News • VITT reseach
A mechanism that led some patients to experience cases of deadly clotting following some types of Covid-19 vaccination has been identified in new research.
A mechanism that led some patients to experience cases of deadly clotting following some types of Covid-19 vaccination has been identified in new research.
German scientists have developed a magnetically controlled soft medical robot with a unique, flexible structure inspired by the body of a pangolin, that could heat up to mitigate bleeding.
A new method for cheaply producing heart valves in the span of minutes shows great promise. The scientists describe the method as "a cotton-candy machine with a hair dryer behind it."
Researchers have developed a new tool and technique that uses “vortex ultrasound” – a sort of ultrasonic tornado – to break down blood clots in the brain.
Breast cryoablation is an emerging treatment for early-stage, localized breast cancer that destroys malignant tumours by freezing them. During the past decade, it has been increasingly utilized as an alternative to lumpectomy, but its long-term benefits compared to other breast cancer treatments are still unproven.
Researchers at McMaster University create device to replicate conditions in blood vessels after grafts.
Rapid technical advances in ultrasound and increasingly tight healthcare budgets call for a change in ultrasound practice, experts explained in a session at the ECR in Vienna. Two experts presented possible models for the next two decades.
Around one in 500 men could be carrying an extra X or Y chromosome – most of them unaware – putting them at increased risk of diseases such as type 2 diabetes, atherosclerosis and thrombosis.
In a new study, scientists from the Hematology Department, University Hospital of Clermont-Ferrand, have successfully evaluated the analytical performance of the Yumizen G DDi 2 hemostatic immunoassay.
A team of researchers are developing the use of an artificial intelligence (AI) algorithm with the aim of diagnosing deep vein thrombosis (DVT) more quickly and as effectively as traditional radiologist-interpreted diagnostic scans, potentially cutting down long patient waiting lists and avoiding patients unnecessarily receiving drugs to treat DVT when they don’t have it.
Researchers from the University of Oxford have announced the results of a study into thrombocytopenia (a condition with low platelet counts) and thromboembolic events (blood clots) following vaccination for Covid-19, some of the same events which have led to restricted use of the Oxford-AstraZeneca vaccine in a number of countries.
A new study of patients with cerebral venous thrombosis (CVT) following Covid-19 vaccination provides a clearer guide for clinicians trying to diagnose and treat patients. The research, led by University College London (UCL) and UCL Health and published in The Lancet, is the most detailed account of the characteristics of CVT, when it is caused by the novel condition vaccine-induced immune…
Medical monitoring tech company Umana Medical announced a collaboration with the Preventive Cardiology and Medical Prevention, Center of Cardiology at the University Medical Center Mainz and Bayer AG on a clinical study (MyoMobile study) to explore a novel real-time remote cardiac monitoring device in patients with heart failure.
Interdisciplinary team from Washington University School of Medicine in St. Louis and the university’s McKelvey School of Engineering finds better way to design clot-prone grafts currently used for dialysis.
A large study from Denmark and Norway published by The BMJ sheds more light on the risk of rare blood clots in adults receiving their first dose of the Oxford-AstraZeneca Covid-19 vaccine. The findings show slightly increased rates of vein blood clots including clots in the veins of the brain, compared with expected rates in the general population. However, the researchers stress that the risk of…
A team led by a clinical academic at University College London (UCL) has outlined the mechanism behind rare cases of blood clots and low platelets seen in patients who have had the Oxford/AstraZeneca vaccine. The new study, published in the New England Journal of Medicine, highlights the importance of rapidly spotting this new syndrome, known as vaccine-induced thrombosis and thrombocytopenia…
Researchers at the University of Oxford report that the risk of the rare blood clotting known as cerebral venous thrombosis (CVT) following Covid-19 infection is around 100 times greater than normal, several times higher than it is post-vaccination or following influenza. The study authors, led by Professor Paul Harrison and Dr Maxime Taquet from Oxford University’s Department of Psychiatry and…
Researchers investigated whether the vaccine recipients developing unusual thrombotic events and thrombocytopenia could have a prothrombotic disorder caused by platelet-activating antibodies directed against a platelet protein, as a similar mechanism is known to be caused by heparin and sometimes other environmental triggers.
Acute stroke in children has the same incidence as brain tumours and can seriously affect a patient’s life. Two kinds of arteriopathies are common drivers of paediatric acute stroke and radiologists must learn to distinguish their signs as early as possible to improve prognosis, according to Béatrice Husson, a paediatric radiologist at Le Kremlin Bicêtre Hospital in Paris.
Injuries in the nervous system of patients with severe COVID-19 are revealed by magnetic resonance imaging (MRI) and computed tomography (CT). In a study of 185 patients, researchers at Karolinska Institutet (KI) and Karolinska University Hospital show an affection of microscopic blood vessels and inflammation in the brain, meninges and nerves. The results are published in Radiology.
An overactive defense response may lead to increased blood clotting, disease severity, and death from COVID-19. A phenomenon called NETosi is part of an immune response that becomes increasingly hyperactive in people on ventilators and people who die from the disease.
A course of action to early detect and treat severe courses of COVID-19 infections has been developed by an expert-team of the University Medical Center Goettingen (UMG). A simple urine test is intended to help medical professionals to recognize warning signs of future decompensation of COVID-19 infections earlier. With the help of a few parameters, the treatment of imminent complications can…
A University of Leeds spin-out company has secured £3.14m to develop a next generation drug that aims to prevent blood clots forming, without the risk of bleeding present in currently available drugs. Currently, anticoagulants have a relatively narrow margin between beneficial effects and undesirable bleeding, so new approaches are in demand. These could allow more patients that have a higher…
A new survey will give patients, carers and members of the public the opportunity to have their say in what they think is important for future research for vascular conditions. The Vascular Priority Setting Partnership (PSP) survey, developed in partnership with the James Lind Alliance aims to identify unanswered questions about the prevention, diagnosis and treatment of vascular conditions from…
Scientists have developed minute flexible robots that could help revolutionise drug delivery in the future. These ‘microrobots’ are so small that they could be ingested, or inserted into human veins to deliver drug therapies directly to diseased body areas.
The World Health Organisation's (WHO) Essential Medicines List and List of Essential Diagnostics are core guidance documents that help countries prioritize critical health products that should be widely available and affordable throughout health systems. Now, updated versions of the two lists have been published, focusing on cancer and other global health challenges, with an emphasis on effective…
Researchers at The Ohio State University College of Medicine and The Ohio State University Wexner Medical Center have developed a novel stroke therapy that, when tested in mice and dogs, has proven superior to the standard of care therapy now offered to patients suffering a stroke. Findings of the study are published online in Molecular Therapy. “We have shown that our drug, which is completely…
It’s undeniable: the bulk of our population is growing older. Yet, this demographic change has not altered laboratory medicine: the reference values for many analyses are still based on data of a younger cohort. Inevitably this could lead to serious errors in the interpretation of older patients’ test results.
A first-in-human study reports that the novel positron emission tomography/computed tomography (PET/CT) tracer 18F-GP1 showed excellent image quality and a high detection rate for the diagnosis of acute venous thromboembolism (VTE). Well-tolerated in patients, 18F-GP1 PET/CT also identified blood clots in distal veins of the leg below the knee, where conventional imaging has limitations.
Radiometer Limited’s AQT90 FLEX analysers have been used in a successful trial to asses D-dimer point-of-care testing (POCT) for suspected lower limb deep vein thrombosis (DVT). The editorial piece, published in Emergency Nurse, describes a reduction in patient waiting times of up to 75%. The article, authored by Neal Aplin, Advanced Clinical Practitioner at the Great Western Hospitals NHS…
Horiba Medical announces the availability of a D-Dimer reagent for their semi-automated Hemostasis instruments. The D-Dimer is a key measurement and the reference exclusion test for the diagnosis of deep vein thrombosis or pulmonary embolism and may also be used for monitoring Disseminated Intravascular Coagulation. The new Yumizen D-Dimer reagent kit is available for Yumizen G hemostasis…
Researchers at McMaster University have solved a vexing problem by engineering surface coatings that can repel everything, such as bacteria, viruses and living cells, but can be modified to permit beneficial exceptions. The discovery holds significant promise for medical and other applications, making it possible for implants such as vascular grafts, replacement heart valves and artificial joints…
Although blood transfusion today is a well-established and safe procedure, the medical science community has not yet arrived at a consensus regarding appropriate patient blood management (PBM) methods. ‘Many PBM approaches have not yet been scientifically validated; consequently over- as well as under-transfusion might be associated with adverse events and complications for the patient,’…
An international research group, including scientists at the University of Maryland School of Medicine, studying 520,000 people from around the world has identified 22 new genetic risk factors for stroke, tripling the number of gene regions known to affect stroke risk. The results show that stroke shares genetic influences with other vascular conditions, especially blood pressure, but also…
The first comprehensive European advice on deep vein thrombosis is published in the current issue of European Heart Journal. The recommendations were produced by the European Society of Cardiology (ESC) Working Group on Aorta and Peripheral Vascular Diseases and Working Group on Pulmonary Circulation and Right Ventricular Function.
The taller you are, the more likely you may be to develop blood clots in the veins, according to new research in the American Heart Association journal Circulation: Cardiovascular Genetics.
The first health economics data from the Global Anticoagulant Registry in the Field – Atrial Fibrillation (GARFIELD-AF) was presented at ESC Congress 2017, organised by the European Society of Cardiology, in Barcelona, Spain.
Electrospun materials bring a spark of hope to a cardiovascular landscape darkened by setbacks for reabsorbable stents. It was famously said that implanting a device in a person to cure a disease is to implant a new disease. Simply put, the human body will continually fight against foreign materials, leading to chronic inflammations or repeated interventions.
Coronary angioplasty is arguably the most revolutionary breakthrough in the history of cardiology. While the technique is today performed on millions of patients worldwide, its origins can be traced back to Zurich, Switzerland, in the late 1970s.
It is a collaboration that could push vascular imaging to a new level.
‘It’s like a new lease on life,’ says Wolfgang R, ‘I can feel the difference between grass and concrete again.’ Eight years ago the Austrian teacher‘s lower leg had to be amputated following thrombosis. Today, he is the first leg amputee, worldwide, to sport a sensory-enhanced prosthesis. ‘For the wearer the prosthesis is not a numb object, but a part of the body,’ says Dr Hubert…
A nanofiber hydrogel infused with snake venom may be the best material to stop bleeding quickly, according to Rice University scientists.
2.5 million radial arterial catheters (RAC) are used annually in Europe (USA: 8 million), commonly to monitor arterial blood pressure and take blood samples in surgical, A&E and ICU units. They can fail. For a study of mechanisms that might lie behind premature RAC failure and complications related to RAC in clinical use*, at team at the Radiology/Ultrasound and Anaesthesiology Department,…
Blood clots often form when lipid-rich plaques on the inner surface of arteries rupture and platelets aggregate at the site of injury. LMU cardiologists have now compared the effects of two new platelet aggregation inhibitors.
This article discusses examples of applications of genetic analyses in coagulation disorders and haematological and oncological diseases. Professor Christine Mannhalter highlights the impact changes have on the occurrence and severity of diseases and their influence on therapy response. Report: Christine Mannhalter
The majority of hospitals participating in the American College of Surgeons National Surgical Quality Improvement Project (ACS NSQIP®) improve surgical outcomes over time, and improvement continues with each year that hospitals participate in the program.
'In paediatric cardiology, echocardiography is the method of choice for preoperative diagnostic purposes,' explains Professor Dr Emanuela Valsangiacomo-Büchel, senior cardiologist and director of cardiovascular imaging at the University Children’s Hospital Zurich, Switzerland. Report: Axel Viola
Research being conducted in the United Kingdom is focusing on techniques to help improve the weaning process for patients coming off mechanical ventilation in hospital intensive care units. Report: Mark Nicholls
New approaches, solutions and outlooks on biologised medical technology developed in the Berlin metropolitan region were presented at this year’s annual 'Medical technology meeting place' in Berlin, which presents the latest research, new product developments and best practice examples from the greater-Berlin area. report: Bettina Döbereiner
French authorities have given the green light for continuing the clinical trial for the first fully implantable mechanical heart after a four-month review of the device and the causes of death of the first patient to receive the prosthesis
‘Elastography is in a position much like Doppler 20 years ago,’ according to David Cosgrove, BMBCh, MA, FRCR, FRCP, Professor of Clinical Ultrasound at Imperial College School of Medicine in London.
Fully implantable mechanical hearts bring hope to 121,000 heart failure patients who will never receive a heart transplant
Clinical chemistry influences almost all medical disciplines: most diagnoses are made or confirmed only after the laboratory has determined at least one or two parameters.
Simultaneous surgical successes open new perspectives for multiple transplants
Despite receiving blood thinners and other clot prevention treatment, some patients still develop potentially lethal blood clots in the first month after their operations anyway, especially if they developed a surgical-site infection while in the hospital, according to results of a study at Johns Hopkins.
Initially limited to the aortic valve, interventions are becoming routine for the mitral valve. Thus the only available product has enjoyed huge commercial success – until now. Report: Holger Zorn
The biggest cause of death for most adult women in industrialised nations is coronary heart disease (CHD). Why the disease affects the genders differently is still not fully understood. European Hospital Editor Brigitte Dinkloh asked Professor Rafaelle Bugiardini MD FESC, from the Department of Internal Medicine Department, University of Bologna, whether he could explain the reasons and what…
John Brosky reports on a ground-breaking trial and how CT-FFR may change the practice of invasive cardiology and cardiac surgery.
Suspicion of venous thromboembolism (VTE) in a pregnant patient will quickly bring a radiologist to a choice, where the next step holds potentially significant consequences for both the mother and unborn child.
Imaging of the chest is the most common radiological examination worldwide. With the incidence of respiratory problems and lung cancer growing, all radiologists should be familiar with the appropriate imaging protocols. In a field dominated by chest x-ray (CXR) and CT, controlling radiation dose is mandatory.
The list of post-operative complications is long. Most common are fever, chest infection, pneumonia, wound infection, bleeding or deep vein thrombosis. As these post-surgical complications can range from minor, self-limiting problems to major life-threatening events, their definition and severity staging can be challenging.
A registry -which includes every patient in Sweden having percutaneous coronary intervention (PCI) for the treatment of acute and stable coronary artery disease- has found that PCI implantations using a new generation of drug-eluting stents is associated with lower rates of relapse (restenosis), stent thrombosis and subsequent mortality than older generation drug-eluting stents and bare-metal…
Devices to treat chronic cardiac disease are winning credibility with new evidence from large-scale patient registries, John Brosky reports
Point of care technologies (POCT) have an important, quality enhancing, risk-reducing and cost-impacting role within the extremely time-critical medical decision structures of a central Accident and Emergency department, says Professor Wilfried von Eiff, Centre for Hospital Management, University of Muenster, Germany.
However, the PROlonging Dual antiplatelet treatment after Grading stent-induced Intimal hyperplasia studY (PRODIGY) also found a consistently greater risk of haemorrhage in the 24-month dual therapy group according to all prespecified bleeding definitions, including the recently proposed Bleeding Academic Research Consortium classification. The need for transfusion was also increased in the…
France – Re-opening clogged arteries with metal stents has proved a life-saver for a majority of patients with coronary disease. Yet the high rates of complications and mortality for patients with diabetes following a percutaneous coronary intervention (PCI) continue to baffle cardiologists. Report: John Brosky
Jean-Louis Vincent, Chairman of the Dept of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, welcomes visitors to this year’s International Symposium on Intensive Care and Emergency Medicine.
Prior to October’s 3rd Annual Congress of the Austrian Society for Laboratory Medicine and Clinical Chemistry in Salzburg, Austria, laboratory experts conveyed their opinions in an interview with Michael Krassnitzer from European Hospital.
Today in most countries of the world almost 50 % of patients in hospital for a cardiac condition began their treatment as emergency cases: chest pain at home . . . a cardiac arrest in the street. Thus, according to Dr Peter Clemmensen, of the 22 million hospital admissions in Europe each year for acute cardiac events, more than 10 million of them would have begun as an emergency and without…
Computer stored data from German health insurers are still inadequate for health services research, according to a study* led by Prof. Wolfgang Greiner, Head of the Healthcare Management department at Bielefeld University, working with his research team in cooperation with the health insurance fund Techniker Krankenkasse.
Drug-eluting stents to treat narrowed coronary vessels met with sensational success, and then things became rather quiet. Now, two new developments from Cordis and Biotronik are being tested at Essen University Hospital, Germany. We asked Professor Holger Eggebrecht, head of the hospital’s cardiac catheter lab, why these new models look important.
Patients with heart failure with normal ejection fraction (HFNEF) also referred to as ‘stiff heart’, show a normal ejection fraction and severe diastolic dysfunction. President of the Austrian Society of Cardiology, Professor Irene Lang warns: ‘It is particularly concerning that stiff heart is a little known and insufficiently researched cardiac condition -- a stepchild in research,…
At 12 months the NEVO Sirolimus-eluting Coronary Stent has continued to demonstrate excellent safety and efficacy outcomes compared to Taxus Liberte according to new data presented today from the NEVO RES-I clinical trial. These results were presented as a late breaking trial at EuroPCR, the leading medical conference in Europe for physicians specializing in interventional cardiovascular…
Hot topics to be covered during the EuroPCR Forum sessions are the challenging implementation of the best standard of care for STEMI patients throughout Europe (with the timely use of stents), the introduction of transcatheter aortic valve implantation (TAVI) in clinical practice and the challenges related to bifurcation treatment options.
Cardiologists are looking beyond on-screen images of the heart to extract data behind these scans that describe coronary dysfunctions and can reveal hard evidence of the cause of disease reports John Brosky.
Pain is the most common symptom of any illness thus having an alerting function to evoke protective responses. If tissue damage has happened as a consequence of surgery, obstruction, injuries, or cancer a cascade of changes in the peripheral and central nervous system occurs leading to physical inactivation, an increase of morbidity thus delaying hospital stay and treatment costs.
A system of national quality registers, established in recent decades in Sweden's health and medical services, now numbers 64 registers. Along with three competence centres, these cover, for example, diabetes mellitus (NRD), dementia (SeDEM), Swedish intensive care (SIR) and acute coronary care (RIKS-HIA), and the Register Ulcer Treatment (RUT), which was added at the dawn of 2007. The latter has…
Concerns over whether the tests a treatment undergoes before general release are enough to ensure its long-term safety have been raised in an editorial by Dr Vijay Sharma, Clinical Editor of BMJ Clinical Evidence. He suggests that treatments should be introduced gradually so that evidence can be built up and the treatment can find its proper niche.
GE Healthcare's first Discovery PET/CT 600-series scanners are being installed in a number of leading clinics around the world. "This first set of installations is a big step forward in the diagnosis and monitoring of disease", said Terri Bresenham, newly appointed vice- president and general manager of GE Healthcare's global Molecular Imaging business.
Investigating the appropriate use of procedures to open narrowed coronary arteries, e.g. angioplasty and stenting, researchers at UCSF (University of California, USA) found that less than 50% of Medicare patients had documented non-invasive stress testing prior to elective percutaneous coronary intervention, or PCI (clinical name for these procedures).
ArjoHuntleigh, formed in 2007 from the merger of ARJO and Huntleigh Healthcare, is showing a broad portfolio of products and services for patient care.
Between June 2004 and April 2008 the Dutch DECREASE III Study observed patients treated with Fluvastatin. The results show that Fluvastatin XL therapy can be associated with improved postoperative cardiac outcome in high-risk patients undergoing elective vascular surgery.
High-Density-Lipoprotein-Cholesterol is a so-called "good" cholestoral because it seems to protect the vessels from fat deposits. Hereby they can prevent atherosclerosis. The Whitehall II Study in the UK searched for the specific connection between low level of HDL and dementia risk and published now their results.
Not only for green tea fanciers. A recent study published in the European Journal of Cardiovascular Prevention and Rehabilitation shows that drinking green tea improves the function of cells lining the vascular system and therefore protect vessels from atherosclerosis, reported the European Society of Cardiology.
In the EU blood clots are responsible for killing 544.000 people each year. Rivaroxaban, a new oral given anticoagulant drug from Bayer Healthcare, is significantly more effective than the current standard of care, according to three recent studies. The number of blood cluts in Europe is about 1.5 million per year, more than thirty percent of the patients affected die.
Ian Mason reports from Chicago
A five-year study of 516 participants with coronary artery disease showed that patients who reduced their anxiety levels or kept them steady were 60% less likely to have a heart attack or die compared with those who had increased anxiety levels.
Boston Scientific Corporation has announced results from a pooled analysis of patients from its TAXUS IV and TAXUS V randomised clinical trials to compare the safety and efficacy of the TAXUS Express Paclitaxel-Eluting Coronary Stent System in diabetic versus non-diabetic patients.
A 320-row CT scanner (Aquilion One, Toshiba Medical Systems Co., Tokyo, Japan) was installed for the first time in Europe, at the Charité University Hospital, Berlin, Germany, in November 2007. Its capability to cover the whole brain in a single rotation means this new type of scanner has the potential to impact strongly on the field of neuro-imaging.
Where are the most high-tech start-ups? That`s an easy one: Silicon Valley. But who comes in a close second? Surprisingly: Israel. Further: Israel ranks Number 1 in terms of availability of scientists and engineers and Number 2 in quality of higher education. The result of this impressive track record is a wide range of successful enterprises and products, particularly related to the life…
The suppression of angiogenesis is an established procedure used to make a positive impact on tumour growth and the development of metastases - with varying success.
Cordis Corporations' CYPHER stent is a Sirolimus-eluting coronary stent used for treatment of patients with coronary artery disease. The five-year results of the E-Sirius Trial show that in comparison to bare metal stents the CYPHER stent offers sustained clinical benefits.
Coronary stents provide wall wrapping of dissection, prevent elastic recoil, and reduce restenosis after percutaneous transluminal coronary angioplasty. In addition, drug eluting stents loaded with antiproliferative agents inhibit intimal hyperplasia and offer a further reduction of restenosis.
Ultrasound scanning with CCDS is an established technique in shunt diagnostics and allows non-invasive assessment of vascular flow. Stenosing changes to walls of vessels used as a dialysis shunt should be detected as early as possible to avoid occlusion by a thrombus. High occlusion rates with volume flow reduced by up to 45% in one year demand ultrasound screening. The risk of haemodynamically…
Intravascular contrast medium is essential for enhancement of vessels and parenchyma. In this way the relation between vessels and tumours can be detected. Factors that influence the time required for a contrast bolus are the cardiac output of a patient, body weight, hydration status and the condition of the vessels. When a main vessel is occluded because of thrombosis, embolia or trauma a…
Nutrition-induced obesity is a physical and budgetary problem. For example, in Germany alone, an estimated €20 billion has been spent on obesity related health problems.
Gadofosveset trisodium (trade name: Vasovist) is the first approved blood pool contrast agent worldwide for the diagnosis of vascular disease, Bayer Schering Pharma AG reports.
The objective of the CNIC is to lead cardiovascular research in Spain and establish itself as a leading international centre.
By Stefan G Ruehm MD PhD, Associate Professor of Radiology, at the David Geffen School of Medicine, UCLA, California
Dr Hanns-Joachim Weinmann, Diagnostics and Radiopharmaceuticals, Magnetic Resonance Imaging & X-Ray Research, Schering AG, examines what is feasible and what still lies only at a tantalising distance.
Experts call for screening of surgical and medical patients, and thromboprophylaxis for those at risk.
´CT has been revolutionizing the understanding and treatment of stroke´ - that is the summary of Dr. Dzialowski.
The recent 26th International Symposium of Intensive Care and Emergency Medicine - the largest annual meeting of its kind - attracted around 5,000 participants, who travelled to Brussels from over 80 countries.
The fundamental role of inflammation in almost all disease processes has been increasingly recognised over several years.
The 26th International Symposium of Intensive Care and Emergency Medicine in Brussels: A resumee.
Five years of therapy with the drug tamoxifen has become the norm for postmenopausal women with hormone-sensitive breast cancer. However, this has several adverse side effects, and studies have continued to compare the effects of other drug therapies with tamoxifen.
France - Four studies of three TAXUS paclitaxel-eluting stents have demonstrated their safety and efficacy, according to the maker, Boston Scientific Corporation of Natick, Maryland, USA.