News • Intracardiac nervous system
The heart has its own ‘brain’
Scientists have now discovered that the heart has its own complex nervous system – a 'mini brain', if you will – that is crucial to controlling its rhythm.
Search for: "Single-cell RNA sequencing" - 27 articles found
News • Focus on ILC immune cells
Research reveals cause for lupus kidney damage
Systemic lupus erythematodes can lead to severe kidney damage. However, until now, the cause for this remained unclear. New research has now revealed the underlying mechanism.
News • Tumor assessment via chromatin imaging
From DCIS to IDC: AI identifies breast cancer stages
Researchers at MIT and ETH Zurich developed an AI model that identifies certain breast cancer stages likely to progress to invasive forms of cancer.
News • Memory impairment
"Chemo brain": gamma waves may be key to protection
Researchers have now shown that a noninvasive treatment that stimulates gamma frequency brain waves may hold promise for treating memory impairment and other cognitive effects of chemotherapy.
News • Cytokine reference
New “dictionary” reveals suprising complexity of immune responses
Scientists map the effects of 86 immune-signaling molecules called cytokines on every major immune cell type, creating a reference for studying the inner workings of the immune system.
News • Common liver cancer in children
Potential targets to treat hepatoblastoma identified
A collaborative study, led by Cima Universidad de Navarra, has identified key epigenetic targets for the treatment of hepatoblastoma, the most frequent liver cancer in childhood.
News • Study shows potential to reverse paralysis
Another step towards regeneration after spinal cord injuries
Swiss scientists report that they have developed a gene therapy that was proven in mice to stimulate nerve regrowth across spinal cord injuries and guide nerves to reconnect to their natural targets.
News • Chronic myeloid leukaemia
CML therapy response predicted by AI "crystal ball"
AI could find critical biomarkers that predict non-response to conventional treatment in patients with chronic myeloid leukaemia (CML) more quickly, researchers in Singapore find.
News • Neuroscience & Alzheimer's disease
Researchers identifiy subset of neurons that are most susceptible to Alzheimer's disease
Neurodegeneration, or the gradual loss of neuron function, is one of the key features of Alzheimer's disease. However, it doesn't affect all parts of the brain equally.
News • Immunotherapy effectiveness
Sex differences in pancreatic cancer: researchers reveal possible explanation
For pancreatic cancer, the effect of immunotherapy is limited and differs between men and women. Researchers at Karolinska Institutet have now found a possible explanation for this sex difference.
News • Regenerative medicine
Tapping into a tumor's power to heal non-healing wounds
Scientists have discovered a way to train healthy immune cells to acquire the skills of some tumor cells for a good purpose: to accelerate diabetic wound healing.
Article • Don't miss:
Talks and panel discussion at the Labmed forum
At this year's Medica tradefair, laboratory medicine, medical technology and life sciences give new impulses to the entire healthcare market - especially in times of the corona pandemic. An overview.
News • Hopeful study
A noninvasive way to diagnose endometriosis
Women can suffer for years with the debilitating pain and medical complications of endometriosis without a diagnosis. Now, researchers believe they may be able to diagnose the condition using just menstrual blood.
News • Cardiomyopathy research
Genetic defects can cause heart failure
Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports.
News • Computational disease models
Digital twins aid patient treatment
Researchers have developed advanced computer models, or “digital twins”, of diseases, with the goal of improving diagnosis and treatment.
News • Relapse research
Multiple myeloma: Tracking down resistant cancer cells
In multiple myeloma, a cancer of the bone marrow, relapse almost always occurs after treatment. Initially, most patients respond well to therapy. However, as the disease progresses, resistant cancer cells spread in the bone marrow, with fatal consequences for the patients. Scientists at the German Cancer Research Center (DKFZ), Heidelberg University Hospital (UKHD) and the National Center for…
News • Infection research
Understanding lung damage in Covid-19 patients
Covid-19 disease severity is determined by the individual patient’s immune response. The precise mechanisms taking place inside the lungs and blood during the early phase of the disease, however, remain unclear. Researchers from Charité – Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC) and Freie Universität Berlin have now studied the cellular mechanisms…
News • Tiny changes, huge effects
Finding causes of disease with induced pluripotent stem cells
Induced pluripotent stem cells (iPSC) are suitable for discovering the genes that underly complex and also rare genetic diseases. Scientists from the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory (EMBL), together with international partners, have studied genotype-phenotype relationships in iPSCs using data from approximately one thousand donors. Tens of…
Video • Regenerative medicine
Lab-grown ‘mini-bile ducts’ to repair human livers
Scientists have used a technique to grow bile duct organoids – often referred to as ‘mini-organs’ – in the lab and shown that these can be used to repair damaged human livers. This is the first time that the technique has been used on human organs. The research paves the way for cell therapies to treat liver disease – in other words, growing ‘mini-bile ducts’ in the lab as…
News • Caught in the loop
How COVID-19 leads the immune system astray
Contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction – rather, the immune response is caught in a continuous loop of activation and inhibition.
News • Hidden in our genes
scHOT: Discovering the fate of cell development
As cells develop, changes in how our genes interact determines their fate. Differences in these genetic interactions can make our cells robust to infection from viruses or make it possible for our immune cells to kill cancerous ones. Understanding how these gene associations work across the development of human tissue and organs is important for the creation of medical treatments for complex…
News • Light or severe progression
The dangerous dual role of the immune system in COVID-19
Infection with the novel coronavirus SARS-CoV-2 follows a highly variable course: some of those infected do not even notice it, while others become so seriously ill that their lives are placed at risk. Scientists from the Berlin Institute of Health (BIH) and Charité – Universitätsmedizin Berlin and their colleagues from Leipzig and Heidelberg have now discovered that the immune system has a…
News • Research from Karolinska Institutet
High-resolution mapping of cell types with improved single-cell sequencing
Single-cell RNA sequencing (scRNA-seq) has revolutionized the ability to characterize cell types and their gene expression programs in organisms and tissues.
News • Personalised medicine
Why digital twins could be the ideal therapy testbed
Advanced computer models of diseases can be used to improve diagnosis and treatment. The goal is to develop the models to “digital twins” of individual patients. Those twins may help to computationally identify and try the best medication, before actually treating a patient. The models are the result of an international study, published in the open access journal Genome Medicine.
News • Precision medicine
Europe looks to cells for a healthier future
How can we detect the first signs of disease as early as possible? Could closer investigation at the cellular level help to quickly prevent disease progression through appropriate treatment? The European Union is now investing a million euros over a one-year period to devise the plan for a fundamentally new approach to understanding the constant changes within cells and their relationships to one…
News • Bacterial antigens
Machine learning tool predicts peptides' potential as immune activators
A deep neural network algorithm called BOTA uses bacterial genomes to identify unrecognized bacterial antigens.
News • Molecular Genetics
How a Bacterial Cell Recognizes its Own DNA
It may come as a bit of a surprise to learn that bacteria have an immune system – in their case to fight off invasive viruses called phages. And like any immune system – from single-celled to human – the first challenge of the bacterial immune system is to detect the difference between “foreign” and “self.” This is far from simple, as viruses, bacteria and all other living things…