Search for: "arthritis" - 97 articles found

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Titanium-alloy knee plates

3D printing simplifies high tibial osteotomy

3D metal printing technology is producing personalised medical-grade titanium-alloy plates that perfectly fit individuals suffering arthritis of the knee. Engineers at the University of Bath’s Centre for Therapeutic Innovation (CTI) working with 3D Metal Printing Ltd, are using the TOKA (Tailored Osteotomy for Knee Alignment) treatment to improve the surgical procedure and fit of high-tibial…

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Coronavirus protein and antibody detection

Bioluminescence lights up traces of Covid-19 in the blood

Home test kits to check for Covid-19 spike proteins and anti-Covid-19 antibodies are fast and simple to use but lack the sensitivity and accuracy of laboratory tests. Researchers from Eindhoven University of Technology with Utrecht University have developed a new type of sensor that combines the sensitivity and accuracy of current laboratory-based measurements with the speed and low-cost of…

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Here comes the tooth fairy

New drug shows promise for regenerating lost teeth

A new study by scientists at Kyoto University and the University of Fukui may offer hope for adults who have lost their teeth. The team reports that an antibody for one gene - uterine sensitization associated gene-1 or USAG-1 - can stimulate tooth growth in mice suffering from tooth agenesis, a congenital condition. The paper was published in Science Advances. Although the normal adult mouth has…

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Women's health

Hypertension symptoms in women often mistaken for menopause

Pregnancy complications and early menopause increase women’s future risk of heart disease. Cardiologists, gynaecologists and endocrinologists recommend how to help middle-aged women prevent later heart problems in a European Society of Cardiology (ESC) consensus document published in European Heart Journal, a journal of the ESC.

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Microneedles

No more needles for bloodtests?

Blood draws are no fun. They hurt. Veins can burst, or even roll — like they’re trying to avoid the needle, too. Oftentimes, doctors use blood samples to check for biomarkers of disease: antibodies that signal a viral or bacterial infection, such as SARS-CoV-2, the virus responsible for COVID-19, or cytokines indicative of inflammation seen in conditions such as rheumatoid arthritis and…

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IT analysis and study

Optimising OR procedures in orthopaedic surgery

Could surgical procedures for hip or knee arthritis be improved? IT specialists at Leipzig University Hospital’s Innovation Center for Computer-Assisted Surgery (ICCAS), and physicians in the Department of Orthopaedic, Trauma and Plastic Surgery department, analysed and optimised the operating room (OR) setup, legwork and instruments handling. We asked project manager Juliane Neumann, at…

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"Faces" of the disease

Covid-19: researchers identify at least 5 variants

According to current studies, the Covid-19 disease which is caused by the SARS-CoV-2 coronavirus comprises at least five different variants. These differ in how the immune system responds to the infection. Researchers from the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, together with other experts from Germany, Greece and the Netherlands, present these findings…

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Success in Düsseldorf

virtual.Medica receives international resonance

For the first time in the history of MEDICA, the world-leading medical trade fair, and the industry’s number one platform for the suppliers of the medical technology industry, COMPAMED, held from 16 to 19 November 2020, took place entirely online due to the pandemic - but still won over their audiences due to their high degree of international resonance in this format too, as virtual.MEDICA and…

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Uncommon, but reversible

Sudden deaf: permanent hearing loss linked to COVID-19

Although uncommon, sudden permanent hearing loss seems to be linked to COVID-19 infection in some people, warn doctors, reporting the first UK case in the journal BMJ Case Reports. Awareness of this possible side effect is important, because a prompt course of steroid treatment can reverse this disabling condition, they emphasise. Sudden hearing loss is frequently seen by ear, nose and throat…

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Improving mobility after hip or knee replacement surgery

Wearable device research: "GaitSmart" to help orthopaedic patients

Patients who have hip or knee replacements are set to get more support with their recovery following the launch of a new research study that uses wearable technology to monitor walking patterns. The Norfolk and Norwich University Hospital (NNUH) has joined forces with Dynamic Metrics Ltd (DML) to develop and test a system to study mobility and improve a patient’s gait after a joint replacement.

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ER-positive tumour BC

Drug target for aggressive breast cancer found

A team of British and American scientists have discovered a way to slow the growth of breast cancer stem cells in the lab. The study led by Dr Bruno Simões and Professor Rob Clarke from The University of Manchester could eventually lead to combination drug therapies on previously untreatable breast cancers. Around three quarters of women who have breast cancer have what are known as oestrogen…

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Algorithmic enhancement

Improved MRI scans could aid in development of arthritis treatments

An algorithm that analyses MRI images and automatically detects small changes in knee joints over time could be used in the development of new treatments for arthritis. A team of engineers, radiologists and physicians, led by the University of Cambridge, developed the algorithm, which builds a three-dimensional model of an individual’s knee joint in order to map where arthritis is affecting the…

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A novel method

Precise delivery of of therapeutics into the body

A new way to deliver therapeutic proteins inside the body uses an acoustically sensitive carrier to encapsulate the proteins and ultrasound to image and guide the package to the exact location required, according to Penn State researchers.

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After the denoidectomy

Using tonsils as an 'immune testbed'

Biomedical researchers in Munich have isolated immune cells from human tonsils obtained following routine surgery, and used them to analyze aspects of the immune response and test the effects of anti-inflammatory agents at the cellular level. Human tissues that have been surgically removed from patients are normally treated as waste, especially when they are derived from a ‘dispensable’ organ…

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Regeneration vs. osteoarthritis

Regrow cartilage in joints? Science says you can

Contrary to popular belief, cartilage in human joints can repair itself through a process similar to that used by creatures such as salamanders and zebrafish to regenerate limbs, researchers at Duke Health found. This process could be harnessed as a treatment for osteoarthritis. Publishing in the journal Science Advances, the researchers identified a new mechanism for cartilage repair.

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Cognitive chemical manufacturing

‘Lab-bot’ could revolutionise hunt for cancer drugs

A robot-controlled laboratory where decisions are made by artificial intelligence will change the way new drugs are discovered, says a leading researcher. The engineer leading a project to develop a prototype "lab-bot" says it will reduce the time it takes to identify and synthesise molecules for new medicines – a process that can take years as scientists refine the shape and property…

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Personalised medicine

Why digital twins could be the ideal therapy testbed

Advanced computer models of diseases can be used to improve diagnosis and treatment. The goal is to develop the models to “digital twins” of individual patients. Those twins may help to computationally identify and try the best medication, before actually treating a patient. The models are the result of an international study, published in the open access journal Genome Medicine.

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Heart and bones

Osteoarthritis linked to cardiovascular disease

Researchers at Lund University in Sweden have investigated the link between osteoarthritis and mortality in an epidemiological study. It was shown that the risk of dying from cardiovascular disease was higher for people with osteoarthritis than for the rest of the population. Using population registers, the researchers studied approximately 469 000 people living in Skåne, Sweden, who in 2003…

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Global health

WHO updates list of essential medicines and diagnostics

The World Health Organisation's (WHO) Essential Medicines List and List of Essential Diagnostics are core guidance documents that help countries prioritize critical health products that should be widely available and affordable throughout health systems. Now, updated versions of the two lists have been published, focusing on cancer and other global health challenges, with an emphasis on effective…

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Autoimmune disease

Detecting rheumatoid arthritis with infrared light

A new way of detecting rheumatoid arthritis using infrared light could offer an objective way of diagnosing the disease and monitoring treatment effectiveness, a University of Birmingham study shows. The rapid, non-invasive technique could help clinicians diagnose the disease earlier, and assess how effectively the selected treatment is controlling the progression of the disease. Rheumatoid…

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Meeting of the generations

We need a Senior Laboratory

It’s undeniable: the bulk of our population is growing older. Yet, this demographic change has not altered laboratory medicine: the reference values for many analyses are still based on data of a younger cohort. Inevitably this could lead to serious errors in the interpretation of older patients’ test results.

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Endoprosthetics

Joint efforts: New guidelines for arthroplasty

According to the Swedish Knee Arthroplasty Register, knee arthroplasty – with a revision rate of five percent after ten years – is one of the most successful surgical interventions of the post-World War II decades. The most frequent reasons for revision are loosening or infections, whereas patient dissatisfaction is often caused by mobility impairment and pain. Since many adverse events are…

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Time for a revolution?

About the end of medicine, as we know it

Currently many researchers and experts assume that the next great socio-economic revolution will include a completely new definition of health and how we define illnesses and therapies. “Our health system today can no longer be sustained in its existing form. It has become too expensive and too ineffective,” Professor Harald Schmidt, head of the Department of Pharmacology and Personalised…

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Orthopedic surgery

The knee – correlations of MRI and arthroscopy

Magnetic resonance imaging (MRI) exams of the knee are essential to orthopedic surgeons for diagnosing the cause of symptoms in patients with knee pain and planning arthroscopic treatment. Yet the surgeons who treat patients based on knee MRIs and the radiologists who interpret those knee MRIs often work in their own silos of specialization, rarely communicating and sharing information, according…

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Guselkumab vs Secukinumab

Psoriasis: New data point to improved treatment

The Janssen Pharmaceutical Companies of Johnson & Johnson announced results from the ECLIPSE study demonstrating that Tremfya® (guselkumab) was superior to Cosentyx® (secukinumab)* in treating adults with moderate to severe plaque psoriasis for the primary endpoint assessed at week 48. Data from the multicentre, randomised, double-blind head-to-head Phase 3 study demonstrated that 84.5…

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Hope against arthritis

Growing cartilage – how does it work?

Anyone with arthritis can appreciate how useful it would be if scientists could grow cartilage in the lab. To this end, Keck School of Medicine of USC scientists in the USC Stem Cell laboratory of Denis Evseenko, MD, PhD, collaborated with colleagues at several institutions to provide new insights into how gene activity drives the development of cartilage. Their findings appear in Nature…

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Dupuytren's disease

New hope for patients with incurable, disabling hand condition

Researchers at the Kennedy Institute and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, working with clinicians at NHS Lothian, have found that injection of the anti-TNF drug adalimumab into Dupuytren's disease nodules results in the reduction of the cell characteristics responsible for progression of Dupuytren's disease.

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Arthoplasty

Can weight loss surgery improve knee replacement outcomes?

Could weight loss surgery before knee replacement improve outcomes or even eliminate the need for joint replacement in severely overweight patients? A study by researchers at Hospital for Special Surgery (HSS) aims to answer that question. Orthopedic surgeons often encourage obese patients considering knee replacement to try to lose weight before the procedure. The study, known as SWIFT (Surgical…

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Bone health

Osteoporosis defined: causes, symptoms and treatments

Weak, easily broken bones are an epidemic in the United States. They’re often tied to osteoporosis, a disease that causes bones to degenerate over time. This makes them less flexible, more brittle, and easier to break. According to the International Osteoporosis Foundation, more than 44 million Americans aged 50 and older either have or face the threat of developing osteoporosis due to low bone…

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Immunological memory

Our brains 'remember' inflammation and diseases

Inflammatory reactions can change the brain’s immune cells in the long term – meaning that these cells have an ‘immunological memory’. This memory may influence the progression of neurological disorders that occur later in life, and is therefore a previously unknown factor that could influence the severity of these diseases. Scientists at the German Center for Neurodegenerative Diseases…

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Medical myths

Joint cracking: Is it healthy?

It’s not unusual for your body to make “popping” or “cracking” sounds as you lean over, twist or reach for something. Fortunately, it’s also typically not a cause for worry. Dr. Aman Dhawan, an orthopedic sports medicine specialist at Penn State Health Milton S. Hershey Medical Center, said complaints about such joint sounds are common, but are usually nothing to be concerned about.…

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No more joint replacement?

Small molecule could make a big difference for arthritis patients

Will there come a time when a patient with arthritis can forgo joint replacement surgery in favor of a shot? Keck School of Medicine of USC scientist Denis Evseenko, MD, PhD, has reason to be optimistic. In a new publication in the Annals of Rheumatic Diseases, Evseenko’s team describes the promise of a new molecule aptly named “Regulator of Cartilage Growth and Differentiation,” or RCGD…

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Efferocytosis

Can stem cell exosome therapy reduce fatal heart disease in diabetes?

Macrophage cells routinely remove dead or dying cells to maintain the body homeostasis. Such removal becomes crucial after serious injury, especially the repair of dead heart muscle after a heart attack. University of Alabama at Birmingham researchers have preliminary data, with cultured cells or diabetic hearts, that diabetes impairs this removal of dead heart-muscle cells. They believe this…

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Christmas isolation

Holiday loneliness can be harmful to seniors’ health

The holidays are supposed to be a happy time of the year, but many isolated seniors often are left feeling lonely — which can be harmful to their health. Loneliness is linked to serious medical conditions, including Alzheimer’s disease, stroke and heart disease as well as a higher risk of premature death. But loneliness can be easily overlooked as a health risk because healthcare providers…

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Russian biotechnology

Biocad prepares to enter the European market

The Russian biotechnology company Biocad plans to enter the European market with oncological and autoimmune medicines. So far, there are seven molecules in the European portfolio of Biocad. The biosimilar products could be used in treatment of melanoma, breast, stomach, kidney and lung cancer, rheumatoid arthritis, psoriasis and multiple sclerosis.

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Prenatal care

Fever itself in early pregnancy might cause birth defects

Duke researchers now have evidence to suggest the fever itself, not its root source, could interfere with the development of the heart and jaw during the first three to eight weeks of pregnancy. Researchers have known for decades that fevers in the first trimester of pregnancy increase risk for some heart defects and facial deformities such as cleft lip or palate. Exactly how this happens is…

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Rheumatoid arthritis

Hibernation causes inflammation

A research team found that in patients suffering from rheumatoid arthritis, a special cell population called innate lymphoid cells are in a state of hibernation which is why these patients suffer from persistent inflammation.

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Contamination

Painful knee prosthesis: loose, infected or both?

The implantation of knee and hip joints is considered one of the success stories of recent years. But periprosthetic joints infections (PJI) are one of the severe complications, with an infection rate of 2%. The probability of revision surgery increases with concomitant diseases such as rheumatoid arthritis, with fracture prosthesis or after previous surgery.

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Therapy

Nanoparticle injections may be future of osteoarthritis treatment

Osteoarthritis is a debilitating condition that affects at least 27 million people in the United States, and at least 12 percent of osteoarthritis cases stem from earlier injuries. Over-the-counter painkillers, such as anti-inflammatory drugs, help reduce pain but do not stop unrelenting cartilage destruction. Consequently, pain related to the condition only gets worse.

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Mobility

Hitachi puts punch in portablility

When Ferdinando Draghi, M.D. speaks, the world of ultrasound listens carefully. The Editor-in-Chief of the Journal of Ultrasound, the author of 90 publications that have been cited in other peer-reviewed publications hundreds of times, Dr. Draghi is widely known for his authoritative knowledge in diseases affecting the musculoskeletal (MSK) system.

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Fight inflammation

Stem cells engineered to grow cartilage

With a goal of treating worn, arthritic hips without extensive surgery to replace them, scientists have programmed stem cells to grow new cartilage on a 3-D template shaped like the ball of a hip joint. What’s more, using gene therapy, they have activated the new cartilage to release anti-inflammatory molecules to fend off a return of arthritis. The technique was demonstrated in a collaborative…

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Discovery

Potential genetic trigger of autoimmune disease

Researchers at Hospital for Special Surgery (HSS) have uncovered a potential genetic trigger of systemic autoimmune disease. The study, the culmination of more than 10 years of research, discovered virus-like elements within the human genome linked to the development of two autoimmune diseases: lupus and Sjogren's syndrome.

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OnSight 3D Extremity System

Carestream Submits Application for FDA 510(k) Clearance

Carestream Health has filed a 510(k) application with the FDA for clearance of its CARESTREAM OnSight 3D Extremity System that uses cone beam CT (CBCT) technology to capture weight-bearing and other types of patient extremity images. This affordable system is designed to offer high-quality, low-dose 3D imaging for use by orthopaedic and sports medicine practices, hospitals, imaging centers,…

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Arthritis

Modular partial wrist implant may help with pain

Studies are underway to determine if a new modular partial wrist replacement will allow for better movement and last longer than traditional implants for people seeking relief from painful wrist arthritis. Although current options such as total wrist replacement and wrist fusion can alleviate pain, patients are often limited in performing certain activities after surgery.

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Research breakthrough in fight against muscle wasting diseases

It is estimated that half of all cancer patients suffer from a muscle wasting syndrome called cachexia. Cancer cachexia impairs quality of life and response to therapy, which increases morbidity and mortality of cancer patients. Currently, there is no approved treatment for muscle wasting but a new study from the Research Institute of the McGill University Health Centre (RI-MUHC) and University…

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mTOR

Cells in limbo hold clues for tackling cancer and ageing

For some, TOR may bring to mind a Celtic mountain or perhaps an Internet privacy group. In the world of molecular biology it’s a cellular pathway that’s found in everything from yeast to mammals. mTOR (as it’s called in mammals) plays a central role in instructing the cell to grow and divide in response to nutrients. When it’s turned down, the cell shifts into a second, tidying mode,…

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Orthopedics

Bioactive gel to treat knee injuries

Knee injuries are the bane of athletes everywhere, from professionals and college stars to weekend warriors. Current surgical options for repairing damaged cartilage caused by knee injuries are costly, can have complications, and often are not very effective in the long run. Even after surgery, cartilage degeneration can progress leading to painful arthritis. But a University of Iowa orthopedics…

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Simply Superb Microvascular Imaging

‘An intelligent imaging tool, Superb Microvascular Imaging (SMI) moves beyond conventional colour Doppler technology by applying a unique algorithm allowing visualisation of small vessels with low velocity, while maintaining high resolution, minimal motion artefacts and high frame rates,’ Toshiba proudly reports.

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Chronic disease

There is a global shortage of doctors that is getting worse every year. With the demographic shift in many countries from a predominantly young to an increasing aging population, a steep increase in chronic disease is occurring.

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A new paradigm in early arthritis patients - proteomic biomarkers

Early arthritis is characterized by autoreactivity (reactivity against self-antigens) of T-B lymphocytes and by the synthesis of autoantibodies crucial for diagnosis (biomarkers). Detection of panels of autoantibodies increases the sensitivity and specificity for the diagnosis of arthritis. The variability in the performance of autoantibody assays may impact the predictive value. Confirmation of…

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Autoimmune disease risk

Silicone gel breast implants and connective tissue

Silicone breast implants are the most popular type of implant. The postulated relation between silicone breast implants and the risk of connective tissue and autoimmune diseases has generated intense medical and legal interest during the past decade. Considerable controversy has surrounded the long-term safety of silicone breast implants.

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EHFG 2011 - ‘There are too many unnecessary operations!’

Participants at European Health Forum Gastein 2011 (EHFG) agreed: the tendency in Germany and Austria is to operate far too soon (particularly for hip, knee and disc surgery), and many surgical interventions are unnecessary, posing a particular and increasingly urgent problem especially in industrialised countries. Hans-Christian Pruszinsky reports

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Personalized medicine could help to save 100 billion Euros

Despite huge increases in spending over the last three decades, progress in dealing with the most frequent and burdensome diseases is appalling. The EU Flagship Pilot IT Future of Medicine (ITFoM) could remedy that. The flagship‘s investments of 1 billion euros in the course of the next decade are expected to save up to 100 billion euros per year in health expenditures in the future.

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Fusion and Fly Thru - the new Aplio 500

Catastrophes draw people closer, as demonstrated by the development of the new high-end ultrasound scanner Aplio 500 from Toshiba. The clinical evaluation period took place during the tsunami and the nuclear catastrophe in Fukusima. Professor Thomas Fischer at the Radiological Institute, Charité Clinic in Berlin, was impressed by the enormous commitment shown by the Japanese firm’s engineers…

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The 3rd Annual General Meeting of the Austrian Society for Laboratory Medicine and Clinical Chemistry

Different tests bring different results, and results of the same types of test vary from laboratory to laboratory. "In the case of test procedures for autoimmune diseases there are incredible discrepancies," confirmed Professor Manfred Herold, head of the Laboratory for Rheumatism at the University Clinic for Internal Medicine One, Innsbruck. The reason: "There are no standards for…

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Superantigens could be behind several illnesses

Superantigens, the toxins produced by staphylococcus bacteria, are more complex than previously believed, reveals a team of researchers from the University of Gothenburg in an article published today in the scientific journal Nature Communications. Their discovery shows that the body’s immune system can cause more illnesses than realised.

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Biomarkers - Keys to prevention and early detection

Biomarkers as the key to prevention and early detection were the subject this autumn at the 7th Annual Congress of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL) in Mannheim. For the DGKL president Professor Karl J Lackner MD, Director of the Institute for Clinical Chemistry and Laboratory Medicine at Johannes Gutenberg University, Mainz, the topic is of increasing…

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1st partial knee system launched in Europe

Until now, orthopaedic surgeons have had limited options for the treatment of progressive degradation of the knee joints (osteoarthritis) in active patients who require care, but are not yet ready for a total knee replacement. DePuy Orthopaedics EMEA now launches the first complete surgical system Sigma® High Performance Partial Knee, specifically designed to treat progressive osteoarthritis…

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Negative pressure wound healing technology

Despite some uncertainty about how it works, there is a growing consensus that Negative Pressure Wound Therapy (NPWT) – also known as Vacuum Assisted Closure (VAC) – is revolutionising wound care. Speaking at the 1st International Surgical Wound Forum, held recently in Amsterdam, surgeons from Europe and the USA predicted the growing use of this innovative technology across the spectrum of…

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The 11th EFORT Congress

This year's European Congress for Orthopaedics, Orthopaedic Surgery and Traumatology, organised by the European Federation of National Associations of Orthopaedics and Traumatology (EFORT) and which will in tandem with the Spanish Orthopaedic and Traumatology Society (SECOT) Congress, is expected to draw 7,500 international participants.

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NHS needs to invest in increasing specialists´nurses

The Royal College of Nursing (RCN) has joined forces with almost 40 of the UK's leading health organisations to warn that cutting specialist nurse services for people with long term conditions would be a "false economy", as they began a campaign for guaranteed access to specialist nursing care for all patients with long term conditions.

Blood test to predict rheumatoid arthritis

Researchers from University Hospital in Umea, Sweden, have identified several cytokines, cytokine-related factors, and chemokines that increase significantly prior to rheumatoid arthritis (RA) disease onset. These findings confirm those of earlier studies which suggest that the risk of developing RA can be predicted and disease progression may be prevented. Complete findings of this study are…

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The GE Venue 40 series

GE Healthcare is presenting its new Venue ultrasound product line at Medica. The Venue 40, the first product launched, provides visualisation for needle guidance procedures and rapid diagnostics in real-time at the bedside. These point-of-care (POC) settings are the fastest growing in ultrasound internationally (USA growth: 30% average in the last four years. Source: industry report by Klein…

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A 7-Tesla in clinical diagnostics?

Most of the 30 institutes around the world that work with a 7-Tesla MRI scanner do not focus on answering questions about the clinical benefit of this field strength; their efforts revolve around the brain and neurosciences. One exception is the Erwin L Hahn, at the Institute for Magnetic Resonance Imaging, which is based at the Zollverein Coal Mine Industrial Complex, a World Heritage Site in…

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RUT -

A system of national quality registers, established in recent decades in Sweden's health and medical services, now numbers 64 registers. Along with three competence centres, these cover, for example, diabetes mellitus (NRD), dementia (SeDEM), Swedish intensive care (SIR) and acute coronary care (RIKS-HIA), and the Register Ulcer Treatment (RUT), which was added at the dawn of 2007. The latter has…

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Lighting for health and healing

Hardly any other area demands such complex lighting solutions as healthcare and nursing, given that it is essential to create optimal conditions to fulfil an extremely wide range of requirements.

Device helps heal the meniscus

Faced with meniscus injuries surgeons usually decide to remove the torn meniscal cartilage, which typically leaves the deficient knee vulnerable to future arthritis, because the padding that provides shock absorption and joint stability has been removed, causing bone to rub on bone.

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Acupuncture What others say…

During the last ten years or so, there has been a convergence of modern international science with traditional Chinese medicine, with research carried out in physiology, biochemistry and pharmacology.

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