A newly developed ‘biocooperative’ material based on blood can guide key processes taking place during the natural healing of tissues to create living materials that enhance tissue regeneration.
To take cell therapy in regenerative medicine to a new level, experts consider 3D bioprinting a key technology. However, there are still quality issues that need to be overcome to achieve this.
A crucial component in joints, cartilage is notoriously difficult to repair. Now, US researchers have developed a promising bioactive material to regenerate cartilage in knee joints.
A band-aid for the heart? US researchers have developed a new way to 3D print material that is at once elastic, tough, and shapable enough to fit a patient’s unique heart or joint defects.
A new heart valve comprised of biological material obtained from human cells, opens up new therapeutic avenues for patients with paediatric heart diseases, such as tetralogy of Fallot.
A new research project focuses on creating a 3D printed device to grow a human spinal cord organoid for the study of spinal cord injury and subsequent drug testing.
Researchers have discovered how the mechanical properties of tumours - their softness, for example - can prime cancer cells to better survive their spread to other organs.
A newly-developed material made of proteins shows promise for targeted cancer therapies: Like secretory granules in the endocrine system, it delivers nanoparticles which attack specific cancer cells.
In a breakthrough for personalised oncology, scientists have developed and demonstrated a novel platform that can significantly reduce the time needed to determine the efficacy of anti-cancer drugs.
Researchers present new 3D-printable materials that can be easily monitored using X-ray or CT imaging. This has great potential to expand the possibilities of reconstructive and plastic surgery.
A fully digital design-to-manufacturing process developed at Loughborough University has the potential to revolutionise lower limb socket production by allowing printing outside of hospital settings.
Half as thick as a human hair: Researchers at TU Munich have developed the world's first microrobot capable of navigating within groups of cells and stimulating individual cells.
Researchers at Mayo Clinic have developed a 3D prototype of human skin bioprinted to model inflammatory skin disease such as atopic dermatitis — more commonly known as eczema.
A team at the Finnish research institute VTT has created a biodegradable ECG patch, aiming to pave the way to a more sustainable future for wearable electronic devices.
Researchers at the University of New South Wales unveil prototype device that can directly 3D print living cells onto internal organs and potentially be used as an all-in-one endoscopic surgical tool.
German researchers present a novel method for testing chemical agents that could help in the development of drugs against neurodegenerative diseases such as Alzheimer's.
The specialty chemicals company Evonik and the Swiss plastics specialist Samaplast are combining their expertise in the development of an osteoconductive PEEK biomaterial for injection molding.
Researchers have developed 3D printed artificial heart valves designed to allow a patient’s own cells to form new tissue.
Newly engineered in vitro tumour models open ways to better understand the crosstalk between liver cancer cells and their microenvironment, researchers from Singapore found.
Researchers have developed an ultrasound-guided cancer immunotherapy platform that generates systemic antitumor immunity and improves the therapeutic efficacy of immune checkpoint blockade.
Biomaterial engineers have developed the first-ever hydrophobic fluid, which instantly displaces body fluids surrounding an injury allowing for near-instantaneous gelling, sealing, and healing of injured tissue.
A chip-based infection model developed by Jena researchers enables live microscopic observation of damage to lung tissue caused by the invasive fungal infection aspergillosis.
An international team of engineers is bioprinting bone along with two growth factor encoding genes that help incorporate the cells and heal defects in the skulls of rats.
A new kind of bone implant reduces the chance of infection, and therefore significantly decreases implant failure rates.
Evonik offers a comprehensive portfolio of 3D printable med-tech biomaterials that can be used to produce medical devices with temporary or permanent body contact. Marc Knebel, head of Medical Systems at Evonik, explains the benefits and applications of the new high-performance polymer VESTAKEEP Care M40 3DF.
Loosening hip implants can cause major damage to the bone and a simple replacement won’t suffice to carry the load during movements. “To solve this problem we have to turn to innovative technologies such as bioprinting. Scaffolds are required that – while adapting slowly – offer long-term stability,” says Professor Dr Dieter Wirtz, Director of the Department of Orthopaedics and Trauma…
Combining knowledge of chemistry, physics, biology, and engineering, scientists from McGill University develop a biomaterial tough enough to repair the heart, muscles, and vocal cords, representing a major advance in regenerative medicine.
A bionic eye being developed by a team of biomedical researchers has shown to be safe and stable for long-term implantation in a three-month study, paving the way towards human trials.
Treating diseases such as Alzheimer’s or Parkinson’s is a challenge because drugs have to be able to cross the blood–brain barrier. As a result, the doses administered must be high and only a small fraction reaches the brain, which can lead to significant systemic side effects.
In the fight against diseases like amyotrophic lateral sclerosis (ALS), biomedical engineering researchers at the University of Southern California have created a powerful lab model to better see how our muscles and neurons connect.
Covid-19 disease severity is determined by the individual patient’s immune response. The precise mechanisms taking place inside the lungs and blood during the early phase of the disease, however, remain unclear. Researchers from Charité – Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC) and Freie Universität Berlin have now studied the cellular mechanisms…
University of Birmingham scientists have developed a new microscopic imaging approach to take a closer look at 3D-printing for developing future patient implants, as well as improved disease modelling and drug screening. Additive manufacturing (3D printing) platforms create bioprinted structures by moving a special bioink, containing cells, biomolecules and materials, through a narrow tube, but…
Researchers at Chalmers University of Technology, Sweden, have developed a new material that prevents infections in wounds – a specially designed hydrogel, that works against all types of bacteria, including antibiotic-resistant ones. The new material offers great hope for combating a growing global problem. The World Health Organization describes antibiotic-resistant bacteria as one of…
New research by University of Texas at Dallas scientists could help solve a major challenge in the deployment of certain Covid-19 vaccines worldwide — the need for the vaccines to be kept at below-freezing temperatures during transport and storage. In a study published online in Nature Communications, the researchers demonstrate a new, inexpensive technique that generates crystalline…
Joint cartilage usually regenerates very poorly. The matrix of cartilage (scaffolding) contains very few cells in deep layers. Moreover, joint cartilage is highly isolated: there are neither regenerative cells in the immediate vicinity that could migrate into the site of the defect and trigger repair, nor vessels that could transport regenerative cells to the cartilage. Unsurprisingly,…
Prostate cancer is one of the most common cancers among men. Patients are determined to have prostate cancer primarily based on PSA, a cancer factor in blood. However, as diagnostic accuracy is as low as 30%, a considerable number of patients undergo additional invasive biopsy and thus suffer from resultant side effects, such as bleeding and pain.
Researchers at Duke University and the University of California, Los Angeles, have developed a biomaterial that significantly reduces scar formation after wounding, leading to more effective skin healing. This new material, which quickly degrades once the wound has closed, demonstrates that activating an adaptive immune response can trigger regenerative wound healing, leaving behind stronger and…
A bioactive polymer-ceramic composite for fixing implants and restoring bone defects in the skull was developed by an international group of materials scientists from the Russian National University of Science and Technology (NUST) MISIS Center for Composite Materials. An innovative composition of the material based on eggshell-derived bioceramic provides increased strength and biointegration of…
A new polymeric heart valve with a life span potentially longer than current artificial valves that would also prevent the need for the millions of patients with diseased heart valves to require life-long blood thinning tablets has been developed by scientists at the universities of Bristol and Cambridge. The team's latest in-vitro results, published in Biomaterials Science, suggest that the…
Researchers at the University of Zurich have developed a new X-ray contrast agent which is easier to use and distributes into all blood vessels more reliably, increasing the precision of vascular imaging. This reduces the number of animals required in research experiments. Various diseases in humans and animals – such as tumors, strokes or chronic kidney disease – damage the blood vessels.…
Omnia Medical’s ‘Boxcar’ has been granted the first US FDA 510(k) clearance for a cervical vertebral body replacement (VBR) system manufactured from PEEK-OPTIMA HA Enhanced polymer. The system has been designed for use in cervical-corpectomy procedures – the replacement of a collapsed, damaged, or unstable vertebral body located in the cervical spine. Robert Gewirtz, MD - Neurosurgeon,…
Tiny particles that can fight cancer or that can easily pass through any interface within our body are a great promise for medicine. But there is little knowledge thus far about what exactly will happen to nanoparticles within our tissues and whether or not they can cause disease by themselves. Within an international research consortium, Empa scientists have now developed guidelines that should…
Researchers at the University of Helsinki in collaboration with researchers from Åbo Akademi University (Finland) and Huazhong University of Science and Technology (China) have developed a new anti-cancer nanomedicine for targeted cancer chemotherapy. This new nano-tool provides a new approach to use cell-based nanomedicines for efficient cancer chemotherapy. Exosomes contain various molecular…
The future of medicine is biological – and scientists hope we will soon be using 3D-printed biologically functional tissue to replace irreparably damaged tissue in the body. A team of researchers from the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB has been working with the University of Stuttgart for a number of years on a project to develop and optimize suitable…
In a major medical breakthrough, Tel Aviv University researchers have "printed" the world's first 3D vascularised engineered heart using a patient's own cells and biological materials. Until now, scientists in regenerative medicine — a field positioned at the crossroads of biology and technology — have been successful in printing only simple tissues without blood vessels. "This…
A material based on a natural product of bones and citrus fruits, called citrate, provides the extra energy stem cells need to form new bone tissue, according to a team of Penn State bioengineers. The new understanding of the mechanism that allows citrate to aid in bone regeneration will help the researchers develop slow-release, biodegradable citrate-releasing scaffolds to act as bone-growth…
Researchers have developed laser-activated nanomaterials that integrate with wounded tissues to form seals that are superior to sutures for containing body fluids and preventing bacterial infection. Tissue repair following injury or during surgery is conventionally performed with sutures and staples, which can cause tissue damage and complications, including infection. Glues and adhesives have…
The fact that genetic research can reveal hereditary diseases has been transferred to medical practice for some time and, since 2010, the Gene Diagnostics Act (GenDG) has regulated permissible DNA tests in medical diagnostics and pedigree in Germany. The procedure has great potential, says Professor Jochen Taupitz - but also great risks are associated with it.
Most of us don’t think about our teeth and bones until one aches or breaks. A team of engineers at Washington University in St. Louis looked deep within collagen fibers to see how the body forms new bone and teeth, seeking insights into faster bone healing and new biomaterials. Young-Shin Jun, professor of energy, environmental & chemical engineering in the School of Engineering &…
Population imaging is key to determining disease prediction and risk prevention, and Big Data will be key to extracting information and drawing analysis from imaging results, experts highlighted during the annual meeting of the European Society of Magnetic Resonance in Medicine and Biology (ESMRMB) held in Barcelona in October. Interest in cohort studies has been increasing over the years and…
Geometry is often referenced for matters of the heart. Marriage has been described as “two parallel lines,” and others have compared love to an “irrational equation” or as unending as “pi.” But when it comes to the medical matters of the heart, geometry can be a lonely and dangerous affair. “The shape and size of a heart is not the same for every person, and a diseased heart, such…
T cells play a key role in the body’s immune response against pathogens. As a new class of therapeutic approaches, T cells are being harnessed to fight cancer, promising more precise, longer-lasting mitigation than traditional, chemical-based approaches. These “living drugs” are poised to transform medicine, with a growing number of cellular therapies receiving FDA-approval. A current…
Sutures and staples are the traditional methods for closing surgical incisions and wounds in emergency situations. However, these methods can be inadequate in complex surgeries and cannot make an air-tight or liquid-tight seal on a lung or artery wound or incision. Now researchers funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have created a surgical glue that…
A tiny robot that gets into the human body through the simple medical injection and, passing healthy organs, finds and treats directly the goal – a non-operable tumor… Doesn’t it sound at least like science-fiction? To make it real, a growing number of researchers are now working towards this direction with the prospect of transforming many aspects of healthcare and bioengineering in the…
Our knowledge of causes and mechanisms of current and future diseases is on ice – not the perpetual ice of the polar caps but artificial ice. It is stored in biobanks at -80 to -160 °C.
A Northwestern University research team has developed a 3D printable ink that produces a synthetic bone implant that rapidly induces bone regeneration and growth. This hyperelastic “bone” material, whose shape can be easily customized, one day could be especially useful for the treatment of bone defects in children.
As a former top-flight athlete with the French national gymnastics team, physiotherapist Luc D'Asnières de Veigy appreciates the value of rapid diagnosis, treatment and rehabilitation following an injury. A specialist in the treatment of shoulder disorders, he explains how using point-of-care ultrasound systems helps in his day-to-day practice at Monte Carlo Joint Repair.
Liposomes are currently used as drug delivery vehicles but recognized by the immune system. Scientists from the universities of Basel and Fribourg have shown that special artificial liposomes do not elicit any reaction in human and porcine sera as well as pigs. The study was published in the Journal Nanomedicine: Nanotechnology, Biology, and Medicine.
Partners from Germany, Israel, Latvia and Italy will systematically advance the use of biophotonic technologies for industrial, clinical and medical applications in the Biophotonic Technologies for Tissue Repair (BI-TRE) project. As part of the transnational BiophotonicsPlus initiative, the German consortium commenced its activities on September 1, 2015. The goal is to supply oral and…
A new injectable “biogel” is effective in delivering anti-cancer agents directly into cancerous tumours and killing them. This technology, developed by researchers at the University of Montreal Hospital Research Centre (CRCHUM), has already been successfully tested in the laboratory. If it works in patients, the therapy could one day revolutionize treatment for many forms of cancer.
A nanofiber hydrogel infused with snake venom may be the best material to stop bleeding quickly, according to Rice University scientists.
Virtual models can be created in the angiography room thanks to an approach developed by researchers at the University of Montreal Hospital Research Centre (CRCHUM) and the university’s departments of radiology, radiation oncology, and nuclear medicine. The latest advances were presented by Dr. Gilles Soulez at the Cardiovascular and Interventional Radiology Society of Europe (CIRSE) conference…
Researchers funded by the National Institute of Biomedical Imaging and Bioengineering at Tufts University and their collaborators have successfully developed a 3-dimensional (3D) tissue-engineered model of bone marrow that can produce functional human platelets outside the body (ex vivo).
The European Society of Clinical Microbiology and Infectious Disease (ESCMID) advocates the need for greater education, guidance and research on the build-up, treatment and prevention of biofilms, which contribute to antimicrobial resistance.
Autografts, the gold standard of bone grafts, have several limitations. As a result, new orthobiologics products are being developed for the benefit of patients as well as surgeons. Innovations in biomaterials and graft design have enabled these advanced products that mimic the natural human bone and speed up bone repair and regeneration.
Researchers at the University of Toronto design diagnostic chip to reduce testing time from days to one hour, allowing doctors to pick the right antibiotic the first time.
The research objective of Dr.-Ing. Laura De Laporte, junior group leader at DWI – Leibniz Institute for Interactive Materials in Aachen, is to develop a minimally invasive therapy for spinal cord injury. Her goal and her scientific approach to develop an injectable material with the ability to provide biochemical and physical guidance for regenerating nerves across the injury site, was selected…
Artificial vascular trees, the growing of heart tissue, nerve regeneration: The World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) held in Vienna this October offered an impressive display of current developments in tissue reconstruction and regeneration, Michael Krassnitzer reports
ILJIN, the shareholder of Alpinion Medical Systems, which began as a Korean die-casting and electrical business 44 years ago, is today an international high-tech company.
Modern medical technology is evidently held in high esteem by the general population. In a recent survey conducted by the market research institute Emnid commissioned by the industry association SPECTARIS, about 80% of the patients surveyed said that under certain circumstances they would be willing to pay more for their health insurance in return for consistent treatment with state-of-the-art…
Mother Nature has provided the lizard with a unique ability to regrow body tissue that is damaged or torn - if its tail is pulled off, it grows right back. She has not been quite so generous with human beings. But we might be able to come close, thanks to new research from Tel Aviv University.
The inflammatory process in the brain of multiple sclerosis patients is triggered by their own immune system. However, there is one type of immune cells that seems to fight against the destructive progress - and might be used for therapeutic purposes in future.
EH correspondent David Loshak reports
In the sixth in his series for European Hospital, Professor Stefan Schönberg (left) of the Institute of Clinical Radiology and Nuclear Medicine (IKRN), University Hospital Mannheim, Medical Faculty of Mannheim, University of Heidelberg, invited colleagues from Mannheim and Vienna for a round-table discussion on:
The construction of the first fully functional laser in 1960 was not just an important milestone in physics; it paved the way for numerous innovations in various medical applications. Recent technologic developments and the latest results from research and application in laser driven therapy, diagnostics, and production, were presented and discussed in the context of a workshop,
This was it, 15th May, the big day: Johnson & Johnson's Worldwide Mesh Technology Centre was officially opening in Norderstedt near Hamburg, Germany.
The latest textile technologies go along with fabric integrated sensors, or computers, to measure e.g. the functioning of a patient's cardiovascular system.
It occupies approximately the same space as one to three atoms.
Implants presently in use consist of a smooth or textured silicone shell filled with a silicone gel or saline solution. The latter has one decisive drawback - the breast may cool considerably in winter. Smooth silicone implants may also shift or turn.
