Biogel

Intelligent gel attacks cancer

A new injectable “biogel” is effective in delivering anti-cancer agents directly into cancerous tumours and killing them. This technology, developed by researchers at the University of Montreal Hospital Research Centre (CRCHUM), has already been successfully tested in the laboratory. If it works in patients, the therapy could one day revolutionize treatment for many forms of cancer.

Sophie Lerouge and Réjean Lapointe examine the cancer fighting biogel they...
Sophie Lerouge and Réjean Lapointe examine the cancer fighting biogel they have developped.
Source: Universite de Montreal

Unlike “jello,” the biogel is liquid at room temperature and gels at 37 degrees Celsius – human body temperature. "The strength of this biogel is that it is compatible with anti-cancer immune cells. It is used to encapsulate these cells and eventually administer them using a syringe or catheter into the tumour or directly beside it. Instead of injecting these cells or anti-cancer drugs throughout the entire body via the bloodstream, we can treat the cancer locally. We hope that this targeted approach will improve current immunotherapies,” said Réjean Lapointe, co-author of a study on the technology that was recently published in Biomaterials.

One form of immunotherapy involves treating cancer patients with anti-cancer immune cells. This is called adoptive cell therapy. These cells (T lymphocytes or T cells) are produced naturally by the body and have the ability to destroy cancer cells, but they are generally too weak and too few to eradicate the cancer alone. T cells are therefore cultivated in the laboratory – often the patient’s own cells – and then reinjected into the patient’s blood. While this form of immunotherapy has shown promising results in cases of advanced cancer, it is not always possible to generate enough T cells. Moreover, high doses of interleukin-2, a hormone added to maximize the therapy have a toxic effect. “With our technique, we only need to administer a few dozen million T cells, instead of the billions currently required. We can also administer compounds that ‘awaken’ the immune system to fight against cancer,” explained Lapointe, who is a researcher at the CRCHUM and professor at the University of Montreal.

The recipe for this promising biogel was developed by Sophie Lerouge, a researcher at the CRCHUM and professor in the Department of Mechanical Engineering at the École de technologie supérieure. “The compound is made from chitosane, a biodegradable material extracted from the shells of crustaceans, to which gelling agents are added. “The formulation is liquid at room temperature, which facilitates its injection, but quickly takes on a cohesive and resistant structure at 37 degrees. We also needed a hydrogel that was non-toxic for the body and provided excellent survival and growth of the encapsulated cells," said the engineer. A real challenge for Lerouge’s team, who tested several formulations before arriving at this “intelligent” biogel.

The biogel was successfully tested in several in vitro models, including melanoma and kidney cancer. “The T lymphocytes in the gel are functional and can grow for two to three weeks, be released from the gel, and kill the cancerous cells,” explained Lapointe. The next step is to demonstrate the effectiveness of the biogel in animals and humans. If the trials are successful, this new approach could be added to current cancer therapies in a few years.


Source: Universite de Montreal

10.12.2015

Related articles

Photo

News • Adaptive mutability

How bowel cancer flips the switch to avoid immune detection

Why does the immune system sometimes fail to control the development of bowel cancer? UK and Dutch researchers discovered how cancer cells use a genetic "switch" to evade detection.

Photo

News • Research on DNA danage

Surprise finding on cancer cell death to impact therapies

Chemotherapy kills cancer cells – but how? New research suggests that the mechanisms are different than previously understood. The finding will have implications for future cancer treatments.

Photo

News • 6.5 million European funding

Fighting cancer with artificial cells and tissue

Artificial cells to combat cancer: Research groups are working to create synthetic micro-organisms capable of detecting the presence of the disease and delivering anti-cancer therapies.

Related products

Subscribe to Newsletter