Integrating bacterial genomic data with detailed human mobility data makes it possible to see how pathogens causing pneumonia and meningitis, move between regions and evolve over time.
Metabolic disorders, renal failure, UTIs, sepsis, poisoning: The higher temperatures climb in summer, the more people are hospitalized, a study shows - with some groups being more at risk than others.
Primary ciliary dyskinesia (PCD) is a rare inherited multi-organ condition, which can lead to inflammation of the airways and infections. Now, scientists have found what causes PCD.
Takotsubo cardiomyopathy (‘broken heart syndrome’) is a known complication of Guillain-Barré, but not much is known about the association between the two. New research aims to change this.
Instead of killing viruses and bacteria with chemical disinfection, a new approach uses minuscule spikes to skewer them. This could be used to prevent surface contamination in hospitals or labs.
Researchers have created a first-of-its-kind immune cell atlas of the developing lung, revealing coordination between the immune and respiratory systems much earlier than previously thought.
New research suggests a new approach to precision radiotherapy can reduce the risk of swallowing problems for patients, without impacting the success of treatment.
Incidence of lung cancer among people who never smoked is rising. A new AI tool opens the door for opportunistic screening for this group, using existing chest X-rays in the electronic medical record.
Should a hospital cover all specialties, or focus to excel at one area? US researchers have assessed the impact of a hospital’s portfolio strategy on patient demand.
Scientists have developed an ingestible device that can safely monitor vital signs like breathing and heart rate from inside humans, providing accessible and convenient care for people at risk of opioid overdose.
The enhanced infection safety measures installed for the Covid-19 pandemic also had a beneficial effect on hospital-acquired infections (HAIs) overall, a new US study suggests.
Scientists at the University of Applied Sciences Krems (IMC Krems) show that CRISPR-Cas9 can also be used to inhibit viruses such as adenoviruses in cell cultures.
French scientists are developing and testing a new vaccine to combat allergic asthma. Their latest study results pave the way for the organization of a clinical trial.
Researchers have developed an inhalable powder that could protect lungs and airways from invasion from the coronavirus or flu viruses by reinforcing the body’s own mucosal layer.
A new study has found that antibodies produced in the nose decline nine months after Covid-19 infection, while antibodies found in the blood last at least a year.
Eunsin Bae, M.D. specializes in laboratory medicine and leads the Institute of Clinical Research at Seegene Inc. Her research focuses on microbiology, molecular biology, and hematology. Dr. Bae is currently working toward implementing a global clinical study and establishing an international network of clinical investigations.
The diminished power of the immune system in older adults is usually blamed on the aging process. But a new study shows that decades of particulate air pollution also take a toll.
Until now, it was feared that vaccination against Covid-19 could reduce the success of treatment for patients with nasopharyngeal cancer. A recent study now gives the all-clear in this regard.
With the rise of syndrome-style infections, co-infections and the current antimicrobial resistance challenges, the need for multiplexed diagnostics is now more important than ever.
Antibiotic prescribing in primary care could be monitored using health insurance data. And reduced with a simple test.
A research group has revealed that SARS-CoV-2 disrupts the vascular endothelial barrier by suppressing the expression of Claudin-5 (CLDN5) to invade the blood vessels.
The search for rare mutations in bacterial genome could lead to better diagnostics and treatments – reducing morbidity caused by the deadly disease.
Traces of the SARS-CoV-2 coronavirus that causes COVID-19 can be detected in microscopically small fluid droplets exhaled during a very short time span.
Scientists have confirmed that an inhaled form of COVID vaccine can provide broad, long-lasting protection against the original strain of SARS-CoV-2 and variants of concern.
Bitter taste receptors do not only support humans in tasting. They are also found on cancer cells. A team led by Veronika Somoza from the Faculty of Chemistry at the University of Vienna and the German Leibniz Institute for Food Systems Biology at the Technical University of Munich has investigated the role they play there. For this purpose, the scientists compiled and evaluated extensive…
Hope for a future without fear of Covid-19 comes down to circulating antibodies and memory B cells. Unlike circulating antibodies, which peak soon after vaccination or infection only to fade a few months later, memory B cells can stick around to prevent severe disease for decades. And they evolve over time, learning to produce successively more potent “memory antibodies” that are better at…
Covid-19 disease severity is determined by the individual patient’s immune response. The precise mechanisms taking place inside the lungs and blood during the early phase of the disease, however, remain unclear. Researchers from Charité – Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC) and Freie Universität Berlin have now studied the cellular mechanisms…
When viruses infect cells, changes in the cell nucleus occur, and these can be observed through fluorescence microscopy. Using fluoresence images from live cells, researchers at the University of Zurich have trained an artificial neural network to reliably recognize cells that are infected by adenoviruses or herpes viruses. The procedure also identifies severe acute infections at an early stage.
Researchers from the German Center for Infection Research (DZIF) at Charité – Universitätsmedizin Berlin and the University of Bonn have examined the way in which SARS-CoV-2 reprograms the metabolism of the host cell in order to gain an overall advantage. According to their report in Nature Communications, the researchers were able to identify four substances which inhibit SARS-CoV-2…
Inspired by kirigami, the Japanese art of folding and cutting paper to create three-dimensional structures, MIT engineers and their collaborators have designed a new type of stent that could be used to deliver drugs to the gastrointestinal tract, respiratory tract, or other tubular organs in the body.
One in 7 (14%) adults with coronavirus infection developed at least one new condition that required medical care during the post-acute phase of illness, which is 5% higher than adults with no coronavirus infection in 2020, finds a US study published by The BMJ. The post-acute phase in this study started 21 days (or 3 weeks) after initial infection.
Diagnostic data from the massive amounts of testing being conducted can help make health systems more resilient in dealing with future health crises and pandemics. The importance of diagnostic data was explored during the Medtech Europe online session, “Unlocking the Value of Diagnostic Information – how to make European Health Systems more resilient?” where delegates heard that…
Vigorous and rapid air exchanges might not always be a good thing when it comes to addressing levels of coronavirus particles in a multiroom building, according to a new modeling study. The study suggests that, in a multiroom building, rapid air exchanges can spread the virus rapidly from the source room into other rooms at high concentrations. Particle levels spike in adjacent rooms within 30…
When airborne pollen levels are higher, increased SARS-CoV-2 infection rates can be observed. These results were determined by a large-scale study conducted by an international team headed by researchers at the Technical University of Munich (TUM) and the Helmholtz Zentrum München. Members of high-risk groups could protect themselves by watching pollen forecasts and wearing dust filter masks.
University of Minnesota Medical School researchers studied SARS-CoV-2 infections at individual cellular levels and made four major discoveries about the virus, including one that validates the effectiveness of remdesivir – an FDA-approved antiviral drug – as a form of treatment for severe Covid-19 disease. “Since the start of the Covid-19 pandemic, the way that each individual responds…
The variety and volume of bacteria in the gut, known as the microbiome, may influence the severity of Covid-19 as well as the magnitude of the immune system response to the infection, suggests research published online in the journal Gut. Imbalances in the make-up of the microbiome may also be implicated in persisting inflammatory symptoms, dubbed ‘long Covid’, the findings suggest. Covid-19…
Measures to reduce the spread of Covid-19 through non-pharmaceutical interventions (NPIs) such as mask wearing and social distancing are a key tool in combatting the impact of the ongoing coronavirus pandemic. These actions also have greatly reduced incidence of many other diseases, including influenza and respiratory syncytial virus (RSV).
Safety and protection for patients and healthcare professionals during routine procedures is imperative for Fujifilm, which it intends to pursue by constantly innovating its offering of accessories and instruments for endoscopy. The company announced the launch of the Mouthpiece “B1” incorporating a sponge rubber, a droplet reduction accessory, and a drape shield specifically created to catch…
Specialists from the Department of Fundamental Medicine of Far Eastern Federal University (FEFU) with Russian and Japanese colleagues have probed into mechanisms of COVID-19 inside-the-body distribution linked to erythrocytes damaging.
This year, the MEDICA LABMED FORUM will offer a high-profile programme with top speakers which is free for registered online visitors.
‘Mini-lungs’ grown from tissue donated to Cambridge hospitals has provided a team of scientists from South Korea and the UK with important insights into how COVID-19 damages the lungs. Writing in the journal Cell Stem Cell, the researchers detail the mechanisms underlying SARS-CoV-2 infection and the early innate immune response in the lungs.
Adequate levels of vitamin D reduces complications and deaths among COVID-19 patients, reveals new research performed at the Boston University School of Medicine. Hospitalized COVID-19 patients who were vitamin D sufficient, with a blood level of 25-hydroxyvitamin D of at least 30 ng/mL (a measure of vitamin D status), had a significant decreased risk for adverse clinical outcomes including…
An infection with the coronavirus SARS-CoV-2 can affect multiple organs. With this in mind, researchers of the German Center for Neurodegenerative Diseases (DZNE) and Cornell University in the US have investigated cellular factors that could be significant for an infection. To this end, they analysed the activity of 28 specific genes in a wide range of human tissues.
A Hong Kong man who recovered from COVID-19 was infected again four-and-a-half months later in the first documented instance of human re-infection, researchers at the University of Hong Kong reported.
Contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction – rather, the immune response is caught in a continuous loop of activation and inhibition.
Infection with the novel coronavirus SARS-CoV-2 follows a highly variable course: some of those infected do not even notice it, while others become so seriously ill that their lives are placed at risk. Scientists from the Berlin Institute of Health (BIH) and Charité – Universitätsmedizin Berlin and their colleagues from Leipzig and Heidelberg have now discovered that the immune system has a…
Nanoparticles cloaked in human lung cell membranes and human immune cell membranes can attract and neutralize the SARS-CoV-2 virus in cell culture, causing the virus to lose its ability to hijack host cells and reproduce.
Scientists at the University of Cambridge have found an association between living in an area of England with high levels of air pollution and the severity of COVID-19, the disease caused by the SARS-CoV-2 virus. Because of the urgent need to share information relating to the pandemic, the researchers have published their report on MedRXiv. It has not yet been peer-reviewed. However, the…
Though the coronavirus disease COVID-19 so far appears to be largely sparing children, researchers are cautioning that it is critical to understand how the virus affects kids to model the pandemic accurately, limit the disease’s spread and ensure the youngest patients get the care they need. The warning comes from Steven L. Zeichner, MD, PhD, the head of UVA Health’s Division of Pediatric…
Investigators at Hannover Medical School (MHH) in Germany have developed a molecular assay for detecting the novel coronavirus SARS-CoV-2 (previously 2019-nCoV) on the automated Panther Fusion system by Hologic. The preclinical assay is described online in the Journal of Clinical Virology. “Rapid diagnosis is critical to combatting the spread of pandemics, and the Panther Fusion system is well…
Antibiotic-resistant pathogens pose one of the greatest threats to public health worldwide. In the near future, harmless bacterial infections may no longer be treatable and may again become the most common non-natural cause of death. At the same time, the available repertoire of antibacterial agents is becoming increasingly smaller as resistance rates rise.
Chronic inflammatory diseases, such as allergies and asthma, are not only an acute problem but also a major research and prevention challenge. We spoke with Professor Harald Renz, Director of the Institute for Laboratory Medicine at the University Hospital Gießen/Marburg, Germany, and discussed the major reason for increases in the number of these widespread diseases.
Scientists at the University of Surrey have discovered that a natural antioxidant commonly found in green tea can help eliminate antibiotic resistant bacteria...
Healthcare is going digital worldwide at an incredibly rapid pace. More and more applications for prevention, diagnostics and therapy are being made into apps (with matching hardware) for smartphones and tablets or are even available as wearables for direct use on the body. Digitalisation is also striding forward in Germany, where doctors, therapists and patients still take a fairly analogue…
A team of researchers from Versailles Saint-Quentin-en-Yvelines University (UVSQ), Inserm and Pasteur Institute has been able to provide for the first time an accurate estimate of both the incidence (annual number of new cases) and added direct cost of infections due to antibiotic-resistant bacteria in patients hospitalised in French hospitals during 2015 and 2016.
In patients with kidney failure, influenza-like illness (ILI) likely contributes to more than 1,000 deaths per year. The finding, which comes from a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN), points to the importance of protection against, surveillance of, and, where possible, treatment of such infections in patients with kidney dysfunction.…
Artificial intelligence (AI) will increase efficiency and improve quality as well as clinical outcomes – and thus strengthen rather than weaken the role of radiologists, said Dr Joon Beom Seo at ECR 2018. A spectre is haunting radiologists – the spectre of artificial intelligence. Is AI about to replace radiologists? Wrong question,’ declared radiologist Dr Joon Beom Seo, professor at the…
The need to do more to combat resistance in Germany was keenly emphasised by delegates at the VDGH (The German Diagnostics Industry Association) event held in Berlin this May. Only the answer, or at least the common will, is missing to bring this threat under control via a concerted concept.
Antibiotics are mostly prescribed for acute respiratory infections (ARIs), yet most of these infections are viral. A new study shows that inappropriate antibiotics prescriptions are widespread, contributing dangerously helping antibiotic-resistant organisms to grow. Overuse could be due to attitudes among patients and clinicians, current George Washington University research suggests.
Antimicrobial resistance is on the rise worldwide. This is becoming a problem for infectious diseases like tuberculosis as there are only a few active substances available to combat such diseases. Pharmacists at Martin Luther University Halle-Wittenberg (MLU) have now found a way to increase the efficacy of a common tuberculosis agent while, at the same time, reducing resistance to it. The…
A recently identified pig virus can readily find its way into laboratory-cultured cells of people and other species, a discovery that raises concerns about the potential for outbreaks that threaten human and animal health. Researchers at The Ohio State University and Utrecht University in the Netherlands collaborated to better understand the new virus and its potential reach. Their study, the…
Partners who could hardly be further apart – yet have a lot in common – have united to fight resistant pathogens. The International Consortium for Anti-Infective Research (iCAIR) is based in Germany and Australia – separated by nearly 16,000 km as the crow flies. This has not stopped the research cooperation from achieving its objectives: the development of new agents against infections.
Respiratory infections peak during the winter months, and most people recover within a few weeks. But for those with a rare genetic lung disease, the sniffling, coughing and congestion never end. The tiny hairlike structures called cilia that normally sweep mucus through the airways don’t work properly in people with what’s known as primary ciliary dyskinesia. When the cilia don’t brush…
3-D visualisation, augmented reality, automated tumour classification – today, the Republic of China produces cutting-edge medical technology and it’s a long time since ‘Made in Taiwan’ stood for inferior, copied products. Over recent years, this island state has successfully morphed into a productive and, above all, innovative manufacturer of medical technology available on the world…
For many of us, a flu shot is a fall routine. Roll up a sleeve, take a needle to the upper arm and hope this year’s vaccine matches whichever viruses circulate through the winter. The most common method to make that vaccine is now more than 70 years old. It requires growing viruses in special, pathogen-free chicken eggs. It’s not a quick and easy manufacturing process. And, at best, it…
Testing for fever, high pulse rate, crackly breath sounds, and low oxygen levels could be key to helping GPs distinguish pneumonia from less serious infections, according to a large study published in the European Respiratory Journal. Pneumonia is a severe lung infection that can be life-threatening and often requires treatment with antibiotics. However, it is notoriously difficult to…
Respiratory tract infections in young children are linked to an increased risk of asthma and worse lung function in later life, according to new research to be presented at the European Respiratory Society International Congress.
Chronic lung infections caused by the bacterium Pseudomonas aeruginosa require complex and, in most cases, long-term treatment with antibiotics—new medication is badly needed.
While new agents to fight virulent pathogens are in the pipeline, a new study pinpoints where a recent addition is already being applied in the clinic.
New criteria used as an initial screening tool in the emergency department need to be re-evaluated, a specialised surgeon highlighted in a dedicated talk during the Spanish national congress of surgery this November.
Philips and Diagnostics Development, a P&M Venge company, evaluate the novel human neutrophil lipocalin (HNL) biomarker for the rapid detection of bacterial infection. Based on Philips’ Minicare I-20 handheld diagnostics platform, the Minicare HNL assay is recognized for its potential to provide physicians with 10-minute confirmation of bacterial infection, helping to ensure that…
Parents may soon be able to watch their unborn babies grow in realistic 3D immersive visualizations, thanks to new technology that transforms MRI and ultrasound data into a 3D virtual reality model of a fetus, according to research being presented next week at the annual meeting of the RSNA.
No one knows for sure how they got there. But the discovery that bacteria that normally live in the gut can be detected in the lungs of critically ill people and animals could mean a lot for intensive care patients.
An international team of including the Lomonosov Moscow State University researchers discovered which enzyme enables Escherichia coli bacterium (E. coli) to breathe.
Since 2012, at least 1,500 individuals have developed Middle East respiratory syndrome (MERS), resulting in more than 500 fatalities. Only now are results being reported of the first autopsy of a MERS patient, which was performed in 2014. Not only do these findings, published in The American Journal of Pathology, provide unprecedented, clinically-relevant insights about how MERS progresses, they…
Australian researchers develop a new technique that tricks bacterial biofilms into dislodging from their protective matrix, making them vulnerable to treatment with antibiotics.
With every breath you take, microbes have a chance of making it into your lungs. But what happens when they get there? And why do dangerous lung infections like pneumonia happen in some people, but not others? Researchers at the University of Michigan Medical School have started to answer these questions by studying the microbiome of the lungs – the community of microscopic organisms that are…
The challenges and advantages of using echocardiography as an invaluable tool in the assessment of Hypertrophic Cardiomyopathy have been highlighted at a major UK cardiology conference.
Taking antibiotics may increase the risk that a child will develop juvenile arthritis, according to a study from Rutgers University, University of Pennsylvania and Nemours A.I. duPont Hospital for Children published today in Pediatrics.
Although Romania joined the EU in 2007, only recently has its macroeconomic increases influenced a rise in a middle class and dented the country’s widespread poverty. However, development is still hampered by corruption and red tape in its commercial world. Report: Daniela Zimmermann/Brenda Marsh
Curetis AG, a developer of next-level molecular diagnostic solutions, announced the successful completion of the clinical and analytical CE performance evaluation of its next-generation Unyvero P55 Pneumonia Application. The upgraded cartridge will launch at the 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID, April 25 – 28, 2015 in Copenhagen, Denmark) and is…
Internet-based training for clinicians could help lower antibiotic prescribing rates for acute respiratory tract infections by as much as 62%, according to British researchers.
Shocking: Air quality checks are infrequent and insufficient in operating theatres. The good news: a new device can now measure pathogens circulating during surgical procedures, John Brosky reports
To avoid any misunderstanding, ten years from today CT and MRI will still be the pillars of lung imaging. However, Hans-Ulrich Kauczor, Professor of Radiology and Medical Director of the radiology clinic at Heidelberg University Hospital, is convinced the emphasis will have changed.
At first sight magnetic resonance imaging (MRI) does not seem to be particularly well suited for lung diagnostics: too much air, too much movement and too little water make image acquisition a real challenge. Nevertheless, MRI is useful and in certain cases even superior to CT say the members of HTIP (Heidelberg Thorax Imaging Plattform), an association of the radiology departments of the…
Used in numerous orthopaedic medical procedures, PMMA is a self-curing two component system that includes liquid and powder components. The liquid is methylmethacrylate monomer, a known deadly toxin, and PMMA toxicity is well documented in medical journals and regulatory publications. After many years of reported patient issues related to PMMA, doctors began calling these surgical complications…
In hospitals, MRSA is considered Public Enemy Nr 1, and the increase in nosocomial infections, worldwide, has drawn universal attention to this ‘superbug’. However, Staphylococcus aureus is not alone – other pathogens are proving their resistance to antibiotics, in the last decade, gram-negative enterobacteria, which form the enzyme extended-spectrum beta-lactimases (ESBL), have joined the…
Admittedly not one of the easiest names to pronounce but a name to note: Luhacovice in the Czech Republic.
The future of the in vitro diagnostics (IVD) market looks promising. According to a new analysis from Frost & Sullivan, Western European IVD Market is estimated to reach $12.65 billion in 2014. The reason: Diseases depending on an aging population, such as infections, hike the demand for automated diagnostic tools.
As nosocomial, or healthcare-related infections (HAIs), continue to escalate in the US, and protocols to manage this problem remain complex and confusing, surveillance healthcare IT systems offer hope to gain control of the situation. These offer the potential for data to be uniformly collected, quantified, and assessed. How rapidly they will be implemented enough is unknown.
Every kindergarten undergoes it several times a year: the German measles. Nobody knew exactly how measles enter the body. But it has been thought they come through the surface of airways and lungs. But that is wrong, as researchers from the Mayo Clinic in Minnesota found recently.
During the last ten years or so, there has been a convergence of modern international science with traditional Chinese medicine, with research carried out in physiology, biochemistry and pharmacology.
Greece, Luxembourg, the Netherlands, Scotland, Spain and Switzerland are the first European countries affected by an increase of the influenza virus. Other countries will follow over the coming weeks and should prepare.
Belgium and United Kingdom - Two researchers, Dr Charles Pilette, currently at the Pneumology Department, University Hospital of Louvain, St-Luc, Belgium, and Dr William Man, who is completing specialist clinical training in Respiratory Medicine and General Internal Medicine, in London, have received this year's awards for research into Chronic Obstructive Pulmonary Disease (COPD), granted by…
From burden to therapy. By Andrea Rossi MD, Director of the Respiratory Division at Bergamo General Hospital Bergamo, Italy, and Chair of the Scientific Committee of the European Respiratory Society
