A person’s age, sex and location are correlated with the chance that they have a bloodstream infection that is resistant to antibiotics, according to a new study.
Once a patient’s body has been colonized by resistant bacteria, they can persist for a long time, a new study by the University and University Hospital of Basel shows.
Researchers have analysed the rise of antibiotic resistance over the last 20 years in the UK and Norway, highlighting that antibiotic use is not the only factor in the increase.
With the help of AI, a team at Caltech has designed a new type of catheter tube that impedes the upstream mobility of bacteria, without the need for antibiotics or chemical antimicrobial methods.
A model organism used in laboratories for the past 100 years has evolved so extensively that it may no longer be fit for purpose, according to a new study on bacterial strain Escherichia coli K-12.
Some hospitalized patients’ infections may develop from their own bacteria, new research results suggest. The study in mice indicates that medical interventions can awaken dormant, hidden bacteria.
An international research team has provided valuable new information about what drives the global spread of genes responsible for antimicrobial resistance (AMR) in bacteria.
Development of effective live bacterial therapeutics may depend more on using and re-introducing native microbes that can stick around than how the microbes are modified.
Indwelling catheters through the urethra often cause bacterial infections. A newly discovered synthetic peptide is a promising treatment option, even against antibiotic-resistant pathogens.
Bacteriophages – viruses that kill bacteria – could be a solution for fighting antibiotic-resistant pathogens, French researchers have developed a model to better predict their efficacy.
In the human intestine, Escherichia coli is mostly harmless, but in certain conditions causes bladder infections and even sepsis - but why? Researchers went to the bottom of this transformation.
An international team of scientists have shown that small and large bacterial populations follow qualitatively different evolutionary paths to develop antibiotic resistance.
Researchers have developed an inexpensive, non-toxic coating for almost any fabric that decreases the infectivity of the virus that causes COVID-19 by up to 90 per cent.
An invisible protective wall of UV-C light developed by researchers in Munich could reliably curb the spread of viruses and other pathogens in rooms while allowing total freedom of movement.
Researchers at the University of Rochester, and Delft University of Technology in the Netherlands recently developed a 3D printing technique to engineer and study biofilms—three-dimensional communities of microorganisms, such as bacteria, that adhere to surfaces. The research provides important information for creating synthetic materials and in developing drugs to fight the negative effects of…
The sharpest images ever of living bacteria have been recorded by researchers at University College London, revealing the complex architecture of the protective layer that surrounds many bacteria and makes them harder to be killed by antibiotics.
A new project led by University of California San Diego Biological Sciences graduate student Joshua Borin has provided evidence that phages that undergo special evolutionary training increase their capacity to subdue bacteria.
Using higher doses of antibiotics in a bid to tackle the growing problem of drug resistance may end up strengthening certain bacteria, according to research that highlights a previously unthought-of risk.
Researchers from Tel Aviv University have created an artificial intelligence platform that can identify the specific proteins that allow bacteria to infect the intestines.
Potentially game-changing research led by McMaster University scientists may finally bring relief to millions of people worldwide living with Crohn’s disease. Investigator Brian Coombes said his team identified a strain of adherent-invasive E-coli (AIEC) that is strongly implicated in the condition and is often found in the intestines of people with Crohn’s disease. “If you examine the gut…
Researchers are developing a COVID-19 vaccine that could provide protection against both existing and future strains of the COVID-19 virus, and other coronaviruses, and cost about $1 a dose has shown promising results in early animal testing.
Bacteria have many ways to evade the antibiotics that we use against them. Each year, at least 2.8 million people in the United States develop an antibiotic-resistant infection, and more than 35,000 people die from such infections, according to the U.S. Centers for Disease Control. Most of the mutations known to confer resistance occur in the genes targeted by a particular antibiotic. Other…
Bacterial infections have become one of the biggest health problems worldwide, and a recent study shows that COVID-19 patients have a much greater chance of acquiring secondary bacterial infections, which significantly increases the mortality rate.
Scientists at Nanyang Technological University, Singapore (NTU Singapore) have developed a synthetic peptide that can make multidrug-resistant bacteria sensitive to antibiotics again when used together with traditional antibiotics, offering hope for the prospect of a combination treatment strategy to tackle certain antibiotic-tolerant infections.
Blood stem cells have a surprising ability. In addition to ensuring the continuous renewal of blood cells, they keep track of past infections so that faster and more effective immune responses can be triggered in the future.
A probiotic drink could become a promising new weapon in the battle against antibiotic resistant bacteria, after a team of scientists at the University of Birmingham engineered and patented a key genetic element that can tackle the genetic basis of resistance. The team is now seeking funding for a clinical trial for the drink which has potential to work against many resistant bacteria commonly…
“Proteins are the workers in the cell, and it's important to know their shape,” says Chris Sander, PhD, director of Dana-Farber’s cBio Center in the Department of Data Sciences. Sander and his colleagues have now demonstrated a powerful “experimental evolution” method to discover details of protein shape and function, and the method may find uses across a very broad spectrum of…
Layering minute amounts of Manuka honey between layers of surgical mesh acts as a natural antibiotic that could prevent infection following an operation, new research has shown. Meshes are used to help promote soft tissue healing inside the body following surgery and are common in operations such as hernia repair. However, they carry with them an increased risk of infection as the bacteria are…
Bacteria are becoming increasingly resistant to common antibiotics. Often, resistance is mediated by resistance genes, which can simply jump from one bacterial population to the next. It’s a common assumption that the resistance genes spread primarily when antibiotics are used, a rationale backed up by Darwin's theory: only in cases where antibiotics are actually being used does a resistant…
Imperial medical students have helped to devise a new type of ‘decoy’ drug to tackle infections that are resistant to antibiotics. In lab tests on bacterial cultures, the new drug successfully killed a strain of drug-resistant bacteria. It works by delivering two antibiotics, one of which is effectively hidden. When the bacteria fight against the first ‘decoy’ antibiotic, this action…
Grocery store aisles are stocked with products that promise to kill bacteria. People snap up those items to protect themselves from the germs that make them sick. However, new research from Washington University in St. Louis finds that a chemical that is supposed to kill bacteria is actually making them stronger and more capable of surviving antibiotic treatment. The study, available online in…
The holiday season just wouldn't be the same without delicious Christmas cookies. Impatience in the bakery, however, might be penalized with some unpleasant or even dangerous side-effects. Bruce Ruck, managing director of the New Jersey Poison Control Center at Rutgers University Medical School, talks about the risks associated with eating raw cookie dough: “It’s a potential recipe for food…
Hip and dental implant operations are routine. But not entirely risk-free. They may result in infection that is difficult to control with oral or intravenous antibiotics. In such cases, the implant will probably need to be replaced. Fraunhofer researchers can now apply a precisely matched drug directly to the replacement implant while significantly increasing the effectiveness of the antibiotic…
Sepsis remains a common and deadly condition that occurs when the body reacts to an infection in the bloodstream. Scientists know little about the early stages of the condition; however, physicians must act fast. Every hour that passes without one or more of the few treatments available increases the risk of death.
A team of researchers at the University of Cologne's Faculty of Medicine and the German Center for Infection Research (DZIF) use a novel immunochromatographic method to detect bacteria that are resistant to the antibiotic group carbapenemes within 20 to 45 minutes from blood cultures with 100 percent certainty.
WHO’s first release of surveillance data on antibiotic resistance reveals high levels of resistance to a number of serious bacterial infections in both high- and low-income countries. WHO’s new Global Antimicrobial Surveillance System (GLASS) reveals widespread occurrence of antibiotic resistance among 500 000 people with suspected bacterial infections across 22 countries.
Bacteria are stealthy organisms. They can multiply in minutes and evolve to survive what we throw at them—including antibiotics. The World Health Organization calls antibiotic resistance “one of the biggest threats to global health, food security, and development today.” Each year, about 2 million people in the United States become infected with antibiotic-resistant bacteria, according to…
Antibiotic resistant bacteria lead to infections that are difficult to treat, particularly in hospitals. Multidrug-resistant Escherichia coli bacteria which have developed special enzymes that render antibiotics ineffective frequently cause such infections. DZIF scientists from Gießen University examined these bacteria more precisely and discovered a strain of Escherichia coli that has been…
Cancer researchers in the UK may have stumbled across a solution to reverse antibiotic drug resistance and stop infections like MRSA. Experts warn we are decades behind in the race against superbugs having already exploited naturally occurring antibiotics, with the creation of new ones requiring time, money and ingenuity. But a team of scientists at the University of Salford say they may have…
Scientists on the Florida campus of The Scripps Research Institute (TSRI) have improved a state-of-the-art gene-editing technology to advance the system’s ability to target, cut and paste genes within human and animal cells—and broadening the ways the CRISPR-Cpf1 editing system may be used to study and fight human diseases.
‘The literature on hand washing, while extensive, often contains conflicting data, and key variables are only superficially studied, or not studied at all. Some hand washing recommendations are made without scientific support, and agreement between recommendations is limited,’ explained Professor Donald W Schaffner at Rutgers University, New Jersey, USA, who has led a team of researchers to…
Trips around the globe, healthcare tourism, migration; we are mobile – and so are bacteria. Particularly dreaded are multi-drug resistant bacteria that ‘hop’ on their host during a hospital stay and are carried across the border. At MEDICA 2017 Labmed Forum Dr Andreas Ambrosch, Head of the Central Lab at Krankenhaus Barmherzige Brüder in Regensburg, Germany, will discuss these unwelcome…
The majority of women suffering with pain when urinating, or needing to urinate often or urgently probably do have a bacterial infection, even when nothing is detected by standard urine testing.
Following a top level EU report showing antimicrobial resistance (AMR) remains high, Professor Mike Catchpole, Chief Scientist at the European Centre for Disease Prevention and Control (ECDC), has warned that stricter use of antibiotics is critical.
The increasing numbers of bacteria resistant to the newer generations of antibiotics is a public health problem on a global scale. Bacteria have an extraordinary capacity for adaptation, mutating permanently to overcome the action of our increasingly impotent antimicrobial armamentarium. A situation further aggravated by the use of the powerful ‘large spectrum’ antibiotics, creating further…
Most people recoil at the thought of ingesting E. coli. But what if the headline-grabbing bacteria could be used to fight disease? Researchers experimenting with harmless strains of E. coli — yes, the majority of E. coli are safe and important to healthy human digestion — are working toward that goal. They have developed an E. coli-based transport capsule designed to help next-generation…
Bacterial infections that don't respond to antibiotics are of rising concern, as is sepsis - the immune system's last-ditch, failed attack on infection that ends up being lethal itself. Reporting online in "Nature", researchers at Boston Children's Hospital describe new potential avenues for controlling both sepsis and the runaway bacterial infections that provoke it.
The mechanism by which drug-resistant bacteria maintain a defensive barrier has been identified by researchers at England’s University of East Anglia (UEA) and their findings could result in a new wave of drugs that can bring down those defensive walls rather than attack the bacteria – thus they may not develop drug-resistance at all.
An international team of including the Lomonosov Moscow State University researchers discovered which enzyme enables Escherichia coli bacterium (E. coli) to breathe.
Data presented at the European Congress of Clinical Microbiology and Infectious Diseases diseases has highlighted how a recently-discovered mechanism could mean one of the last-resort antibiotics is under threat. Evidence put before ECCMID suggested the genetic mechanism allowing bacteria to develop and transfer resistance to colistin has been present in several countries around the world –…
Several bacterial species have pledged promise in fighting tumors. However, most of them are pathogens. In order to use them as a weapon against cancer and other diseases in humans, researchers must find a balance between their therapeutic aggressiveness and safety for the patient. To overcome this problem, researchers at the Helmholtz Centre for Infection Research (HZI) have shifted their focus…
Researchers presented findings on the prevalence of the mcr-1 gene, a transferable genetic mechanism of antimicrobial-resistance to colistin - the last resort antibiotic in a number of circumstances. At a session dedicated to late-breaking abstracts on colistin resistance, researchers presented evidence on the prevalence of the gene in bacteria (including Enterobacteriaceae such as Escherichia…
A multi-disciplinary group of researchers at the University of Maryland School of Medicine (UM SOM) have for the first time determined the genetic makeup of various strains of E. coli, which every year kills hundreds of thousands of people around the world.
Inexpensive packing material pops up as an alternative to high-cost glass lab equipment for simple diagnostic tests, a potential boon in developing nations.
Curetis AG, a developer of next-level molecular diagnostic solutions, announced the successful completion of the clinical and analytical CE performance evaluation of its next-generation Unyvero P55 Pneumonia Application. The upgraded cartridge will launch at the 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID, April 25 – 28, 2015 in Copenhagen, Denmark) and is…
A new extracorporeal nanotech device addresses the root cause of sepsis by removing pathogens and endotoxins simultaneously from blood even before their identification – this genetically engineered mannose-binding lectin protein can also latch on to the Ebola virus... Report: Cynthia E Keen
Approach could improve treatment of drug-resistant infections. Combining a PET scanner with a new chemical tracer that selectively tags specific types of bacteria, Johns Hopkins researchers - working with mice report - have devised a way to detect and monitor in real time infections with a class of dangerous Gram-negative bacteria.
Doctor Véronique Mondain from Nice explains the ambitious project she and colleagues have put in place to help combat the rise of these resistant pathogens.
There is no other way: We need a comprehensive approach, with everyone living up to their responsibility to combat this serious health threat in their respective areas. The most basic instinct of every living organism is survival. What selects one organism or species over another, in fact, is its capacity to withstand any kind of adverse condition that comes its way – what scientist Herbert…
The secret to the deadly 2011 E. coli outbreak in Germany has been decoded, thanks to research conducted at Michigan State University.
Professionals back EU-wide action on cross-border health emergencies: A new cross-border Health Security initiative should refine EU preparations for, and response to, health crises ranging from terrorist attacks to SARS epidemics, experts reported at the European Health Forum Gastein. If Europe was to be serious about facing up to major threats a real change of mind-set was of the essence,…
In Europe, nosocomial infections cause about 25,000 deaths every year. Copper has strong antibiotic effects and may reduce hospital acquired infections.
Professor Bill Keevil, Director of the Environmental Healthcare Unit at University of Southampton’s School of Biological Sciences, was among the first microbiological researchers to experiment on copper’s efficiency against pathogenic and nonpathogenic strains of E. coli bacteria and demonstrate the inherent anti-microbial property of the metal.
In late May, a particularly aggressive and new strain of enterohaemorrhagic Escherichia coli (EHEC) posed an enormous challenge for northern German hospitals. In Hamburg, the focus of the epidemic, more than 1,000 people fell ill, about 180 of them seriously, after getting into contact with the bacterium. Report: Meike Lerner
Poor gut flora is believed to trigger obesity. In the same way, healthy gut flora could reduce the risk. This has shown to be the case in tests on rats. Daily intake of a lactic acid bacteria, which has been given the name Lactobacillus plantarum HEAL19, appears to be able to prevent obesity and reduce the body’s low-level inflammation.
A change in political control naturally creates change in the way things are run, and the jaw-jutting ‘Get tough’ nature of the UK’s new coalition Government is palpable. For hospitals, one early change relates to data reporting on MRSA bloodstream infections and C. Difficile. Up to now, these were published monthly by the National Health Service (NHS) Trust; soon they will be published…
That computer keyboards harbour bacteria is well known. Studies have determined that 3,295 germs accumulate per square inch on a standard keyboard. By comparison, a sanitary toilet has 49 germs per square inch.
The temporal artery thermometer was developed in response to the clinical requirements for a truly non-invasive, accurate method of taking temperature. GE now offers, in Germany and Middle-East, the Exergen handheld temporal artery thermometer TAT 5000, which provides several benefits including accuracy, ease of use and cost effectiveness.
Surgical Site Infection is the most important problem facing surgeons today, according to Professor Miguel Cainzos, of Santiago de Compostela, Spain, speaking at the 2nd EMEA Symposium on New Non-Pharmaceutical ways to reduce surgical site infection.
Scientists found out that particles of titanium dioxide, which is e.g. contained in the white lines at tennis courts, can kill bacteria and destroy dirt when activated by fluorescent light. Added in paints, the nanotitanium can kill superbugs on all surfaces in hospitals.
Engineers from the University of Michigan are seeking to develop a "lab-on-a-chip" kit that people can assemble on their own. It could bring a new generation of instant home tests checking out for illnesses, food contaminants and toxic gases.
The UK's MRSA rates have been declining since 2006 — and this year could be 50% lower than in 2004. This increasing control over dangerous pathogens has not been achieved without considerable hospital staff efforts, relentless public and government pressures on them, and in-house malcontent about the out-sourcing of cleaning work. Given the cost of nosocomial infections to patients, the NHS…
Ireland - Researchers are investigating a new breed of bacteria that carry extended spectrum beta-lactimases (ESBLs) enzymes which can destroy many common antibiotics, including penicillins and cephalosporins.
Surgeons Sergey V Stonogin, specialist in infectious cases, Eugeny V Dvorovenko, Head of Emergency Surgery, and Vladimir A Chaplin, endoscopy specialist - report on results from their study to assess the most effective, safe combination of antibiotics to treat patients with acute appendicitis complicated by chickenpox
To establish which materials allow pathogens to survived best, micro-organisms such as bacteria living in wet and dry environments, pathogenic fungi and the bacterium Escherichia coli, have been studied during comparative tests undertaken at the Hygiene Institute of the University of Leipzig.
Lack of clean water causes as well as perpetuates diseases. Nonetheless, filtration systems have remained beyond the budgets of those most threatened by waterborne pathogens - until now.