For 25 years, Dr. Soulez has been involved in developing medical imaging technologies to prevent complication for, operate on, and monitor patients with abdominal aortic aneurysms. The main problem has been the ability to properly visualize the area to be treated. “Remarkable advances in imagery have improved surgery and helped to develop less invasive interventions. But the images are still far from being perfect. We want to develop new software to maximize the use of images generated with current ultrasound, scanning, and magnetic resonance imaging (MRI) technologies to ultimately provide more personalized treatments,” he explained.
On the screen is a coloured image of an abdominal aorta, a large blood vessel that begins at the heart and travels down to the abdomen distributing blood throughout the body. But there’s something wrong with the photo: an enlarged area that looks like a small balloon. It's an abdominal aortic aneurysm, a disease caused by weakening of the vessel wall. Linked to atherosclerosis risk factors such as hypertension and smoking, the disease is the 13th cause of death in North America. It especially affects men. “If you have a ruptured aneurism, you have a one in two chance of dying,” Dr. Soulez said.
To operate, or not to operate?
Currently, a simple abdominal ultrasound or measurement of the aorta with a scanner can detect patients at risk of aneurysm rupture. Beyond 5 cm for women and 5.5 cm for men, surgery is usually recommended. But operations have their own risks, so researchers want to refine screening to provide the most appropriate treatments for patients who really need surgery.
To avoid rupturing the small balloon formed by the abdominal aortic aneurysm, two treatment options exist: open surgery to replace the diseased section or endovascular grafting, in which a catheter is inserted in the groin to deliver a stent-graft through the blood vessels to the aneurysm. This option is less invasive, but in some patients, the morphology of the aneurysm is not suited to this kind of treatment. Using scanner images, Soulez’s research provides three-dimensional images of all components of the aneurysm, i.e., the light, the thrombus or clot, the wall, and the calcification. “The grid is used to establish growth profiles of the aneurysm. We are now working to create simulations to better predict the risk of rupture, adding biomechanical properties such as tissue elasticity and connectivity at each pixel of the grid,” he explained.
Simulations will also help in the operating room. Currently, the operation is performed using static images taken by a scanner before the procedure. The procedure itself is done under fluoroscopy by injecting dye into the vessels to be treated. “The image produced by X-ray shows the dye in the vessels and the stent being inserted, but not the wall. This approach requires a lot of dye, which can be toxic for the patient if used in excessive amounts,” said the radiologist.
It’s thanks to a grant from the Canadian Institutes of Health Research (CIHR), in partnership with Siemens, that Dr. Soulez’s laboratory has been able to develop this approach that combines all available data. “We superimpose the images, and this helps to visualize the area to be treated. But in reality, the tools we introduce into the body during the procedure deform the organs. We are testing at the CHUM and in Halifax right now a new approach that uses a computer to automatically recognize the tools introduced into the body and correct the deformities they cause,” he said. “We hope this simulation-operation model will improve the accuracy of the procedure.”
Dr. Soulez’s research in interventional radiology also aims to ensure that the “plumbing" installed in patients fits in place. Sometimes the pipes leak, which can cause an aneurysm rupture, which is what was trying to be avoided in the first place. Following the stent-graft operation, patients have an annual scan. A new ultrasound technology called elastography that was developed in collaboration with Guy Cloutier, also of the University of Montreal Hospital Research Centre, holds the promise of not only effectively identifying leaks, but also evaluating how the aneurysm is healing. And finally, the last word in endovascular repair is the bioactive stent and injection of a gel around the implant to prevent or stop leaks. These new biomaterials are being developed in collaboration with Soulez and Cloutier’s colleague Sophie Lerouge.
Source: University of Montreal Hospital Research Centre (CRCHUM)