News • Customized to the patient
Organ-on-a-chip systems go 'plug and play'
A major advance demonstrates first multi-organ chip made of engineered human tissues linked by vascular flow for improved modeling of systemic diseases like cancer.
Tissue
News • The fatal signalling pathway
How liver fibrosis causes tissue scarring
An international research team has now found an approach to lower the activation of hepatic stellate cells (HSCs) and reduce the associated development of liver fibrosis.
News • Regenerative medicine
Injectable stem cell assembly for cartilage regeneration
Researchers have established an injectable hybrid inorganic nanoscaffold-templated stem cell assembly and applied it to the regeneration of critically-sized cartilage defects.
News • Aspergillosis monitoring
Chip-based model to observe fungal spread in the lung
A chip-based infection model developed by Jena researchers enables live microscopic observation of damage to lung tissue caused by the invasive fungal infection aspergillosis.
News • Magnetic tentacle
A small robot to explore the lungs
A proof of concept for a robot that can reach some of the smallest bronchial tubes in the lungs to take tissue samples or deliver cancer therapy.
News • New hope
Using AI and robotics to treat spinal cord injuries
By employing artificial intelligence (AI) and robotics to formulate therapeutic proteins, researchers promoted tissue regeneration.
News • Tissue regeneration
Repairing intestinal damage with 3D cell transplants
Researchers from Tokyo Medical and Dental University (TMDU) develop a protocol to transplant 3D cellular structures that could regenerate damaged intestine.
News • Bone healing
"Microrobots”: material morphs into bone
Researchers have developed a combination of materials that can morph into various shapes before hardening. The material is initially soft, but later hardens through a bone development process that uses the same materials found in the skeleton.
News • Multiple tumor tissue biomarkers
MOSAICA: next-generation biopsy technology
A new biopsy tool will enable scientists and clinicians to simultaneously profile many biomarkers in cells and tissues.
News • In cardiac cells
Pop-up sensors measure electronic signals
A tiny ‘pop-up’ sensor monitors the electrical activity inside heart cells. The device could provide new insights into cardiac diseases, including myocardial infarction and arrhythmias.
News • Tissue scarring
How a Covid-19 infection can damage the kidneys
The Coronavirus SARS-CoV-2 infects the kidneys and contributes to tissue scarring, as shown by researchers from Germany and the Netherlands.
News • Intra-nasal administration
Microrobots for treating neurological diseases
The joint research team of Prof. Hongsoo Choi (DGIST) & Prof. Sung Won Kim (Seoul St. Mary’s Hospital), developed an hNTSC-based microrobot for minimally invasive delivery into the brain tissue via the intranasal pathway.
News • Immunological memory
How our lungs 'remember' a Covid-19 infection
After infection with SARS-CoV-2, where does the immune system store the memory to provide long-term protection against reinfection? Though numerous studies have examined blood to track immune responses to SARS-CoV-2, a new study of Covid survivors shows that the memory of the infection is primarily stored in T and B cells within the lung and the lymph nodes surrounding the lung.
News • Organoid research
Structure formation in mini-organs
Many of the organ systems found in animals exhibit highly complex structures, which are essential for their various functions. How such structures develop during embryonic development is a central question in biology. Physicists led by Erwin Frey (Professor of Statistical and Biological Physics at LMU Munich) and Andreas Bausch (Professor of Cellular Biophysics at the Technical University of…
News • After a heart attack
3D mapping of post-infarction scarring increases prognostic potential of cardiac MRI
A multidisciplinary team of scientists based at the Universidad de Valladolid and the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has developed a highly efficient method for identifying the 3-dimensional features of the scar tissue formed after a myocardial infarction. The study was carried out in partnership with scientists and clinicians at Hospital Clínico San Carlos, Hospital…
News • Up-converting nanoparticles technology
Digital pathology: tissue imaging patent granted
Imaging company Lumito has secured a European patent for an instrument and staining reagents based on UCNPs (up-converting nanoparticles) for imaging in scattering materials, such as human tissue. The instrument is intended for use in tissue diagnostics, to provide pathologists visual depictions of tissue samples as an input for making diagnosis. The technology is patented across three global…
News • Hydrogel framework
Synthetic tissue with growing blood vessels developed
Using lab-created tissue to heal or replace damaged organs is one of the great visions for the future of medicine. Synthetic materials could be suitable as scaffolding for tissue because, unlike natural tissues, they remain stable in the organism long enough for the body to form new natural structures. A fundamental requirement for functional tissue is that blood vessels must be able to grow in…
News • Tissue dissection
World‘s first automated high throughput tissector launched
Molecular pathology company Xyall BV launches its Tissector High Throughput (HT) system for precision diagnostics. This is a world first – enabling high volume, molecular diagnostic laboratories to capitalize commercially on the company’s automated tissue dissection technology.
News • Automated image analysis
Algorithm detects biomarker in aggressive breast cancer
A researcher at the Technical University of Denmark (DTU) has developed a mathematical model for use in automated image analysis of tissue samples. The model provides the possibility for better and more similar cancer prognosis and treatment.
News • Customer Reference
And still it scans! 15 years of experience with Hamamatsu Photonics NanoZoomer
We recently had the pleasure of interviewing Dr. Peter Riegman from Erasmus University. Dr. Riegman is a Molecular Biologist and head of the Erasmus MC Tissue Bank. As an early adopter of digital pathology, Dr. Riegman purchased his first Hamamatsu Photonics whole slide scanner in 2005. It was a NanoZoomer HT, one of Hamamatsu’s very first production units, and it is still in daily use at…
News • Preventing long-term damage
How Covid-19 attacks lung tissues
La Trobe University researchers are the first in the world to characterize precisely how Covid-19 attacks lung tissues — an important step in preventing long-term damage.
Article • Digital pathology
Today’s tissue for tomorrow’s research
Specialist biorepositories are helping advance personalised medicine by supporting the availability of human tissue for research using digital pathology techniques. The pivotal role of the Glasgow Tissue Research Facility (GTRF) in making tissue available to shape new therapies and treatments was outlined in a presentation to the online “Transforming Digital Pathology – Integrating AI to Move…
News • Nano science
Conductive hydrogel could replace brain tissue
Due to their tissue-like mechanical properties, hydrogels are being increasingly used for biomedical applications; a well-known example are soft contact lenses. These gel-like polymers consist of 90 percent water, are elastic and particularly biocompatible. Hydrogels that are also electrically conductive allow additional fields of application, for example in the transmission of electrical signals…
News • Curbing collaterals
High energy radiotherapy ‘paints’ tumours, avoids healthy tissue
A radiotherapy technique which ‘paints’ tumours by targeting them precisely, and avoiding healthy tissue, has been devised in research led by the University of Strathclyde. Researchers used a magnetic lens to focus a Very High Electron Energy (VHEE) beam to a zone of a few millimetres. Concentrating the radiation into a small volume of high dose will enable it to be rapidly scanned across a…
Video • Regenerative medicine
Lab-grown ‘mini-bile ducts’ to repair human livers
Scientists have used a technique to grow bile duct organoids – often referred to as ‘mini-organs’ – in the lab and shown that these can be used to repair damaged human livers. This is the first time that the technique has been used on human organs. The research paves the way for cell therapies to treat liver disease – in other words, growing ‘mini-bile ducts’ in the lab as…