The lab of Kai Johnsson at EPFL, led by Alberto Schena and Rudolf Griss, were able to add a small chemical tag on the enzyme luciferase, which produces the light of fireflies. The tag detects a target protein, and the luciferase gives out a light signal that can be seen with a naked eye.
Johanna Olson, MD, and her colleagues at Children's Hospital Los Angeles, provide care for the largest number of transyouth in the U.S. and have enrolled 101 patients in a study to determine the safety and efficacy of treatment that helps patients bring their bodies into closer alignment with their gender of identity.
A new drug acts as a roadblock for malaria, curing mice of established infection, according to a study in The Journal of Experimental Medicine. Treatment was not associated with obvious side effects, suggesting that the drug may also be safe and effective in humans.
Whether for individual micro-implants or for micro-implants with medicine depots – additive processes are ideally suited for manufacturing such components. In the project “REMEDIS”, scientists at the Laser Zentrum Hannover e.V. (LZH) have established a highly automated laser melting process to produce or coat implants made of platinum, nickel-titanium (NiTi) or stainless steel.
Every time a cell divides, the ends of chromosomes – the threads of DNA residing in the nucleus – shorten a bit. Once the chromosome ends, called telomeres, become too short, cells normally stop dividing. Scientists from the German Cancer Research Center (DKFZ) have now discovered how cancer cells make use of specific DNA repair enzymes to extend the telomeres. In this way, they escape the…
Use of heroin in the United States has surged dramatically in the past decade, a new study finds. The news follows earlier reports that fatal overdoses from heroin have quadrupled since 2002, suggesting that the country is facing a new epidemic of opiate dependence.
Inexpensive packing material pops up as an alternative to high-cost glass lab equipment for simple diagnostic tests, a potential boon in developing nations.
The view across the Atlantic – it fills Professor Fabian Kiessling, Chair of Experimental Molecular Imaging at the RWTH Aachen (Rhine-Westphalia Institute of Technology Aachen), with optimism. The USA offers more opportunities for molecular imaging. Only recently, new tracers for Alzheimer’s were accepted as reimbursable in some centres, whilst the development of new diagnostics in Europe…
New research in The FASEB Journal suggests that clinical trials of omega-3 and antioxidant supplementation should be undertaken for people with Alzheimer's disease with mild clinical impairment.
A group of researchers, lead by Vasily M. Studitsky, professor at the Lomonosov Moscow State University, discovered a new mechanism of DNA repair, which opens up new perspectives for the treatment and prevention of neurodegenerative diseases. The article describing their discovery is published in AAAS' first open access online-only journal Science Advances.
Danish researchers from the University of Copenhagen have discovered what controls the enzyme that aids the growth of cancer tumours. These findings could be of great value to cancer treatments and has just been published in the renowned journal, Nature Communications.
Fructose not only results in a lower level of satiety, it also stimulates the reward system in the brain to a lesser degree than glucose. This may cause excessive consumption accompanied by effects that are a risk to health, report researchers from the University of Basel in a study published in the scientific journal PLOS ONE. Various diseases have been attributed to industrial fructose in…
Tumor suppressor genes protect against cancer. Until now, scientists have had to perform complex experiments to detect whether or not a mutation or loss of this gene type does, in fact, cause cancer. Scientists from the German Cancer Research Center (DKFZ) have now used a new gene technology method called CRISPR/Cas9 technology for this detection.
‘Health insurers should keep a tighter rein on the quality of endoscopic interventions because, mostly, they represent a gentler alternative to surgery,’ asserts international expert Horst Neuhaus, during an EH interview. Report: Daniela Zimmermann/Juliane Dannert
Lung cancer is the leading cause of cancer death worldwide, responsible for some 1.59 million deaths a year. That figure is due, in part, to the fact that the cancer often returns after what, at first, seems to be successful treatment. And the recurring cancer is often resistant to the chemotherapy and other drugs that originally drove it into remission. According to new research by the Weizmann…
Painful insulin injections could become a thing of the past for the millions of Americans who suffer from diabetes, thanks to a new invention from researchers at the University of North Carolina and NC State, who have created a “smart insulin patch” that can detect increases in blood sugar levels and secrete doses of insulin into the bloodstream whenever needed.
It may come as a bit of a surprise to learn that bacteria have an immune system – in their case to fight off invasive viruses called phages. And like any immune system – from single-celled to human – the first challenge of the bacterial immune system is to detect the difference between “foreign” and “self.” This is far from simple, as viruses, bacteria and all other living things…
Urinary tract infections (UTIs) are common, and widespread antibiotic resistance has led to urgent calls for new ways to combat them. Researchers at University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences report that an experimental drug that stabilizes a protein called HIF-1alpha protects human bladder cells and mice against a major UTI…
Hyperactivity and social abnormalities are defining characteristics of ADHD and autism, two developmental disorders that parents and scientists around the world are struggling to understand. At the RIKEN Brain Science Institute in Japan, researchers have identified the protein IRBIT as a key player in preventing these behaviors from developing.
Clinical trials are under way at two NHS hospitals in England to assess breathalyser technology to detect lung cancer. Phase I clinical trials of a diagnostic breathalyser developed by Cambridge-based Owlstone Ltd have shown accurate identification of 12 lung cancer biomarkers in breath specimens. A Phase II trial is now targeting development of a small, handheld device that can be used in GP…
The focus of the 2015 Diabetes Congress held in Berlin this May was ‘Personalised diabetes treatment: innovative – individual – sustained’. EH reports on points aired during the supporting press briefing. Report: Bettina Döbereiner
New figures for the UK’s key National Health Service (NHS) Trusts have revealed their total deficit of more than €1.1 billion for the year 2014-15. This rise on the previous year’s deficit of €160m comes against a backdrop of health authorities being required to find ‘efficiency savings’ of almost €1.4bn over the last five years. The NHS was also a major issue in the recent UK…
A new study group that aims to establish guidelines on forensic microbiology sampling and encourage increased communications between European and global organisations, has been launched by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID).
Since 2009, as part of diagnostic and antimicrobial stewardship strategies, Hampshire Hospitals National Health Service (NHS) Trust has used serum procalcitonin (PCT) – an innovative and highly specific marker to diagnose clinically relevant bacterial infections and sepsis. Report: Mark Nicholls
National Institutes of Health (NIH) researchers and their colleagues have developed a "placenta-on-a-chip" to study the inner workings of the human placenta and its role in pregnancy.
