News • Filopodia research
'Sticky fingers' in cells keep breast cancer contained
Researchers in Finland have identified that finger-like cellular extensions called filopodia contribute to building a barrier surrounding breast tumours.
Tumour
Article • AI provides prognostic information
Next-generation deep learning models predict cancer survival
Deaths from cancer are currently estimated at 10 million each year worldwide. Conventional cancer staging systems aim to categorize patients into different groups with distinct outcomes. ‘However, even within a specific stage, there is often substantial variation in patient outcomes,’ Markus Plass, academic researcher from the Medical University of Graz, Austria, explained to Healthcare in…
CNN applications in pathology
‘Deep learning can predict survival directly from histology in clear cell renal cell carcinoma’
Renal cell carcinoma is among the fifteen most common cancers worldwide. Dr Titus Brinker, from the German Cancer Research Center (DKFZ), looked at whether a convolutional neural network (CNN) can extract relevant image features from a typical H&E-stained slide to predict 5-year overall survival.
Article • Patient care
Molecular Tumour Board for better decision-making
As more genomic alterations become targets for therapy, health institutions and hospitals are creating specialist Molecular Tumour Boards to support better decision-making for patient care. This evolving team, and its role, was highlighted in a presentation at the 34th European Congress of Pathology in Basel, Switzerland.
News • Appeal for imaging improvements
Study reveals alarming failures in pancreatic cancer detection
Pancreatic cancer tumours are being missed on CT and MRI scans, narrowing the window for life-saving curative surgery, research presented at UEG Week 2022 has revealed.
News • New imaging method
Delayed fluorescence for effective surgical tumor removal
Researchers propose a new approach to identify cancerous tissue for surgical removal, based on real-time imaging of tissue oxygen concentration.
News • Alveolar rhabdomyosarcoma
Promising new treatment for deadly pediatric tumor
Alveolar rhabdomyosarcoma is a rare pediatric tumor. For more than 40 years there has not been any new development regarding treatment. Research led by Prof. Dr. Anton Henssen at Charité University Berlin has now identified a new therapeutic option, using a drug that is currently under investigation for other types of cancer.
News • Lung adenocarcinoma
Therapeutic target against common lung cancer identified
A new study led by researchers in Barcelona has determined the protein TIMP-1 as a valuable biomarker for the progression of lung adenocarcinoma. The results open the door to new treatments.
Article • Interpreter of maladies
Will AI help realize the promise of precision medicine?
Machine learning and artificial intelligence (AI) have the potential to transform cancer treatment management worldwide. Their ability to rapidly analyse and integrate routinely acquired diverse data will improve the accuracy and effectiveness of precision medical treatments.
News • Precision oncology
What's new in cancer therapy?
Researchers from the University of Bern and Inselspital provide an overview of the latest technologies in precision oncology. Translating these into clinical application is still a major challenge.
News • Desperate cancer cells
How tumors mutate their way out of a crisis (and become drug-resistant)
Researchers discovered that cancer cells mobilize a SOS response when they are desperate to resist anticancer drugs. The team also came up with an anti-SOS approach that blocked the mechanism in mice.
News • Impact of body constitution
Breast cancer: Tumour environment can affect prognosis
The interplay between the patient’s BMI, tumour size and cancer-specific proteins is of importance for the prognosis of breast cancer, a study from Sweden shows.
News • High-glade glioma research
Understanding why deadly brain cancer comes back
A surprising mechanism explains why high-grade gliomas, the deadliest form of brain cancer, returns: The tumours adapt to treatment by recruiting help from nearby healthy tissue.
News • Tumor identification in CUP patients
Cancer of unknown primary: comprehensive molecular analysis can improve therapy
A considerable proportion of patients suffering from cancer of unknown primary (CUP) could benefit from comprehensive molecular analysis and molecularly-informed targeted therapies.
News • First-time use of new tool
Cardiologists use retrieval 'basket' to remove heart tumor
Interventional cardiologists in Seattle recently performed a first-in-human procedure, successfully employing a catheter-delivered device to retrieve a benign tumor from inside a patient’s heart.
Video • Clonal somatic mutations
How does cancer grow? Genetic mapping gives new insight
Researchers from the UK and Sweden have found that individual prostate tumours contain a previously unknown range of genetic variation.
News • Liquid biopsy for early detection of brain tumours
Glioblastoma: Mathematical modelling could lead to simple blood test
The development of a simple blood test for glioblastomas could mean earlier diagnosis and more effective and personalised treatment options against the most common type of malignant brain cancer.
News • Tumour shrinking
"Downstaging" liver cancer before transplant improves outcomes
Treating liver cancer tumours to shrink them in order to allow the patient to qualify for a liver transplant leads to excellent 10-year post-transplant outcomes, according to new research.
News • Identification of treatment barriers
Immunotherapy: The right environment for fighting cancer
Cancer immunotherapy is a successful treatment form in oncology, but it doesn't work for every patient. One problem may be the lack of a specific type of immune cell in the tumor, researchers found.
News • Better outcomes, fewer costs
Experts propose less invasive bowel cancer treatment approach
New research suggests that providing a break in treatment to patients with advanced bowel cancer could not only benefit a patient’s quality of life but could also help reduce costs.
News • Radiophysiomics
Diagnosing brain tumors using machine learning
The classification of brain tumors—and thus the choice of optimal treatment options—can become more accurate and precise through the use of artificial intelligence in combination with physiological imaging.
Article • Multimodal analysis approach
Novel AI model predicts thyroid cancer from routine ultrasound images
An artificial intelligence (AI) model combining four methods of machine learning (ML) to accurately detect thyroid cancer from routine ultrasound image data has been developed by US researchers.
News • Biomarker from blood test
Lung cancer: Liquid biopsy accurately predicts immunotherapy response
A simple blood test could be a better predictor of whether cancer immunotherapy will be successful for a patient with lung cancer than an invasive tumor biopsy procedure.
News • HCC in vitro research
Organoids give new clues to liver cancer progression
Newly engineered in vitro tumour models open ways to better understand the crosstalk between liver cancer cells and their microenvironment, researchers from Singapore found.
News • Cancer treatment
Ultrasound-guided microbubbles boost immunotherapy efficacy
Researchers have developed an ultrasound-guided cancer immunotherapy platform that generates systemic antitumor immunity and improves the therapeutic efficacy of immune checkpoint blockade.