Cancer

Supervised learning approach

A new deep learning-based algorithm to predict relapse-free survival in papillary thyroid carcinoma

The tall cell variant (TCV) is an aggressive subtype of papillary thyroid carcinoma (PTC). Sebastian Stenman, researcher from the Institute for Molecular Medicine, and the Department of Pathology at the University of Helsinki, Finland, is developing and training a deep learning algorithm using supervised learning to detect and quantify the proportion of tall cells in PTC.

Article • Patient care

Molecular Tumour Board for better decision-making

As more genomic alterations become targets for therapy, health institutions and hospitals are creating specialist Molecular Tumour Boards to support better decision-making for patient care. This evolving team, and its role, was highlighted in a presentation at the 34th European Congress of Pathology in Basel, Switzerland.

Article • Prediction for breast, ovarian, cervical, and endometrial carcinoma

New test detects four women’s cancers from cervical screening samples

What if a test analysing cervical cells from a gynaecological swab could be used to detect four different female cancers at an early stage and also predict cancer risk over a healthy woman's lifetime? Researchers at the EUTOPS Institute in Innsbruck, Austria, are developing tests to do just that for breast, ovarian, cervical, and endometrial cancer detection.

News • Appeal for imaging improvements

Study reveals alarming failures in pancreatic cancer detection

Pancreatic cancer tumours are being missed on CT and MRI scans, narrowing the window for life-saving curative surgery, research presented at UEG Week 2022 has revealed.

News • New imaging method

Delayed fluorescence for effective surgical tumor removal

Researchers propose a new approach to identify cancerous tissue for surgical removal, based on real-time imaging of tissue oxygen concentration.

News • Prevention measure scrutinised

Colorectal cancer: colonoscopy screening not as effective as previously believed

A randomized study shows colonoscopy screening reduces the risk of colorectal cancer by 18 percent. The reduction is much smaller than experts previously assumed.

News • Model system shows tumor grwoth

Novel organoid model for pancreatic cancer

Researchers in Munich have developed a novel model system that can be used to precisely track the growth steps and three-dimensional arrangement of pancreatic cancer cells.

News • Insights into stem cell behaviour

Breast cancer: new mechanism of drug resistance discovered

Scientists in Italy discovered a new drug-resistance mechanism in breast cancer that leads to the formation of cancer stem cells. They also devised an experimental therapy to bypass or prevent this.

News • How cancer spreads

Cancer metastasis: Breakthrough to lead to better treatments

Cambridge scientists have discovered that cancer cells ‘hijack’ a process used by healthy cells to spread around the body, completely changing current ways of thinking around cancer metastasis.

News • Cancer research

Key function of important leukemia gene demystified

The oncogene EVI1 causes an aggressive type of leukemia, but its exact function has been a mystery. A research team now showed that EVI1's cancer causing effect relies on activating a single gene — the stem cell transcription factor ERG.

Article • Patient front and centre

One-Stop Clinic: diagnosis and treatment in one day, on one site, by one team

Cancer – one word that turns the patients’ world upside down. In addition to uncertainty and fear, they often face an unnerving series of exams and treatments. With its new One-Stop Clinic concept, GE Healthcare now wants to help make this journey as smooth as possible. At a single location, in an environment designed for comfort, the patients undergo all necessary steps within a short period…

News • Alveolar rhabdomyosarcoma

Promising new treatment for deadly pediatric tumor

Alveolar rhabdomyosarcoma is a rare pediatric tumor. For more than 40 years there has not been any new development regarding treatment. Research led by Prof. Dr. Anton Henssen at Charité University Berlin has now identified a new therapeutic option, using a drug that is currently under investigation for other types of cancer.

News • Lung adenocarcinoma

Therapeutic target against common lung cancer identified

A new study led by researchers in Barcelona has determined the protein TIMP-1 as a valuable biomarker for the progression of lung adenocarcinoma. The results open the door to new treatments.

Article • Interpreter of maladies

Will AI help realize the promise of precision medicine?

Machine learning and artificial intelligence (AI) have the potential to transform cancer treatment management worldwide. Their ability to rapidly analyse and integrate routinely acquired diverse data will improve the accuracy and effectiveness of precision medical treatments.

News • Precision oncology

What's new in cancer therapy?

Researchers from the University of Bern and Inselspital provide an overview of the latest technologies in precision oncology. Translating these into clinical application is still a major challenge.

News • Desperate cancer cells

How tumors mutate their way out of a crisis (and become drug-resistant)

Researchers discovered that cancer cells mobilize a SOS response when they are desperate to resist anticancer drugs. The team also came up with an anti-SOS approach that blocked the mechanism in mice.

Article • Modelling systems for human biology

Organoid technology: new opportunities for drug discovery

Two-dimensional (2D) cultured cell lines and animal models have been the principal research tools for the past decade, but have several shortcomings. Three-dimensional cell cultures, or organoids, show great promise here.

News • Impact of body constitution

Breast cancer: Tumour environment can affect prognosis

The interplay between the patient’s BMI, tumour size and cancer-specific proteins is of importance for the prognosis of breast cancer, a study from Sweden shows.

News • High-glade glioma research

Understanding why deadly brain cancer comes back

A surprising mechanism explains why high-grade gliomas, the deadliest form of brain cancer, returns: The tumours adapt to treatment by recruiting help from nearby healthy tissue.

News • Tumor identification in CUP patients

Cancer of unknown primary: comprehensive molecular analysis can improve therapy

A considerable proportion of patients suffering from cancer of unknown primary (CUP) could benefit from comprehensive molecular analysis and molecularly-informed targeted therapies.

Video • Clonal somatic mutations

How does cancer grow? Genetic mapping gives new insight

Researchers from the UK and Sweden have found that individual prostate tumours contain a previously unknown range of genetic variation.

News • Live bacterial therapeutics

Engineering the microbiome to potentially cure disease

Development of effective live bacterial therapeutics may depend more on using and re-introducing native microbes that can stick around than how the microbes are modified.

News • Throat surgery

After laryngectomy: AI screens voice pathologies

Striving to improve the patient’s quality of life after laryngectomy, researchers conducted a study, during which they searched for pathologies in patients’ voices using artificial intelligence (AI).

News • Liquid biopsy for early detection of brain tumours

Glioblastoma: Mathematical modelling could lead to simple blood test

The development of a simple blood test for glioblastomas could mean earlier diagnosis and more effective and personalised treatment options against the most common type of malignant brain cancer.

News • Determining aggressiveness

New discovery improves prostate cancer prognosis

Researchers in Sweden have now discovered a faster and easier way to determine who has an aggressive form of prostate cancer, and who has not.

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