Roche announced the decision to discontinue dosing in the Phase III GENERATION HD1 study of tominersen (previously IONIS-HTTRx and RG6042) in manifest Huntington’s disease (HD). The decision was based on the results of a pre-planned review of the data from the Phase III study conducted by an unblinded Independent Data Monitoring Committee (iDMC). The iDMC made its recommendation based on the…
A new blockchain-based data analysis app aims to drive collaboration and insights across clinical trials. The tool, developed by software company Clintex, is designed to boost trial efficiency, help drive down the cost of new medicines and expediting their delivery to patients.
A study by an international research group identified 15 novel biomarkers that are linked to late-onset dementias. These biomarkers are proteins, which predict cognitive decline and subsequent increased risk of dementia already 20 years before the disease onset. The proteins are related to immune system dysfunction, blood-brain-barrier dysfunction, vascular pathologies, and central insulin…
A newly targeted therapy could help millions of lung cancer patients worldwide keep their cancers from spreading, says an expert at Cleveland Clinic, on the occasion of World Lung Cancer Day. Dr. Khaled Hassan, of the Hematology and Medical Oncology Department at Cleveland Clinic, explains the concept of KRAS targeted therapy – and why the approach should not be mistaken for a cancer cure.
A novel therapy engineered by Northwestern Medicine investigators improved progression-free and overall survival for patients with newly diagnosed malignant gliomas, according to results from a recent phase I clinical trial.
El laboratorio de Genómica Biomédica del IRB Barcelona (Institute for Research in Biomedicine) ha desarrollado un método computacional que identifica las mutaciones causantes del cáncer para cada tipo de tumor.
The Biomedical Genomics laboratory at the Institute for Research in Biomedicine (IRB) Barcelona has developed a computational tool that identifies cancer driver mutations for each tumour type. This and other developments produced by the same lab seek to accelerate cancer research and provide tools to help oncologists choose the best treatment for each patient. The study has been published in the…
How long do coronaviruses remain infectious on banknotes and coins? Is it possible to become infected through contact with cash? Experts at the European Central Bank, in collaboration with the Department of Medical and Molecular Virology at Ruhr-Universität Bochum, wanted to clarify this question. The researchers led by Professor Eike Steinmann and Dr. Daniel Todt developed a method specifically…
In view of the continuing high numbers of infections, vaccination offers important protection against severe Covid-19 disease. Scientists from the Faculty of Medicine – University of Freiburg have now been able to determine in detail at what time point initial immune protection is established after vaccination with an mRNA-based vaccine and how the reactions of the various components of the…
Using lab-created tissue to heal or replace damaged organs is one of the great visions for the future of medicine. Synthetic materials could be suitable as scaffolding for tissue because, unlike natural tissues, they remain stable in the organism long enough for the body to form new natural structures. A fundamental requirement for functional tissue is that blood vessels must be able to grow in…
A team of scientists at Argonne National Laboratory has leveraged artificial intelligence to train computers to keep up with the massive amounts of X-ray data taken at the Advanced Photon Source.
Cancer informatics and digital pathology provider Inspirata announced that King’s Health Partners ECMC and Guy’s and St Thomas’ NHS Foundation Trust will pilot its Trial Navigator software as part of an evaluation the organisations are conducting into how artificial intelligence based automation can improve the identification and efficiency of matching patients with cancer to early phase…
Antibiotic-resistant pathogens have become one of the greatest threats to public health. The basic mechanisms of resistance evolution have been well studied experimentally and are an important research field at Kiel University. An important factor in this context, but one that has received little attention so far, is the population size of the respective pathogen. Over the course of an infection…
Scientists from the German Cancer Research Center and Heidelberg University Hospital have for the first time been able to delay the development of hereditary colorectal cancer with a protective vaccination. Mice with a hereditary predisposition to colorectal cancer survived significantly longer after vaccination than unvaccinated animals. Combining the vaccination with an anti-inflammatory drug…
Efforts to understand cardiac disease progression and develop therapeutic tissues that can repair the human heart are just a few areas of focus for the Feinberg research group at Carnegie Mellon University. The group's latest dynamic model, created in partnership with collaborators in the Netherlands, mimics physiologic loads on engineering heart muscle tissues, yielding an unprecedented view of…
With the application of a novel 3D imaging technology, researchers at Karolinska Institutet have discovered that one portion of the autonomic nervous system in the liver undergoes severe degeneration in non-alcoholic fatty liver disease. The study, which is conducted in mice and human liver tissue, shows that the degeneration of nerves is correlated with the severity of liver pathology. The…
Magnetic fields can be used to stimulate blood vessel growth, according to a new study. The findings, published in the journal Science and Technology of Advanced Materials by researchers at the Técnico Lisboa and NOVA School of Science and Technology in Portugal, could lead to new treatments for cancers and help regenerate tissues that have lost their blood supply.
Remote 24-hour monitoring for cancer patients receiving chemotherapy helps to better manage side effects and improve quality of life, finds a study published by The BMJ. The researchers say remote monitoring can provide a safe, secure, and “real time” system that optimises symptom management and supports patients to remain at home - and is particularly relevant in the context of the Covid-19…
Patients who experience long Covid have reported more than 200 symptoms across 10 organ systems, in the largest international study of ‘long-haulers’ to date, led by scientists at University College London together with a patient-led research collaborative.
A study of more than 18 million pregnancies has shown a strong and graded relationship between women’s heart health and pregnancy outcomes. The research is published in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC). The researchers examined the presence of four risk factors for cardiovascular disease in women prior to pregnancy: unhealthy…
Medical data management company Flywheel announced a partnership and enterprise license agreement with Siemens Healthineers. Under the agreement, Flywheel will deliver a cloud-based research collaboration solution on the Siemens Healthineers teamplay digital health platform. Rolling out first in North America, the teamplay collaboration solution will enable Siemens Healthineers and its many…
Why do alterations of certain genes cause cancer only in specific organs of the human body? Scientists at the German Cancer Consortium (DKTK), the Technical University of Munich (TUM), and the University Medical Center Göttingen have now demonstrated that cells originating from different organs are differentially susceptible to activating mutations in cancer drivers: The same mutation in…
To date, there are no effective antidotes against most virus infections. An interdisciplinary research team at the Technical University of Munich (TUM) has now developed a new approach: they engulf and neutralize viruses with nano-capsules tailored from genetic material using the DNA origami method. The strategy has already been tested against hepatitis and adeno-associated viruses in cell…
Age-related macular degeneration (AMD) is the most common cause of blindness in developed countries affecting seven million in total in Germany, from which 500,000 people are suffering from late stage disease, around half of whom are registered as visually impaired. There are two forms of AMD, ‘wet’ and ‘dry’. There are currently no treatments available for the dry form of the disease…
Athletes appear to be almost two and half times more likely than non-athletes to experience irregular heart rhythms (atrial fibrillation), suggests new research. In addition, those athletes involved in mixed sports such as football, rugby or netball appear to have the highest risk when compared with athletes taking part in endurance sports such as Nordic skiing, orienteering or rowing.
