This transmission electron microscope image shows SARS-CoV-2 isolated from a...
This transmission electron microscope image shows SARS-CoV-2 isolated from a patient in the US. Virus particles are shown emerging from the surface of cells cultured in the lab. The spikes on the outer edge of the virus particles give coronaviruses their name, crown-like.

Source: NIAID-RML

News • Vaccine

AI-Tool helps in the fight against Covid-19 mutations

USC researchers have developed a new method to counter emergent mutations of the coronavirus and hasten vaccine development to stop the pathogen responsible for killing thousands of people and ruining the economy. Using artificial intelligence (AI), the research team at the USC Viterbi School of Engineering developed a method to speed the analysis of vaccines and zero in on the best potential preventive medical therapy.

The method is easily adaptable to analyze potential mutations of the virus, ensuring the best possible vaccines are quickly identified—solutions that give humans a big advantage over the evolving contagion. Their machine-learning model can accomplish vaccine design cycles that once took months or years in a matter of seconds and minutes, the study says. This AI framework, applied to the specifics of this virus, can provide vaccine candidates within seconds and move them to clinical trials quickly to achieve preventive medical therapies without compromising safety," said Paul Bogdan, associate professor of electrical and computer engineering at USC Viterbi and corresponding author of the study. "Moreover, this can be adapted to help us stay ahead of the coronavirus as it mutates around the world."

Recommended article

Photo

News • Viral sequencing

How SARS-CoV-2 spreads and evolves

The emergence of SARS-CoV-2 virus variants that are adding twists in the battle against COVID-19 highlight the need for better genomic monitoring of the virus, says Katia Koelle, associate professor of biology at Emory University.

When applied to SARS-CoV-2 - the virus that causes COVID-19 - the computer model quickly eliminated 95% of the compounds that could've possibly treated the pathogen and pinpointed the best options, the study says. The AI-assisted method predicted 26 potential vaccines that would work against the coronavirus. From those, the scientists identified the best 11 from which to construct a multi-epitope vaccine, which can attack the spike proteins that the coronavirus uses to bind and penetrate a host cell. Vaccines target the region - or epitope - of the contagion to disrupt the spike protein, neutralizing the ability of the virus to replicate.
Moreover, the engineers can construct a new multi-epitope vaccine for a new virus in less than a minute and validate its quality within an hour. By contrast, current processes to control the virus require growing the pathogen in the lab, deactivating it and injecting the virus that caused a disease. The process is time-consuming and takes more than one year; meanwhile, the disease spreads.

Source: University of Southern California

07.02.2021

Read all latest stories

Related articles

Photo

Article • AI in public health

Inspiring women to create technology that impacts society

Some people change the narrative about technology and society. One of them is Nuria Oliver, Chief Data Scientist at Data-Pop Alliance, Chief Scientific Advisor at the Vodafone Institute, and…

Photo

News • „Swarm Learning“

AI with swarm intelligence to analyse medical data

Communities benefit from sharing knowledge and experience among their members. Following a similar principle - called “swarm learning” - an international research team has trained artificial…

Photo

News • Model analysis

Machine learning for Covid-19 diagnosis: promising, but still too flawed

Systematic review finds that machine learning models for detecting and diagnosing Covid-19 from medical images have major flaws and biases, making them unsuitable for use in patients. However,…

Related products

3DQuorum SmartSlices

Artificial Intelligence

Hologic · 3DQuorum SmartSlices

Hologic, Inc.
Advanced intelligent Clear-IQ Engine for MR

Artificial Intelligence

Canon · Advanced intelligent Clear-IQ Engine for MR

Canon Medical Systems Europe B.V.
AI-Rad Companion

Artificial Intelligence

Siemens Healthineers · AI-Rad Companion

Siemens Healthcare GmbH
Aquilion Exceed LB

Oncology CT

Canon · Aquilion Exceed LB

Canon Medical Systems Europe B.V.
Aquilion Lightning

20 to 64 Slices

Canon · Aquilion Lightning

Canon Medical Systems Europe B.V.
Subscribe to Newsletter