Adults who had amblyopia (lazy eye) in childhood are more likely to experience hypertension, obesity, and metabolic syndrome as an adult, as well as a higher heart attack risk, finds a new study.
Scientists have pinpointed likely ‘cells-of-origin’, the source cells that can grow into breast cancer, in women carrying a faulty BRCA2 gene who are at high risk of developing the disease.
Having coronary heart disease at a younger age was associated with an increased risk of dementia, Alzheimer’s disease and vascular dementia, a new study finds.
A paper published in Trends in Cancer explains the advantages of RENACER, the world’s first repository of brain metastases live samples, created by researchers at CNIO.
The earlier it starts, the more type 2 diabetes shaves off of a person's life expectancy. For people in their 30s, this can be as much as 14 years less, new research finds.
A genetic test for BRCA1 or BRCA2 gene mutations may drive women to undergo breast cancer surgery, even though their risk might not even be drastically affected by this, a new study finds.
Using data from more than 400,000 individuals, researchers have created a platform for predicting the risk of developing blood cancers such as acute myeloid leukaemia over a 10-15-year period.
What will the future structure for artificial intelligence in health imaging across Europe look like? While the algorithms show great promise in collecting, storing, analysing, and using data to advance healthcare, delegates to a session on the topic at ECR 2023 in Vienna, also heard that it was important for the use of AI to move from research and more toward practical applications for patients.…
Folate-based radiopharmaceuticals can be used in positron emission tomography (PET) imaging to detect folate receptors in brain tumours, researchers from the University of Turku report.
New research suggests that combining blood biomarkers with genomic information more accurately, cost-effectively predicts the risk of developing diseases.
Researchers from the Organoid group (Hubrecht Institute) and UMC Utrecht have developed a biobank with organoids derived from patients with head and neck cancer (HNC).
Wearable devices such as smart watches could be used to detect a higher risk of developing heart failure and irregular heart rhythms in later life, suggests a new study led by researchers from University College London (UCL).
A new study led by the University of Edinburgh has identfied areas of the brain susceptible to damage from high blood pressure, affecting memory loss, thinking skills and dementia.
A pioneering new method to assess the quality of organs for donation has the potential to revolutionise the transplant system, saving lives and tens of millions of pounds.
In a promising study, Canadian researchers have shown for the first time in mice that modifying intestinal flora before surgery could reduce postoperative complications in colorectal cancer patients.
A collaborative study has defined five new subgroups of the most common type of blood cancer, chronic lymphocytic leukaemia (CLL), and associated these with clinical outcomes.
Two-dimensional (2D) cultured cell lines and animal models have been the principal research tools for the past decade, but have several shortcomings. Three-dimensional cell cultures, or organoids, show great promise here.
Around one in 500 men could be carrying an extra X or Y chromosome – most of them unaware – putting them at increased risk of diseases such as type 2 diabetes, atherosclerosis and thrombosis.
Scientists have discovered a means of identifying the risk of breast and ovarian cancer by measuring epigenetic changes in cervical samples from over a thousand women.
Researchers at King's College Hospital and Queen Mary University of London have shown that a new computer-based algorithm can rank drugs used to treat primary liver cancer, based on their efficacy in reducing cancer cell growth.
The impact of the coronavirus pandemic on lung cancer patient care across Europe, and the contribution lung pathologists, have led to a better understanding of Covid-19, as outlined during the 33rd European Congress of Pathology, Within ‘The lung pathologist in the Covid-19 pandemic’ session, speakers detailed how the pandemic has affected patients, diagnosis and clinical trials, yet also…
Some blood lipid biomarkers linked to cardiovascular disease risk are also associated with a lower risk of amyotrophic lateral sclerosis (ALS) suggest the findings of a large epidemiology study. ALS is the commonest form of motor neuron disease - a progressive nervous system disease that destroys nerve cells responsible for voluntary movement such as walking and talking.
In a new study, researchers at Lund University and Uppsala University have seen a clear connection between how long a person sleeps and a number of biomarkers linked to cardiometabolic diseases such as cardiovascular disease and type 2 diabetes.
People who work night shifts are at increased risk of developing an irregular and often abnormally fast heart rhythm called atrial fibrillation (AF), according to research published in the European Heart Journal. The study is the first to investigate the links between night shift work and AF. Using information from 283,657 people in the UK Biobank database, researchers found that the longer and…
Scientists are using artificial intelligence (AI) and the Cambridge-1 supercomputer to synthesise artificial 3-D MRI images of human brains and create models that show disease states across various ages and genders. The Synthetic Brain Project is focused on building deep learning models which have been developed by King’s College London (KCL) and NVIDIA data scientists and engineers as part of…
Uppsala University scientists have designed a new mouse model that facilitates study of factors contributing to the progression of human bladder cancer and of immune-system activation when the tumour is growing. Using this model, they have been able to study how proteins change before, while and after a tumour develops in the bladder wall. The study has now been published in the scientific…
A new generation of tissue microarrays are delivering more efficient and time-effective solutions to answering complex clinical and scientific questions. Sitting at the core of this new approach is digital pathology, allowing specific and targeted analysis of small areas of tissue.
Healthcare workers are 7 times as likely to have severe Covid-19 infection as those with other types of ‘non-essential’ jobs, finds research focusing on the first UK-wide lockdown. And those with jobs in the social care and transport sectors are twice as likely to do so, emphasising the need to ensure that essential (key) workers are adequately protected against the infection, say the…
Higher than normal blood pressure is linked to more extensive brain damage in the elderly, according to a new study published in the European Heart Journal. In particular, the study found that there was a strong association between diastolic blood pressure (the blood pressure between heart beats) before the age of 50 and brain damage in later life, even if the diastolic blood pressure was within…
This year, the MEDICA LABMED FORUM will offer a high-profile programme with top speakers which is free for registered online visitors.
A study of almost 400,000 British participants has identified a new link between raised levels of the growth factor IGF-1 and increased thyroid cancer risk and has confirmed associations with breast, prostate and colorectal cancer. This could lead to new preventative strategies, including diet and lifestyle interventions.
Bacteria and other microorganisms in the digestive tract are linked with dozens of health conditions including high blood pressure, high blood lipids, and body mass index (BMI) according to research presented at ESC Congress 2020. “Our study indicates that microbiota might have an important role in maintaining health and could help us develop novel treatments,” said study author Dr. Hilde…
More than 73,000 users collaborate on new online platform set up by the European Open Science Cloud Initiative, where scientists share COVID-19 data and accelerate our understanding of the virus to help develop treatments and vaccines quicker.
Why does every person react differently to an infection with the coronavirus SARS-CoV-2? Why do some people have no symptoms or only mild symptoms of COVID-19, the disease which it causes? And why do some people become so severely ill that they require ventilators or even die? These questions are being investigated by Professor Mascha Binder, director of the Department of Internal Medicine IV at…
A growth hormone called insulin-like growth factor-1 (IGF-1) is likely to play a role in the development of breast cancer, according to new research published in the leading cancer journal Annals of Oncology. IGF-1 is already known to encourage the growth and proliferation of cancer cells. Now, two analyses of information from several hundred thousand women enrolled in the UK Biobank study have…
The advent of digital pathology is helping to address some of the challenges surrounding tissue microarrays as they are integrated into the digital workflow, in some ways giving them ‘a new lease of life’, according to Professor Inti Zlobec, who spoke at the Digital Pathology and AI Congress in London last December. As Head of the Translational Research Unit at the Institute of Pathology,…
The Queen Mary University of London team applied an artificial intelligence (AI) technique to analyse the heart MRI images of 17,000 healthy UK Biobank volunteers. They found that genetic factors accounted for 22-39 per cent of variation in the size and function of the heart’s left ventricle, the organ’s main pumping chamber. Enlargement and reduced pumping function of the left ventricle can…
When it comes to genetics, Estonia is considered a trailblazer, as the ambitious Estonian Genome Project (Eesti Geenivaramu) shows. Its objective is to test the genome of every citizen for the risk of diseases. Dr Jaanus Pikani talks about the initial difficulties which the genome project encountered and about its potential for Estonian – and possibly worldwide – healthcare.
La Fe University and Polytechnic Hospital in Valencia, Spain, is coordinating EU-funded program PRIMAGE, which uses precision information from medical imaging to advance knowledge of the most lethal paediatric tumours, by establishing their prognosis and expected treatment response using radiomics, imaging biomarkers and artificial intelligence (AI).
Genes alone cannot be used to determine an individual’s sexual orientation. A study published in the journal Science found only five out of hundreds of thousands genetic variants occurred somewhat more often in people who had had same-sex partners. This suggests human sexuality is influenced by a complex mix of genetic and environmental factors, according to the researchers. The study is based…
Fourteen metabolic biomarkers can predict long term mortality in individuals helping to determine life expectancy in general populations, a new study in the journal Nature Communications reports. In the largest study of its kind, researchers from Leiden University Medical Center in the Netherlands and the University of Surrey investigated predictors of long-term mortality risk. Current predictors…
A genetic mutation that a Chinese scientist attempted to create in twin babies born last year, ostensibly to help them fend off HIV infection, is also associated with a 21% increase in mortality in later life, according to an analysis by scientists from UC Berkeley. The researchers scanned more than 400,000 genomes and associated health records contained in a British database, UK Biobank, and…
Having a genetic predisposition to high testosterone levels could play a role in the development of major heart problems in men, such as blood clots and heart failure, finds a study published by The BMJ. The findings may also have implications for men who take testosterone supplements to boost energy levels and sex drive. Some evidence suggests that genetically predicted (“endogenous”)…
It is non-invasive, delivers a chance of early diagnosis, prognostic information and sequential monitoring, and, believes Professor Francesco Salvatore, the enormous potential of liquid biopsies has still to be reached. However, the positive results obtained so far have ‘opened the door to a promising new multi-faceted group of tumour markers, at present collectively designated “liquid…
As in many other countries, Belgium faces a significant shortage of health professionals – particularly pathologists to guarantee the diagnostic quality necessary for adequate therapeutic choice. A digital pathology platform can be a true ally; the Brussels Erasmus Hospital opted for that solution. Project manager Dr Ali Ramadhan shared his experience – the good, the bad and the ugly – at…
Around one percent of people infected with HIV produce antibodies that block most strains of the virus. These broadly acting antibodies provide the key to developing an effective vaccine against HIV. Researchers from the University of Zurich and the University Hospital Zurich have now shown that the genome of the HI virus is a decisive factor in determining which antibodies are formed.
The fact that genetic research can reveal hereditary diseases has been transferred to medical practice for some time and, since 2010, the Gene Diagnostics Act (GenDG) has regulated permissible DNA tests in medical diagnostics and pedigree in Germany. The procedure has great potential, says Professor Jochen Taupitz - but also great risks are associated with it.
People who consume an egg a day could significantly reduce their risk of cardiovascular diseases compared with eating no eggs, suggests a study carried out in China, published in the journal Heart. Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, including China, mostly due to ischaemic heart disease and stroke (including both haemorrhagic and ischaemic…
The idea that it might be possible to be overweight or obese but not at increased risk of heart disease, otherwise known as the “obesity paradox”, has been challenged by a study of nearly 300,000 people published in in the European Heart Journal.
Population imaging is key to determining disease prediction and risk prevention, and Big Data will be key to extracting information and drawing analysis from imaging results, experts highlighted during the annual meeting of the European Society of Magnetic Resonance in Medicine and Biology (ESMRMB) held in Barcelona in October. Interest in cohort studies has been increasing over the years and…
People living within a kilometre of physical activity facilities, such as gyms, swimming pools and playing fields, have smaller waist circumferences, lower BMI and lower body fat percentages than people who have no nearby exercise facilities, according to an observational study published in The Lancet Public Health. Living further away from a fast food outlet was also weakly associated with a…
Scientists are honing in on a potential treatment for osteoporosis, after performing the largest ever genetic study of the common age-related bone-thinning disease.
In the nineties Deep Blue, the famous chess computer, defeated Kasparow. Only a year ago Google’s Deepmind managed to master the ancient Chinese Go, known for its utmost complexity.
A new study suggests that middle-aged people who report that they are slow walkers could be at higher risk of heart disease compared to the general population.
Pancreatic cancer is one of the most deadly types of malignancies, with a 5-year survival rate after late diagnosis of only about 5%. The majority of patients—about 80%—receive their diagnosis too late for surgery. The disease spreads quickly and resists chemotherapy. In short, there is an urgent need for diagnostic tools to identify this cancer in its earliest stages.
Visiopharm A/S announces the first result of their multifaceted strategy to apply Deep Learning technologies to its leading image analysis solution for cancer research and diagnostics. Visiopharm considers Deep Learning an important technological breakthrough for tissue pathology that offers the potential to make a real difference in the assessment of tissue structures, which is probably one of…
By definition, biobanks are collections of specimens of human bodily substances, such as tissue, cells, DNA, proteins, blood or other fluids, with data on the donor attached.
Structured reporting in radiology is easier to say than do. Initially radiologists must agree on the structure of the report itself. Then they need to agree on what to report. Those two very different challenges help to explain why migration into the Digital Age of radiology reports is moving at Ice Age speed.
n type 1 diabetes, the body attacks its own insulin-producing cells. Scientists at Helmholtz Zentrum München, partner in the German Center for Diabetes Research, and their colleagues at Technical University of Munich have now reported in the journal ‘PNAS’ about a mechanism used by the immune system to prepare for this attack. They were able to inhibit this process through targeted…
Our knowledge of causes and mechanisms of current and future diseases is on ice – not the perpetual ice of the polar caps but artificial ice. It is stored in biobanks at -80 to -160 °C.
Scientists at the University of British Columbia and Vancouver Coastal Health have proven that multiple sclerosis (MS) can be caused by a single genetic mutation – a rare alteration in DNA that makes it very likely a person will develop the more devastating form of the neurological disease.
Healthcare is going digital. No doubt about it, Prof. Hufnagl predicts. Information and communication technologies have gone beyond moving data from one place to the other; they are triggering stellar improvements in healthcare: diagnoses are becoming ever more precise, therapies ever more personalised. The extent to which the individual clinical disciplines have progressed in their technological…
Personalised medicine relies strongly on biobanking in which medical data are collected on a large scale. Large scale refers both to the amount of data collected per patient as well as to the large number of patients included in the data collection. Although most attention in biobanking has been given to genetic data, proteomics, metabolomics and other –omics technologies, imaging is also being…
The European Society of Radiology (ESR) and the Biobanking and Biomolecular Resources Research Infrastructures – European Research Infrastructure Consortium (BBMRI-ERIC) announce the beginning of an official collaboration.
ECR 2015 evoked Shakespeare´s repertoire as delegates were asked to ponder the ethical implications of incidental findings in large population imaging studies in Vienna. Report: Mélisande Rouger
The fourth Management in Radiology (MIR) Symposium to be held during the ECR will focus on key issues in the profession, including quality and safety.
Integration of imaging biomarkers in Europe is a challenge, and a number of issues must be overcome so that the full potential of quantitative imaging can be realised, renowned researchers will show in a session today at the ECR.
During an exclusive European Hospital interview, in the run up to ECR 2015, Professor Lluís Donoso-Bach MD PhD, incoming President of the European Society of Radiology (ESR), outlines his plans to tackle challenges facing radiology in Europe – and anticipates a brighter future in Spain.
Researchers at the Hubrecht Institute and the University Medical Center (UMC) Utrecht successfully developed a culturing system for human liver stem cells as well as stem cells from pancreatic cancer. They describe the development of these culturing systems in two articles in this week’s edition of Cell magazine.
Patients are no longer content to be passive recipients of medical care, and are instead taking a more active role in their treatment, says Kathy Oliver, Chair co-director of the International Brain Tumour Alliance (IBTA). Report: Frank Swain
Radiologists, EU policy makers and medical industry in drive to strengthen collaboration on personalised medicine
While clinical labs and lab IT solutions appear to be able to meet current requirements, biobanking presents a whole new world of challenges to data flows and IT systems. Report: Michael Reiter
Held every three years, a very important healthcare IT event is to be held in Europe after a gap of 14 years. From November 15-19, healthcare managers and suppliers from 37 countries will arrive in Milan to discuss the future of world’s electronic health services at the 16th Congress of IFHRO (International Federation of Health Records Organisations), held in collaboration with the WHO.
Ten years ago, molecular biologist Dr Peter H J Riegman set up a unique bio-bank for medical research at the pathology department of Erasmus Medical Centre, Rotterdam, The Netherlands. The Erasmus MC Tissue Bank now holds 30,000 samples from about 15,000 patients. However, when Dr Riegman discusses his bio-bank with international colleagues they do not immediately associate it with a clinic or…
Researchers from University Hospital in Umea, Sweden, have identified several cytokines, cytokine-related factors, and chemokines that increase significantly prior to rheumatoid arthritis (RA) disease onset. These findings confirm those of earlier studies which suggest that the risk of developing RA can be predicted and disease progression may be prevented. Complete findings of this study are…
Hunt Biobank, Norway's biggest research biobank, is using Thermo Fisher Scientific Inc's Nautilus LIMS in its HUNT 3 study, to gather, store, manage, track and retrieve the biological data of approximately 100,000 people from Nord-Trøndelag County.
This was the motto of the ECR 2007 in Vienna, where a group of high-ranking experts discussed diseases of the 21st century; research competition between the US and Europe; the conditions needed to progress leading medical R&D - moderated by Congress President Professor Christian J Herold.