A specific subtype of a microbe commonly found in the mouth has been identified that is able to travel to the gut and grow within colorectal cancer tumors, driving cancer progression.
Using 3D bioprinting to accurately replicate the biological environment surrounding gastric cancer cells, researchers predicted a patient’s response to anticancer drugs during the preclinical stage.
US oncologists are exploring a new combined chemotherapy and surgical approach to safely remove advanced pancreatic tumors that were previously considered inoperable.
When your stomach is full after a large meal, certain receptors are activated to tell the brain. A newly developed capsule could provoke this fullness signal early, potentially helping with treating obesity.
Cancer has become strikingly more common in people under 50 in the past three decades, an international research team finds. The reseachers explore what this means for future death tolls.
Researchers from the US, Singapore and Geneva have developed a novel combination therapy using an anticancer agent for treating vancomycin-resistant Enterococcus faecalis (VRE).
Innovative gastrointestinal imaging, medical panel PCs with hygiene optimisation, smartphone-based diagnostic tools, and sustainable hardware setups: At Medica 2022, manufacturers from Taiwan again showed their capability to adapt and provide solutions for a world radically changed by the Covid-19 pandemic. Under the “Taiwan Excellence” banner, outstanding products from the island nation’s…
New tests can identify over 50 types of cancer and boost detection of traditionally elusive cancers from tumour DNA in blood, researchers showed at the ESMO congress in September. These multi-cancer early detection (MCED) tests in development can spot common cancer signals and predict where the signal comes from in the body, results from a prospective investigation suggest.
A newly developed capsule that tunnels through mucus in the GI tract could be used to orally administer large protein drugs such as insulin.
Two-dimensional (2D) cultured cell lines and animal models have been the principal research tools for the past decade, but have several shortcomings. Three-dimensional cell cultures, or organoids, show great promise here.
Faulty versions of the BRCA1 and BRCA2 genes are well known to increase the risk of breast and ovarian cancer. Now, they have been linked to several other cancers, including those that affect men.
Experts at University College London (UCL) and spinout company Odin Vision working with clinicians at UCLH have used artificial intelligence (AI) to help detect early signs of oesophageal cancer. The first procedure in the world using the AI technology was performed at University College Hospital by UCLH consultant gastroenterologist Dr Rehan Haidry. The system, called CADU, uses AI to support…
Final results from a study of a blood test that can detect more than 50 types of cancer have shown that it is accurate enough to be rolled out as a multi-cancer screening test among people at higher risk of the disease, including patients aged 50 years or older, without symptoms. In a paper published in the cancer journal Annals of Oncology, researchers report that the test accurately detected…
Statin use among patients with heart failure is associated with a 16% lower risk of developing cancer compared with non-statin users during an average of four years of follow-up. This is according to new research published in the European Heart Journal. In addition, the study found that statin use was associated with a 26% reduced risk of dying from cancer over the same period.
First you see it as a transparent shape on a computer screen – a small electronic replica of the human pancreas. Then just 30 seconds later the tissue is printed out on a bioprinter, blood vessels and all, from a sample of human stem cells. This amazing feat is possible thanks to new technology created at EPFL’s Laboratory of Applied Photonics Devices (LAPD) and further developed by…
Researchers have called on European policymakers to make adequate resources available to tackle pancreatic cancer, a disease that is almost invariably fatal and where little progress has been made over the past 40 years. In the latest predictions for cancer deaths in the EU and UK for 2021, published in the cancer journal Annals of Oncology, researchers led by Carlo La Vecchia (MD), a professor…
Researchers from the University of Nottingham have discovered a novel antiviral property of a drug that could have major implications in how future epidemics/pandemics – including Covid-19 – are managed. The study, published in Viruses, shows that thapsigargin is a promising broad‑spectrum antiviral, highly effective against SARS-CoV-2, a common cold coronavirus, respiratory syncytial virus…
Cancer ranks as a leading cause of death in every country in the world, and, for the first time, female breast cancer is the most commonly diagnosed cancer, overtaking lung cancer, according to a collaborative report, Global Cancer Statistics 2020, from the American Cancer Society (ACS) and the International Agency for Research on Cancer (IARC). Data show that 1 in 5 men and women worldwide…
A team of scientists at the National University of Singapore (NUS) led by Dr Polly Leilei Chen from the Cancer Science Institute of Singapore and Yong Loo Lin School of Medicine has discovered a previously unknown mechanism of cancer formation, the understanding of which may lead to more effective treatment. Their findings concern a process called RNA editing. The DNA code of a gene gets…
Olympus Corporation announced the launch of Endo-Aid, a platform powered by artificial intelligence (AI) that includes the endoscopy application Endo-Aid CADe (computer-aided detection) for the colon. This new AI platform enables real-time display of automatically detected suspicious lesions and works in combination with Olympus’ recently introduced EVIS X1, its most advanced endoscopy system…
Setting up ‘COVID-19 free’ hospital areas for surgical patients could save lives during the second wave of the pandemic – reducing the risk of death from lung infections associated with coronavirus, a new global study reveals. Researchers working together in Brazil and beyond found that that patients who had their operation and hospital care in ‘COVID-19 free’ areas had better outcomes.…
A ‘pill on a string’ test can identify ten times more people with Barrett’s oesophagus than the usual GP route, a new study shows. The test, which can be carried out by a nurse in a GP surgery, is also better at picking up abnormal cells and potentially early-stage cancer. Barrett’s oesophagus is a condition that can lead to oesophageal cancer in a small number of people. It’s usually…
Death rates from prostate cancer are predicted to fall in 2020 in the EU, largely due to better diagnosis and treatment, according to new research published in the leading cancer journal Annals of Oncology. In the latest predictions for cancer deaths in the EU for 2020, researchers led by Carlo La Vecchia (MD), Professor at the School of Medicine, University of Milan (Italy), show that since 2015…
Aspirin is associated with a reduction in the risk of developing several cancers of the digestive tract, including some that are almost invariably fatal, such as pancreatic and liver cancers.
Researchers have developed the first blood test that can accurately detect more than 50 types of cancer and identify in which tissue the cancer originated, often before there are any clinical signs or symptoms of the disease. In a paper published in the leading cancer journal Annals of Oncology, the researchers show that the test, which could eventually be used in national cancer screening…
One of the causes of breast cancer may be inflammation triggered by harmful bacteria say researchers. Scientists say their idea – as yet unproven – is supported by the available evidence, which is that bacterial induced inflammation is linked to cancer. The paper in the journal Medical Hypotheses is by Lancaster University medical student Auday Marwaha, Professor Jim Morris from the…
A team of researchers from the National University of Singapore (NUS) has discovered a new personalised tool to detect cancer, predict patient survivability and how well a cancer patient would respond to immunotherapy. This tool is a specially-designed cancer 'scorecard' to be used with the standard blood test for cancer (also known as liquid biopsy). This 'scorecard', which the team termed as…
Patients with colorectal cancer have a greater chance of survival if they are operated in hospitals with a high case load. This is because complications that can occur after surgery can be better managed there. Tumours of the colon, so-called colorectal carcinomas, are the second to third most frequent tumours in women and men in Germany. The surgical removal of the tumours is a central component…
A study led by scientists from Cornell University provides important new insights into a common and deadly type of gastric cancer. Incidence of this cancer, called gastric squamous-columnar junction (SCJ) cancer, also known as gastroesophageal cancer, rose 2.5 times in the United States between the 1970s and 2000s, while cases of all gastric cancers have decreased by more than 80% since the…
More than one in ten cancer patients do not die from their cancer but from heart and blood vessel problems instead, according to new research published in the European Heart Journal. For some cancers, like breast, prostate, endometrial, and thyroid cancer, around half will die from cardiovascular disease (CVD). Dr Nicholas Zaorsky, a radiation oncologist, and Dr Kathleen Sturgeon, an assistant…
The results of a major study across 195 countries, presented at UEG Week Barcelona 2019, indicate that global death rates for pancreatic cancer and incidence rates for colorectal cancer both increased by 10% between 1990 and 2017. The Global Burden of Disease study, is the first to provide comprehensive worldwide estimates of the burden, epidemiological features and risk factors of a number of…
Scientists have uncovered a novel antibiotic-free approach that could help prevent and treat one of the most widespread bacterial pathogens, using nanocapsules made of natural ingredients. Helicobacter pylori is a bacterial pathogen carried by 4.4 billion people worldwide, with the highest prevalence in Africa, Latin America and the Caribbean. Although the majority of infections show no symptoms,…
Targeting medical treatment to an ailing body part is a practice as old as medicine itself. A Band-Aid is placed on a skinned knee. Drops go into itchy eyes. A broken arm goes into a cast. But often what ails us is inside the body and is not so easy to reach. In such cases, a treatment like surgery or chemotherapy might be called for. A pair of researchers in Caltech's Division of Engineering and…
More cancer, more cardiovascular disease: The relaxation of UK industry regulation of salt content in food was – to put it lightly – a very bad idea, say researchers from Imperial College London and the University of Liverpool. They have linked the change in regulation with 9,900 additional cases of cardiovascular disease (CVD), and 1,500 cases of stomach cancer. The researchers analysed the…
Image analysis of prostate cancer is a challenging area for clinicians. The disease shows a low mutation burden compared to melanoma and stomach cancer, for example, making morpho-molecular correlation more difficult, and there is often very low inflammation. With the role of tumour infiltrating lymphocytes in prostate cancer currently unclear – and with the advent of new approaches to prostate…
Changes in certain sections of the genetic material of cancer cells, so-called microsatellites, can provide an important indication of whether immunotherapy may be successful in a patient with stomach or colorectal cancer. Scientists from Uniklinik RWTH Aachen, the German Cancer Research Center (DKFZ), the German Cancer Consortium (DKTK) and the National Center for Tumor Diseases Heidelberg (NCT)…
Engineers have developed a prototype endoscope which they say could cut the cost of manufacture from £80,000 to just £40. The redesigned device has the potential to revolutionise cancer screening in low-to-middle income countries where the cost of equipment makes screening prohibitively expensive. The endoscope is designed to see inside the upper part of the digestive tract for signs of…
The U.S. Food and Drug Administration (FDA) granted accelerated approval to Balversa (erdafitinib), a treatment for adult patients with locally advanced or metastatic bladder cancer that has a type of susceptible genetic alteration known as FGFR3 or FGFR2, and that has progressed during or following prior platinum-containing chemotherapy. Patients should be selected for therapy with Balversa…
A significantly more effective, minimally invasive treatment for pancreatic tumors may be on the horizon, thanks to a new endoscopy tool created in the Penn State Department of Mechanical Engineering. On average, only about 20 percent of pancreatic cancer patients are eligible for a surgical removal of the tumor, which is currently the most-effective treatment option. The location of the pancreas…
Scientists working to bioengineer the entire human gastrointestinal system in a laboratory now report using pluripotent stem cells to grow human esophageal organoids.
Weak, easily broken bones are an epidemic in the United States. They’re often tied to osteoporosis, a disease that causes bones to degenerate over time. This makes them less flexible, more brittle, and easier to break. According to the International Osteoporosis Foundation, more than 44 million Americans aged 50 and older either have or face the threat of developing osteoporosis due to low bone…
The decline in cancer of the intestines – colorectal cancer – is one of the major success stories of the past 30 years in Europe say researchers, as they predict that in 2018 death rates from the disease will continue to fall by around seven per cent compared to 2012. In a study published in the leading cancer journal Annals of Oncology, researchers predict that death rates in the European…
While gastritis and gastric ulcer disease used to be put down to stress and dietary factors, it was discovered in the 1980s that the actual culprit is infection with a bacterium, H. pylori. This pathogen is now classed as a type I carcinogen by the WHO, as it is the major risk factor for development of gastric carcinoma. Attempts to develop a vaccine against H. pylori have been unsuccessful and…
Testing cancer drugs on miniature replicas of a patient’s tumour could help doctors tell in advance which treatments will work, a major new study reports. The exciting new technique involves growing ‘mini tumours’ from biopsy samples – and could help end reliance on trial and error in selecting cancer treatments for patients where genetic tests are not predictive of response. Researchers…
Johns Hopkins Kimmel Cancer Center researchers developed a single blood test that screens for eight common cancer types and helps identify the location of the cancer. The test, called CancerSEEK, is a unique noninvasive, multianalyte test that simultaneously evaluates levels of eight cancer proteins and the presence of cancer gene mutations from circulating DNA in the blood. The test is aimed at…
The Russian biotechnology company Biocad plans to enter the European market with oncological and autoimmune medicines. So far, there are seven molecules in the European portfolio of Biocad. The biosimilar products could be used in treatment of melanoma, breast, stomach, kidney and lung cancer, rheumatoid arthritis, psoriasis and multiple sclerosis.
Columbia University Medical Center (CUMC) researchers have identified cells in the upper digestive tract that can give rise to Barrett’s esophagus, a precursor to esophageal cancer. The discovery of this “cell of origin” promises to accelerate the development of more precise screening tools and therapies for Barrett’s esophagus and esophageal adenocarcinoma, the fastest growing form of…
The Breast International Group (BIG), an international not-for-profit organisation that represents the largest global network of academic research groups dedicated to finding cures for breast cancer, is welcoming three new members in East Asia: the Breast Disease Professional Committee of CMEA (BDPCC), China; the Korean Cancer Study Group (KCSG), South Korea; and the Thai Society of Clinical…
Raising the age limit for routine genetic testing in colorectal cancer could identify more cases of families affected by Lynch syndrome, a condition that accounts for around 5% of all colon cancers, according to new research to be presented at the annual conference of the European Society of Human Genetics.
Children with cancer could be spared dozens of doses of general anaesthesia by projecting a video directly on to the inside of a radiotherapy machine during treatment, according to research presented at the ESTRO 36 conference.
The Technion breathalyzer would give pathology groups and medical laboratories unprecedented ability to support physicians in diagnosing and treating cancers, chronic diseases, and other illnesses.
Endoscopy Devices Market Report, published by Allied Market Research, forecasts that the global market is expected to garner $40,854 million by 2022 from $27,273 million in 2015, registering a CAGR of 5.7% during the period 2016 to 2022. The flexible endoscopes are expected to dominate the global endoscopy devices market. North America is projected to continue its lead, accounting for more than…
Focused ultrasound can effectively destroy tumor cells. Until now, this method has only been used for organs such as the prostate and uterus. At the European Congress of Radiology, Fraunhofer researchers will present a method, developed as part of the TRANS-FUSIMO EU project, that enables focused ultrasound treatment of the liver, an organ that moves while breathing. In the future, this could…
Researchers at Cincinnati Children’s Hospital Medical Center grew functional stomach and intestinal tissues to study diseases and new drugs. They use pluripotent stem cells to generate human stomach tissues in a petri dish that produce acid and digestive enzymes.
An international team of 56 researchers in five countries has confirmed a hypothesis first proposed by the ancient Greeks – that different diseases are characterized by different “chemical signatures” identifiable in breath samples. The findings by the team led by Professor Hossam Haick of the Technion-Israel Institute of Technology Department of Chemical Engineering and Russell Berrie…
Many drug treatments do not work due to their poor ability to reach their intended targets inside patients’ cells. To address this, researchers at Cardiff University’s Schools of Pharmacy and Pharmaceutical Sciences, and Biosciences have designed a highly efficient method to improve the delivery of therapeutic molecules into diseased cells such as those in stomach cancer, breast cancer and…
No self-respecting TV crime series is without a pathologist – but the fictitious pathologist who incessantly solves crimes has little to do with reality.
Scientists from MIPT (Moscow Institute of Physics and Technology), MSU (Moscow State University), and National University of Science and Technology "MISIS" provided an overview of the most promising compounds which can be used as medications for prostate cancer. The article was published in the Journal of Drug Targeting.
It is estimated that half of all cancer patients suffer from a muscle wasting syndrome called cachexia. Cancer cachexia impairs quality of life and response to therapy, which increases morbidity and mortality of cancer patients. Currently, there is no approved treatment for muscle wasting but a new study from the Research Institute of the McGill University Health Centre (RI-MUHC) and University…
‘Health insurers should keep a tighter rein on the quality of endoscopic interventions because, mostly, they represent a gentler alternative to surgery,’ asserts international expert Horst Neuhaus, during an EH interview. Report: Daniela Zimmermann/Juliane Dannert
Clinical trials are under way at two NHS hospitals in England to assess breathalyser technology to detect lung cancer. Phase I clinical trials of a diagnostic breathalyser developed by Cambridge-based Owlstone Ltd have shown accurate identification of 12 lung cancer biomarkers in breath specimens. A Phase II trial is now targeting development of a small, handheld device that can be used in GP…
In certain types of cancer, nerves and cancer cells enter an often lethal and intricate waltz where cancer cells and nerves move toward one another and eventually engage in such a way that the cancer cells enter the nerves.
Iron deficiency and resulting anaemia cause fatal comorbidities worldwide. Despite this, they are generally underestimated. Professor Lothar Thomas, specialist in laboratory medicine at the Central Laboratory in the Frankfurt/Main University Hospital, is seeking more information about new laboratory parameters for diagnosis and monitoring of iron deficiency and iron substitution therapy. The…
The human gut literally teems with microorganisms from at least 1,000 different species that are increasingly considered to be a valuable resource for the prediction, aetiology and prognosis of disease. Due to continual contact with the environment, primarily via food, the gut is susceptible to infection when a virus, parasite or bacterium enters and disrupts normal gut microbiota (or flora).
At the close of the Gastrointestinal Medicine and Surgery meeting in Leipzig, Professor Peter R Galle, Congress President of the German Society for Gastroenterology, Digestive and Metabolic Diseases, spoke with EH about today’s emphasis on interdisciplinary exchange and the need to augment cooperation even further. Report: Chrissanthi Nikolakudi
Scientists at Imperial College in London, United Kingdom, have developed an ‘intelligent knife’ that instantly informs surgeons whether the tissue they are operating on is cancerous.
Israel - Researchers are using breath-test technology to detect volatile organic compounds to tell whether a patient has stomach cancer.
The future will be aesthetic or, put another way, Art meets Science. With this motto, the 43rd Congress of the German Society for Endoscopy and Imaging Procedures e.V., jointly held in Munich with six other specialist associations, demonstrated that aesthetic means the brilliance of images generated by the latest generation of X-ray, CT, MRI and ultrasound equipment.
Simultaneous surgical successes open new perspectives for multiple transplants
Meeting with EH editor Brigitte Dinkloh, Congress Secretary Professor Alexis Ulrich MD (left), Assistant Medical Director at the Clinic for General, Visceral and Transplant Surgery at the University of Heidelberg, outlined the scientific programme, discussed some impressive advances in surgical procedures, and explained why the gathering bears the slogan Surgery in Partnership.
Excising the entire cancer tumour from the stomach prevents relapses. This procedure can now be performed endoscopically. Holger Zorn reports from the Visceral Medicine 2011 Congress in Leipzig.
Sahlgrenska University Hospital provides emergency and basic care for the 700,000 inhabitants of the Gothenburg region. It also provides highly specialised care for the 1.7 million inhabitants in Sweden’s west because, in this country, endoscopic ultrasound examinations are only provided in university hospitals. Thus Sahlgrenska’s physicians receive referrals of difficult diagnostic cases…
There will be nearly 1.3 million deaths from cancer in Europe in 2011 according to predictions from a study published in the cancer journal, Annals of Oncology. The estimates, which have been reached after researchers used for the first time in Europe a new mathematical model for predicting cancer mortality, show a fall in overall cancer death rates for both men and women when compared to 2007.
In 2000, the Israeli firm Given Imaging introduced Video Capsule Endoscopy (VCE), a new technology initially devoted to small bowel examination. Since then, the EndoCapsule from Olympus Japan, MiroCam from IntroMedic Korea and some less advanced devices from China have been introduced as technical competition for some new areas, such as oesophagus or colon.
On this years ECR Siemens Healthcare presents its dedicated MRI breast scanner. With it's pink design it immediately catches the eye on the company's booth. In an interview with EH, Boris Tolkien, Vice President Marketing Magnetic Resonance, Siemens Healthcare pointed out the highlights of the 1.5 Tesla system beyond its colour.
High resolution endoscopy triggers new approaches to the detection and resection of early-stage carcinomas. Zoom, Narrow Band Imaging and HDTV allow significant magnification of the endoscopic image and increasingly detailed rendering of the mucous membrane.
Almost all stomach cancers not related to the heart develop from the stomach ulcer causing bug H. pylori. A Japanese study shows that treatment to eradicate the mikrobe reduces the risk of developing new gastric carcinoma in patients.
Gastric polyps (GP) are typically found incidentally, when upper gastrointestinal (GI) endoscopy is performed for an unrelated indication. Gastric polyps are uncommon and have an incidence of less than one percent. Only rarely do they cause symptoms or other clinical signs.
Artiste is a linear accelerator and CT scanner combined. At the German Cancer Research Centre, a team of scientists led by Professors Wolfgang Schlegel and Uwe Oelfke of the Medical Physics in Radiation Oncology division, contributed substantially to the technical development of the Artiste platform. They report that users will be able to observe and correct the actual position, extension and…
A new American Cancer Society report estimates that there will be over 12 million new cancer cases and 7.6 million cancer deaths (about 20,000 cancer deaths a day) worldwide in 2007. The estimate comes from the first-ever Global Cancer Facts & Figures, the latest addition to the American Cancer Society's family of Facts & Figures publications.
Endoscopic ultrasound (EUS) is the combination of ultrasound and endoscopy, which allows placement of high-frequency transducers close to the intestinal wall and adjacent structures. As EUS enters its third decade, it is used for locoregional staging of many upper gastrointestinal malignancies, including cancers of the oesophagus, stomach, duodenum, ampulla of Vater, extrahepatic bile ducts and…
The interest in using traditional Chinese medicine (TCM) alongside conventional Western medical care has steadily increased among European physicians; it is no longer unusual, for example, for acupuncture to be suggested by a doctor to help fight tobacco addiction, or to ease a persistent musculoskeletal problem.
The well-known Whipple procedure, or pancreaticduodenectomy, recently underwent a transformation due to the skills of Nerijus Kaselis MD, Head of Abdominal and Endoscopic Surgery at Klaipeda District Hospital.
By Professor Horst Neuhaus MD, Head of Internal Medicine at the Evangelical Hospital, Dusseldorf, describes highlights during April's 33rd Congress of the German Society of Endoscopy and Imaging Procedures (DGE-BV).