizin Berlin and from the Berlin Institute of Health (BIH), along with colleagues from the United Kingdom, Germany and the United States, have…

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News • Digital health

AI test rules out Covid-19 diagnosis within one hour

An Artificial Intelligence test has been shown to be able to rapidly screen patients arriving in Emergency Departments for Covid-19, using clinical information routinely available within the first hour of coming to hospital. Results of the CURIAL study, published in The Lancet Digital Health, show that the AI test correctly predicted the Covid-19 status of 92.3% of patients coming to Emergency…

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News • Pandemic problems

Covid-19: risk increased sevenfold for healthcare workers

Healthcare workers are 7 times as likely to have severe Covid-19 infection as those with other types of ‘non-essential’ jobs, finds research focusing on the first UK-wide lockdown. And those with jobs in the social care and transport sectors are twice as likely to do so, emphasising the need to ensure that essential (key) workers are adequately protected against the infection, say the…

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Article • Diagnosing SARS-CoV-2

The arsenal: Molecular (PCR), antigen and antibody testing

Germany’s lack of diagnostic ability led to significantly underestimation of its own as well as global Covid-19 infection levels during the first wave. Now, however, improved testing and diagnosis of the condition more realistically reveal nearer 20,000 new cases a day across the country, according to Professor Hendrik Streeck, one of the country’s leading virologists. Speaking at a virtual…

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News • Coronavirus genome folding

Researchers prepare for “SARS-CoV-3”

For the first time, an international research alliance has observed the RNA folding structures of the SARS-CoV2 genome with which the virus controls the infection process. This could not only lay the foundation for the targeted development of novel drugs for treating Covid-19, but also for occurrences of infection with new corona viruses that may develop in the future.

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News • Success in Düsseldorf

virtual.Medica receives international resonance

For the first time in the history of MEDICA, the world-leading medical trade fair, and the industry’s number one platform for the suppliers of the medical technology industry, COMPAMED, held from 16 to 19 November 2020, took place entirely online due to the pandemic - but still won over their audiences due to their high degree of international resonance in this format too, as virtual.MEDICA and…

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News • Coronavirus assay receives CE Mark

Quantitative Covid-19 test to measure neutralizing antibodies

Siemens Healthineers announced its SARS-CoV-2 IgG Antibody Test (sCOVG) has proven to measure neutralizing antibodies and has achieved CE Mark. The test is an enhanced version of the assay which became available globally this summer. It demonstrates the ability to detect neutralizing antibodies and reports quantitative results measuring the amount of neutralizing antibodies present in a patient's…

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News • New gargle test

Mass spectrometry to improve Covid testing

A UK biotech laboratory has used mass spectrometry in a new approach to coronavirus testing. MAP Sciences developed a gargle test, which collects samples from the back of the throat, and avoids the unpleasant sensation of the current PCR (polymerase chain reaction) swab tests. From there, the sample is tested for coronavirus using mass spectrometry (MS) with high levels of accuracy.

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Article • Profiling the coronavirus

Experts unlock Covid-19 secrets

Experts have identified two distinct immunological and cellular profiles in the lungs of Covid-19 patients which they believe could help define treatment pathways. From some of the earliest Covid-19 autopsies conducted in Europe, Swiss-based researchers have performed integrative digital pathology and transcriptomic analyses of lung tissues of 16 coronavirus patients who died from respiratory…

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News • Interview

Disinfection: let mist do the work

Healthcare settings require sharp weapons to fight both hospital-acquired infections and pathogens like SARS-CoV-2. Besides protective equipment, regular room disinfection is one of them. So, why not fog the room? Read more in the MEDICA magazine.

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News • The countdown is on

virtual.MEDICA starts off with full programme and innovations

For the first time in their history, the world-leading medical trade fair MEDICA and the international number one event for the medical manufacturing supply market, COMPAMED, will be held entirely online as virtual.MEDICA and virtual.COMPAMED from Monday, with around 1,400 exhibitors hailing from 56 countries. Throughout the four days of the trade fair (16 – 19 November 2020), international…

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News • In countries accepting CE Mark

Beckman Coulter launches SARS-CoV-2 IgM antibody test

Beckman Coulter announced the launch of its Access SARS-CoV-2 Immunoglobulin M (IgM) assay in countries accepting the CE Mark. The new IgM antibody test demonstrated 99.9% specificity with 1,400 negative samples and 100% sensitivity at >18 days post symptom onset and post positive PCR. Beckman Coulter’s IgM assay is part of a full suite of testing solutions the company is developing to…

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News • False positive results

Accuracy of rapid covid test may be lower than previously suggested

The accuracy of a rapid finger-prick antibody test for SARS-CoV-2, the virus responsible for covid-19 infection, may be considerably lower than previously suggested, finds a study published by The BMJ. The results suggest that if 10% of people given the test had previously been infected, around 1 in 5 positive test results would be incorrect (false positive results). These conclusions contrast…

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News • Preclinical data

COVID-19 vaccine candidate designed via computer

An innovative nanoparticle vaccine candidate for the pandemic coronavirus produces virus-neutralizing antibodies in mice at levels ten-times greater than is seen in people who have recovered from COVID-19 infections. Designed by scientists at the University of Washington School of Medicine in Seattle, the vaccine candidate has been transferred to two companies for clinical development.

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News • Block of erythrocytes formation

SARS-CoV-2 might attack red marrow

Specialists from the Department of Fundamental Medicine of Far Eastern Federal University (FEFU) with Russian and Japanese colleagues have probed into mechanisms of COVID-19 inside-the-body distribution linked to erythrocytes damaging.

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News • Autopsy study

Myocarditis linked to COVID-19 not as common as believed

A study conducted by Richard Vander Heide, MD, PhD, Professor and Director of Pathology Research at LSU Health New Orleans School of Medicine, and Marc Halushka, MD, PhD, Professor of Pathology at Johns Hopkins University School of Medicine, suggests myocarditis caused by COVID-19 may be a relatively rare occurrence.

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News • Using virus particles in exhaled breath

New SARS-CoV-2 test to deliver results in under 5 minutes

Research and innovation hub Imec announced that it has started developing a groundbreaking SARS-CoV-2 test. Unlike current approaches (using blood, saliva, or a nasopharyngeal swab), the new test will identify SARS-CoV-2 virus particles in a person’s exhaled breath. The solution promises the accurate identification of a contagious case in less than five minutes.

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News • Neuropilin-1 as a 'helper' for COVID-19

Coronavirus: Study finds further 'door opener' into the cell

The coronavirus SARS-CoV-2 is known to infect cells via the receptor ACE2. An international research team under German-Finnish coordination has now identified neuropilin-1 as a factor that can facilitate SARS-CoV-2 entry into the cells’ interior. Neuropilin-1 is localized in the respiratory and olfactory epithelia, which could be a strategically important localization to contribute to…

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News • Therapy development

New approach to 'BEAT' COVID-19

The present Coronavirus pandemic with all its effects on society – both health and economic – highlights the urgency of developing new therapies for COVID-19 treatment. At the same time, it demonstrates the necessity to become well prepared for new virus infections we may be facing in the future. To help control the current pandemic and brace for novel pathogens that may cause future…

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News • COVID immunity research

Coronavirus re-infection: what we know so far – and the vital missing clues

As President Trump claims that he is immune to COVID-19 and isolated reports emerge of reinfection, what is the truth about immunity to COVID-19? To date, there have been six published cases of COVID-19 reinfection, with various other unverified accounts from around the world. Although this is a comparably small fraction of the millions of people known to have been infected, should we be…

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News • Infection with Covid-19

The antiviral effect of innate immunity

Innate immunity is the fastest-acting component of the immune system, but so far little is known about its role during infection with SARS-CoV-2. A few hours after an infection, the body emits an alarm signal, interferon, enabling cells that have not yet been infected to produce antiviral proteins. This phenomenon occurs well before the production of neutralizing antibodies. Scientists from the…

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Sponsored • Challenges in acute care

POCT: Understanding sources of error

In an emergency, point-of-care-testing can provide results in minutes. However, sources of error must be understood to ensure result accuracy and confident diagnosis (particularly important during the current pandemic). Medical teams frequently use POCT devices to assess acutely ill patients; a hospital’s diagnostic laboratory is responsible for the analysers, plus training non-laboratory…

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News • Uncommon, but reversible

Sudden deaf: permanent hearing loss linked to COVID-19

Although uncommon, sudden permanent hearing loss seems to be linked to COVID-19 infection in some people, warn doctors, reporting the first UK case in the journal BMJ Case Reports. Awareness of this possible side effect is important, because a prompt course of steroid treatment can reverse this disabling condition, they emphasise. Sudden hearing loss is frequently seen by ear, nose and throat…

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Video • New insights on the virus' ‘survivability’

How long does SARS-CoV-2 last on surfaces?

Researchers at CSIRO, Australia's national science agency, have found that SARS-CoV-2, the virus responsible for COVID-19, can survive for up to 28 days on common surfaces including banknotes, glass – such as that found on mobile phone screens - and stainless steel.

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News • Simulation model for pathological mechanisms

Understanding the progress of viral infections

It is only 120 millionths of a millimetre in size but can bring entire countries to a standstill: the Corona virus. Even if it were to disappear one day, viral infections will still be among the most frequent and difficult-to-treat diseases in humans. Even decades of research have only produced a few standardized vaccines and strategies for treatment to combat just a small number of viruses. Nor…

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News • Using artificial lungs

How COVID-19 causes blood clots

Scientists at EPFL are using technology to better understand how coronavirus causes blood clots in some patients. They have developed a simplified model of a lung that lets them observe, for the first time, how the virus attacks the cells lining blood vessels.

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News • Strict separation policy

Creating 'COVID-19 free' hospital areas to save lives after surgery

Setting up ‘COVID-19 free’ hospital areas for surgical patients could save lives during the second wave of the pandemic – reducing the risk of death from lung infections associated with coronavirus, a new global study reveals. Researchers working together in Brazil and beyond found that that patients who had their operation and hospital care in ‘COVID-19 free’ areas had better outcomes.…

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News • Fending off the coronavirus

The role of T-cells in SARS-CoV-2 virus defense

Our immune system can efficiently fend off viral diseases. Two types of immune cells play an important role in this process: The T-cells, which firstly can directly destroy virus-infected cells and secondly enable the formation of efficient, virus-neutralizing antibodies by B-cells. These two cell types also play a crucial role in the immune defense against SARS-CoV-2 infection. Whereas antibody…

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News • Reduced complications, death

COVID-19: The benefits of vitamin D

Adequate levels of vitamin D reduces complications and deaths among COVID-19 patients, reveals new research performed at the Boston University School of Medicine. Hospitalized COVID-19 patients who were vitamin D sufficient, with a blood level of 25-hydroxyvitamin D of at least 30 ng/mL (a measure of vitamin D status), had a significant decreased risk for adverse clinical outcomes including…

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News • Basis for a passive vaccination

Researchers identify highly effective antibodies against SARS-CoV-2

Researchers at the German Center for Neurodegenerative Diseases (DZNE) and Charité - Universitätsmedizin Berlin have identified highly effective antibodies against the coronavirus SARS-CoV-2 and are now pursuing the development of a passive vaccination. In this process, they have also discovered that some SARS-CoV-2 antibodies bind to tissue samples from various organs, which could potentially…

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Article • Nitrogen dioxide levels

Air pollution linked to higher COVID-19 mortality

Scientists have unearthed a possible link between the severity of COVID-19 and air quality. The preliminary study – looking at whether areas with higher levels of air pollutants in England are associated with a larger number of cases/deaths from COVID-19 – was conducted by a team from the University of Cambridge. Aware of the effects that air pollutants have on human health – and that…

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News • Silent alarm

‘Silent’ COVID-19 patients may still act as a spreader, warn experts

People with ‘silent’ COVID-19 infection have as much coronavirus in their noses and throats as those with symptoms, reveals research published online in the journal Thorax. Given how many of these people there are---a fifth of those infected, the study findings show--they may have a key role in driving the spread of COVID-19, warn the researchers, who go on to suggest that this warrants…

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News • Prevalence prediction

COVID-19 will probably become seasonal, but...

Researchers predict that COVID-19 will likely become seasonal, waning in the summer and prevalent in the winter. But, only once herd immunity is achieved through natural infection or vaccinations. Until then, COVID-19 will be here year-round.

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News • Taking control

How the coronavirus hijacks cells

Researchers at ETH Zurich and the University of Bern have discovered a mechanism by which the coronavirus manipulates human cells to ensure its own replication. This knowledge will help to develop drugs and vaccines against the coronavirus.

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Article • Non-pulmonary aspects

The cardiovascular impact of Covid-19

The increased Covid-19 risk to cardiac patients was discussed during an online presentation at ECR 2020. Focusing on the prevalence of pulmonary embolism in Covid-19 patients, Dr Karl-Friedrich Kreitner, Professor of Radiology at the Department of Diagnostic and Interventional Radiology at the Johannes-Gutenberg University in Mainz, Germany, discussed hypotheses which can explain cardiac…

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News • Coronavirus

“Hotspots” of a corona infection in the human body

An infection with the coronavirus SARS-CoV-2 can affect multiple organs. With this in mind, researchers of the German Center for Neurodegenerative Diseases (DZNE) and Cornell University in the US have investigated cellular factors that could be significant for an infection. To this end, they analysed the activity of 28 specific genes in a wide range of human tissues.

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News • Prototype

Portable point-of-care for Covid-19 tests

As COVID-19 continues to spread, bottlenecks in supplies and laboratory personnel have led to long waiting times for results in some areas. In a new study, University of Illinois, Urbana-Champaign researchers have demonstrated a prototype of a rapid COVID-19 molecular test and a simple-to-use, portable instrument for reading the results with a smartphone in 30 minutes, which could enable…

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News • Aerosol recommendations

How humidity affects indoor spread of SARS-CoV-2

The airborne transmission of the coronavirus SARS-CoV-2 via aerosol particles in indoor environment seems to be strongly influenced by relative humidity. This is the conclusion drawn by researchers from the Leibniz Institute for Tropospheric Research (TROPOS) in Leipzig and the CSIR National Physical Laboratory in New Delhi from the analysis of 10 most relevant international studies on the…

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News • Research shows

Children are silent spreaders of COVID-19 virus

In the most comprehensive study of COVID-19 pediatric patients to date, Massachusetts General Hospital (MGH) and Mass General Hospital for Children (MGHfC) researchers provide critical data showing that children play a larger role in the community spread of COVID-19 than previously thought. In a study of 192 children ages 0-22, 49 children tested positive for SARS-CoV-2, and an additional 18…

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News • Electrostatic interactions

New research exposes weak spot in SARS-CoV-2

Northwestern University researchers have uncovered a new vulnerability in the novel coronavirus’ infamous spike protein — illuminating a relatively simple, potential treatment pathway. The spike protein contains the virus’ binding site, which adheres to host cells and enables the virus to enter and infect the body. Using nanometer-level simulations, the researchers discovered a positively…

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Article • Re-evaluation of the coronavirus disease

COVID-19: A tale of two conditions

The SARS CoV-2 virus which causes COVID-19 may have been named prematurely. As more has become known about the infection, the severe disease does not appear to be a respiratory syndrome at all. Patients who only have a respiratory illness tend not to have a severe condition, while patients who develop a severe condition tend to have non-respiratory conditions, primarily thrombotic or hyper-immune…

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News • Pregnancy risk

Coronavirus could infect embryos as early as the first trimester

Genes that are thought to play a role in how the SARS-CoV-2 virus infects our cells have been found to be active in embryos as early as during the second week of pregnancy, say scientists at the University of Cambridge and the California Institute of Technology (Caltech). The researchers say this could mean embryos are susceptible to COVID-19 if the mother gets sick, potentially affecting the…

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News • Corona in radiology

Revealing COVID-19-related brain injury in MRI and CT imaging

Injuries in the nervous system of patients with severe COVID-19 are revealed by magnetic resonance imaging (MRI) and computed tomography (CT). In a study of 185 patients, researchers at Karolinska Institutet (KI) and Karolinska University Hospital show an affection of microscopic blood vessels and inflammation in the brain, meninges and nerves. The results are published in Radiology.

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News • Combined against corona

COVID-19: promising drug combination opens up new therapeutic avenues

As the COVID-19 pandemic continues, finding a treatment to effectively fight the disease remains a major research challenge. Researchers from Inserm, CNRS, Université Claude Bernard Lyon 1 and ENS Lyon within the International Center for Infectious Disease Research (CIRI) have developed a unique strategy for selection, evaluation and repositioning of drugs already on the market to assess their…

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News • Coronavirus

Lab-made virus mimics COVID-19 virus

Airborne and potentially deadly, the virus that causes COVID-19 can only be studied safely under high-level biosafety conditions. Scientists handling the infectious virus must wear full-body biohazard suits with pressurized respirators, and work inside laboratories with multiple containment levels and specialized ventilation systems. While necessary to protect laboratory workers, these safety…

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News • Congenital defect reconstruction

Pectus Excavatum: First-in-human trial of novel reconstruction scaffold

Medtech company BellaSeno announced the initiation of a first-in-human trial of its novel, absorbable soft tissue reconstruction scaffold (Senella). A patient with Pectus Excavatum congenital defect has undergone surgery at Princess Alexandra Hospital in Brisbane, Australia, earlier this month. The procedure was performed by Dr. Michael Wagels, Principal Investigator of the trial and Plastic and…

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News • Self-sanitising surfaces

First long-lasting surface treatment to kill coronavirus launched

Chemical binding company Affix Labs has created the first long-lasting surface treatment proven to kill COVID-19. Si-Quat combines a safe and well-established disinfectant and a proprietary chemical binding technique, so that the active ingredient can kill viruses, including SARS-CoV-2. Testing at Portugal’s Biochemistry Institute at the University of Lisbon proves that Si-Quat effectively…

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Video • 'ChAdOx1' delivers promising results

Breakthrough for coronavirus vaccine candidate

A team of scientists at Oxford University’s Jenner Institute and Oxford Vaccine Group has taken the next step towards the discovery of a safe, effective and accessible vaccine against coronavirus. The results of the Phase I/II trial published in the scientific journal, The Lancet, indicate no early safety concerns and induces strong immune responses in both parts of the immune system.

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Video • Immune system sabotage

SARS-CoV-2 induces shutdown of protein synthesis

Although its name is relatively unspecific and indeed opaque, the Nonstructural Protein 1 (Nsp1) encoded by the coronavirus SARS-CoV-2, which is responsible for the current pandemic, has now been shown to have a devastating effect on host cells. Nsp1 is in fact one of the central weapons used by the virus to ensure its own replication and propagation in human hosts. Nsp1 was identified as a…

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News • COVID-19

Scientists uncover SARSCoV-2-specific T cell immunity in recovered patients

The T cells, along with antibodies, are an integral part of the human immune response against viral infections due to their ability to directly target and kill infected cells. A Singapore study has uncovered the presence of virus-specific T cell immunity in people who recovered from COVID-19 and SARS, as well as some healthy study subjects who had never been infected by either virus.

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Article • Coronavirus in radiology

Why we need a global view of COVID-19

There are major complications from COVID-19 – ARDS, pulmonary embolism and neurological – that imaging can help detect, manage and/or follow up in the long term, radiologists from France and the UK explained during a recent ESR Connect session. ARDS is the most dreaded complication and the number one morbidity in COVID-19 patients. The incidence was up to 30% of patients in initial reports.…

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News • Coronavirus research

How type 1 interferon deficiency hints at severe forms of COVID-19

Which patient will develop a severe form of COVID-19? This is an essential question which must be answered in order to improve the individual management and the prognosis of these patients. In a publication in the journal Science, teams from the Assistance publique – Hôpitaux de Paris (AP-HP), Inserm, Université de Paris, Institut Pasteur and Institut Imagine describe a unique and unexpected…

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Article • Corona management in Taiwan

Standing united against COVID-19

Despite its proximity to China, Taiwan contained COVID-19 successfully, without a lockdown or movement restriction measures introduced elsewhere. With few new cases reported, life almost returned to normal. Behind the scenes, however, efforts have continued to maintain that positive situation.

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Article • Imaging workflow challenges

The long-term impact of Covid-19 on teleradiology

The coronavirus pandemic created unprecedented upheaval and challenges within health systems, economies, and society. In hospitals, new ways of working had to evolve. Social distancing led to virtual consultations and teleradiology has found an added dimension. We asked three radiologists about the relevance of teleradiology during the epidemic, and what the future holds.

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News • COVID-19

Four commercial immunoassay tests for detection of antibodies

Public Health England, in partnership with the University of Oxford, recently conducted a head-to-head evaluation of four commercial immunoassay tests available in the UK and used for the detection of SARS-CoV-2 antibodies.

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News • SARS-CoV-2

COVID-19: why do patients immune response differ?

It remains one of the key questions of the current corona pandemic: Why do people infected with SARS-CoV-2 experience varying degrees of COVID-19, the disease which it triggers? Researchers, led by Professor Mascha Binder from University Hospital Halle (Saale), have investigated more than 14 million receptor sequences of B and T cells, i.e. immune cells, obtained from blood samples of COVID-19…

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News • Blocking coronavirus entry portals

Cell ‘membrane on a chip’ could speed up COVID-19 drug screening

Researchers have developed a human cell ‘membrane on a chip’ that allows continuous monitoring of how drugs and infectious agents interact with our cells, and may soon be used to test potential drug candidates for COVID-19. The researchers, from the University of Cambridge, Cornell University and Stanford University, say their device could mimic any cell type - bacterial, human or even the…

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News • Airborne droplet travel distance

Why you shouldn't underestimate the reach of COVID-19

A plea issued by 239 scientists from around the world to recognise and mitigate airborne transmission of COVID-19 addressed to international health authorities is published in the journal Clinical Infectious Diseases. Led by internationally recognised air quality and health expert Professor Lidia Morawska from Queensland University of Technology (QUT), the appeal is to address the overwhelming…

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News • COVID-19 diagnostics

SARS-CoV-2 IgG antibody test receives FDA Emergency Use Authorization

Beckman Coulter announced that its Access SARS-CoV-2 IgG assay has received Emergency Use Authorization (EUA) from the U.S. Food & Drug Administration (FDA). Beckman Coulter has already shipped tests to more than 400 hospitals, clinics and diagnostics laboratories in the U.S., and has begun distribution of the new antibody test globally to countries that accept the FDA EUA and CE Mark. The…

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News • UK experts raise concerns

COVID-19 antibody tests: Not a game-changer after all?

A group of senior clinical academics and physicians are concerned about the rapid roll out of COVID-19 antibody testing in England and are publicly questioning how good the tests are - or even what they mean. In a letter to The BMJ, they argue that there is currently no valid clinical reason for large scale testing, test performance has not yet been adequately assessed, and testing risks…

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News • Light or severe progression

The dangerous dual role of the immune system in COVID-19

Infection with the novel coronavirus SARS-CoV-2 follows a highly variable course: some of those infected do not even notice it, while others become so seriously ill that their lives are placed at risk. Scientists from the Berlin Institute of Health (BIH) and Charité – Universitätsmedizin Berlin and their colleagues from Leipzig and Heidelberg have now discovered that the immune system has a…

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News • Coronavirus and gender

Why COVID-19 hits men harder than women

When infected by the new coronavirus, women may mount a more potent adaptive immune response than do men, a new study suggests. By comparison, the male immune response appears to progress less effectively, fostering inflammation that’s harmful to the body. This study is the first to delve into sex differences in how the immune system defends itself against the virus SARS-CoV-2. It could help…

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Article • Virtual consultations

COVID-19 pandemic boosts telemedicine in Spain

The coronavirus crisis has accelerated the use of telemedicine in Spain with an increase in virtual consultation and positive impact on workflow. The challenge will be to make these changes permanent, according to a panel of experts who took part in a conference last June in Barcelona. Spanish patients and healthcare professionals have widely accepted virtual consultation as a new alternative to…

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Sponsored • Corporate responsibility

A reliable partner in a crisis

In many areas of our daily life, plastic is seen in a negative light. However, the ongoing SARS CoV-2 pandemic has profoundly changed our society with intensive efforts being made to find a way out of the crisis.

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News • Innovative textiles

Researchers develop face mask that takes out SARS-CoV-2

Researchers from Freie Universität Berlin at the Institute for Animal and Environmental Hygiene and the Institut für Textiltechnik (ITA) of RWTH Aachen University are collaborating on the topic of alternative personal protection equipment. The testing was conducted in the context of the EIT Health Project ViruShield, supported by the European Union, with the objective to discover alternative…

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News • Protective equipment

Face masks could shrink the 'R' number and prevent a second COVID-19 wave

Population-wide use of facemasks keeps the coronavirus ‘reproduction number’ under 1.0, and prevents further waves of the virus when combined with lockdowns, a modelling study led by the University of Cambridge suggests. The research suggests that lockdowns alone will not stop the resurgence of SARS-CoV-2, and that even homemade masks with limited effectiveness can dramatically reduce…

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News • Increased risk for severe infections

Up in smoke: Smoking increases SARS-CoV-2 receptors in the lung

New research suggests that cigarette smoke spurs the lungs to make more ACE2 (angiotensin-converting enzyme 2), the protein that the coronavirus responsible for COVID-19 grabs and uses to enter human cells. The findings, reported in the journal Developmental Cell, may explain why smokers appear to be particularly vulnerable to severe infections. The analysis also indicates that the change is…

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Article • Re-establishing routine workloads

Restoring radiology to the 'new normal' after COVID-19

Diagnostic imaging examinations and radiology departments have been essential in the care of the millions of COVID-19 patients. As the virus abates, how should radiology departments return to “normal” operations? The American College of Radiology (ACR) and the Radiological Society of North America (RSNA) have published recommendations and guidelines.

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News • Predictive proteins

Biomarkers in COVID-19 patients could predict how ill they become

Researchers at the Francis Crick Institute and Charité – Universitätsmedizin Berlin have identified 27 protein biomarkers that could be used to predict whether a patient with COVID-19 is likely to become severely ill with the disease. People infected with SARS-CoV-2, the virus which causes COVID-19, respond differently. Some do not develop any symptoms, some need to be hospitalised and, for…

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News • Lack of ventilation increases risk

Experts explore COVID-19 airborne transmission

Preventing airborne transmission of COVID-19 should be the next front of the battle against the virus, argue experts from the University of Surrey. In a study published by the City and Environment Interaction journal, scientists from Surrey’s Global Centre for Clean Air Research (GCARE), together with partners from Australia’s Queensland University and Technology, argue that the lack of…

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News • Immunology

COVID-19 study reveals universally effective antibodies

The first round of results from an immunological study of 149 people who have recovered from COVID-19 show that although the amount of antibodies they generated varies widely, most individuals had generated at least some that were intrinsically capable of neutralizing the SARS-CoV-2 virus. Antibodies vary widely in their efficacy. While many may latch on to the virus, only some are truly…

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News • Synapse 3D visualization tool

Improving diagnostic management of patients during the COVID-19 pandemic

The novel Coronavirus infection (severe acute respiratory syndrome SARS-CoV-2), which has led to the spread of COVID-19 around the world, has upset normal workflow in hospitals. The increased workload and stress, due to the necessity of implementing safe and separate diagnostic pathways, and the need to constantly monitor the development of the disease after its onset, continues to have a…

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News • COVID-19 detection

New analyzer detects virus antibodies in 20 minutes

Researchers at Hokkaido University have succeeded in detecting anti-avian influenza virus antibody in blood serum within 20 minutes, using a portable analyzer they have developed to conduct rapid on-site bio tests. If a suitable reagent is developed, this technology could be used to detect antibodies against SARS-CoV-2, the causative virus of COVID-19.

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News • Deadly mechanism uncovered

Inside COVID-19's 'cytokine storm'

Leading immunologists in Japan are proposing a possible molecular mechanism that causes massive release of proinflammatory cytokines, or a cytokine storm, leading to the acute respiratory distress syndrome (ARDS) in COVID-19 patients. Their suggestions, published in the journal Immunity, are based on recent findings that explain how SARS-CoV-2 enters human cells.

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News • Changes in cells caused by coronavirus

Potential targets for COVID-19 therapy discovered

A team of biochemists and virologists at Goethe University and the Frankfurt University Hospital were able to observe how human cells change upon infection with SARS-CoV-2, the virus causing COVID-19 in people. The scientists tested a series of compounds in laboratory models and found some which slowed down or stopped virus reproduction. These results now enable the search for an active substance…

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News • Adapt and overcome

Coronavirus evolving: How SARS-CoV-2 mutations could delay vaccine development

A new analysis of the worldwide effort to sequence the coronavirus genome has revealed the scale of the genetic changes that are occurring in the virus known as SARS-CoV-2, as it spreads across the world. These changes have important implications for molecular diagnostics and potentially vaccine success. Led by the London School of Hygiene & Tropical Medicine, the research identified several…

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News • Coronavirus disease symptom

Exploring why COVID-19 makes people lose their sense of smell

Doctors have reported that partial or total loss of the sense of smell is often an early symptom of infection with SARS-CoV-2, the virus that causes COVID-19. Now, researchers reporting in ACS Chemical Neuroscience have shown that in mice, two proteins required for SARS-CoV-2 entry are produced by cells of the nasal cavity that contribute to odor detection.

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News • Symptom study app

AI diagnostic to predict COVID-19 without testing

Researchers at King’s College London, Massachusetts General Hospital and health science company ZOE have developed an artificial intelligence (AI) diagnostic that can predict whether someone is likely to have COVID-19 based on their symptoms. Their findings are published in Nature Medicine. The AI model uses data from the COVID Symptom Study app to predict COVID-19 infection, by comparing…

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News • Utilizing findings from cancer research

Understanding immunity to SARS-CoV-2

Why does every person react differently to an infection with the coronavirus SARS-CoV-2? Why do some people have no symptoms or only mild symptoms of COVID-19, the disease which it causes? And why do some people become so severely ill that they require ventilators or even die? These questions are being investigated by Professor Mascha Binder, director of the Department of Internal Medicine IV at…

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News • What radiologists need to know

How lung disorders like COVID-19 affect children

Although the clinical symptoms of new pediatric lung disorders such as severe acute respiratory syndrome (SARS), swine-origin influenza A (H1N1), Middle East respiratory syndrome (MERS), e-cigarette or vaping product use-associated lung injury (EVALI), and coronavirus disease (COVID-19) pneumonia may be nonspecific, some characteristic imaging findings "have emerged or are currently…

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Video • Going viral

Coronavirus clone produced in the lab

Researchers in virology and veterinary bacteriology at the University of Bern have cloned the novel coronavirus (SARS-CoV-2). The synthetic clones are being used by research groups worldwide to test corona samples, find antiviral drugs and develop vaccines as quickly as possible. The method developed in Bern can also be used in future to combat other highly infectious viruses. In the…

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News • Coronavirus origins

Researchers crack COVID-19 genome signature

Using machine learning, a team of Western computer scientists and biologists have identified an underlying genomic signature for 29 different COVID-19 DNA sequences. This new data discovery tool will allow researchers to quickly and easily classify a deadly virus like COVID-19 in just minutes – a process and pace of high importance for strategic planning and mobilizing medical needs during a…

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Article • Coronavirus countermeasures

Learning from China – the role of radiology in combatting COVID-19

As the first country to be hit by COVID-19, China learned a number of early lessons into how to combat the highly-infectious disease. With radiology teams playing an important role and utilising CT chest scans as a diagnostic tool against coronavirus, Chinese practitioners have found themselves well-placed to offer a valuable insight on how to combat and contain COVID-19. In a special webcast –…

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News • Coronavirus analysis

AI-generated design blueprints for SARS-CoV-2 vaccines published

NEC Corporation announced analysis results from efforts using AI prediction platforms to design blueprints for SARS-CoV-2 vaccines that can drive potent T-cell responses in the majority of the global population. This initiative by the scientific teams within the NEC Group to help combat outbreaks of COVID-19 and support international vaccine development efforts is led by NEC OncoImmunity (NOI) in…

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News • COVID-19 gateway

Nose cells identified as likely coronavirus entry points

Two specific cell types in the nose have been identified as likely initial infection points for COVID-19 coronavirus. Scientists discovered that goblet and ciliated cells in the nose have high levels of the entry proteins that the COVID-19 virus uses to get into our cells. The identification of these cells by researchers from the Wellcome Sanger Institute, University Medical Centre Groningen,…

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News • COVID incidence at airports and in hospitals

Biosensor to detect coronavirus in crowded places

A team of researchers from Empa, ETH Zurich and Zurich University Hospital has succeeded in developing a novel sensor for detecting the new coronavirus. In future it could be used to measure the concentration of the virus in the environment - for example in places where there are many people or in hospital ventilation systems. Jing Wang and his team at Empa and ETH Zurich usually work on…

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News • Coronavirus research

COVID-19 severity and air pollution: exploring the connection

Scientists at the University of Cambridge have found an association between living in an area of England with high levels of air pollution and the severity of COVID-19, the disease caused by the SARS-CoV-2 virus. Because of the urgent need to share information relating to the pandemic, the researchers have published their report on MedRXiv. It has not yet been peer-reviewed. However, the…

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News • Dealing with the disease

Leading European cancer centers share their corona knowledge

Cancer patients are particularly at risk for infections because of their disease and its treatment. Due to the rapid spread of the coronavirus in Europe, cancer centers within a short period were faced with the challenge of minimizing the risk of infection for these patients while at the same time not compromising the provision of the necessary treatments. Seven leading European cancer centers…

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News • Coronavirus mutations

Tracking COVID-19 with genetic ‘barcode’

Drexel University researchers have reported a method to quickly identify and label mutated versions of the virus that causes COVID-19. Their preliminary analysis, using information from a global database of genetic information gleaned from coronavirus testing, suggests that there are at least six to 10 slightly different versions of the virus infecting people in America, some of which are either…

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News • Existing solutions to a new problem

COVID-19 vaccine candidate could cover global demand

Any new coronavirus vaccine that works well and is safe will still have the daunting challenge of needing to be produced to scale in a very short amount of time. It will also have to be safely delivered into the hands of the most remote populations. The more complex and untested the vaccine approach, the more difficult it will be to both scale its production and deliver it around the world. By…

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News • Coronavirus treatment

Promising trial drug blocks early stages of COVID-19

An international team led by University of British Columbia (UBC) researcher Dr. Josef Penninger has found a trial drug that effectively blocks the cellular door SARS-CoV-2 uses to infect its hosts. The findings, published in Cell, hold promise as a treatment capable of stopping early infection of the novel coronavirus that, as of April 2, has affected more than 981,000 people and claimed the…

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News • COVID-19 research

Clues to coronavirus’s vulnerability emerge from SARS antibody

An antibody recovered from a survivor of the SARS epidemic in the early 2000s has revealed a potential vulnerability of the new coronavirus at the root of COVID-19, according to a study from scientists at Scripps Research. The study, published in Science, is the first to map a human antibody’s interaction with the new coronavirus at near-atomic-scale resolution. Although the antibody was…

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News • IgM/IgG identification

Coronavirus antibody test in development

In response to the global COVID-19 pandemic, Beckman Coulter announced that it is developing assays to identify IgM and IgG antibodies to the coronavirus or SARS-CoV-2. The assays will be designed for use on any of its high-throughput Access family of immunoassay systems, including the Access 2 and DxI series installed globally. Research has shown that after infection with SARS-CoV-2, viral…

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News • COVID-19 diagnostics

Corona 'pool testing' increases worldwide capacities many times over

Researchers at the German Red Cross Blood Donor Service in Frankfurt headed by Professor Erhard Seifried, and the Institute for Medical Virology at the University Hospital Frankfurt at Goethe University headed by Professor Sandra Ciesek succeeded in developing a procedure that makes it possible to immediately and dramatically increase worldwide testing capacities for detecting SARS-CoV-2.

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News • Cultural differences matter

Study shows: Hand washing is key against COVID-19

Countries where people do not have a habit of washing their hands automatically tend to have a much higher exposure to coronavirus, a new study reveals. University of Birmingham researchers have discovered that at least 50% of people do not have a habit of automatic handwashing after using the toilet in China (77%), Japan (70%), South Korea (61%) and the Netherlands (50%). These countries are…

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News • Coronavirus disease diagnostics

Emergency Use Authorization for COVID-19 test

French in vitro diagnostics company bioMérieux announced that its subsidiary, BioFire Defense, has received Emergency Use Authorization (EUA) by the U.S. Food and Drug Administration of its BioFire COVID-19 test for use in CLIA moderate and high complexity clinical laboratories to detect the novel coronavirus SARS-CoV-2. The test detects SARS-CoV-2 in approximately 45 minutes from a…

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Video • Coronavirus in laboratory medicine

Video: COVID-19 at a glance

To provide reliable information about the coronavirus disease COVID-19, Professor Giuseppe Lippi, Director of the Laboratory for Clinical Chemistry and Hematology at the University Hospital of Verona, Italy, gives an overview on the current state of scientific knowledge on COVID-19 and the SARS-CoV-2 virus. The video was provided by the American Association for Clinical Chemistry (AACC), who…

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News • Flu forecast

Portable AI device predicts outbreaks based on coughing

University of Massachusetts Amherst researchers have invented a portable surveillance device powered by machine learning – called FluSense – which can detect coughing and crowd size in real time, then analyze the data to directly monitor flu-like illnesses and influenza trends. The FluSense creators say the new edge-computing platform, envisioned for use in hospitals, healthcare waiting rooms…

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News • SARS-CoV-2 durability

New coronavirus can remain stable for hours on surfaces

The virus that causes coronavirus disease 2019 (COVID-19) is stable for several hours to days in aerosols and on surfaces, according to a new study from National Institutes of Health, CDC, UCLA and Princeton University scientists in The New England Journal of Medicine. The scientists found that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detectable in aerosols for up to three…

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Article • Coronavirus disease research

Seeking a COVID-19 antidote: the potential of ACE2

As coronavirus disease COVID-19 continues to jet and alight invisibly around the globe, scientists now report that the virus has mutated to become two strains: the older ‘S-type’ appears milder and less infectious, while the later-emerging ‘L-type’, is more aggressive, spreads more quickly, and currently accounts for about 70 per cent of cases. Worldwide, medical researchers are exploring…

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Interview • Chest X-ray, CT and more

Imaging the coronavirus disease COVID-19

Chest X-ray is the first imaging method to diagnose COVID-19 coronavirus infection in Spain, but in the light of new evidence this may change soon, according to Milagros Martí de Gracia, Vice President of the Spanish Society of Radiology (SERAM) and head of the emergency radiology unit at La Paz Hospital in Madrid, one of the hot spots for viral re-production of COVID-19.

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News • RT-PCR for COVID-19

First of 3 diagnostic tests for SARS-CoV-2 coronavirus available

Biotechnology company bioMérieux, a world leader in the field of in vitro diagnostics, is announcing the forthcoming launch of 3 different tests to address the COVID-19 epidemic and to meet the different needs of physicians and health authorities in the fight against this emerging infectious disease. bioMérieux has finalized the development of the SARS-CoV-2 R-Gene test. This real-time PCR test…

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News • Pandemic prevention

German lab developed coronavirus detection method

Investigators at Hannover Medical School (MHH) in Germany have developed a molecular assay for detecting the novel coronavirus SARS-CoV-2 (previously 2019-nCoV) on the automated Panther Fusion system by Hologic. The preclinical assay is described online in the Journal of Clinical Virology. “Rapid diagnosis is critical to combatting the spread of pandemics, and the Panther Fusion system is well…

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News • Dutch experts discuss

On the implications of the coronavirus

The coronavirus last week reached the Netherlands and began to spread around the country. How has the Dutch population reacted? What is a useful frame of reference for this situation? And what are the legal guidelines for dealing with the outbreak? Four researchers from the University of Amsterdam – a clinical microbiologist, an anthropologist, a social scientist and a health lawyer – explain…

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News • Pilot clinical trial

China to test targeted therapy for COVID-19

A University of British Columbia (UBC) researcher is part of an international team working with a biotechnology company on a pilot clinical trial of a potential new treatment for patients with severe coronavirus infections in China. Dr. Josef Penninger, director of UBC’s Life Sciences Institute and Canada 150 Chair in Functional Genetics, is working closely with Vienna-based Apeiron Biologics…

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News • Myths around SARS-CoV-2 busted

Coronavirus FAQ to dispel fake and harmful advice

The current outbreak of the novel coronavirus disease (COVID-19) is making headlines by the minute. However, some less-than-trustworthy advice can be found among the information. Understandably, many people are concerned and confused. To prevent unnecessary panic, the World Health Organisation (WHO) has assembled advice for the public. Is it safe to receive parcels from China? Will sesame oil…

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News • COVID-19 infection control

Combatting the novel coronavirus with thorough hand hygiene

WHO Chief Adhanom Ghebreyesus has declared the novel coronavirus (SARS-CoV-2) a global health emergency. He said the decision was reached not because of the situation in China, but because of, “what is happening in other countries.” On Feb. 17, the number of infections totaled around 71,000 globally based on data of the WHO. COVID-19 – the official shorthand name of the novel corona virus…

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News • Smart infection control

China uses AI to combat the novel coronavirus outbreak

Infrared thermometers are now used in most subway stations in China to prevent the spread of novel coronavirus (SARS-CoV-2) pneumonia (MCP). Many stations have implemented an artificial intelligence (AI) based fever screening system developed by the Beijing-based company Megvii Technology Limited. The system supports non-contact remote temperature screening from a distance of 3 meters. "This…

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Video • New virus 2019-nCoV

Scientists grow Wuhan coronavirus in the lab

Scientists from The Peter Doherty Institute for Infection and Immunity in Melbourne have successfully grown the Wuhan coronavirus (also known as SARS-CoV-2) from a patient sample, which will provide expert international laboratories with crucial information to help combat the virus. This is the first time the virus has been grown in cell culture outside of China. The Royal Melbourne Hospital’s…

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News • SARS-like virus from China

What we know about the new corona virus

Nine people have died and more than 400 have been sickened by the new corona virus spreading in China. A few cases have been confirmed in Taiwan, Thailand, South Korea, Japan and the U.S., and on Wednesday, the World Health Organization is holding an emergency meeting on the outbreak. How worried about a new pandemic should we be? Virus researcher Ali Mirazimi, adjunct professor at the Department…

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Article • MERS-CoV

Seeking answers to combat Middle East respiratory syndrome

With a case fatality rate of 35 percent, a Middle East respiratory syndrome-related coronavirus (MERS-CoV) infection – also called camel flu – is a dangerous disease. About seven years ago, when the virus was first isolated, mortality was close to 100 percent since only severe infections that led to the patient being in intensive care were recorded. Today the environment of each victim is…

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Article • Tomosynthesis

Catching more invasive cancers earlier

What beats digital mammography to detect breast cancer in asymptomatic women? Digital breast tomosynthesis (DBT) – was a big discussion at RSNA 2017. Sarah M Friedewald MD, medical director of the Lynn Sage Comprehensive Breast Center of Northwestern Memorial Hospital in Chicago and its division chief of breast and women’s imaging, discussed the clinical implications of DBT for routine…

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News • Exhibition

Medical Fair Thailand 2017 sold out

Medical Fair Thailand 2017 will be its largest edition yet, with booth space fully sold out since May, featuring 700 exhibitors from 45 countries including 18 National Pavilions and country groups on a show floor that has expanded by 20% compared to 2015, at the Queen Sirikit National Convention Center. Held biennially, Medical Fair Thailand 2017 confirms its position as Thailand’s most…

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News • Cardiology

Previewing the impact of new technology

As well as this year’s programme being the biggest yet, with 76 plenary sessions, there are also sponsored symposia from Janssen and CamNutra. Additionally, the USA’s Mayo Clinic will provide the Cardiology Review Course, with representatives from Rochester, Minnesota, delivering some sessions.

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Virtual anatomy

In 2007, Sara Doll (Institute for Anatomy and Cell Biology, Heidelberg University) and Dr Frederik Giesel (Managing Senior Physician, Radiology Clinic, Department of Nuclear Medicine at Heidelberg University Hospital) initiated the development of virtual anatomy for a seminar aimed at students in the pre-clinical phase of their medical degree course.

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MERS-CoV: Global action needed?

The World Health Organisation (WHO) recently formed an international emergency committee to decide whether Middle East Respiratory Syndrome Coronavirus (MERS-CoV) should be ascribed Public Health Emergency of International Concern (PHEIC) status, amid reports of a lack of information from the worst affected countries.

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Article • Infections

Maintain perioperative normothermia

Even mild perioperative hypothermia can have significant effects on rates of surgical site infections (SSIs), morbid myocardial outcomes, blood loss and transfusion requirements, altering the response to drugs, extending recovery rates, hospital stay and patient discomfort.

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Ingenia, the first-ever digital broadband MRI system

At the 96th annual meeting of the Radiological Society of North America (RSNA) in Chicago, Philips showcased Philips Ingenia, the first-ever digital broadband magnetic resonance imaging (MRI) solution. Driven by Philips’ commitment to developing innovative patient care solutions, Ingenia MR delivers exceptional image clarity, scanning efficiency and scalability. The Philips Ingenia MR system is…

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Thermofocus

"Thermofocus* is the first non-contact clinical thermometer in the world and the only one working at an accurate and determinate distance," Tecnimed srl, its manufacturer, reports. "Body temperature is measured in less than one second by pointing Thermofocus at the centre of the forehead."

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Article • Covid-19

Coronavirus update

Years after the first outbreak and spread of coronavirus Sars-CoV-2, its impact can still be felt in everyday life. Keep up-to-date with the latest research news, political developments, and background information on Covid-19.

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