Article • Cases rise
Should we screen for sickle cell disease?
Every year around a quarter of a million children worldwide die from sickle cell disease. In Germany around 3,000 people suffer from this rare inherited blood disorder.
Microscopy
News • Pen-sized microscope
Identifying cancer cells in operating rooms
Surgeons removing a malignant brain tumor don't want to leave cancerous material behind. But they're also trying to protect healthy brain matter and minimize neurological harm.
Suitable protein tags for nanoscopy
Scientists of the Göttingen Cluster of Excellence CNMPB and the EMBL describe efficient fluorescence tag for super-resolution microscopy.
Quickly identifying tumors by using antibodies
Antibodies combat viruses and bacteria. They also attach themselves to cancer cells – in a typical, characteristic way. Fraunhofer scientists are using this property to detect cancer cells in tissue samples. Such rapid tests can already be applied by surgeons during operations – within a few minutes and without expensive equipment.
News • Surfing DNA
Enzyme catches a ride to fight infection
Scientists have shown for the first time that an enzyme crucial to keeping our immune system healthy “surfs” along the strands of DNA inside our cells. The researchers used extremely powerful microscopy to watch how the enzyme AID (activation-induced deoxycytidine deaminase) moves around and interacts with other molecules.
News • State-of-the-art
First pictures of cells' DNA-copying machinery
The first-ever images of the protein complex that unwinds, splits, and copies double-stranded DNA reveal something rather different from the standard textbook view. The electron microscope images, created by scientists at the U.S. Department of Energy's Brookhaven National Laboratory with partners from Stony Brook University and Rockefeller University, offer new insight into how this molecular…
Sponsored • Technology
Panasonic set to launch 4K Ultra HD Micro Camera
Panasonic will launch a 4K Ultra HD micro camera at the forthcoming Compamed tradeshow in Düsseldorf, starting on Monday 16 November. The 4K micro camera (GP-UH532) has 3840x2160 resolution at 60p. It is capable of outputting images at up to 1600 TV lines, for smooth, detailed images and accurate colour reproduction.
News • Brain tumor surgery
Laser-based imaging tool could increase accuracy
Brain tumor tissue can be hard to distinguish from normal brain during surgery. Neurosurgeons use their best judgment in the operating room but often must guess exactly where the edges of the tumor are while removing it.
Article • Myocardial infarction
Advanced imaging techniques reveal T-tubules
Research conducted by Dr Ashraf Kitmitto and colleagues at the University of Manchester provides new information as to why some cells do not work properly following a heart attack.
Imaging glucose uptake inside single cells
Researchers at Columbia University have reported a new approach to visualize glucose uptake activity in single living cells by light microscopy with minimum disturbance.
Article • Science
Alternative routes to immortality
Every time a cell divides, the ends of chromosomes – the threads of DNA residing in the nucleus – shorten a bit. Once the chromosome ends, called telomeres, become too short, cells normally stop dividing. Scientists from the German Cancer Research Center (DKFZ) have now discovered how cancer cells make use of specific DNA repair enzymes to extend the telomeres. In this way, they escape the…
Article • Gentle intervention
Endoscopy jumps the boundaries
‘Health insurers should keep a tighter rein on the quality of endoscopic interventions because, mostly, they represent a gentler alternative to surgery,’ asserts international expert Horst Neuhaus, during an EH interview. Report: Daniela Zimmermann/Juliane Dannert
News • Figthing cancer
Triple treatment keeps cancer from coming back
Lung cancer is the leading cause of cancer death worldwide, responsible for some 1.59 million deaths a year. That figure is due, in part, to the fact that the cancer often returns after what, at first, seems to be successful treatment. And the recurring cancer is often resistant to the chemotherapy and other drugs that originally drove it into remission. According to new research by the Weizmann…
News • 3D nano-images
Revealing ‘bicycle spoke’ structure of heart cells
Newly released images revealing the ‘bicycle spoke’ structure of a heart cell may hold key clues to reducing damage from a heart attack.
News • Microscope technique
Speeding identification of deadly bacteria
A new way of rapidly identifying bacteria, which requires a slight modification to a simple microscope, may change the way doctors approach treatment for patients who develop potentially deadly infections and may also help the food industry screen against contamination with harmful pathogens, according to researchers at the Korea Advanced Institute of Science and Technology (KAIST) in Daejeon,…
Researchers grow cardiac tissue on “spider silk” substrate
Genetically engineered fibers of the protein spidroin, which is the construction material for spider webs, has proven to be a perfect substrate for cultivating heart tissue cells, MIPT researchers found. They discuss their findings in an article that has recently come out in the journal PLOS ONE.
Blood vessel lining cells control metastasis
Scientists from the German Cancer Research Center in Heidelberg and from the Medical Faculty Mannheim of Heidelberg University treated mice with a combination of a low-dose metronomic chemotherapy and an antibody against Ang-2, a regulatory protein of the blood vessel lining cells. The treated animals had significantly less metastases.
Article • Digital pathology
Biopsy results
Gideon Ho, CEO and co-founder of Singapore-based HistoIndex is confident: ‘After a biopsy a patient waits in a hospital bed, but now, instead of waiting a couple days until doctors know how to treat this patient, we can deliver results while the patient is still in the hospital.’ Report: John Brosky
Article • Infectious diseases
New biospleen blood cleansing excites experts
A new extracorporeal nanotech device addresses the root cause of sepsis by removing pathogens and endotoxins simultaneously from blood even before their identification – this genetically engineered mannose-binding lectin protein can also latch on to the Ebola virus... Report: Cynthia E Keen
Article • Organ donation
The liquid biopsy
Donor transplant rejection and cancer relapse have two things in common: early recognition is vital and monitoring is hugely challenged.
Instantaneous imaging, without the need for a computer
Olympus has released a new standalone controller for the 5 megapixel DP26 camera. Using the controller, it is possible to view samples and capture images directly on a monitor screen with no need for a dedicated computer.
Molecular diagnostics
Research in the field is booming thanks to newly arriving methods to identify gene sequences. Scientists are interested in a wide range of issues from disease-relevant variations of human genetic information to the detection of viral genetic material that supports therapies. Several highlights of current research were presented this spring at the 9th International Symposium on Molecular…
Laboratory challenges in disasters and world tragedies
This May, IFCC WorldLab Berlin with its manifold scientific programme gives clinical lab physicians the opportunity to see over the rim of the tea cup of their working field. Within the congress theme ‘Healing the world’ comes an exciting lecture on laboratory work in third world countries and disaster areas.
The Confocal Laser Endomicroscope
A new technique to aid the early detection and diagnosis of inflammatory bowel disease has been developed by UK and Germans researchers. The Confocal Laser Endomicroscope (CLE) contains a powerful microscope that allows clinicians to view bacteria in the intestine that are thought to trigger bowel diseases such as Crohn’s and ulcerative colitis.
£1 million to take forward breakthrough research in heart disease
Clues to the causes of serious, and often fatal, diseases and conditions, such as heart disease, stroke and high blood pressure, are being investigated at the Universities of Strathclyde and Glasgow, both in Scotland, with the use of a £1 million grant.