Catheter ablation of atrial fibrillation is an important treatment option for heart rhythm maintenance and symptom reduction. Now, an international consensus statement reflects new techniques.
Warfarin is sometimes prescribed after heart surgery, but getting the dose right requires a personalised approach for each patient. A new AI tool is designed to help with this complex task.
A new, large-scale study from Sweden underlines the importance of vaccination against Covid-19: The research shows that an infection raises the risk of heart rhythm disturbances.
Dutch researchers successfully inserted magnet-controlled miniature robots into an aorta model with kidneys. In the future, this technology could be used to remove blood clots.
Highlights:Dosinaco is the first commercial LC-MS / MS reagent kit for anticoagulants in plasma.Anticoagulants are used to treat and prevent blood clots prevalent in cardiovascular diseases. Direct oral anticoagulants (DOACs) have recently been developed, aiming to modulate factor X in a dose dependent manner. Their precise quantification is necessary to determine the concentration or to identify…
Neurobiologists in Sweden have discovered a way to partially restore communication between nerve cells in the brain after a stroke. This could lead to future treatments, the researchers say.
Researchers have developed a method for assessing the number and structure of aggregated blood platelets (or thrombocytes) that can potentially help quantify the risk of a severe Covid-19 infection. As a result, they have identified a predictive biomarker for the seriousness of a Covid-19 infection. This will allow physicians to adjust treatment at an early stage. The researchers used a method…
Using small blood vessels grown in the lab, researchers discover how vascular leaks leading to dementia and stroke emerge – and how this damage might be fixed.
A mechanism that led some patients to experience cases of deadly clotting following some types of Covid-19 vaccination has been identified in new research.
Postpartum hemorrhage is a leading cause of maternal mortality at birth, especially after cesarean deliveries. Now, anesthesiologists propose two simple solutions to help prevent the severe bleeding.
Neurologists at Amsterdam UMC have developed a special sensor cap that interprets EEG brain waves to early detect signs of an ischemic stroke while the patient is in the ambulance.
Stark inequalities in diagnosis and treatment of four of the most common heart conditions in the UK have been revealed in new research led by a team at the University of Leeds.
The consortium Holland Hybrid Heart will receive €10 million to develop a soft robotic heart suitable for transplantation.
Photon-counting CT allows for a comprehensive, simultaneous evaluation of lung structure and function, something not possible with standard CT, according to a new study.
Genes are full of clues about a person's health and might also show the way for stroke recovery.
A pioneering new method to assess the quality of organs for donation has the potential to revolutionise the transplant system, saving lives and tens of millions of pounds.
A new blood product combining red blood cells and plasma in one bag is associated with a better survival from a penetrating major trauma injury, a new study has found.
Researchers have developed a new tool and technique that uses “vortex ultrasound” – a sort of ultrasonic tornado – to break down blood clots in the brain.
A new X-ray technology has been used to identify a link between the damage that severe Covid-19 can inflict on lungs and pulmonary fibrosis, a disease that causes severe scarring of lung tissue.
Researchers at McMaster University create device to replicate conditions in blood vessels after grafts.
The main goal of arthroplasty is to relieve pain, improve and restore joint function and recover quality of life. Periprosthetic joint infection remains a complication that has to be taken seriously.
A spin-off from ETH Zürich has developed a magnetically steerable catheter for quick and safe stroke treatment that no longer requires surgeons to be on site.
Patients are 20% less likely to die of sepsis because a new AI system developed at Johns Hopkins University catches symptoms hours earlier than traditional methods, an extensive hospital study shows.
Similar to the way exercise helps muscles adapt to workouts, short, repeated bouts of reduced circulation with a blood pressure cuff may help prevent the worst outcomes of heart attacks and strokes.
Networks adapt over time and in this way form a kind of memory. German researchers show that the structure of blood vascular network is dynamic and can adapt to external factors.
When every minute counts: A Swiss team is currently developing a diagnostic procedure that can be used to start a tailored therapy for acute stroke in a timely manner.
In patients with serious and long-term Covid-19, disturbed blood coagulation is often observed. Now, Swedish researchers found a connection between harmful amyloid production and Covid-19 symptoms.
Cognitive impairment as a result of severe Covid-19 is similar to that sustained between 50 and 70 years of age and is the equivalent to losing 10 IQ points, scientists found.
Portable MRI machines detected ischemic strokes, or strokes caused by clotting, in 90% of patients scanned.
Engineers at the Massachusetts Institute of Technology (MIT) have developed a telerobotic system to help surgeons quickly and remotely treat patients experiencing a stroke or aneurysm.
A new biodegradable gel improves the immune system’s ability to keep cancer at bay after tumors are surgically removed.
For people with atrial fibrillation, one of our most common cardiac disorders, dementia risk is elevated.
The appearance of ovarian lesions on ultrasound is an effective predictor of cancer risk that can help women avoid unnecessary surgery.
A literature review fleshes out key issues currently preventing the proliferation of robotic procedures, specifically their use in image-guided interventional procedures in the brain.
When a patient suffers a stroke, speed in treatment can mean the difference between successful recovery, permanent disability, or death. For Christopher Hess, success in stroke diagnosis is a question of workflow and efficient care delivery.
Doctors work on initiatives to cut down the steps that need to happen between the time a stroke patient is wheeled through the ambulance bay until treatment can begin.
A new pilot study suggests that machine learning algorithms which fuse electrocardiogram (ECG) and electronic health record data may help doctors screen for dangerous, lung-clogging blot clots.
Doctors in Lisbon report on the case of a 61-year-old man who received a double lung transplant after his lungs were irreparably damaged by Covid-19.
Speed in treatment of ischemic stroke can mean the difference between successful recovery versus permanent disability caused by brain tissue damage or death. Time is of the essence to perform thrombolysis with a tissue plasminogen activate (tPA), a protein that can dissolve blood clots causing the stroke or intra-arterial thrombolytic therapy (IAT) because of large-vessel occlusion.
A commonly available imaging technique can identify stroke patients most likely to benefit from a procedure to restore blood flow, a potential breakthrough in care that could save thousands of lives every year
The damage caused by Covid-19 to the lungs’ smallest blood vessels has been intricately captured using high-energy X-rays emitted by a special type of particle accelerator. Scientists used a new imaging technology called Hierarchical Phase-Contrast Tomography (HiP-CT), to scan donated human organs, including lungs from a Covid-19 donor.
A study found that women who contract Covid-19 during pregnancy are at significantly higher risk of developing pre-eclampsia. In their study, researchers said their systematic review shows that women with SARS-CoV-2 infection during pregnancy had 62% higher odds of developing preeclampsia than those without the infection during pregnancy.
A team of researchers are developing the use of an artificial intelligence (AI) algorithm with the aim of diagnosing deep vein thrombosis (DVT) more quickly and as effectively as traditional radiologist-interpreted diagnostic scans, potentially cutting down long patient waiting lists and avoiding patients unnecessarily receiving drugs to treat DVT when they don’t have it.
Researchers from the University of Oxford have announced the results of a study into thrombocytopenia (a condition with low platelet counts) and thromboembolic events (blood clots) following vaccination for Covid-19, some of the same events which have led to restricted use of the Oxford-AstraZeneca vaccine in a number of countries.
A new study of patients with cerebral venous thrombosis (CVT) following Covid-19 vaccination provides a clearer guide for clinicians trying to diagnose and treat patients. The research, led by University College London (UCL) and UCL Health and published in The Lancet, is the most detailed account of the characteristics of CVT, when it is caused by the novel condition vaccine-induced immune…
The tell-tale signs of a person’s susceptibility to a stroke may appear up to 10 years before the event, suggests research published online in the Journal of Neurology Neurosurgery & Psychiatry. Stroke patients experienced much steeper declines in cognitive abilities and routine daily functioning, starting around a decade before their first stroke, than people who didn’t have a stroke,…
A study involving virtual rather than real patients was as effective in evaluating a medical device used to treat brain aneurysms, according to new research. The findings are proof of concept for what are called in-silico trials, where instead of recruiting people to a real-life clinical trial, researchers build digital simulations of patient groups, loosely akin to the way virtual…
After a stroke, doctors can try to remove clots in blood vessels to keep blood flowing freely to the brain. But even though most of these procedures are successful, less than half of people have a successful recovery from the stroke. A new study published in the medical journal Neurology sheds light on why that may be. The study found that trying more than once during a procedure to retrieve a…
Interdisciplinary team from Washington University School of Medicine in St. Louis and the university’s McKelvey School of Engineering finds better way to design clot-prone grafts currently used for dialysis.
New artificial intelligence (AI) technology to scan for heightened blood vessel inflammation can calculate a person’s risk of death from Covid-19 and its variants.
For the first time, a prospective, international study has shown that chest pain caused by problems with the very small vessels supplying blood to the heart is an important health problem that increases the risk of heart attacks, stroke and death due to cardiovascular reasons. The study, which is published in the European Heart Journal, recruited 686 patients from 14 institutions in seven…
Researchers used AI to identify which daily changing clinical parameters best predict intervention responses in critically ill Covid-19 patients. The investigators used machine learning to predict which patients might get worse and not respond positively to being turned onto their front in intensive care units (ICUs) - a technique known as proning that is commonly used in this setting to improve…
A large study from Denmark and Norway published by The BMJ sheds more light on the risk of rare blood clots in adults receiving their first dose of the Oxford-AstraZeneca Covid-19 vaccine. The findings show slightly increased rates of vein blood clots including clots in the veins of the brain, compared with expected rates in the general population. However, the researchers stress that the risk of…
A major study from the Washington University School of Medicine details numerous long-term effects of COVID-19, pointing to massive health burden.
The largest study of its kind in the UK has identified differences in the immune response to Covid-19 between people with no symptoms, compared to those suffering a more serious reaction to the virus. The research by Newcastle University and collaborators within the Human Cell Atlas initiative found raised levels of specific immune cells in asymptomatic people. They also showed people with more…
A team led by a clinical academic at University College London (UCL) has outlined the mechanism behind rare cases of blood clots and low platelets seen in patients who have had the Oxford/AstraZeneca vaccine. The new study, published in the New England Journal of Medicine, highlights the importance of rapidly spotting this new syndrome, known as vaccine-induced thrombosis and thrombocytopenia…
In just the last two years, artificial intelligence has become embedded in scores of medical devices that offer advice to ER doctors, cardiologists, oncologists, and countless other health care providers. But how much do either regulators or doctors really know about the accuracy of these tools? A new study led by researchers at Stanford, some of whom are themselves developing devices, suggests…
Researchers at the University of Oxford report that the risk of the rare blood clotting known as cerebral venous thrombosis (CVT) following Covid-19 infection is around 100 times greater than normal, several times higher than it is post-vaccination or following influenza. The study authors, led by Professor Paul Harrison and Dr Maxime Taquet from Oxford University’s Department of Psychiatry and…
Researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have developed a mass spectrometry-based technique capable of measuring samples containing thousands of proteins within just a few minutes. It is faster and cheaper than a conventional blood count. To demonstrate the technique’s potential, the researchers used blood plasma collected from Covid-19 patients.…
Around 50% of patients who have been hospitalised with severe Covid-19 and who show raised levels of a protein called troponin have damage to their hearts. The injury was detected by magnetic resonance imaging (MRI) scans at least a month after discharge, according to new findings published in the European Heart Journal. Damage includes inflammation of the heart muscle (myocarditis), scarring or…
Patients given preventive blood thinning drugs (prophylactic anticoagulants) within 24 hours of admission to hospital with Covid-19 are less likely to die compared with those who do not receive them, a new study finds. Clinical trials are now underway to see if prophylactic anticoagulants could be an effective treatment for Covid-19. In the meantime, the researchers say these findings provide…
Someone has a stroke every 40 seconds in the US, resulting in death every 4 minutes. Stroke is the leading cause of disability from a medical condition. When it happens, blood clots or bleeds kill a part of the brain – it goes dark – and can no longer control part of the body. People stop being able to walk, see, talk, or control their hand or arm the way they once did. Although treatments…
Pregnancy complications and early menopause increase women’s future risk of heart disease. Cardiologists, gynaecologists and endocrinologists recommend how to help middle-aged women prevent later heart problems in a European Society of Cardiology (ESC) consensus document published in European Heart Journal, a journal of the ESC.
Brain metastases can only develop if cancer cells first exit the fine blood vessels and enter into the brain tissue. To facilitate this step, cancer cells influence blood clotting, as scientists from the German Cancer Research Center and Heidelberg University Hospital have now been able to show in mice. The cancer cells actively promote the formation of clots, which helps them to arrest in the…
Cancer cells spread by switching on and off abilities to sense their surroundings, move, hide and grow new tumors, a new study has found. This sensitivity to their surroundings is the key ability that makes small numbers of cancer cells better at spreading than other cells in a tumor.
Asian ethnicity is strongly linked to COVID-related stroke, reveals an analysis of stroke centre activity in England and Scotland during the first wave of the coronavirus pandemic, and accepted for publication in the Journal of Neurology Neurosurgery & Psychiatry.
Specialists from the Department of Fundamental Medicine of Far Eastern Federal University (FEFU) with Russian and Japanese colleagues have probed into mechanisms of COVID-19 inside-the-body distribution linked to erythrocytes damaging.
Scientists at EPFL are using technology to better understand how coronavirus causes blood clots in some patients. They have developed a simplified model of a lung that lets them observe, for the first time, how the virus attacks the cells lining blood vessels.
COVID-19 patients can suffer long-term lung and heart damage but, for many, this tends to improve over time, according to the first, prospective follow-up of patients infected with the coronavirus, presented at the European Respiratory Society International Congress. [1]
The SARS CoV-2 virus which causes COVID-19 may have been named prematurely. As more has become known about the infection, the severe disease does not appear to be a respiratory syndrome at all. Patients who only have a respiratory illness tend not to have a severe condition, while patients who develop a severe condition tend to have non-respiratory conditions, primarily thrombotic or hyper-immune…
An overactive defense response may lead to increased blood clotting, disease severity, and death from COVID-19. A phenomenon called NETosi is part of an immune response that becomes increasingly hyperactive in people on ventilators and people who die from the disease.
A new polymeric heart valve with a life span potentially longer than current artificial valves that would also prevent the need for the millions of patients with diseased heart valves to require life-long blood thinning tablets has been developed by scientists at the universities of Bristol and Cambridge. The team's latest in-vitro results, published in Biomaterials Science, suggest that the…
Biomedical engineering researchers at Texas A&M University designed a medical device that mimics blood vessels to design and monitor drugs for patients with clotting disorders. This approach could be especially beneficial for pediatric patients. Unlike what a biology textbook may show, blood vessels are not straight cylinders. They are tortuous, meaning they have complex curves, spirals and…
COVID-19 can cause serious cardiovascular complications including heart failure, heart attacks and blood clots that can lead to strokes, emergency medicine doctors at the University of Virgina report in a new scientific paper. They also caution that COVID-19 treatments can interact with medicines used to manage patients’ existing cardiovascular conditions.
As Covid-19 spreads throughout the country, much attention has been paid to the devastating effects of the virus on the lungs. But doctors are learning how the virus may affect other organs, including the brain. Some patients with Covid-19 have had neurological symptoms, which may include an increased risk of stroke.
A course of action to early detect and treat severe courses of COVID-19 infections has been developed by an expert-team of the University Medical Center Goettingen (UMG). A simple urine test is intended to help medical professionals to recognize warning signs of future decompensation of COVID-19 infections earlier. With the help of a few parameters, the treatment of imminent complications can…
Sepsis—the body's own immune response gone against it—is a major health problem worldwide. It is basically a "hyper" immune response by the body to infection or injury, and is characterized by hyperinflammation, immune system paralysis, cell death, liver and kidney failure, blood clots, and even hemorrhage. An estimated 30 million people suffer from sepsis every year, of which 20%…
Within the framework of an international study, Lund University and Skåne University Hospital have started treating patients with hemophilia with gene therapy, something that began in January this year. The hope is that the new treatment will significantly simplify everyday life for those with severe hemophilia. Hemophilia is a genetic disease where the body does not produce one of the clotting…
Scientists from India and the USA, along with a team of international collaborators from academia and industry report the sequencing and assembly of a high-quality genome of the highly venomous, medically important Indian cobra (Naja naja). Using a combination of cutting-edge genomic technologies, the authors have assembled the most contiguous genome of this iconic venomous snake. Venom is a…
A University of Leeds spin-out company has secured £3.14m to develop a next generation drug that aims to prevent blood clots forming, without the risk of bleeding present in currently available drugs. Currently, anticoagulants have a relatively narrow margin between beneficial effects and undesirable bleeding, so new approaches are in demand. These could allow more patients that have a higher…
Scenario: A physiotherapist arrives in a ward pushing a new device towards a patient in bed. There, she introduces rehabilitation robot Robert and points to its multi-jointed arm. She places a cuff around the patient’s lower leg to link it to Robert’s arm and presses the start button; Robert raises the leg slightly. Manually, the physiotherapist performs movements, which Robert memorises to…
A partnership between the Royal Stoke University Hospital, part of the University Hospitals of North Midlands NHS Trust, and a UK industry-leading medical devices company have been rewarded for its use of an innovative bioelectronic technology to prevent life-threatening blood clots in acute stroke patients – winning in the category: Best use of technology (acute care), at the Building Better…
For decades now, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing processes and systems for cleaning, sterilization, and surface modification. The newly in-house developed process, called SULEEI, makes it possible to sterilize (S) and preserve decellularized pericardial tissue by means of photo-initiated ultraviolet (U) crosslinking…
More than 1,125,000 men around the world have the inherited bleeding disorder of hemophilia, and 418,000 of those have a severe version of the mostly undiagnosed disease, says a new study led by McMaster researchers. This is three times what was previously known. Only 400,000 people globally were estimated to have the disorder which is caused by a defect in the F8 or F9 gene which encodes…
The U.S. Food and Drug Administration approved Ofev (nintedanib) capsules to slow the rate of decline in pulmonary function in adults with interstitial lung disease associated with systemic sclerosis or scleroderma, called SSc-ILD. It is the first FDA-approved treatment for this rare lung condition. “Patients suffering from scleroderma need effective therapies, and the FDA supports the efforts…
A new study, presented as ‘Late Breaking Science’ at the European Society of Cardiology (ESC) annual congress, highlights the feasible use of mobile health (mHealth) devices to help with the screening and detection of atrial fibrillation (AF), a common heart condition. AF causes an irregular and sometimes, abnormally fast heart rate. The heart’s upper chambers (atria) contract randomly and…
A new survey will give patients, carers and members of the public the opportunity to have their say in what they think is important for future research for vascular conditions. The Vascular Priority Setting Partnership (PSP) survey, developed in partnership with the James Lind Alliance aims to identify unanswered questions about the prevention, diagnosis and treatment of vascular conditions from…
Blood clotting is one of the most critical, protective processes in human physiology. When something goes wrong with clotting, either because there is too much clotting, leading to a stroke, or not enough, leading to internal bleeding, the outcome can be catastrophic. Now, University at Buffalo researchers have established an in vitro model of this process that will help clinicians improve…
It appears that an influenza vaccine does not just work when it comes to influenza. A new study shows that elderly people who have been admitted to an intensive care units have less risk of dying and of suffering a blood clot or bleeding in the brain if they have been vaccinated. And this is despite the fact that they are typically older, have more chronic diseases and take more medicine then…
Help for patients with sickle cell disease may soon come from gene editing to fix the mutation that causes the disease and boost the patient's own protective fetal hemoglobin.
Researchers at The Ohio State University College of Medicine and The Ohio State University Wexner Medical Center have developed a novel stroke therapy that, when tested in mice and dogs, has proven superior to the standard of care therapy now offered to patients suffering a stroke. Findings of the study are published online in Molecular Therapy. “We have shown that our drug, which is completely…
Researchers have discovered that a family of lipids (fats) contribute to the development of a serious aortic disease, by driving clotting in the blood vessel wall. The findings could lead to the development of new treatments for this potentially life threatening condition. The team, led by researchers at Cardiff University, in collaboration with colleagues at Oxford and Erlangen, discovered that…
Non-alcoholic fatty liver disease is among the most common chronic hepatic disorders in Western industrial countries and the rate is also rapidly rising in newly industrialized countries. Experts estimate that about 30 to 40 percent of the population worldwide develop this liver condition. In the United States, this disease is well on the way to becoming the most frequent indication for liver…
Researchers at Karolinska Institutet have found that type IgG antibodies play an unexpected role in atherosclerosis. A study on mice shows that the antibodies stabilise the plaque that accumulates on the artery walls, which reduces the risk of it rupturing and causing a blood clot. It is hoped that the results, which are published in the journal Circulation, will eventually lead to improved…
Having a genetic predisposition to high testosterone levels could play a role in the development of major heart problems in men, such as blood clots and heart failure, finds a study published by The BMJ. The findings may also have implications for men who take testosterone supplements to boost energy levels and sex drive. Some evidence suggests that genetically predicted (“endogenous”)…
A new study published in the Journal of Gerontology Series A has found that eating blueberries can lead to an improvement in blood vessel function and a decrease in systolic blood pressure. Researchers from King’s College London and the University of Surrey studied 40 healthy volunteers for one month. They were randomly given either a drink containing 200g of blueberries, or a matched control…
A first-in-human study reports that the novel positron emission tomography/computed tomography (PET/CT) tracer 18F-GP1 showed excellent image quality and a high detection rate for the diagnosis of acute venous thromboembolism (VTE). Well-tolerated in patients, 18F-GP1 PET/CT also identified blood clots in distal veins of the leg below the knee, where conventional imaging has limitations.
The pill could be blurring your social judgement ‒ but perhaps not enough so you'd notice. By challenging women to identify complex emotional expressions like pride or contempt, rather than basic ones like happiness or fear, scientists have revealed subtle changes in emotion recognition associated with oral contraceptive pill (OCP) use. Published in Frontiers in Neuroscience, their study found…
A new analysis from University College London, King's and the University of Manchester finds an extra 69 lives are being saved every year as a result of further centralisation of services in Greater Manchester. In London, where earlier research had shown that centralising acute stroke services saved an extra 96 extra lives per year, these improvements have been sustained over time.
For decades, women have shouldered most of the burden of contraception. However, long-term use of female birth control pills could increase the risk for side effects such as blood clots or breast cancer. Now, inspired by colorful layered cocktails, researchers have developed a medium-term, reversible male contraceptive. They report their results in the journal ACS Nano. Common forms of male…
When Olivia Nelson was 3 years old, her parents noticed that she had a fever that wouldn’t get better. They brought her to a nearby hospital, where she spent about two weeks being screened for diseases. As doctors tried to find a diagnosis, a lymph node on Olivia’s neck became swollen. Alarmed and wanting an answer, the Nelsons asked to transfer to Seattle Children’s. “It was very…
Rutgers researchers have found a way to reduce bleeding in patients following bariatric surgery. The study, which appeared in the journal Surgery for Obesity and Related Disorders, was conducted by Luigi Brunetti and Leonid Kagan at the Rutgers Ernest Mario School of Pharmacy in collaboration with Ragui Sadek at Advanced Surgical and Bariatrics of New Jersey. More than 30 percent of adults in the…
Here at Medica, the Taiwanese start-up Maisense is demonstrating Freescan, its artificial intelligence (AI) based solution to screen for stroke through the early detection of atrial fibrillation (AFib). Speaking of the system’s aims, Maisense summed up this huge health problem. ‘Every four minutes, someone dies of stroke. Thirteen percent of these are classified as haemorrhagic stroke. When…
Researchers at McMaster University have solved a vexing problem by engineering surface coatings that can repel everything, such as bacteria, viruses and living cells, but can be modified to permit beneficial exceptions. The discovery holds significant promise for medical and other applications, making it possible for implants such as vascular grafts, replacement heart valves and artificial joints…
One in two women and one in three men will likely be diagnosed with dementia, Parkinson's disease, or stroke in their lifetime, estimate Dutch researchers in an observational study
Pre-analytics, in particular venous blood sampling has a major impact on the quality of laboratory diagnostic results. An estimated 75 percent of all "lab errors" are caused by errors during pre-analytics. Thus, the German Medical Association’s national guideline on laboratory diagnostics includes detailed guidance on pre-analytics, in particular venous blood sampling. In their…
When delegates from around 150 countries converge on Munich for ESC Congress 2018 they will no doubt reflect on what they themselves eat. Yes, nutrition is up for debate, questioning, for example, whether weight loss therapies can also prevent heart attacks and strokes. Results from the CAMELLIA-TIMI 61 trial of 12,000 overweight individuals with established cardiovascular disease or diabetes…
Neurologist who coined the phrase "Time is Brain" says message is not so simple anymore. Rather there should be no hard-and-fast rule governing when therapy can be given because strokes progress differently in different patients.
Transgender individuals may be at higher risk for myocardial infarction and death due to cardiovascular disease, according to several studies. This increased risk may be due to the hormone therapy that transgender patients take for masculinization or feminization. A review authored by Michael S. Irwig, MD, associate professor of medicine at the George Washington University (GW) School of Medicine…
A scientist has discovered a gene-editing technology that could efficiently and accurately correct the genetic defects that underlie certain diseases, positioning the new tool as the basis for the next generation of genetic therapies.
Donating blood is a tangible way to help people who are struggling with serious health conditions, yet many people may not think about it or make time for it. In January – which the American Red Cross has dubbed National Blood Donor Month – blood bank supplies are typically among the lowest of the year, as many people have been traveling or busy with the holidays. Inclement weather can also…
Treating stroke has long been governed by the clock. If it has been less than three hours since the onset of symptoms, the clot-busting drug t-PA will likely work. If it has been four and a half hours, some selected patients might benefit. However, if it has been more than six hours, treatment options have been few. Now that conventional wisdom has been turned on its head. The final results of…
Not long ago, POCT was a specialist diagnostic discipline used by only few laboratory staff. This has changed considerably over recent years. Initially, the main focus had been on determining electrolytes, blood gases, blood clotting and blood count, but further parameters, such as kidney function, cardiac enzymes, urine tests and testing for autoimmune diseases have now been added. Whilst the…
Blood-thinning drugs not only reduce the risk of stroke in patients with atrial fibrillation (AF) but are also associated with a significant reduction in the risk of dementia, according to new research published today in the European Heart Journal.
Despite prevention efforts, researchers have found a significant increase over a 10-year period in the percentage of people with stroke who have high blood pressure, diabetes, smoking and other risk factors for stroke. “An estimated 80 percent of all first strokes are due to risk factors that can be changed, such as high blood pressure, and many efforts have been made to prevent, screen for and…
The first comprehensive European advice on deep vein thrombosis is published in the current issue of European Heart Journal. The recommendations were produced by the European Society of Cardiology (ESC) Working Group on Aorta and Peripheral Vascular Diseases and Working Group on Pulmonary Circulation and Right Ventricular Function.
The taller you are, the more likely you may be to develop blood clots in the veins, according to new research in the American Heart Association journal Circulation: Cardiovascular Genetics.
The stimulant methamphetamine, also popularly known as ‘speed,’ ‘ice’ and ‘meth,’ is linked to a heightened risk of stroke among young people, reveals a review of the available evidence, published online in the Journal of Neurology Neurosurgery & Psychiatry.
A certain immune reaction is the key, not to slowing atherosclerosis like cholesterol-lowering drugs do, but instead to reversing a disease that gradually blocks arteries to cause heart attacks and strokes. This is the finding of a study in mice led by researchers at NYU Langone Medical Center.
Researchers have found that people with A, B, and AB blood types may be at greater risk of cardiovascular events - particularly heart attack - than individuals with O blood types.
Faster and better recovery after stroke may be the result of a newly discovered treatment strategy that created new nerve synapses in the brain—a key factor for learning. A study at Sahlgrenska Academy showed improved ability to use the affected paw in mice that received the treatment.
Using specialized CT scans of a healthy heart and one with heart disease, a team of Johns Hopkins cardiologists and biomedical engineers say they've created computer models of the "shape" of blood flow through the heart's upper left chamber that someday may help predict stroke risk.
In a groundbreaking new study led by University of Minnesota biomedical engineers, artificial blood vessels bioengineered in the lab and implanted in young lambs are capable of growth within the recipient. If confirmed in humans, these new vessel grafts would prevent the need for repeated surgeries in some children with congenital heart defects.
A study published in the prestigious New England Journal of Medicine offers the most in-depth assessment yet of the safety and effectiveness of a high-tech alternative to brain surgery to treat the uncontrollable shaking caused by the most common movement disorder. And the news is very good.
In the fast-evolving field of left atrial appendage closure a new study has delivered data that could benefit thousands of patients at risk of stroke. Led by Professor Martin Bergmann, head of Interventional Cardiology at Cardiologicum Hamburg in Germany, the EWOLUTION study was conducted to evaluate the Watchman Left Atrial Appendage (LAA) closure device from manufacturer Boston Scientific.
Authors Guiseppe Lippi, Chiara Bovo and Emmanuel J. Favaloro offer a glimpse into a new generation of hematology analyzers and discuss the concepts of redesigning coagulation analyzers to fit the most important aspects of the preanalytical, analytical and postanalytical phases in hemostasis testing. The aim of this opinion article is to provide some personal ideas, based on experience and…
In a study of stroke patients, investigators confirmed through MRI brain scans that there was an association between the extent of disruption to the brain's protective blood-brain barrier and the severity of bleeding following invasive stroke therapy. The results of the National Institutes of Health-funded study were published in Neurology.
A new study by a Yale researcher may support the use of a device for patients suffering from irregular heart rhythms.
Vanderbilt University Medical Center nephrologist and associate professor of medicine Dr. William H. Fissell IV, is making major progress on a first-of-its kind device to free kidney patients from dialysis. He is building an implantable artificial kidney with microchip filters and living kidney cells that will be powered by a patient’s own heart.
What doesn't kill you could cure you. A growing interest in the therapeutic value of animal venom has led a pair of Columbia University data scientists to create the first catalog of known animal toxins and their physiological effects on humans.
A nanofiber hydrogel infused with snake venom may be the best material to stop bleeding quickly, according to Rice University scientists.
Virtual models can be created in the angiography room thanks to an approach developed by researchers at the University of Montreal Hospital Research Centre (CRCHUM) and the university’s departments of radiology, radiation oncology, and nuclear medicine. The latest advances were presented by Dr. Gilles Soulez at the Cardiovascular and Interventional Radiology Society of Europe (CIRSE) conference…
Researchers funded by the National Institute of Biomedical Imaging and Bioengineering at Tufts University and their collaborators have successfully developed a 3-dimensional (3D) tissue-engineered model of bone marrow that can produce functional human platelets outside the body (ex vivo).
Vascular surgeon Pat Kelly of Sanford Health in Sioux Falls, South Dakota, knew his patients were doing better with the stent graft he designed, but he wanted a better understanding of the mechanics before testing the device more widely in a clinical trial. For that, he reached out to South Dakota State University. Associate professor Stephen Gent in mechanical engineering had done computational…
They did it for heart attacks. Can cardiologists now lead an effort to speed up the emergency medical response for stroke? Over the past five years, the Stent for Life initiative organised by interventional cardiologists has pushed majors medical centres to assure 24/7 coverage and reduce the time to treatment for patients showing up with severe chest pain.
A blood clot is a dangerous health situation with the potential to trigger heart attacks, strokes and other medical emergencies. To treat a blood clot, doctors need to find its exact location. But current clinical techniques can only look at one part of the body at a time, slowing treatment and increasing the risk for complications. Now, researchers are reporting a method, tested in rats, that…
Blood clots often form when lipid-rich plaques on the inner surface of arteries rupture and platelets aggregate at the site of injury. LMU cardiologists have now compared the effects of two new platelet aggregation inhibitors.
Results from six international randomised controlled studies conclusively and uniformly confirm, for the very first time, the effectiveness of thrombectomy in patients with acute, severe ischaemic strokes caused by a blood clot in one of the proximal cerebral arteries. The endovascular procedure is an add-on to conventional thrombolysis. EH reports from a German Stroke Society (DSG) press…
A research paper published in the New England Journal of Medicine (NEJM) today confirms earlier findings that a procedure called endovascular therapy (ET) for ischemic stroke is the best treatment option for many patients by reducing the incidents of disability. This is the fourth research paper published this year that confirms the efficacy of the treatment.
Stroke resulting from rupture or interruption of blood flow in brain vessels can lead to devastating consequences for patients, their families and society. Steady progress has been achieved in the last 20 years in stroke treatment through better prevention, establishment of stroke care units and the use of clot-busting drugs (intravenous thrombolysis).
A study from Northwestern Medicine and the American College of Surgeons suggests that penalizing hospitals for patient readmissions following surgery may be ineffective, and even counterproductive, for improving the quality of hospital care in America.
Sucking up blood spilt during a major surgical procedure, or drained from a heart-lung machine after surgery, the Hemosep cell concentration system has a blood bag that uses a chemical sponge technology and mechanical agitator to filter red and white blood cells and platelets through a plastic membrane so that they can then be returned to the patient by intravenous transfusion. Report: Mark…
A new extracorporeal nanotech device addresses the root cause of sepsis by removing pathogens and endotoxins simultaneously from blood even before their identification – this genetically engineered mannose-binding lectin protein can also latch on to the Ebola virus... Report: Cynthia E Keen
French authorities have given the green light for continuing the clinical trial for the first fully implantable mechanical heart after a four-month review of the device and the causes of death of the first patient to receive the prosthesis
Although nosocomial infections and medical accidents have declined, over 750 hospitals with the highest number of such cases now face penalties – amounting to an estimated $330 million a year – issued by Medicare.
Bayer HealthCare has entered into a definitive agreement to sell its Interventional device business to Boston Scientific for $415 million (about EUR 300 million), including fees for transitional services. The sale will include the AngioJet (thrombectomy) and Jetstream (atherectomy) systems, and the Fetch2 Aspiration Catheter used in cardiology, radiology and peripheral vascular procedures.
Neurologists keenly debate the value of mechanical reopening of blocked blood vessels in the brain, as demonstrated during the 21st World Congress for Neurology (WCN) in Vienna this September. Theoretically, endovascular thrombolysis can only be considered for 20-30% of all incidents of stroke.
Clinical chemistry influences almost all medical disciplines: most diagnoses are made or confirmed only after the laboratory has determined at least one or two parameters.
We must not forget that despite advances, cardiovascular disease remains the number one killer in Europe.
Despite receiving blood thinners and other clot prevention treatment, some patients still develop potentially lethal blood clots in the first month after their operations anyway, especially if they developed a surgical-site infection while in the hospital, according to results of a study at Johns Hopkins.
If the hopes of inventors are to be believed, in around 20 years’ time there will be ‘real artificial lungs -- for now the endpoint of a history that began 84 years ago with the invention of the iron lung. Until then, non-invasive and invasive mechanical respiration will continue to dominate the hospital, complemented by extracorporeal procedures for blood oxygenation and decarbonisation,…
Johns Hopkins neurologists report success with a new means of getting rid of potentially lethal blood clots in the brain safely without cutting through easily damaged brain tissue or removing large pieces of skull. The minimally invasive treatment, they report, increased the number of patients with intracerebral hemorrhage (ICH) who could function independently by 10 to 15 percent six months…
The theme of this year's World Stroke Day on 29 October is "One in Six", referring to the facts that one in six people will have a stroke at some point in their lifetime, and that a stroke will be the cause of someone's death every six seconds. These, says the World Stroke Organization (WSO), are everyday people leading everyday lives, but around 85% of them will have risk factors…
High flexibility and live conditions contribute towards the high popularity of image-guided interventions, now performed under ultrasound control in 80-90% of cases. However, although minimally-invasive examinations are based on high standards of medical safety, complications can arise that could ultimately lead to litigation. Thus, experienced ultrasound operators would be wise to know the…
Initially meant to bridge the gap before a heart transplant is performed, today ventricular assist devices (VADs) are increasingly considered ‘a lasting therapy option’, according to Professor Heinrich Schima, Head of the Centre for Medical Physics and Biomedical Technology at the Medical University of Vienna.
Neurocardiology – especially atrial fibrillation (AF) – was the key topic during a press conference held during the 55th Annual Congress of the Germany Society for Clinical Neurophysiology and Functional Imaging (DGKN) this March. For good reason: Worldwide, there are around six million AF sufferers -- and it is one of the most common causes of stroke because this cardiac irregularity can…
A little over three decades after the world's first human heart transplant (HT), Carmat’s life-size artificial heart, a mix of animal tissue, titanium and missile technology that perfectly replicate a human heart, might save the lives of thousands.
Often a life-saving intervention, mechanical ventilation also has some serious drawbacks: the need for sedation, the risk of ventilator associated pneumonia, intubation or tracheostomy related complications. In 1972, Donald Hill from Pacific Medical Centre, Los Angeles, reported the first successful long-term mechanical lung assist device with extracorporeal membrane oxygenation (ECMO).
Bedside testing of parameters has been introduced in clinical practice much earlier than laboratory testing: In past centuries, not only were temperature or pulse rate taken at the point of care (POC), but also qualitative blood or urine analysis were performed right next to a patient’s bed
The Siemens sector Healthcare has developed the new consulting model “Act on Stroke”, tailored specifically to clinical workflows in the treatment of stroke. Following models for industry processes, an expert team from Siemens evaluates the maturity level of clinical processes in a hospital.
With the “World Stroke Day” the World Stroke Organization (WSO) aims to communicate a unified message to the world: stroke is a preventable and treatable catastrophe, and together we can fight this growing epidemic. This year’s theme is “Stroke‐What can I do?” The answer is ‐ a lot. The WSO prompts individuals, groups and governments to take action against stroke either at a…
It’s hardly surprising that stroke was a focus at the 20th meeting of the European Neurological Society (ENS) -- every year at least a million people suffer one in the EU. In an interview with Bettina Döbereiner, Professor Karl Max Einhäupl, Director of the Department of Neurology at the Charité - University of Medicine Berlin, of which he is Chairman of the Board and co-chair of the ENS…
Surgeon Alain Carpentier is ready to remove a patient’s heart and replace it with a mechanical device he spent 15 years developing. By 2013 the procedure will be performed on 50 European patients as part of a clinical trial to win CE approval for the world’s first fully implantable artificial heart.
A key development at the Norfolk and Norwich University Hospital (NNUH), east of England, has seen a change in the role of radiology assistants: They now help to prepare patients for radiology scans and look after them -- work previously undertaken by radiographers. The change now allows radiographers more time to concentrate on scanning patients, resulting in faster scanning with quicker…
Like a bolt from the blue ischemic stroke strikes a patient unpredictably. The consequences are devastating: stroke is the number one cause of serious disabilities in adulthood - and, in Europe alone, someone suffers a stroke every 20 seconds. Thrombolysis ensures that blood clots in the brain dissolve. However, the majority of patients do not profit from this therapy.
Patients with atrial fibrillation, so at risk of stroke, are usually treated with medication to prevent coagulation. The Hanover Medical School (MHH) has devised an alternative treatment.
Concerns over whether the tests a treatment undergoes before general release are enough to ensure its long-term safety have been raised in an editorial by Dr Vijay Sharma, Clinical Editor of BMJ Clinical Evidence. He suggests that treatments should be introduced gradually so that evidence can be built up and the treatment can find its proper niche.
In current USA debates on healthcare reform referrals to IT use in Denmark, the Netherlands and the UK are frequent and well supported by studies performed by the Commonwealth Fund.
Testing people for heart disease might be just a finger prick away thanks to a new credit card-sized device created by a team of researchers from Harvard and Northeastern universities in Boston.
The 9th Annual Spring Meeting of the European Society of Cardiology Council on Cardiovascular Nursing and Allied Professions (CCNAP), organised in cooperation with the Irish Nurses Cardiovascular Association (INCA), is being held at the Royal Dublin Society, Dublin, Ireland, on 24-25 April.
Timing, emergency network, reperfusion therapy are central to new recommendations for the management of heart attack which have been developed by a Task Force of the European Society of Cardiology (ESC) and were issued on the 14th November.
Presidential candidates use them to persuade voters, drug companies use them to sell their products, and the media spin them in all kinds of ways, but nobody - candidates, reporters, let alone health consumers - understands them.
The European Commission has granted marketing approval to the Bayer Group for Xarelto (rivaroxaban), an anticoagulant taken as one tablet, once-daily, to prevent venous thrombo-embolic events (VTE) in adults undergoing elective (planned) hip or knee replacement surgery.
Until recently, physicians believed that stenosis was responsible for strokes. But new investigations show that the composition of complicated plaques are the major cause. Canadian researchers now used 3-D MRI to accuratly detect bleeding by those plaques within the vessel walls.
Professor C Mueller adressed the issue of new biomarkers in acute cardiac care on the ESC on Monday, 1st September. Read his comment in the following.
In the EU blood clots are responsible for killing 544.000 people each year. Rivaroxaban, a new oral given anticoagulant drug from Bayer Healthcare, is significantly more effective than the current standard of care, according to three recent studies. The number of blood cluts in Europe is about 1.5 million per year, more than thirty percent of the patients affected die.
The Department for Paediatric Cardiology at the University Medical Centre, at Johannes Gutenberg University, in Mainz, has extended its range of services for lower impact treatment According to the birth register in Mainz, an annual 1.26% of newborns are diagnosed with congenital heart defects, making these the most common malformation.
In his lecture Focus on new therapy strategies for heart attacks, Prof. Hans Michael Piper, President of this year's Congress of the German Cardiac Society, gave some fascinating insights in to therapeutic measures after heart attacks.
Andrea Martini and Joerg Larsen, of the Institute for Roentgendiagnostics, Braunschweig Teaching Hospitals, Germany, discuss nanotechnology, hybrid imaging and the quest for a personalised medicine.
According to a study that was recently published on bmj.com, researchers found evidence that a significant number of patients treated with low doses of aspirin for its antiplatelet effect are actually aspirin resistant. Such a resistance makes patients four times more likely to suffer a life-threatening stroke or heart attack.
By Professor György Harmat MD, Director General of the Budapest Municipal Council Pal Heim Children's Hospital, Hungary
A new research collaboration to study the potential of microbubbles and ultrasound to treat ischemic strokes has been established between ImaRx Therapeutics, a biopharmaceutal company in Tucson, Arizona, and the Philips' Medical Systems division in Andover, Massachusetts.
Currently, to expand and centralise the MRI Department at the University Hospital Schleswig-Holstein in Luebeck, Germany, a new building is being planned.
Stroke risk should determine anti-clotting treatment for people with irregular heartbeat.
By Stefan G Ruehm MD PhD, Associate Professor of Radiology, at the David Geffen School of Medicine, UCLA, California
Dr Hanns-Joachim Weinmann, Diagnostics and Radiopharmaceuticals, Magnetic Resonance Imaging & X-Ray Research, Schering AG, examines what is feasible and what still lies only at a tantalising distance.
Experts call for screening of surgical and medical patients, and thromboprophylaxis for those at risk.
When heart valves need replacing mechanical or biological heart valves are usually used. Both have disadvantages: Mechanical prostheses promote the development of blood clots so that patients need anticoagulant treatment for their lifetime.