News • Tumor assessment via chromatin imaging
From DCIS to IDC: AI identifies breast cancer stages
Researchers at MIT and ETH Zurich developed an AI model that identifies certain breast cancer stages likely to progress to invasive forms of cancer.
Researchers at MIT and ETH Zurich developed an AI model that identifies certain breast cancer stages likely to progress to invasive forms of cancer.
AI models perform increasingly well in answering medical questions. However, when it comes to explaining these answers, shortcomings become apparent, a new study shows.
Researchers have discovered an Achilles heel of migratory metastatic cells: They now investigate how the cell death mechanism ferroptosis can be utilized for future cancer treatments.
A new heart valve comprised of biological material obtained from human cells, opens up new therapeutic avenues for patients with paediatric heart diseases, such as tetralogy of Fallot.
The concept of delivering radiation therapy to cancer patients seated in an upright position is undergoing a major resurgence. Evidence is already highlighting that patients feel more comfortable seated upright and enjoy better communication with radiotherapists during their care. In addition, there are indications of less internal organ movement, enabling more accurate treatment delivery.…
Radiologists and AI don’t always work well together: New research finds that the benefits of using AI tools appear to vary, boosting performance of some clinicians, but hurting others'.
Researchers have now shown that a noninvasive treatment that stimulates gamma frequency brain waves may hold promise for treating memory impairment and other cognitive effects of chemotherapy.
Not all medication can safely be taken together. Using a machine-learning algorithm, researchers predict interactions that could interfere with a drug’s effectiveness.
Combining a biological heart and a silicone robotic pump, researchers created a biorobotic heart that beats like a real one, with a focus on a valve on the left side of the heart.
A research team has developed a nanoparticle-based contrast agent with the properties necessary to successfully use MRI for targeted diagnosis of liver fibrosis.
Using a new technology developed at MIT, diagnosing lung cancer could become as easy as inhaling nanoparticle sensors and then taking a urine test that reveals whether a tumor is present.
When your stomach is full after a large meal, certain receptors are activated to tell the brain. A newly developed capsule could provoke this fullness signal early, potentially helping with treating obesity.
Ten times more detail than current 7T scanners, over 50 times more than 3T: A new type of functional MRI will allow neuroscientists to more precisely localize and trace brain networks.
Scientists have developed an ingestible device that can safely monitor vital signs like breathing and heart rate from inside humans, providing accessible and convenient care for people at risk of opioid overdose.
Voice pathology detection (VPD) can detect abnormal vibrations in the vocal cords caused by conditions like cancer and cysts. Now, researchers have found a way to make the method more reliable.
Engineers from MIT are developing a device containing insulin-producing cells and a tiny oxygen-producing factory to keep the cells of diabetes patients healthy.
Experts presented state-of-the-art and emerging techniques to treat chest tumours and discussed common issues in the management of pneumothorax at RSNA 2022. Current ablation methods in the thorax include radiofrequency ablation (RFA), microwave ablation (MWA), cryoablation (CRYO), irreversible electroporation (IRE) and pulsed electric field.
A new device, designed by MIT researchers, could detect breast cancer earlier. The scanner, which can be incorporated into a bra, could allow more frequent monitoring of high-risk patients.
Ever-more sophisticated robots are advancing healthcare across a wide range of areas. Latest developments and research are being showcased in London from May 29 to June 2 at the 40th International Conference on Robotics and Automation (ICRA). The event is set to be the world’s largest gathering on robotics and automation with pioneers, inventors and innovators coming together with academics,…
Lyme disease, the most common tick-transmitted bacterial infection in the world, is challenging to diagnose. Initial early-stage symptoms may include skin rash, fever, headache, fatigue, swollen lymph nodes, and/or body and joint aches. However, these symptoms are also associated with many other diseases and medical conditions.
New research has identified a potential therapeutic target and developed a unique delivery system to treat osteosarcoma, a bone cancer that primarily affects children and adolescents.
Getting vaccines to people who need them isn't always easy. Many vaccines require cold storage, making it difficult to ship them to remote areas that don't have the necessary infrastructure.
Neurodegeneration, or the gradual loss of neuron function, is one of the key features of Alzheimer's disease. However, it doesn't affect all parts of the brain equally.
As ChatGPT becomes more popular among those seeking health advice, researchers try to find out whether the information provided by the AI chatbot is reliable and accurate.
Researchers from the US, Singapore and Geneva have developed a novel combination therapy using an anticancer agent for treating vancomycin-resistant Enterococcus faecalis (VRE).
Predicting a Covid-19 infection from the sound of a cough? Researchers found that technology using Machine Learning performed no better than simply asking people to report their symptoms.
With the rise of syndrome-style infections, co-infections and the current antimicrobial resistance challenges, the need for multiplexed diagnostics is now more important than ever.
A newly developed capsule that tunnels through mucus in the GI tract could be used to orally administer large protein drugs such as insulin.
A device using next-gen technology to automatically deliver insulin was found to be more effective at maintaining blood glucose levels than standard-of-care management for type 1 diabetes.
A device with the appearance of a Wi-Fi router uses a neural network to discern the presence and severity of one of the fastest-growing neurological diseases in the world: Parkinson's.
The new test measures the level of neutralizing antibodies in a blood sample and could help people decide what protections they should take against infection.
A new device, which doesn’t rely on immunosuppressing drugs, may assist efforts to develop an artificial pancreas to treat diabetes.
MIT researchers produced textiles that sense the wearer’s posture and motions. Their “smart” shoes and mats could be used in applications ranging from health care to prosthetics.
Glucose is absorbed from the foods we eat and fuels every cell in our bodies. But could it also power tomorrow’s medical implants? According to a team of engineers, it might.
Scientists have created a design and fabrication tool for soft pneumatic actuators for integrated sensing, which can power personalized health care.
Engineers at the Massachusetts Institute of Technology (MIT) have developed a telerobotic system to help surgeons quickly and remotely treat patients experiencing a stroke or aneurysm.
The AI-Guided Ultrasound Intervention Device is a lifesaving technology that helps a range of users deliver complex medical interventions at the point of injury.
Using a novel probe for functional magnetic resonance imaging, researchers have devised a way to monitor individual populations of neurons and reveal how they interact with each other.
When it comes to imaging stable cardiac chest pain, which modality should be used as the first-line test to investigate coronary artery disease: CT or MRI? Radiologists discussed the strengths and limitations of the two approaches in a lively Pros and Cons session at ECR Overture.
Researchers have developed a new type of lightweight 3D-printed back brace capable of sensing how effectively it fits patients. Its developers say it could lead to improved treatment for scoliosis.
Engineers at MIT have developed a kind of surgical duct tape — a strong, flexible, and biocompatible sticky patch that can be applied to biological tissues and organs to help seal tears and wounds.
Scientists at have designed a quantum sensor to detect SARS-CoV-2 faster, cheaper, and more accurate than the current gold-standard technique, PCR.
Over the past decade, scientists have been exploring vaccination as a way to help fight cancer. These experimental cancer vaccines are designed to stimulate the body’s own immune system to destroy a tumor, by injecting fragments of cancer proteins found on the tumor.
Inspired by kirigami, the Japanese art of folding and cutting paper to create three-dimensional structures, MIT engineers and their collaborators have designed a new type of stent that could be used to deliver drugs to the gastrointestinal tract, respiratory tract, or other tubular organs in the body.
Over the past decade, hospitals and other healthcare providers have put massive amounts of time and energy into adopting electronic healthcare records, turning hastily scribbled doctors' notes into durable sources of information. But collecting these data is less than half the battle. It can take even more time and effort to turn these records into actual insights — ones that use the learnings…
Over the past decade, the CRISPR-Cas9 gene editing system has revolutionized genetic engineering, allowing scientists to make targeted changes to organisms’ DNA. While the system could potentially be useful in treating a variety of diseases, CRISPR-Cas9 editing involves cutting DNA strands, leading to permanent changes to the cell’s genetic material. Now, in a paper published online in Cell,…
Using an ordinary light microscope, engineers at the Massachusetts Institute of Technology (MIT) have devised a technique for imaging biological samples with accuracy at the scale of 10 nanometers — which should enable them to image viruses and potentially even single biomolecules, the researchers say. The new technique builds on expansion microscopy, an approach that involves embedding…
From swallowing pills to injecting insulin, patients frequently administer their own medication. But they don’t always get it right. Improper adherence to doctors’ orders is commonplace, accounting for thousands of deaths and billions of dollars in medical costs annually. Researchers at the Massachusetts Institute of Technology (MIT) have developed a system to reduce those numbers for some…
In the era of social distancing, using robots for some health care interactions is a promising way to reduce in-person contact between health care workers and sick patients. However, a key question that needs to be answered is how patients will react to a robot entering the exam room. Researchers from MIT and Brigham and Women’s Hospital recently set out to answer that question. In a study…
Bacteria have many ways to evade the antibiotics that we use against them. Each year, at least 2.8 million people in the United States develop an antibiotic-resistant infection, and more than 35,000 people die from such infections, according to the U.S. Centers for Disease Control. Most of the mutations known to confer resistance occur in the genes targeted by a particular antibiotic. Other…
Researchers at the Massachusetts Institute of Technology (MIT) have invented a new type of amputation surgery that can help amputees to better control their residual muscles and sense where their “phantom limb” is in space. This restored sense of proprioception should translate to better control of prosthetic limbs, as well as a reduction of limb pain, the researchers say. In most…
In many ways, our brain and our digestive tract are deeply connected. Feeling nervous may lead to physical pain in the stomach, while hunger signals from the gut make us feel irritable. Recent studies have even suggested that the bacteria living in our gut can influence some neurological diseases. Modeling these complex interactions in animals such as mice is difficult to do, because their…
When cancer is confined to one spot in the body, doctors can often treat it with surgery or other therapies. Much of the mortality associated with cancer, however, is due to its tendency to metastasize, sending out seeds of itself that may take root throughout the body. The exact moment of metastasis is fleeting, lost in the millions of divisions that take place in a tumor. “These events are…
AI can help tackle inequities and bias in healthcare but it also brings partiality issues of its own, experts explained in a Hot Topic session entitled "Artificial Intelligence and Implications for Health Equity: Will AI Improve Equity or Increase Disparities?" at RSNA.
According to Professor Fabian Bamberg, Medical Director at the Clinic for Diagnostic and Interventional Radiology at University Hospital Freiburg, Germany, ‘In recent years, cardiac CT has seen a mindboggling technological evolution.’ It is, he believes, a very robust procedure that allows the routine acquisition of high-resolution images with very few side effects.
Although the Covid-19 pandemic has put wind behind the sails of AI in healthcare, domain specific tools are needed to build and deploy AI and harness its power in data handling, training workflows and reproducibility of state-of-the-art approaches, according to Kimberly Powell, NVIDIA Vice President of Healthcare at the technology firm NVIDIA, presenter of a public address at RSNA 2020.
In the most comprehensive study of COVID-19 pediatric patients to date, Massachusetts General Hospital (MGH) and Mass General Hospital for Children (MGHfC) researchers provide critical data showing that children play a larger role in the community spread of COVID-19 than previously thought. In a study of 192 children ages 0-22, 49 children tested positive for SARS-CoV-2, and an additional 18…
Several thousand strains of bacteria live in the human gut. Some of these are associated with disease, while others have beneficial effects on human health. Figuring out the precise role of each of these bacteria can be difficult, because many of them can’t be grown in lab studies using human tissue. This difficulty is especially pronounced for species that cannot live in oxygen-rich…
Computed tomography (CT) is one of the most important imaging options for the diagnostics of patients. For a long time, in clinical routine CT technology mostly showed the Hounsfield Units (HU) that are indicated in the grayscale. However, the Dual Energy CT (DECT) enables colored X-ray images, therefore significantly improving examination methods. “We can also do material separation and get a…
It’s currently difficult to screen for certain liver diseases and to monitor these conditions once they’re discovered. A team led by investigators at Massachusetts General Hospital (MGH) and the Massachusetts Institute of Technology (MIT) recently developed a non-invasive imaging method that has promising clinical potential to accomplish both goals. The technique is described in a study…
Tissue biopsy slides stained using hematoxylin and eosin (H&E) dyes are a cornerstone of histopathology, especially for pathologists needing to diagnose and determine the stage of cancers. A research team led by MIT scientists at the Media Lab, in collaboration with clinicians at Stanford University School of Medicine and Harvard Medical School, now shows that digital scans of these biopsy…
People who are at high risk of developing lung cancer, such as heavy smokers, are routinely screened with computed tomography (CT), which can detect tumors in the lungs. However, this test has an extremely high rate of false positives, as it also picks up benign nodules in the lungs. Researchers at the Massachussetts Institute of Technology (MIT) have now developed a new approach to early…
Every year, a lack of vaccination leads to about 1.5 million preventable deaths, primarily in developing nations. One factor that makes vaccination campaigns in those nations more difficult is that there is little infrastructure for storing medical records, so there’s often no easy way to determine who needs a particular vaccine. Researchers at the Massachusetts Institute of Technology (MIT)…
Humans are inherently risk-averse: We spend our days calculating routes and routines, taking precautionary measures to avoid disease, danger, and despair. Still, our measures for controlling the inner workings of our biology can be a little more unruly. With that in mind, a team from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) came up with a new system for better…
On the centenary of his birth, Mark Nicholls reflects on the life and legacy of Nobel laureate Sir Godfrey Newbold Hounsfield, the man who pioneered computed tomography. It was a discovery that came from a moment of inspiration during a country walking holiday; the idea that one could determine what was inside a box by taking X-ray readings at all angles around the object. From that, Sir Godfrey…
For patients with kidney failure who need dialysis, removing fluid at the correct rate and stopping at the right time is critical. This typically requires guessing how much water to remove and carefully monitoring the patient for sudden drops in blood pressure. Currently there is no reliable, easy way to measure hydration levels in these patients, who number around half a million in the United…
Artificial intelligence (AI) continues to drive radiologists’ discussions. Among them, Associate Professor Georg Langs, head of the Computational Imaging Research Lab (CIR) at the University Clinic for Radiology and Nuclear Medicine at the Medical University of Vienna, believes: ‘The evaluation of patterns in data from imaging examinations and clinical information about patients using machine…
Molecular imaging is an exciting field for scientists who are willing to explore and innovate, prominent Spanish physicist José María Benlloch pointed out when he reviewed some of the most impacting and recent innovations in his portfolio during a meeting in Valencia. ‘Our mission is to develop innovative sensitive and harmless medical imaging instruments for early detection of diseases and…
A deep neural network algorithm called BOTA uses bacterial genomes to identify unrecognized bacterial antigens.
Researchers recently evaluated the accuracy of a technology to monitor blood glucose levels without needles or a finger prick. Early results show that the noninvasive technology measures blood glucose levels as effectively as a finger prick test — without drawing blood.
Cancer cells often have mutations in their DNA that can give scientists clues about how the cancer started or which treatment may be most effective. Finding these mutations can be difficult, but a new method may offer more complete, comprehensive results. A team of researchers has developed a new framework that can combine three existing methods of finding these large mutations - or structural…
Using a new approach called 'reinforced learning', researchers have taught an artificial intelligence (AI) to responsibly choose the right amount of chemo- and radiotherapy for glioblastoma patients. The technique, which is insprired by behavioural psychology, has given the AI the ability to master the tightrope walk between effective tumor shrinkage and the medications' severe side effects.
Scientists conducting the first comprehensive study of key immune system cells—collected from West African Ebola survivors— have made a surprising discovery that provides important clues to developing effective vaccines against the infection.
Researcher have created an ingestible sensor to non-invasively monitor indicators of disease in the stomach and intestines.
Imagine a small paper device that can rapidly reveal from a drop of blood whether an infection is bacterial or viral. The device could help reduce the overuse of antibiotics – which kill bacteria, not viruses. Misuse of antibiotics has led to antimicrobial resistance, a growing global public health issue. Senior biomedical engineering students at Rutgers University–New Brunswick came up with…
Artificial intelligence (AI) technology and its role and future impact on the radiology profession was the dominant theme at RSNA 2017, whether in scientific presentations or in the technical exhibitions. Keith J Dreyer DO PhD addressed this subject head-on in his presentation ‘Healthcare AI – Radiology’s Next Frontier.’ Dr Keith Dreyer, vice chairman of radiology informatics and chief…
Population imaging is key to determining disease prediction and risk prevention, and Big Data will be key to extracting information and drawing analysis from imaging results, experts highlighted during the annual meeting of the European Society of Magnetic Resonance in Medicine and Biology (ESMRMB) held in Barcelona in October. Interest in cohort studies has been increasing over the years and…
For centuries, hands, eyes and ears were the physicians’ most important instruments when it came to detecting and diagnosing disease. Today, one of the traditional techniques, percussion, is being revived, supported by state-of-the-art technology and dressed in a new name: optoacoustics. In one of the most exciting visionary ideas in modern healthcare short laser pulses (optics) are transmitted…
Researchers have identified mechanisms that drive about 10 percent of high-risk neuroblastoma cases and have used a new approach to show how the cancer genome “hijacks” DNA that regulates other genes. The resulting insights may help scientists develop more effective therapies, including precision medicines. The research involved investigators at St. Jude Children’s Research Hospital;…
Cancer surgeons perform an estimated 1.7 breast biopsies each year, according to the American Association of Preferred Provider Organizations. This makes the procedure a significant proportion of cases referred to anatomic pathologists. This surgery, however, is time-consuming and not always accurate due to shortcomings in existing surgical technology and to human error. Now, a 3D-printed…
Scientists are using Artificial Intelligence (AI) to support more effective breast cancer detection. The researchers at Massachusetts Institute of Technology (MIT) Computer Science and Artificial Intelligence Laboratory (CSAIL), Massachusetts General Hospital (MGH), and Harvard Medical School, are using the machine learning system to predict whether breast lesions identified from a biopsy will…
Current advances such as phase-contrast CT are taking medical imaging further but their use in clinical practice may have to wait up to a decade, prominent physicist predicts.
Bill Kochevar is the first recipient of implanted brain-recording and muscle-stimulating systems reanimates limb that had been stilled for eight years.
An innovative cardiac monitoring system that delivers continuous resynchronisation to patients, has shown a 35% risk reduction of hospitalisation for heart failure (HF) patients. The finding comes from the RESPOND-CRT (cardiac resynchronisation therapy) clinical trial, which was designed to investigate the clinical efficacy and safety of device-based optimisation using the SonR cardiac…
Osnabrueck cognitive scientists and their students are developing new and intelligent expert systems, which help to effectively utilize the flood of daily information in everyday life. To enable working with large amounts of data, the Institute of Cognitive Science at Osnabrück University has engaged in a cooperation with the global corporation IBM, and will be able to access the IBM computer…
Researchers at Massachusetts Institute of Technology research center in Singapore have developed a new microfluidic device that tests the effects of electric fields on cancer cells. They observed that a range of low-intensity, middle-frequency electric fields effectively stopped breast and lung cancer cells from growing and spreading, while having no adverse effect on neighboring healthy cells.
In brief, the new method involves exposing cells to ultrasound when they flow through a so-called micro-channel inside a chip. The individual cells are separated in the acoustic field and by studying the cells’ lateral movement at the end of the channel it is possible to identify the acoustic properties of the cells. Conversely, if you know the cells’ acoustic characteristics, you can detect…
In patients suffering from Type 1 diabetes, the immune system attacks the pancreas, eventually leaving patients without the ability to naturally control blood sugar. These patients must carefully monitor the amount of sugar in their blood, measuring it several times a day and then injecting themselves with insulin to keep their blood sugar levels within a healthy range. However, precise control…
Doctors at the Duke University School of Medicine have tested a new injectable agent that causes cancer cells in a tumor to fluoresce, potentially increasing a surgeon’s ability to locate and remove all of a cancerous tumor on the first attempt. The imaging technology was developed through collaboration with scientists at Duke, the Massachusetts Institute of Technology (MIT) and Lumicell Inc.
In the battle against cancer, which kills nearly 8 million people worldwide each year, doctors have in their arsenal many powerful weapons, including various forms of chemotherapy and radiation. What they lack, however, is good reconnaissance — a reliable way to obtain real-time data about how well a particular therapy is working for any given patient.
By providing tools to allow users to be more productive in working with healthcare big data, several Silicon Valley giants hope to increase their presence in medical services. The latest company to enter the field is Apple Computers. In March it announced the availability of ResearchKit, an open-source software framework that turns the iPhone into a research tool.
‘Elastography is in a position much like Doppler 20 years ago,’ according to David Cosgrove, BMBCh, MA, FRCR, FRCP, Professor of Clinical Ultrasound at Imperial College School of Medicine in London.
Integrated information management reduces risks and cuts cost, Finn Snyder reports. Intensive care units (ICUs) are vital in healthcare. ICUs in US hospitals, for example, treat six million of the sickest and oldest patients annually, according to a document recently published for the Massachusetts Technology Park Corporation, which states that choices about how to manage them carry high stakes:
Susanne Werner reports on the views and revelations of international researchers gathered to deliberate the future potential of reprogrammed human adult stem cells and personalised medical treatments
Delegates at the UKRC 2011 will examine who should deliver 21st century imaging services in the UK, when the relationship between radiologists and radiographers will be the focus of a keynote debate. The session ‘This house believes that radiologists have given up enough of their professional role to radiographers’ will also see delegates vote on this issue.
Early problems of ultra-high field Magnetic Resonance Imaging (MRI) have been overcome by successful development of adequate hardware. In consequence big efforts have been achieved in structural imaging, as well in functional imaging. Basic scientists and physicians who work in ultra-high-field MRI in Europe and the USA, met at the Berlin Ultra-high-field Facility (BUFF), in the Max Dehlbrück…
January's 5-day conference and exhibition that focused on emerging laboratory automation technologies conference and exhibition welcomed 4,237 international academics, commercial and government researchers, scientists and engineers to Palm Springs, California.
President Barack Obama has made e-prescribing an element of his plan to improve the US healthcare system
The American Hospital Association (AHA) issued a report in January 2009 advising of the impact that the steady economic downturn in the US economy will have on hospitals.
Information in patients' records could benefit biomedical research in terms of understanding diseases and their treatments. The drawback is that those records contain confidential information that could identify patients. If that data has to be removed manually, the task is not only painstaking and therefore expensive, but also not foolproof.
Researchers from the Massachusetts Institute of Technology developed a software application to automatically "de-identify" medical records. The software might help to allay patients' fears about who has access to their confidential data. It is capable of deleting details which may identify patients while leaving important medical information intact.
It is hoped that a new technology, digital breast tomosynthesis or 3-D mammography, will overcome three drawbacks of traditional screening mammography: discomfort with breast compression, cancer concealed within overlapping tissue and the limited number of views.
Urinary tract infections caused by catheterisation are a common and nasty affliction for the disabled, elderly and hospital patients.
A new biodegradable solution has stopped bleeding in animals' wounds within seconds, according to a report in the journal Nanomedicine.