News • Double Stokes polarimetric microscopy
New method to help accelerate cancer diagnosis
A new method to quickly and accurately analyze the structure of collagen in tissue shows promise to improve the diagnostics of cancer and other diseases.
Pathology
Article • Digital pathology discussion panel
The AI tools pathologists want and need
The evolving role of AI tools in digital pathology was explored at an open discussion during the annual Digital Pathology and AI Congress in London with a high-level panel of practitioners looking at current and future technology options. The panel of pathologists, scientists and academics from Europe and the USA assessed the tools they currently use and are available to them, and those they…
News • Machine learning analysis
Breast cancer: AI predicts metastasis from recurrence
The location and timing of breast cancer recurrence may allow AI to predict the risk of metastasis, a new study shows. This is an essential step towards developing personalised treatment strategies.
Sponsored • Laboratory automation
Connect, automate and innovate your lab through SMART Automation
In today’s fast-paced healthcare landscape, efficiency and accuracy are essential in overcoming workload challenges. Pathology laboratories are under pressure to keep up with growing demands, all while ensuring standardised, consistent and high-quality results.
News • Intrinsic electrical activity drives cancer progression
SCLC: Deciphering the unusual aggressiveness of small cell lung cancer
New research reveals that self-generated electrical activity of small cell lung cancer (SCLC) directly promotes tumor metastasis and progression. This may provide new avenues for future treatments.
News • Circulating tumor DNA analysis
Liquid biopsy helps reduce chemotherapy in colon cancer patients
For patients, a liquid biopsy which checks for circulating tumour DNA of colon cancer, resembles a standard blood test. However, the method helps avoid chemotherapy for many, a new study finds.
Article • Detection of neurodegenerative condition
Developing blood biomarkers to diagnose Alzheimer’s disease
There is no known cure for Alzheimer’s disease (AD), although prescription drug-based treatments that can slow AD progression in some patients are starting to enter clinical use. Biomarkers, quantifiable characteristics of biological processes or pathological conditions of the body, are making it possible to help identify and measure the presence and extent of AD and its degenerative…
Article • Promising, but in need of further validation
Implementation challenges of blood biomarkers for Alzheimer’s disease
Blood-based biomarker (BBB) tests may represent the best weapon to combat the soaring rates of Alzheimer’s disease (AD) throughout the world. Existing clinically validated tests are currently deployed to facilitate diagnosis, to monitor disease and effectiveness of treatments, to quantify progression, and to determine if a patient is appropriate for treatment or participation in a clinical…
News • Deep and ensemble learning improve performance
New AI tool surpasses previous methods in colorectal cancer tissue analysis
Researchers developed an advanced AI tool for automatic analysis of colorectal cancer tissue slides. The new model outperformed all predecessors in the classification of tissue microscopy samples.
News • Cell-free tumor DNA analysis
Liquid biopsy to unlock breast cancer treatments
New research highlights the potential of circulating tumor DNA (ctDNA) analysis as a non-invasive method to identify actionable biomarkers for breast cancer, enabling individualized therapies.
News • Study explores impact
How brain trauma can trigger Alzheimer's disease
Traumatic brain injury (TBI) increases dementia risk, but the reasons are poorly understood. Now, a study explores the role of the brain's blood vessels as drivers of Alzheimer's disease.
News • Reactive glial responses
Mapping the brain's self-healing ability after stroke
Helping the brain repair itself after a stroke: A new study based on unique tissue samples from Denmark's Brain Bank may pave the way for new treatments that support brain regeneration.
News • Promising prototype
A “diagnostic wand” to detect oral cancer
Liverpool physicists have developed a “diagnostic infrared wand” to more accurately predict the prognosis of oral cancer lesions than current H&E staining techniques.
Article • Keynote on integrated diagnostics
Predicting – and shaping – the future of modern pathology
Complex diseases could require complex biomarkers for accurate diagnosis in the years ahead, according to a leading pathologist. In a keynote address to the 36th European Congress of Pathology in Florence, Italy, Professor Manuel Salto-Tellez highlighted this as one of the major future challenges for the discipline. However, he also believes pathologists will sit at the core of modern medicine.
News • Advances in precision medicine
MASLD: Research reveals two types of fatty liver disease
Metabolic-associated fatty liver disease has 2 types – a liver-specific type and a systemic type that affects other organs and tissues. This discovery could lead to better diagnosis and treatments.
Sponsored • Collaboration in pathology
MEDIPATH makes a step towards lab automation with the help of Sakura Finetek Europe
Sakura Finetek Europe and MEDIPATH, a group of independent French pathologists, announced their collaboration to enhance cancer diagnostics and thus contribute to improved patient therapeutic management. This decision is part of an ongoing commitment to improving the quality of care provided to patients and in response to the significant increase in cancer cases over the last years.
News • Tumour movement across tissues
Understanding metastasis: migration strategies of ovarian cancer
A new study shows how inherent variations in a cancer cell and its interactions with its surroundings mould its migration. The findings provide valuable insights into the processes behind metastasis.
Article • Between good practice and financial pitfalls
Delivering molecular pathology at lower costs
Molecular pathology should become centralised in fewer labs to improve efficiencies and affordability, according to leading European experts.
Article • Transformative technology
Debating the case for AI in pathology
Artificial Intelligence (AI) remains a divisive topic within the discipline of pathology with a range of opinions over its current value and applicability in clinical settings. While most experts agree that the technology will not replace pathologists, it might still spell bad news for those who do not embrace AI in their daily practice. On the other hand, reservations persist about whether…
Article • Molecular meets digital
Single-cell multiplex imaging: a powerful tool for digital pathology
Multiplex imaging can play a critical role in unravelling the tumour microenvironment. The potential and benefits of the emerging approach – a way to extract information from human tissue samples by visualising many more biomarkers than traditional microscopy – was highlighted in presentations during the 36th European Congress of Pathology in Florence, Italy. Speakers also discussed novel…
News • Insights into tumor biology
Breast cancer: Exploring metastasis diversity
In many cases, metastatic breast cancer is still incurable. To improve the odds, researchers have now analyzed the diversity of metastatic cells and their interactions with their cellular environment.
News • Single-cell metabolic profiling
Mass-spec and IMC give deep insights into tumors
By combining mass spectrometry and mass cytometry imaging techniques, researchers can now dive deeper into tumors and map the metabolism of individual cells in tumor tissue.
Sponsored • Tissue-Tek Xpress® x120 Rapid Tissue Processor
Process tissue continuously, safely, and in a standardised way while speeding up your throughput
Sakura Finetek’s Tissue-Tek Xpress® x120 Rapid Tissue Processor is the only instrument on the market that allows for continuous, rapid processing of both biopsy and larger tissue, resulting in a streamlined histology workflow. Being part of Sakura’s SMART Automation concept, this tissue processing solution is designed to automate manual work and create a continuous flow throughout the lab.
News • Achieving and maintaining high service quality
QA in histopathology laboratories from pre- to post-analytic phase
Testing from histopathology laboratories is considered the gold standard for many diseases. To avoid errors that can significantly impact patient outcomes, an expert details on quality assurance (QA).
Article • Interdisciplinary senology
Mammography, ultrasound, MRI: which imaging modality at which time?
Interdisciplinary collaboration between gynaecologists, radiologists, pathologists and breast care nurses following a palpation finding makes a decisive contribution to the success of further breast cancer treatment. This was the consensus among the speakers at the Annual Congress of the German Society of Senology in Dresden. The experts provided clear explanations of which imaging is best for…
