With the injectable gel the researchers were able to grow electrodes in living...
With the injectable gel the researchers were able to grow electrodes in living tissue. Here it is tested on a microfabricated circuit.

Image source: Linköping University; photo: Thor Balkhed

News • Tissue meets tech

Researchers grow electrodes in the brain

The boundaries between biology and technology are becoming blurred. Researchers at Linköping, Lund, and Gothenburg universities in Sweden have successfully grown electrodes in living tissue using the body’s molecules as triggers.

The result, published in the journal Science, paves the way for the formation of fully integrated electronic circuits in living organisms. 

“For several decades, we have tried to create electronics that mimic biology. Now we let biology create the electronics for us,” says Professor Magnus Berggren at the Laboratory for Organic Electronics (LOE) at Linköping University.

Contact with the body’s substances changes the structure of the gel and makes it electrically conductive, which it isn’t before injection

Xenofon Strakosas

Linking electronics to biological tissue is important to understand complex biological functions, combat diseases in the brain, and develop future interfaces between man and machine. However, conventional bioelectronics, developed in parallel with the semiconductor industry, have a fixed and static design that is difficult, if not impossible, to combine with living biological signal systems. 

To bridge this gap between biology and technology, researchers have developed a method for creating soft, substrate-free, electronically conductive materials in living tissue. By injecting a gel containing enzymes as the “assembly molecules”, the researchers were able to grow electrodes in the tissue of zebrafish and medicinal leeches. “Contact with the body’s substances changes the structure of the gel and makes it electrically conductive, which it isn’t before injection. Depending on the tissue, we can also adjust the composition of the gel to get the electrical process going,” says Xenofon Strakosas, researcher at LOE and Lund University and one of the study's main authors.

When the body’s endogenous molecules are added to the gel droplet, it turns...
When the body’s endogenous molecules are added to the gel droplet, it turns blue, which indicates its successful conversion to electrical conductivity.

Image source: Linköping University; photo: Thor Balkhed

The body’s endogenous molecules are enough to trigger the formation of electrodes. There is no need for genetic modification or external signals, such as light or electrical energy, which has been necessary in previous experiments. The Swedish researchers are the first in the world to succeed in this. Their study paves the way for a new paradigm in bioelectronics. Where it previously took implanted physical objects to start electronic processes in the body, injection of a viscous gel will be enough in the future. 

In their study, the researchers further show that the method can target the electronically conducting material to specific biological substructures and thereby create suitable interfaces for nerve stimulation. In the long term, the fabrication of fully integrated electronic circuits in living organisms may be possible.

portrait of Roger Olsson
Roger Olsson, professor at Lund University.

Image source: linköping University; photo: Ingemar Hultquist

In experiments conducted at Lund University, the team successfully achieved electrode formation in the brain, heart, and tail fins of zebrafish and around the nervous tissue of medicinal leeches. The animals were not harmed by the injected gel and were otherwise not affected by the electrode formation. One of the many challenges in these trials was to take the animals’ immune system into account. “By making smart changes to the chemistry, we were able to develop electrodes that were accepted by the brain tissue and immune system. The zebrafish is an excellent model for the study of organic electrodes in brains,” says Professor Roger Olsson at the Medical Faculty at Lund University, who also has a chemistry laboratory at the University of Gothenburg. 

It was Professor Roger Olsson who took the initiative for the study, after he read about the electronic rose developed by researchers at Linköping University in 2015. One research problem, and an important difference between plants and animals, was the difference in cell structure. Whereas plants have rigid cell walls which allow for the formation of electrodes, animal cells are more like a soft mass. Creating a gel with enough structure and the right combination of substances to form electrodes in such surroundings was a challenge that took many years to solve. “Our results open up for completely new ways of thinking about biology and electronics. We still have a range of problems to solve, but this study is a good starting point for future research,” says Hanne Biesmans, PhD student at LOE and one of the main authors. 


Source: Linköping University

27.02.2023

Related articles

Photo

News • Tissue analysis tool

'Smart scalpel' to help remove brain tumours

Researchers have developed the 'iKnife', a smart scalpel that is able to recognise healthy tissue from brain tumour in seconds as it cuts, with more than 98% accuracy.

Photo

News • RENACER repository

Brain cancer tissue samples to gain new insights

A paper published in Trends in Cancer explains the advantages of RENACER, the world’s first repository of brain metastases live samples, created by researchers at CNIO.

Photo

News • Enabling neuronal tissue growth

A hydrogel to heal the brain

Synthetic hydrogels were shown to provide an effective scaffold for neuronal tissue growth in areas of brain damage, providing a possible approach for brain tissue reconstruction.

Related products

Subscribe to Newsletter