New research at the University of Leicester, funded by the British Heart Foundation (BHF), could change the way people living with a debilitating heart condition are treated. The £2.7m clinical trial aims to identify the best time to operate on people living with severe aortic stenosis (AS). AS is a common condition that causes a narrowing of the heart valve, restricting blood flow out of the…
Genetic differences in the immune system shape the collections of bacteria that colonize the digestive system, according to new research by scientists at the University of Chicago. In carefully controlled experiments using germ-free mice populated with microbes from conventionally raised mice, the researchers showed that while the makeup of the microbial input largely determined the resulting…
Pancreatic cancer is one of the leading causes of cancer‑related deaths worldwide. Patients with pancreatic cancer often receive chemotherapy or radiation therapy, which are not always effective and can have toxic side effects. In a collaborative research between Osaka University and the University of Heidelberg, researchers are exploring a new method of treatment that brings powerful yet…
Children who suffer repeated febrile convulsions have an increased risk of developing epilepsy and psychiatric disorders such as schizophrenia and depression later in life. This is shown by a comprehensive register-based study from Aarhus University. The risk of febrile convulsions increases with the child’s fever, and approximately four per cent of Danish children suffer from febrile…
Chronobiologists at Ludwig Maximilian University of Munich, Germany, show in two articles how critical the sleep-wake cycle is for protein and phosphorylation dynamics in synapses to ultimately regulate its activity.
In adolescent and adult patients with cystic fibrosis (CF) taking lumacaftor-ivacaftor (Orkambi), the combination drug appears to improve lung function and body weight and reduce the need for intravenous antibiotic treatment, according to a French study published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine. However, the treatment also…
The potential impact of undiagnosed sexually transmitted chlamydia infection on men’s fertility has been highlighted in an Australian-led study, which for the first time found chlamydia in the testicular tissue biopsies of infertile men whose infertility had no identified cause. The researchers from Queensland University of Technology also found antibodies specific to the bacteria responsible,…
Sensitive synthetic skin enables robots to sense their own bodies and surroundings – a crucial capability if they are to be in close contact with people. Inspired by human skin, a team at the Technical University of Munich (TUM) has developed a system combining artificial skin with control algorithms and used it to create the first autonomous humanoid robot with full-body artificial skin. This…
Contrary to popular belief, cartilage in human joints can repair itself through a process similar to that used by creatures such as salamanders and zebrafish to regenerate limbs, researchers at Duke Health found. This process could be harnessed as a treatment for osteoarthritis. Publishing in the journal Science Advances, the researchers identified a mechanism for cartilage repair that appears to…
A new report by researchers at King’s College London has found that the widespread practice of routine ward rounds in England, known as intentional rounding, may not be the best way for nurses to deliver care to patients. The report also found that intentional rounding makes a minor contribution, if at all, to the way nurses engage with patients. The research was commissioned and funded by the…
Viscosity sensors are used by scientists fighting various diseases, such as Alzheimer's and Diabetes. Vilnius-based chemist Aurimas Vyšniauskas has enhanced their measuring capabilities. This breakthrough will equip researchers with additional tools to study living cells and how they change in a sick organism.
A trial tele-ophthalmology system pioneered by the University of Strathclyde and NHS Forth Valley, has paved the way for what's believed to be one of the world’s first tele-examinations of an eye streamed live using a 5G smart phone. The system uses a live video feed to securely connect doctors, opticians and patient through a mixture of 3-D printed technology developed at Strathclyde, and the…
X-rays could be tuned to deliver a more effective punch that destroys cancer cells and not harm the body, researches from Kyoto University find. Gadolinium delivered into cancer cells releases killer electrons when hit by specially tuned X-rays. The approach, published in the journal Scientific Reports, could pave the way towards a new cancer radiation therapy. “Our method opens up the…
The realization of an artificial womb has come one step closer, thanks to a new €2.9 million grant from the EU program Horizon 2020 for researchers in Eindhoven. The goal of the artificial womb is to increase the chances of survival for extremely premature babies outside the body. Just one year ago, the artificial womb was presented as a first design during the Dutch Design Week. This grant…
A robot-controlled laboratory where decisions are made by artificial intelligence will change the way new drugs are discovered, says a leading researcher. The engineer leading a project to develop a prototype "lab-bot" says it will reduce the time it takes to identify and synthesise molecules for new medicines – a process that can take years as scientists refine the shape and property…
Biologists from the University of California, Irvine have made a major finding on combating inflammation linked to Alzheimer's disease. The School of Biological Sciences researchers’ discovery about the role of a protein called TOM-1 heralds a shift toward examining the molecular underpinnings of Alzheimer’s processes. Their study appears online in Proceedings of the National Academy of…
A study by a team of Victoria University of Wellington scientists spotlights the role of gene networks in how people respond to one of the world’s most prescribed medications. The research team investigated the genetic network response to cholesterol-lowering drugs called statins, a medication prescribed to about 30 million people worldwide. The researchers say it is a significant step towards…
The Nobel Assembly at Karolinska Institutet has today decided to award the 2019 Nobel Prize in Physiology or Medicine jointly to William G. Kaelin Jr., Sir Peter J. Ratcliffe and Gregg L. Semenza for their discoveries of how cells sense and adapt to oxygen availability. Animals need oxygen for the conversion of food into useful energy. The fundamental importance of oxygen has been understood for…
Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of “ammunition” because of more and more frequently occurring resistances. A research team has now elucidated the structure of the proteolytic complex ClpX-ClpP. This is a key to development of innovative antibiotics which target the degradation process of defective proteins…
Immunotherapy is a promising cancer treatment that uses genetically modified immune cells to fight cancer. It can be used as a primary treatment or in combination with other treatments such as radiation and chemotherapy to slow down or stop the growth of cancer cells and prevent them from spreading to other parts of the body. Chimeric Antigen Receptor (CAR)-T cell therapy, for instance, is a…
One of the worst symptoms associated with inflammation or cancer of the pancreas is severe chronic pain. Pancreatic pain is difficult to treat, because many painkillers prove ineffective in pancreatic patients. In a recent study, a team at the Technical University of Munich (TUM) discovered the cause of this phenomenon for the first time: a particular neuroenzyme in the body is present in the…
Spanish researchers in Valencia have identified specific fragments of genetic material that play a role in the development of respiratory failure and sepsis in pneumonia patients. Presenting the research at the European Respiratory Society International Congress, Dr Francisco Sanz said the findings could enable doctors to test quickly for these biological markers when a patient is admitted to…
Most people can continue to eat red and processed meat as they do now. A major study led by researchers at McMaster and Dalhousie universities has found cutting back has little impact on health. A panel of international scientists systematically reviewed the evidence and have recommended that most adults should continue to eat their current levels of red and processed meat. The researchers…
In some forms of epilepsy, the function of certain "brake cells" in the brain is presumed to be disrupted. This may be one of the reasons why the electrical malfunction is able to spread from the point of origin across large parts of the brain. A current study by the University of Bonn, in which researchers from Lisbon were also involved, points in this direction. The results are…
Tiny particles that can fight cancer or that can easily pass through any interface within our body are a great promise for medicine. But there is little knowledge thus far about what exactly will happen to nanoparticles within our tissues and whether or not they can cause disease by themselves. Within an international research consortium, Empa scientists have now developed guidelines that should…