Small cell lung cancer is not usually detected until it is at an advanced stage, when metastases have already formed. Chemotherapy is very effective initially but, within a year, cancer recurs and this time does not respond to a course of chemotherapy. The research group headed by Gerhard Hamilton, University Department of Surgery at MedUni Vienna, has now managed to identify the reason for this…
Johns Hopkins scientists report they have developed an antibody against a specific cellular gateway that suppresses lung tumor cell growth and breast cancer metastasis in transplanted tumor experiments in mice, according to a new study published in the February issue of Nature Communications.
Interstitial lung diseases (ILD) are rare – yet they are far more difficult to diagnose and highly variable. Professor Julien Dinkel, consultant at the Institute of Clinical Radiology, Ludwig Maximilian University Hospital in Munich, deals with these rarities.
Randox Laboratories and Biosystems International have announced the beginning of clinical validation of a lung cancer early detection test.
One goal of immunotherapy is to rally a patient’s often over-burdened immune cells to effectively attack a tumor. Among foot soldiers on the immune front line is a subpopulation of white blood cells called “patrolling monocytes,” whose job is to cruise the bloodstream, cart off cellular debris, and block invasion of a less benign population of inflammatory cells.
Researchers compared an immunotherapy and a chemotherapy drug in patients with non-squamous non-small cell lung cancer (NSCLC) whose disease continued to progress after first-line chemotherapy. They found that nivolumab improved overall survival and was generally well tolerated. The results are significant because options for patients whose lung cancer progresses after initial treatment are…
With more than 50,000 newly diagnosed cases each year, lung cancer is one of the most common types of cancer in Germany. As yet, however, very few statistics are available on the care situation of lung cancer sufferers and the associated costs. Scientists at the Helmholtz Zentrum München have now analyzed comprehensive health insurance data in order to discover the cost of the disease and which…
Lung cancer is the leading cause of cancer death worldwide, responsible for some 1.59 million deaths a year. That figure is due, in part, to the fact that the cancer often returns after what, at first, seems to be successful treatment. And the recurring cancer is often resistant to the chemotherapy and other drugs that originally drove it into remission. According to new research by the Weizmann…
Researchers at the San Diego Supercomputer Center (SDSC) and the Moores Cancer Center at the University of California, San Diego, have described for the first time the molecular mechanism of cancer development caused by well-known "resistance" mutations in the gene called epidermal growth factor receptor (EGFR).
Nanoparticles are extremely small particles that can be modified for a variety of uses in the medical field. For example, nanoparticles can be engineered to be able to transport medicines specifically to the disease site while not interfering with healthy body parts.
Screening for lung cancer saves lives. This fact has been documented by outcomes of the U.S. National Lung Screening Trial (NLST) which showed a 20% reduction in lung cancer-specific deaths in patients who had a chest CT screening. What is controversial is how to establish the radiology resources needed to perform exams for all the people who need it and then how to pay for the exams.
To avoid any misunderstanding, ten years from today CT and MRI will still be the pillars of lung imaging. However, Hans-Ulrich Kauczor, Professor of Radiology and Medical Director of the radiology clinic at Heidelberg University Hospital, is convinced the emphasis will have changed.
Cancer specialists everywhere increasingly face new findings from molecular biology. Genetic profiling of tumours opens up entirely new perspectives on the disease. How to cope with and integrate new insights into cancer diagnosis and treatment was among key issues discussed at the 2nd European Forum on Oncology, held in Berlin this May
At first sight magnetic resonance imaging (MRI) does not seem to be particularly well suited for lung diagnostics: too much air, too much movement and too little water make image acquisition a real challenge. Nevertheless, MRI is useful and in certain cases even superior to CT say the members of HTIP (Heidelberg Thorax Imaging Plattform), an association of the radiology departments of the…
More and more patients with lung cancer are being treated with thermo-ablation techniques, and radiologists are increasingly being confronted with images from these patients that may be difficult to interpret.
Findings from the landmark National Lung screening Trial (NLST) continue to make waves in the United States, and increasingly around the world. The principal investigator for the component of the NLST sponsored by the American College of Radiology Imaging Network (ACRIN), Denise Aberle, MD, said the NLST can provide a road map for public policy regarding lung cancer screening, though she cautions…
When Lorenzo Bonomo, MD, first highlighted the growing importance of imaging for the staging of lung cancers, as the leading author of a highly regarded paper published in European Radiology, it was 1996. At that time the TMN system of descriptors for classification of lung cancers was in its 4th Edition, endorsed by professional societies worldwide, based exclusively though on a single database.
Reliable Cancer Therapies (RCT) celebrates the first anniversary of its website in style. The Swiss non-for-profit organization has completed comprehensive guides for cancer patients and their relatives, which are now available on its website.
Following the acquisition of an Elekta Axesse system, which provides 3-D image guidance technology for conventional and stereotactic radiation therapy techniques, Helsinki University Central Hospital (HUCH) in Finland reports that, after eight months its image guided radiation therapy (IGRT) of lung, brain, pelvis, head and neck tumours has increased by up to 30 patients daily.
In recent years, combined examination methods have increased, whereby two examination methods are used in a parallel examination, rather than performed separately. Frederik Giesel MD, Associate Professor of Radiology at the Nuclear Medicine Department, University of Heidelberg, and Philip Herold (Dipl. Econ.), Project Manager at RICT Heidelberg, report on the benefits.
Lung ultrasound is a technique with widespread uses and advantages in a range of areas from critical care through to less urgent medical areas. Most of all, it is of particular help in the rapid diagnosis of acute respiratory failure. During a session at WFUMB, its benefits and the latest techniques will be outlined by medical intensivist Dr Daniel Lichtenstein -- Lung Ultrasound in Acute…
Dr Helmut Prosch, at the University Clinic for Radio-Diagnostics, Vienna, Austria, is examining the role of imaging in lung cancer diagnosis and staging. The key message of his presentation in the session EUS and EBUS vs. CT, MR and PET-CT in the staging of lung cancer is that the modalities do not compete with one another – as the title suggests – but are perfectly complimentary in the…
There will be nearly 1.3 million deaths from cancer in Europe in 2011 according to predictions from a study published in the cancer journal, Annals of Oncology. The estimates, which have been reached after researchers used for the first time in Europe a new mathematical model for predicting cancer mortality, show a fall in overall cancer death rates for both men and women when compared to 2007.
The earlier cancers can be detected, the better the chances of a cure. Researchers are now working to develop a new diagnostics platform with which the illness can be diagnosed in its early stages, even during a visit to the general practitioner: protein biomarkers in exhaled air divulge the presence of pathological cells in the lung.
The lungs had to be regarded as the black hole for MRI for a long time. However, since the introduction of substantial improvements in hardware and scanner technology, there is certainly light at the end of the tunnel. MRI offers two main advantages for the diagnostic pathways for pulmonary diseases applied today.