How do the three large protein complexes – the ribosome, the SKI complex and the exosome – interact? A team of scientists led by Elena Conti reveals this question in their current study.
Testing from histopathology laboratories is considered the gold standard for many diseases. To avoid errors that can significantly impact patient outcomes, an expert details on quality assurance (QA).
Staphylococcus aureus is a leading cause of hospital-acquired bacterial infection, associated with over one million deaths worldwide each year. Now, researchers could be one step closer to a vaccine.
Primary ciliary dyskinesia (PCD) is a rare inherited multi-organ condition, which can lead to inflammation of the airways and infections. Now, scientists have found what causes PCD.
Stiffness in tissues can be a valuable indicator of cancer formation. Now, researchers have developed a microscopic probe to perform histology at the single cell level inside the human body.
German bioinformaticians have now detected an unexpected diversity of certain cell appendages in the bacterium Acinetobacter baumannii that are associated with its pathogenicity.
Gentle cleansers are just as effective in killing viruses – including coronavirus – as harsh soaps, according to a new study from scientists at the University of Sheffield.
Researchers tracked viruses passing through face masks and compared their failure on the filter layers of different mask types. This could accelerate the development of surfaces that can kill viruses.
Bowel cancer patients could in future benefit from a new 3D bioprinting technology which would use their own cells to replicate the complex cellular environment of solid tumours in 3D models.
When every minute counts: A Swiss team is currently developing a diagnostic procedure that can be used to start a tailored therapy for acute stroke in a timely manner.
Hyperpolarized nuclear magnetic resonance enables major medical advances in molecular diagnostics, for example for cardiovascular diseases or cancer therapy.
Bacteriophages – viruses that kill bacteria – could be a solution for fighting antibiotic-resistant pathogens, French researchers have developed a model to better predict their efficacy.
Scientists from France and Belgium gained insights into the structure and function of a central liver protein: NTCP, a cellular-entry pathway for bile salts – but also for certain hepatitis viruses.
Two successive studies highlight advances in non-invasive 3D ultrasound imaging, making it possible to observe blood flow in real time in the heart and the brain.
Researchers find that drug-resistant bacteria can be distinguished from non-resistant bacteria based on structural changes evident in electron microscope images with high accuracy using deep learning.
Researchers have succeeded in using metal oxide nanoparticles as "radiosensitizers" – and in producing them on an industrial scale.
Scientists have found that fat can help the pancreas adapt to excess sugar, thereby slowing the onset of diabetes.
Ever since the Abbe diffraction limit of conventional microscopy has been surpassed, super-resolution techniques have been diving ever deeper into the most miniscule details of molecular structures. We spoke with Prof. Dominic Zerulla, whose company PEARlabs is developing an imaging technique that sets out to push the boundaries once more – by looking at in-vivo nano-scale processes in motion.
A 'new technology shows promise by analyzing images of suspicious-looking lesions and quickly producing a detailed, microscopic image of the skin, bypassing several standard steps typically used for diagnosis - including skin biopsy, tissue fixation, processing, sectioning and histochemical staining.
The damage caused by Covid-19 to the lungs’ smallest blood vessels has been intricately captured using high-energy X-rays emitted by a special type of particle accelerator. Scientists used a new imaging technology called Hierarchical Phase-Contrast Tomography (HiP-CT), to scan donated human organs, including lungs from a Covid-19 donor.
Although artificial intelligence (AI) tools and smartphone apps that help identify suspicious moles and potential skin cancers are starting to proliferate, dermatology informatics has far to go before becoming a clinically adoptable technology. Many challenges need to be resolved, not least of which is the need for more image data representing people of colour.
Small aggregates of proteins known as Aβ oligomers are suspected as the main cause for the development of Alzheimer’s disease. However, it is not yet clear where and under what conditions these toxic aggregates form.
A team of scientists at Argonne National Laboratory has leveraged artificial intelligence to train computers to keep up with the massive amounts of X-ray data taken at the Advanced Photon Source.
Scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory have published the first detailed atomic-level model of the SARS-CoV-2 "envelope" protein bound to a human protein essential for maintaining the lining of the lungs.
The first known study to measure SARS-CoV-2 viral load in a variety of organs and tissues may aid our understanding of how Covid-19 develops following infection.
Using an ordinary light microscope, engineers at the Massachusetts Institute of Technology (MIT) have devised a technique for imaging biological samples with accuracy at the scale of 10 nanometers — which should enable them to image viruses and potentially even single biomolecules, the researchers say. The new technique builds on expansion microscopy, an approach that involves embedding…
Improving the detection of cancerous cells during surgery – this is the goal of the European research project CARMEN. The research institutes Laser Zentrum Hannover e.V. (LZH) from Germany and Multitel asbl from Belgium work together with companies from both countries, JenLab GmbH, Deltatec, and LaserSpec, to develop a novel, compact and multimodal imaging system. This could even allow the…
Before the pandemic, the lab of Stanford University biochemist Peter S. Kim focused on developing vaccines for HIV, Ebola and pandemic influenza. But, within days of closing their campus lab space as part of Covid-19 precautions, they turned their attention to a vaccine for SARS-CoV-2, the virus that causes Covid-19. Although the coronavirus was outside the lab’s specific area of expertise,…
Researchers at the Francis Crick Institute and the University of Western Australia have developed a new imaging method to see where antibiotics have reached bacteria within tissues. The method could be used to help develop more effective antibiotic treatments, reducing the risk of antibiotic resistance.
For the first time ever, expansion microscopy allows the imaging of even the finest details of cell membranes. This offers new insights into bacterial and viral infection processes.
"Molecular glue degraders" are a new class of cancer drugs, which "glue" cancer growth-promoting proteins directly to the molecular machinery of a cell's disposal system, leading to the subsequent degradation of the cancer-driving proteins and anti-tumor activity. Scientists from Heidelberg and USA have now deciphered another mechanism whereby a small molecule can degrade a…
In a new study, researchers performed a detailed imaging analysis to determine how the virus reprograms infected cells.
In order to analyze tumors, they have to be cut into thin slices. Now, a new technology has been developed that makes pieces of the tumor visible in 3D without cutting them.
Scientists have developed a tool that improves the resolution and accuracy of powerful microscopes that are used to reveal insights into biology and medicine. In a study published in Nature Methods, a multi-institutional team led by Tom Terwilliger from the New Mexico Consortium and including researchers from Lawrence Berkeley National Laboratory (Berkeley Lab) demonstrates how a new computer…
Researchers at ETH Zurich and the University of Bern have discovered a mechanism by which the coronavirus manipulates human cells to ensure its own replication. This knowledge will help to develop drugs and vaccines against the coronavirus.
A team of scientists at the Russian National University of Science and Technology MISiS, together with colleagues from Russia and Germany, have presented a detailed study of magnetite-gold nanohybrids. In the future, such nanoparticles can help in theranostics — the diagnostics and subsequent therapy of oncological diseases. The results of the work have been published in the Journal of…
Although its name is relatively unspecific and indeed opaque, the Nonstructural Protein 1 (Nsp1) encoded by the coronavirus SARS-CoV-2, which is responsible for the current pandemic, has now been shown to have a devastating effect on host cells. Nsp1 is in fact one of the central weapons used by the virus to ensure its own replication and propagation in human hosts. Nsp1 was identified as a…
Could the ability of cancer cells to quickly alter their genome be used as a weapon against malignant tumours? Researchers at Uppsala University have succeeded in developing a substance that has demonstrated promising results in experiments on both animal models and human cancer cells. The study is published in the journal Nature Communications.
Does the blood we thought to know so well contain elements that had been undetectable until now? The answer is yes, according to a team of researchers. The scientistts from Inserm, Université de Montpellier and the Montpellier Cancer Institute (ICM) working at the Montpellier Cancer Research Institute (IRCM), have revealed the presence of whole functional mitochondria in the blood circulation.…
Nine people have died and more than 400 have been sickened by the new corona virus spreading in China. A few cases have been confirmed in Taiwan, Thailand, South Korea, Japan and the U.S., and on Wednesday, the World Health Organization is holding an emergency meeting on the outbreak. How worried about a new pandemic should we be? Virus researcher Ali Mirazimi, adjunct professor at the Department…
Researchers at the Institute of Cancer Research (ICR) have gained new understandings of two key complexes of cancer-related proteins by producing the most detailed ever maps of the structures they form when they come together. The study reveals that the two protein complexes come together in cells in a series of steps that change how their individual component proteins are arranged together. It…
A newly published paper details a research breakthrough that provides a promising starting point for scientists to create drugs that can cure Clostridium difficile (C. diff) — a virulent health care-associated infection that causes severe diarrhea, nausea, internal bleeding, and potentially death. The bacteria affects roughly half-a-million Americans and causes nearly 15,000 deaths in the U.S.…
“Proteins are the workers in the cell, and it's important to know their shape,” says Chris Sander, PhD, director of Dana-Farber’s cBio Center in the Department of Data Sciences. Sander and his colleagues have now demonstrated a powerful “experimental evolution” method to discover details of protein shape and function, and the method may find uses across a very broad spectrum of…
The MKC-X800 ultra-compact camera is a new addition to Ikegami’s range of medical imaging equipment, which, the firm reports, sets higher than ever standards of imaging quality to capture the precise colour and image detail of surgical operations. Measuring just 28x28x52mm WHD and weighing 100g, it can be mounted on a surgical microscope, lightweight support stand or boom. With its 4K-native…
Researchers in Zurich have recently been able to monitor the corrosion of bioresorbable magnesium alloys at the nanoscale over a time scale of a few seconds to many hours. This is an important step towards accurately predicting how fast implants are resorbed by the body to enable the development of tailored materials for temporary implant applications. Magnesium and its alloys are increasingly…
Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of “ammunition” because of more and more frequently occurring resistances. A research team has now elucidated the structure of the proteolytic complex ClpX-ClpP. This is a key to development of innovative antibiotics which target the degradation process of defective proteins…
Immunotherapy is a promising cancer treatment that uses genetically modified immune cells to fight cancer. It can be used as a primary treatment or in combination with other treatments such as radiation and chemotherapy to slow down or stop the growth of cancer cells and prevent them from spreading to other parts of the body. Chimeric Antigen Receptor (CAR)-T cell therapy, for instance, is a…
Vaccinating schoolboys against the potentially deadly human papillomavirus (HPV) could dramatically reduce head and neck cancers in men, according to research involving the University of Strathclyde. The two-year project studied 235 patients in Scotland with head and neck cancer and found that 78% of people with head and neck cancers were men, while HPV was present in 60% of the cancers. This…
Biotechnologists, physicists, and medical researchers at FAU have developed technology for microscopic imaging in living organisms. A miniaturised multi-photon microscope, which could be used in an endoscope in future, excites the body’s own molecules to illuminate and enables cells and tissue structures to be imaged without the use of synthetic contrast agents. The findings have now been…
Portland State University (PSU) researchers have made a significant breakthrough by developing the 3-D structure of proteins from inside the eye lens that control how cells communicate with each other, which could open the door to treating diseases such as cataracts, stroke and cancer. The PSU research team, led by chemistry professor Steve Reichow, used a multimillion-dollar microscope and a…
Scientists at the Virginia Tech Carilion Research Institute (VTCRI) have found evidence that may disrupt conventional understanding about how electrical activity travels in the heart — a discovery that potentially can lead to new insight into medical problems such as heart arrhythmia and sudden cardiac death.
Holography, like photography, is a way to record the world around us. Both use light to make recordings, but instead of two-dimensional photos, holograms reproduce three-dimensional shapes. The shape is inferred from the patterns that form after light ricochets off an object and interferes with another light wave that serves as a reference. When created with X-ray light, holography can be an…
In standard settings, the analysis of each DNA modification requires a carefully optimised assay that runs under specific conditions. This increases cost and labour and is a severe limitation to throughput. Now, however, researchers at Stanford University and the Technical University of Denmark have come up with a new method that will enable doctors to make a more precise diagnosis, prognosis and…
Cell division is an intricately choreographed ballet of proteins and molecules that divide the cell. During mitosis, microtubule-organizing centers (MTOCs) assemble the spindle fibers that separate the copying chromosomes of DNA. While scientists are familiar with MTOCs’ existence and the role they play in cell division, their actual physical structure remains poorly understood. Shruthi…
Indiana University researchers have made an important step forward in the design of drugs that fight the hepatitis B virus, which can cause liver failure and liver cancer. It's estimated that 2 billion people worldwide have had a hepatitis B virus infection in their lifetime, with about 250 million -- including 2 million Americans -- living with chronic infection. Although a vaccine exists, there…
A nanolaser known as the spaser can serve as a super-bright, water-soluble, biocompatible probe capable of finding metastasized cancer cells in the blood stream and then killing these cells, according to a new research study.
Light microscopy today offers a wealth of techniques that provide fascinating insights into life on subcellular level. “In light microscopy these days there are so many new techniques that each of us can only handle a subset of them,” says Christian Tischer, scientific officer in der Advanced Light Microscopy Facility of the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany,…
Precise knowledge of the connections in the brain – the links between all the nerve cells – is a prerequisite for better understanding this most complex of organs. Researchers from Heidelberg University have now developed a new algorithm – a computational procedure – that can extract this connectivity pattern with far greater precision than previously possible from microscopic images of…
When one cell divides into two - that is how all forms of life are propagated - the newly born daughter cells have to be equipped with everything they will need in their tiny lives. Most important of all is that they inherit a complete copy of the genetic information from their mother cell. If this is not the case because a wrong number of chromosomes – on which the genetic information is…
For the first time, scientists know what happens to a virus’ shape when it invades a host cell, thanks to an experiment by researchers at Penn State College of Medicine and University of Pittsburgh School of Medicine. Understanding how the virus shape specifically changes could lead to more effective anti-viral therapies.
Sony Medical offers an end-to-end video processing chain for medical-grade 4K surgical visualisation. The conversion will not happen overnight, but 4K is a natural next step for improving visualisation during surgery, according to John Herman, the European Marketing Manager for Surgical Solutions at Sony Medical.
An international team working at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) has captured the first high-resolution 3-D images from individual double-helix DNA segments attached at either end to gold nanoparticles. The images detail the flexible structure of the DNA segments, which appear as nanoscale jump ropes.
Touch a hot stove, and your fingers will recoil in pain because your skin carries tiny temperature sensors that detect heat and send a message to your brain saying, "Ouch! That's hot! Let go!" The pain is real and it serves a purpose, otherwise we'd suffer greater injury. But for many people with chronic pain, that signal keeps getting sent for months or years, even when there is no…
The first-ever images of the protein complex that unwinds, splits, and copies double-stranded DNA reveal something rather different from the standard textbook view. The electron microscope images, created by scientists at the U.S. Department of Energy's Brookhaven National Laboratory with partners from Stony Brook University and Rockefeller University, offer new insight into how this molecular…
Increasing requirements for specialisation and diagnostic quality in pathology on the one hand and the importance of pathology findings for treatment planning on the other hand call for new solutions in pathomorphological diagnostics. One important starting point is the fast-paced opportunity for digitalisation along with communication systems which facilitate the storage and transfer of large…
A photograph may reveal how something looks, but direct observation can divulge how the objects behave. The difference can mean life or death, especially when it comes to fighting human disease. To help researchers examine exactly how human diseases work at the molecular level, Virginia Tech Carilion Research Institute scientist Deborah Kelly has developed a new set of tools to peer into the…
Proteins called broadly neutralizing antibodies (bNAbs) are a promising key to the prevention of infection by HIV, the virus that causes AIDS, say researchers at California Institute of Technology.
Research conducted by Dr Ashraf Kitmitto and colleagues at the University of Manchester provides new information as to why some cells do not work properly following a heart attack.
Mindray is delighted to present you its latest innovations.
Newly released images revealing the ‘bicycle spoke’ structure of a heart cell may hold key clues to reducing damage from a heart attack.
Olympus has led the field in advancing endoscopic technology. Just when experts and users thought no further optimisation was possible, Olympus placed another major innovation in the marketplace – and the firm has done it again.
Olympus VS120 virtual slide scanning system earns three awards at the prestigious second International Scanner Contest.
Electron microscopy and analysis instruments from Carl Zeiss are redefining the science of brain mapping and 3-D reconstruction. Wide-field, high resolution imaging, huge data storage and manipulation capabilities plus highly automated sample preparation techniques are yielding research results 100-times, or more, faster than ever before.
Olympus is presenting the AU480, the newest member of its clinical chemistry analyser family. With a throughput of up to 800 tests per hour, an ISE module and on board capacity of 63 different analytes, the Olympus AU480 is the ideal main analyser for small to medium-size laboratories.
Olympus will present the latest member of its clinical chemistry analyser family at Medica.
A new type of super-resolution X-ray microscope invented by researchers from Paul Scherrer Institut (PSI) and Ecole Polytechnique Fédérale de Lausanne (EPFL) gives pin sharped insights into the composition of semiconductor devices and cellular structures.
In Genk, Belgium, the Ziekenhuis Oost Limburg hospital simplified surgical workflow by installing a telemedicine system in a newly constructed interdisciplinary surgical wing. Dr Hubert Van der Put, Medical Director of ZOL, recalls its initiation and subsequent success.. In all major projects with lots of participants, success comes from timely planning between every department and company…
Recently in February, Leica Microsystems, Wetzlar, Germany, acquired Bal-Tec AG, Liechtenstein-based manufacturer of optical instruments. This transaction will allow Leica to expand its product portfolio for EM (electron microscopy) specimen preparation significantly.
It took 152 years, but now the ETH (Eidgenössische Technische Hochschule) Zürich for the first time named a femal rector: Prof. Heidi Wunderli-Allenspach. She will succeed the present Rector, Prof. Konrad Osterwalder in September and will join the club of European rectors that has really been a men´s world so far.
Since the human genome was mapped 'systems biology' centres have sprung up all over Europe, including Bioquant in Heidelberg, Germany.
Wilhelm Niedergoeker, Managing Director of the Messe Dusseldorf GmbH, previews this year's events.