Search for: "respiratory distress" - 44 articles found

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Intensive care support

AI predicts daily ICU trajectory for critical Covid-19 patients

Researchers used AI to identify which daily changing clinical parameters best predict intervention responses in critically ill Covid-19 patients. The investigators used machine learning to predict which patients might get worse and not respond positively to being turned onto their front in intensive care units (ICUs) - a technique known as proning that is commonly used in this setting to improve…

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Coronavirus research

'Covid-19 atlas' uncovers differing immune responses in asymptomatic versus severe cases

The largest study of its kind in the UK has identified differences in the immune response to Covid-19 between people with no symptoms, compared to those suffering a more serious reaction to the virus. The research by Newcastle University and collaborators within the Human Cell Atlas initiative found raised levels of specific immune cells in asymptomatic people. They also showed people with more…

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Immunoassays

Beckman Coulter – Access Interleukin-6 (IL-6)

Highlights: The Access Interleukin-6 (IL-6) assay is a fully automated immunoassay designed to measure the IL-6 level in serum and plasma which can be used to assist in identifying severe inflammatory response in patients with confirmed COVID-19 illness to aid in determining the risk of intubation with mechanical ventilation, in conjunction with clinical findings and the results of other…

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Intensive care

Protecting lungs from ventilation-induced injury

An unfortunate truth about the use of mechanical ventilation to save the lives of patients in respiratory distress is that the pressure used to inflate the lungs is likely to cause further lung damage. In a new study, scientists identified a molecule that is produced by immune cells during mechanical ventilation to try to decrease inflammation, but isn’t able to completely prevent…

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Decreasing infection risk

Researchers develop touch-free vital signs monitor

Scientists at Heriot-Watt University have developed a technique that monitors a patient’s vital signs completely touch free. By using a continuous wave radar-based system to sense tiny chest movements, the new method can accurately measure an individual’s heart rate and respiratory rate without the need for wires, probes, wearable technology or other skin attachments. It could also identify…

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List by top clinicians and researchers

Top 10 medical innovations for 2021

An up-and-coming gene therapy for blood disorders. A new class of medications for cystic fibrosis. Increased access to telemedicine. These are some of the innovations that will enhance healing and change healthcare in the coming year, according to a distinguished panel of clinicians and researchers from Cleveland Clinic. In conjunction with the 2020 Medical Innovation Summit, Cleveland Clinic…

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POCT as initial coronavirus screening tool

Ultrasound confirms frontline value in COVID-19 setting

Ultrasound could become the prime modality in emergency settings for tracking disease progression in COVID-19 patients. While chest CT has held a key diagnostic role thus far, many experts now advocate the benefits of ultrasound within the context of the coronavirus epidemic. Dr Rachel Liu, who recently led a high-profile panel discussion with experts from the USA and areas of Europe with high…

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Modality comparison

COVID-19 imaging: lung ultrasound vs chest CT

A recent preprint study in France underpins the debate on whether lung ultrasound (LUS) should be used to triage COVID-19 patients better at the hospital as well as in primary care. The eChoVid study, published as a preliminary report of work on medTrix, shows that LUS enables identification of lung lesions as well as chest CT in COVID-19 patients. A team of French researchers compared routinely…

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Coronavirus in radiology

Why we need a global view of COVID-19

There are major complications from COVID-19 – ARDS, pulmonary embolism and neurological – that imaging can help detect, manage and/or follow up in the long term, radiologists from France and the UK explained during a recent ESR Connect session. ARDS is the most dreaded complication and the number one morbidity in COVID-19 patients. The incidence was up to 30% of patients in initial reports.…

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Coronavirus research

How type 1 interferon deficiency hints at severe forms of COVID-19

Which patient will develop a severe form of COVID-19? This is an essential question which must be answered in order to improve the individual management and the prognosis of these patients. In a publication in the journal Science, teams from the Assistance publique – Hôpitaux de Paris (AP-HP), Inserm, Université de Paris, Institut Pasteur and Institut Imagine describe a unique and unexpected…

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Light or severe progression

The dangerous dual role of the immune system in COVID-19

Infection with the novel coronavirus SARS-CoV-2 follows a highly variable course: some of those infected do not even notice it, while others become so seriously ill that their lives are placed at risk. Scientists from the Berlin Institute of Health (BIH) and Charité – Universitätsmedizin Berlin and their colleagues from Leipzig and Heidelberg have now discovered that the immune system has a…

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BTK inhibitor vs. respiratory distress

Off-label cancer drug shows promise against severe COVID-19

Early data from a clinical study suggest that blocking the Bruton tyrosine kinase (BTK) protein provided clinical benefit to a small group of patients with severe COVID-19. Researchers observed that the off-label use of the cancer drug acalabrutinib, a BTK inhibitor that is approved to treat several blood cancers, was associated with reduced respiratory distress and a reduction in the overactive…

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Deadly mechanism uncovered

Inside COVID-19's 'cytokine storm'

Leading immunologists in Japan are proposing a possible molecular mechanism that causes massive release of proinflammatory cytokines, or a cytokine storm, leading to the acute respiratory distress syndrome (ARDS) in COVID-19 patients. Their suggestions, published in the journal Immunity, are based on recent findings that explain how SARS-CoV-2 enters human cells.

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Coronavirus treatment

Can stem cells treat COVID-19?

Niels-Bjarne Woods, a researcher at Lund University in Sweden, has developed lung-specific mesenchymal stem cells to treat inflammation of the lungs and fibrosis. This research now may be the needed breakthrough for treatment of the severe respiratory issues related to COVID-19. A clinical study may soon be underway contingent on a successful application to the Swedish Medical Products Agency.…

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Blood gas testing

Aiding COVID-19 efforts: FDA clearance for blood gas analyzer

Siemens Healthineers announced that its latest critical care testing solution, the RapidPoint 500e Blood Gas Analyzer, has received clearance from the U.S. Food and Drug Administration (FDA), and is now available in the U.S., Europe and countries requiring the CE mark. The analyzer generates blood gas, electrolyte, metabolite, CO-oximetry, and neonatal bilirubin results, which are used to…

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Chest X-ray, CT and more

Imaging the coronavirus disease COVID-19

Chest X-ray is the first imaging method to diagnose COVID-19 coronavirus infection in Spain, but in the light of new evidence this may change soon, according to Milagros Martí de Gracia, Vice President of the Spanish Society of Radiology (SERAM) and head of the emergency radiology unit at La Paz Hospital in Madrid, one of the hot spots for viral re-production of COVID-19.

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New ideas

MEDICA becomes number one trade fair for health start-ups

Healthcare is going digital worldwide at an incredibly rapid pace. More and more applications for prevention, diagnostics and therapy are being made into apps (with matching hardware) for smartphones and tablets or are even available as wearables for direct use on the body. Digitalisation is also striding forward in Germany, where doctors, therapists and patients still take a fairly analogue…

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Terror protection

Promising vaccines against anthrax, plague and tularemia

Anthrax, plague and tularemia are three potent agents terrorists would be likely to use in an attack, according to the Centers for Disease Control and Prevention. Each is highly and quickly lethal to humans. But there are no licensed vaccines for tularemia and plague, and although there is an anthrax vaccine, it requires a burdensome immunization schedule and has severe side effects. Now, a…

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Research support

Stem cell therapy for traumatic injury on the horizon

The University of Texas Health Science Center at Houston (UTHealth) has received funding through a public/private partnership for the first-ever clinical trial investigating a stem cell therapy for early treatment and prevention of complications after severe traumatic injury. The proposed Phase 2 trial is underwritten with $2 million from the Medical Technology Consortium (MTEC) and $1.5 million…

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Artificial lungs

Easing ARDS and AECOPD

Innovative ‘artificial lungs’, which help the patients to breathe, offer less traumatic treatment for severe diseases such as acute respiratory distress syndrome (ARDS) or chronic obstructive pulmonary disease (COPD/AECOPD). Respiratory failure is one of the most frequent causes of ICU admission. It may occur inter alia in patients with ARDS, a dangerous condition when the respiratory system…

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The interdisciplinary challenge

Evaluating ICU care for cancer patients

Progressive treatments offer new chances for cancer patients, but also could result in as yet unknown complications. The number of cancer patients transferred to the ICU for cancer-specific and internal medicine related reasons is on the increase. Caring for them on the ICU is a complex challenge, with interdisciplinary cooperation playing an essential part. Certain criteria need to be met for…

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Non-invasive sensors

Manometry v. BioBeat

A preliminary human study was conducted to validate an advanced wearable sensor which has been developed by the start-up company BioBeat Technologies Ltd, comparing it to the common manometry method. The 2015 guidelines of the European Society of Hypertension on The requirements of the International Protocol (revision 2010) were used to define the difference between the commonly used device and…

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Respiratory support

Extracorporeal technology eases stress

Conventional therapy for ARDS patients and for patients with exacerbation of chronic obstructive pulmonary disease (COPD) has relied on invasive mechanical ventilation. Mechanical ventilation, however, has several major drawbacks: sedation has to be induced and the air being pressed into the lungs with positive pressure can damage the pulmonary alveoli or the diaphragm. Moreover, even maximum…

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bacterial communities

What’s lurking in your lungs?

With every breath you take, microbes have a chance of making it into your lungs. But what happens when they get there? And why do dangerous lung infections like pneumonia happen in some people, but not others? Researchers at the University of Michigan Medical School have started to answer these questions by studying the microbiome of the lungs – the community of microscopic organisms that are…

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Critical care ventilation

The new Carescape R860 is an intuitive critical care ventilator that uses advanced lung protection tools and an innovative user interface to help improve patient care.

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Anaesthesiology

Accidental awareness under general anaesthesia

A UK study has highlighted the issue of patients waking up from a general anaesthetic while undergoing surgery. The research, which questioned more than 7,100 consultant anaesthetists, revealed that there was about one episode of accidental awareness in every 15,000 general anaesthetics cases in the three million UK operations in 2011.

New cancer therapy to fight cardiovascular diseases?

New drugs that are helping fight a multi-front war on cancer may do the same for cardiovascular disease, Medical College of Georgia researchers said. Cancer and cardiovascular disease, both among top U.S. killers, share inflammation as a cause. Heat shock protein 90 inhibitors as a treatment could become additional common ground, said Dr. John Catravas, director of MCG's Vascular Biology Center.

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Pneumonia research in Spain

In November 2009 about 150 leading infectious disease researchers gathered in Berlin for the National Forum for Innovation in Medicine. During the meeting, Professor Antoni Torres MD (Hospital Clinic-Ciberes, University of Barcelona) gave Meike Lerner insights into community acquired pneumonia research projects and findings

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The 2009 Bernhard Dräger Award

Dr Vasilios Papaioannou, of the Democritus University of Thrace in Alexandroupoli, Greece, received the €15,000 Bernhard Dräger Award for Advanced Treatment of Acute Respiratory Failure during the opening of The European Society for Intensive Care Medicine (ESICM) annual conference in Vienna.

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Public health puzzle - inequalities in health

In almost all of the industrialised countries, the general health status - as indicated for example by infant mortality, prevalence of disease, subjective health and life expectancy - has improved during the last four decades. At the same time, however, there is a proven close correlation between good and poor health and high and low socioeconomic status.

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The contribution of the anaesthesiologist

Since its early beginnings in Europe, during the polio epidemics of the 1950s, intensive care medicine has grown to become a specialty in its own right and the intensive care unit (ICU) occupies an increasingly important position in every hospital. Intensive care doctors are responsible for the management of very sick patients often with multiple and complex disease processes, and ICUs are now…

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Visualising the breathing lung

After previous meetings in the USA (2002) and Japan (2004), this October the 3rd International Workshop of Pulmonary Functional Imaging (IWPFI) took place in the German Cancer Research Centre, based in Heidelberg University, Germany. " 'The clinicians' need for earlier and more detailed diagnosis in pulmonary disease demands a joint interdisciplinary effort to push the limits in pulmonary…

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