In many cases, metastatic breast cancer is still incurable. To improve the odds, researchers have now analyzed the diversity of metastatic cells and their interactions with their cellular environment.
A crucial component in joints, cartilage is notoriously difficult to repair. Now, US researchers have developed a promising bioactive material to regenerate cartilage in knee joints.
A band-aid for the heart? US researchers have developed a new way to 3D print material that is at once elastic, tough, and shapable enough to fit a patient’s unique heart or joint defects.
US researchers applied an injectable new therapy, which harnesses fast-moving “dancing molecules,” to repair damaged human cartilage cells within just 4 hours.
Enzyme-driven nanorobots could be used in the treatment of joint diseases such as arthritis. A new research project explores the potential of this technology.
A whole-body MRI scanner with a compact 0.05 Tesla permanent magnet has been developed that operates on a standard wall power outlet without radiofrequency or magnetic shielding cages.
Patients suffering from cartilage defects in the knee may benefit from a new method in development: Using cartilage from the nose, researchers grow a tailor-made implant.
Material scientists at TU Wien (Vienna) have developed a new approach to producing artificial cartilage tissue: using a 3D printer, cells are grown in microstructures.
Contraception, wound healing, arthritis treatment: Here are three recent papers published in ACS journals that could expand the beneficial uses for nanoparticles, based on results in rats.
AI features for automation, integrated systems and more: the role of medical technology has never been as vital as today, and MedTech companies from Taiwan are putting their best foot forward to contribute. At the 2023 Medica trade fair, visitors of the Taiwanese pavilion not only had the opportunity to see the latest medical products on display, but also get acquainted with Taiwanese culture in…
Surgery to straighten a crooked septum (the thin wall of bone and cartilage dividing the space between the two nostrils) is more effective than nasal sprays, a new study suggests.
When a woman becomes pregnant, sometimes her pre-existing rheumatoid arthritis will 'magically' go away. In others, the condition becomes even worse. Now, US researchers may have found an explanation.
A gel that combines both stiffness and toughness is a step forward in the bid to create biodegradable implants for joint injuries, according to new research from the University of British Columbia.
A Japanese research group has developed a method using iPS cell-derived mesenchymal stem cells (iMSC) to create cartilage spheroids, offering new possibilities for tissue repair.
For young athletes with lateral disc meniscus injuries, a new treatment approach yields promising results, according to researchers from Osaka Metropolitan University.
A custom-made new hip, a knee or maybe a piece of bone? The technology and possibilities for 3D printing are (almost) there. And such an implant from a 3D printer has many advantages, not only for the patient, but also for the surgeon who has to perform the operation. Koen Willemsen, physician, and medical engineer at the University Medical Center Utrecht (UMCU), was at the cradle of the 3D lab…
A research team has created the first gel-based cartilage substitute that is even stronger and more durable than the real thing, offering a promising solution for patient suffering from knee pain.
Researchers have established an injectable hybrid inorganic nanoscaffold-templated stem cell assembly and applied it to the regeneration of critically-sized cartilage defects.
Researchers at the Skolkovo Institute of Science and Technology (Skoltech) led by Professor Dylov and their colleagues from First Pavlov State Medical University of St. Petersburg, Russia, have developed a brand-new approach to the task of 3D image segmentation — figuring out the contours of the constituent parts in a complex structure. While their so-called negative volume segmentation…
Researchers at the University of Southampton have invented a new way to generate human cartilage tissue from stem cells. The technique could pave the way for the development of a much-needed new treatment for people with cartilage damage. Cartilage acts as a shock absorber in joints, but it is susceptible to damage through daily wear-and-tear, or trauma from sports injuries and falls.
Cartilage cells from the nasal septum can not only help repair cartilage injuries in the knee, they can also withstand the chronic inflammatory tissue environment in osteoarthritis and even counteract the inflammation – according to researchers from the University of Basel and the University Hospital Basel.
Joint cartilage usually regenerates very poorly. The matrix of cartilage (scaffolding) contains very few cells in deep layers. Moreover, joint cartilage is highly isolated: there are neither regenerative cells in the immediate vicinity that could migrate into the site of the defect and trigger repair, nor vessels that could transport regenerative cells to the cartilage. Unsurprisingly,…
Anyone needing a tomography gets the clearest possible images of an organ or other body structure slice by slice. But the further inside the potential problem lies, the more difficult it is to obtain high-resolution images in magnetic resonance imaging (MRI). An international team of scientists led by the University of Duisburg-Essen (UDE) has developed a high-frequency coil that allows for much…
Osteoarthritis affects more than 30 million adults and is the fifth-leading cause of disability in the United States. In a new study, scientists have discovered the cellular pathway that leads to the joint disease and have identified a commonly used anti-depressant — paroxetine — that inhibits this pathway.
There is currently no cure for osteoarthritis, but a group of scientists believe they’ve discovered a method through which a simple knee injection could potentially stop the disease’s effects. These researchers showed that they could target a specific protein pathway in mice, put it into overdrive and halt cartilage degeneration over time. Building on that finding, they were able to show that…
Researchers have designed a fluid that works like a luminous ink to obtain very sharp images of damaged tissues, organs and cartilages in diagnostic tests. This new compound, still in the laboratory phase, reduces adverse effects on the human body because it allows lower amounts to be injected and the dose to be targeted only at the affected area.
An algorithm that analyses MRI images and automatically detects small changes in knee joints over time could be used in the development of new treatments for arthritis. A team of engineers, radiologists and physicians, led by the University of Cambridge, developed the algorithm, which builds a three-dimensional model of an individual’s knee joint in order to map where arthritis is affecting the…
Contrary to popular belief, cartilage in human joints can repair itself through a process similar to that used by creatures such as salamanders and zebrafish to regenerate limbs, researchers at Duke Health found. This process could be harnessed as a treatment for osteoarthritis. Publishing in the journal Science Advances, the researchers identified a new mechanism for cartilage repair.
Researchers at Lund University in Sweden have investigated the link between osteoarthritis and mortality in an epidemiological study. It was shown that the risk of dying from cardiovascular disease was higher for people with osteoarthritis than for the rest of the population. Using population registers, the researchers studied approximately 469 000 people living in Skåne, Sweden, who in 2003…
Two millions: this is, worldwide, the number of babies which suffer suffocation during birth every year. A resuscitation procedure is sometimes the key to avert irreparable damages for the baby. And, for successful outcomes, promptness of action and preparation are vital. Researcher Mark Thielen (Industrial Design) from the Eindhoven University of Technology (TU/e) developed a 3D printed baby…
The future of medicine is biological – and scientists hope we will soon be using 3D-printed biologically functional tissue to replace irreparably damaged tissue in the body. A team of researchers from the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB has been working with the University of Stuttgart for a number of years on a project to develop and optimize suitable…
Hackers can access a patient's 3-D medical scans to add or remove images of malignant tumors, thus placing patients at risk of misdiagnoses. The new study, published by Ben-Gurion University of the Negev cybersecurity researchers, showed that the altered scans successfully deceived both radiologists and artificial intelligence algorithms used to aid diagnosis. A 3-D CT (computerized…
AI has made an extraordinary qualitative jump, particularly in machine learning. This can help quantify imaging data to tremendously advance both pathology and radiology. At a recent meeting in Valencia, delegates glimpsed what quantitative tools can bring to medical imaging, as leading Spanish researcher Ángel Alberich-Bayarri from imaging biomarker company Quibim unveiled part of his work.
Magnetic resonance imaging (MRI) exams of the knee are essential to orthopedic surgeons for diagnosing the cause of symptoms in patients with knee pain and planning arthroscopic treatment. Yet the surgeons who treat patients based on knee MRIs and the radiologists who interpret those knee MRIs often work in their own silos of specialization, rarely communicating and sharing information, according…
Scientists from the German Cancer Research Center (DKFZ) and the stem cell institute HI-STEM* have succeeded for the first time in directly reprogramming human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur during the early embryonic development of the central nervous system. They can be modified and multiplied indefinitely…
The ability to accurately check the position of the endotracheal tube for patients in intensive care units is crucial to their wellbeing and safe treatment. A pivotal element of this lies in identifying the position of the carina, a ridge of cartilage in the trachea that occurs between the division of the two main bronchi. Yet highlighting its location often proves problematic on portable chest…
The CRISPR genome editing technique promises to be a "transformative leap" in genetic engineering and therapy, affecting almost every area of medicine. That includes plastic surgery, with potential advances ranging from prevention of craniofacial malformations, to therapeutic skin grafts, to new types of rejection-free transplants, according to a paper in the November issue of Plastic…
Anyone with arthritis can appreciate how useful it would be if scientists could grow cartilage in the lab. To this end, Keck School of Medicine of USC scientists in the USC Stem Cell laboratory of Denis Evseenko, MD, PhD, collaborated with colleagues at several institutions to provide new insights into how gene activity drives the development of cartilage. Their findings appear in Nature…
It’s not unusual for your body to make “popping” or “cracking” sounds as you lean over, twist or reach for something. Fortunately, it’s also typically not a cause for worry. Dr. Aman Dhawan, an orthopedic sports medicine specialist at Penn State Health Milton S. Hershey Medical Center, said complaints about such joint sounds are common, but are usually nothing to be concerned about.…
Will there come a time when a patient with arthritis can forgo joint replacement surgery in favor of a shot? Keck School of Medicine of USC scientist Denis Evseenko, MD, PhD, has reason to be optimistic. In a new publication in the Annals of Rheumatic Diseases, Evseenko’s team describes the promise of a new molecule aptly named “Regulator of Cartilage Growth and Differentiation,” or RCGD…
Macrophage cells routinely remove dead or dying cells to maintain the body homeostasis. Such removal becomes crucial after serious injury, especially the repair of dead heart muscle after a heart attack. University of Alabama at Birmingham researchers have preliminary data, with cultured cells or diabetic hearts, that diabetes impairs this removal of dead heart-muscle cells. They believe this…
Tissue engineering, broadly described as the combination of cells, engineering methods and biochemical factors to create living biological tissue, is a fast-growing field that has the potential to significantly accelerate the advancement of medicine. In IDTechEx’s new report, Tissue Engineering 2018 – 2028: Technologies, Markets, Forecasts, the market for engineered living tissues is…
Could a new weapon in the fight against arthritis be found somewhere beyond the sea? New research from Switzerland encourages this idea.
A research team found that in patients suffering from rheumatoid arthritis, a special cell population called innate lymphoid cells are in a state of hibernation which is why these patients suffer from persistent inflammation.
There hasn't been a gold standard for how orthopedic spine surgeons promote new bone growth in patients, but now Northwestern University scientists have designed a bioactive nanomaterial that is so good at stimulating bone regeneration it could become the method surgeons prefer.
A team of researchers at Sahlgrenska Academy has managed to generate cartilage tissue by printing stem cells using a 3D-bioprinter. The fact that the stem cells survived being printed in this manner is a success in itself. In addition, the research team was able to influence the cells to multiply and differentiate to form chondrocytes (cartilage cells) in the printed structure.
Osteoarthritis is a debilitating condition that affects at least 27 million people in the United States, and at least 12 percent of osteoarthritis cases stem from earlier injuries. Over-the-counter painkillers, such as anti-inflammatory drugs, help reduce pain but do not stop unrelenting cartilage destruction. Consequently, pain related to the condition only gets worse.
When Ferdinando Draghi, M.D. speaks, the world of ultrasound listens carefully. The Editor-in-Chief of the Journal of Ultrasound, the author of 90 publications that have been cited in other peer-reviewed publications hundreds of times, Dr. Draghi is widely known for his authoritative knowledge in diseases affecting the musculoskeletal (MSK) system.
Cold plasma looks like the glow from the “Star Wars” blue light saber but this beam of energy, made of electrons that change polarity at micro-second or nanosecond speeds, could help bones heal faster, according to researcher from the Thomas Jefferson University.
With a goal of treating worn, arthritic hips without extensive surgery to replace them, scientists have programmed stem cells to grow new cartilage on a 3-D template shaped like the ball of a hip joint. What’s more, using gene therapy, they have activated the new cartilage to release anti-inflammatory molecules to fend off a return of arthritis. The technique was demonstrated in a collaborative…
A new technique developed by Gordana Vunjak-Novakovic, the Mikati Foundation Professor of Biomedical Engineering at Columbia Engineering and professor of medical sciences (in Medicine) at Columbia University, repairs large bone defects in the head and face by using lab-grown living bone, tailored to the patient and the defect being treated. This is the first time researchers have grown living…
Emergency medicine requires smooth, patient-oriented and perfectly timed cooperation of several clinical disciplines.
‘In imaging there is a trend towards quantification,’ said Professor Siegfried Trattnig, Medical Director of the High-Field MR Centre (HFMRC) at the Medical University Vienna, Austria. Whilst before, radiologists’ findings were subjective, qualitative results, based on signal intensity and grey scale, he pointed out. ‘Today imaging can draw on quantifiable and comparable parameters with…
In an effort to develop a method for cartilage tissue engineering, researchers at Umeå University in Sweden successfully used cartilage cells from cow knee joints. By creating a successful method with conditions conducive to growing healthy cartilage tissue, the findings could help lead to a new treatment cure for osteoarthritis using stem cell-based tissue engineering. This is according to a…
When surgical residents need to practice a complicated procedure to fashion a new ear for children without one, they typically get a bar of soap, carrot or an apple. To treat children with a missing or under-developed ear, experienced surgeons harvest pieces of rib cartilage from the child and carve them into the framework of a new ear. They take only as much of that precious cartilage as they…
Knee injuries are the bane of athletes everywhere, from professionals and college stars to weekend warriors. Current surgical options for repairing damaged cartilage caused by knee injuries are costly, can have complications, and often are not very effective in the long run. Even after surgery, cartilage degeneration can progress leading to painful arthritis. But a University of Iowa orthopedics…
Genetically engineered fibers of the protein spidroin, which is the construction material for spider webs, has proven to be a perfect substrate for cultivating heart tissue cells, MIPT researchers found. They discuss their findings in an article that has recently come out in the journal PLOS ONE.
At last year’s ECR Toshiba introduced the Vantage Elan 1.5 Tesla system with a lot of innovative features and new techniques, making it a pleasant and helpful new workhorse for small and large clinics. Since this introduction, the Vantage Elan has seen fantastic success in Europe because of the outstanding clinical and economic benefits it brings with advance technologies. The Elan offers…
In many practices and hospitals the X-ray systems need to be modernised. Increasingly, physicians opt for digital radiography (DR) systems, as did Dr Joachim Münch and Dr Dennis Völker who run an orthopaedic and surgical practice in Winsen an der Luhe, Germany.
How does spectral – or dual energy – imaging work? Very similar to red and green light used in black-and-white photography. A black-and-white camera provides information on the colours of the photographed objects: an object that is black under red light is actually green.
Although traditionally exporting timber and machinery, today Finland has established itself as a producer of high-tech products. This includes innovative medical technology.
Countries vary considerably in the number of cases in which artificial knee joints are employed, according to researchers from the Medical University of Graz (Austria) reporting at the EFORT Congress in Istanbul.
Surgical Innovations Clinical Advisory Board member and Harrogate hip surgeon Mr Jon Conroy has today commented on how Lady Gaga’s imminent surgery will help raise the worldwide profile of pioneering minimally invasive hip surgery.
The Robert Koch Foundation congratulates Professor Shinya Yamanaka, the 2008 Robert Koch Award laureate, on being awarded this year’s Nobel Prize in Physiology or Medicine. The award to Yamanaka brings the number of Robert Koch Foundation laureates to receive a Nobel Prize to 11 since 1962.
Modern medical technology is evidently held in high esteem by the general population. In a recent survey conducted by the market research institute Emnid commissioned by the industry association SPECTARIS, about 80% of the patients surveyed said that under certain circumstances they would be willing to pay more for their health insurance in return for consistent treatment with state-of-the-art…
Comprehensive additional training is necessary in Germany, to specialise in paediatric radiology, and only seven among the country’s 35 university hospitals provide paediatric radiology professorships. Thus, there are only about 80 specialists in this field and very few work in private practice
A little over three decades after the world's first human heart transplant (HT), Carmat’s life-size artificial heart, a mix of animal tissue, titanium and missile technology that perfectly replicate a human heart, might save the lives of thousands.
Stroke, breast cancer detection, sports medicine – the clinical programme is an impressive illustration of this year’s congress theme: Radiology is diversity. Florian Schneider asked the joint congress Presidents, Professor Bernd Hamm (Berlin) and Professor Walter Hruby (Vienna) to highlight the major topics at this, the largest medical imaging event (attendance around 7,000) in the…
Pushing the power of scanners creates new world for imaging, but whilst high-field magnets bring new capabilities they also pose new challenges for clinicians. John Brosky reports
Vienna - For the 23rd time, the European Congress of Radiology (ECR) is opening its doors to welcome 19,000 participants from over 90 countries. The scientific exchange of knowledge and the presentation of the latest developments in the field of radiology will again be presented right in the heart of Europea. In an inaugural press conference on March 3rd, the hot topics of the congress were…
Advancing magnetic resonance imaging (MRI) up the Tesla scale may sound good, but will it produce the results and patient safety radiologists actually desire? Faced with the question: ‘How many Tesla should it be?’, Professor Siegfried Trattnig MD, head of the Centre of Excellence in high-field MRI at the University Clinic for Radiodiagnostics, Medical University of Vienna, and Austria’s…
Until now, orthopaedic surgeons have had limited options for the treatment of progressive degradation of the knee joints (osteoarthritis) in active patients who require care, but are not yet ready for a total knee replacement. DePuy Orthopaedics EMEA now launches the first complete surgical system Sigma® High Performance Partial Knee, specifically designed to treat progressive osteoarthritis…
Since June 2009, the focus of research in the European Network for Cell Imaging and Tracking Expertise (ENCITE) has been on finding biomarkers to aid cell transplantation. Funded with €11 million from the European Commission (EC), this major project that runs until 2013, involves 10 countries. Their work is coordinated by the European Institute for Biomedical Imaging Research (EIBIR) network,…
Researchers from University Hospital in Umea, Sweden, have identified several cytokines, cytokine-related factors, and chemokines that increase significantly prior to rheumatoid arthritis (RA) disease onset. These findings confirm those of earlier studies which suggest that the risk of developing RA can be predicted and disease progression may be prevented. Complete findings of this study are…
Most of the 30 institutes around the world that work with a 7-Tesla MRI scanner do not focus on answering questions about the clinical benefit of this field strength; their efforts revolve around the brain and neurosciences. One exception is the Erwin L Hahn, at the Institute for Magnetic Resonance Imaging, which is based at the Zollverein Coal Mine Industrial Complex, a World Heritage Site in…
For the past 30 years, in the former USSR and Russia, laser medicine has been actively developed and regular annual conferences have opened new avenues for its use by the country's doctors.
Open MRI not only provides good clinical images for musculoskeletal diagnoses, but also makes it easier to accommodate big-bodied sportsmen.
As in every medical field, children have special needs in radiology. Increasingly aware of this - and just as they must adapt scanners for increasing numbers of obese patients - manufacturers are sharing lively exchanges with practitioners to develop the most advanced equipment available for very small patients. At the Medical University in Graz, Austria, which has taken a lead in this…
'There is no proof that some new procedures are better than the conventional ones or than clinical examination'
In the sixth in his series for European Hospital, Professor Stefan Schönberg (left) of the Institute of Clinical Radiology and Nuclear Medicine (IKRN), University Hospital Mannheim, Medical Faculty of Mannheim, University of Heidelberg, invited colleagues from Mannheim and Vienna for a round-table discussion on:
Osteoarthritis of the knee is a degenerative disease that causes joint pain, stiffness and decreased function. Its frequency increases dramatically with ageing populations. Treatment is multidisciplinary; combinations of pharmacology, physiotherapy and/or surgery are used for most patients.
Advances in the treatment of cartilage injuries to the knee are very noteworthy. The decisive breakthrough must have been the development of the self-resorbing, bilayer collagen membrane (Chondro-Gide) by Geistlich in Switzerland.
According to a study by the German Aerospace Centre, bedsores are mainly induced by a combination of gravity and immobility. Gravity exerts skin pressure and tissue shearing stress, which in turn provoke pathological changes if patient mobility is not encouraged.
As the opening of the Beijing 2008 Olympic Games nears, the US Olympic Committee (USOC) and the General Electric Company (a Worldwide Partner of the Olympic Games) are running two research programmes aimed at demonstrating that health monitoring and early intervention leads to injury prevention and enhanced health and sports performances for athletes.
Apart from spending a year at Johns Hopkins University Hospital, Baltimore, USA, the professor has never worked anywhere other than at the Radiology Department at the University Hospital of Cattinara Hospital, Trieste, of which she is Chairman. Daniela Zimmermann asked her about what women can achieve in this field, as well as the professor's own multifarious roles and research activities.
Faced with meniscus injuries surgeons usually decide to remove the torn meniscal cartilage, which typically leaves the deficient knee vulnerable to future arthritis, because the padding that provides shock absorption and joint stability has been removed, causing bone to rub on bone.
At the RSNA 2006 Siemens Medical Solutions announced it has received 510(k) approval from the U.S. Food and Drug Administration (FDA) for the first of many syngo® Dual Energy applications for the SOMATOM® Definition - the dual source computed tomography (DSCT) system.
The latest textile technologies go along with fabric integrated sensors, or computers, to measure e.g. the functioning of a patient's cardiovascular system.