An existing malaria drug could improve the effectiveness of a new class of cancer therapies, called glutaminase inhibitors, if used in combination, researchers at Weill Cornell Medicine-Qatar (WCM-Q) discovered in a new study.
The exchange of a single amino acid building block in a metabolic enzyme can lead to cancer. In addition, it can impair the immune system. It thus blocks the body’s immune response in the battle against the mutant molecule and also impedes immunotherapy against brain cancer. This finding opens new insights into cancer development and progression and it also suggests that rethinking antitumor…
Researcher have created an ingestible sensor to non-invasively monitor indicators of disease in the stomach and intestines.
Using high energy ultrasound beams to destroy prostate cancer tumours may be as effective as surgery or radiotherapy, but with fewer side effects. A new study, carried out at six hospitals across the UK, tracked 625 men with prostate cancer who received a type of treatment called high-intensity focused ultrasound (HIFU).
Medicines given to household pets to kill fleas and ticks might be effective for preventing outbreaks of malaria, Zika fever and other dangerous insect-borne diseases that infect millions of people worldwide, according to a new study led by scientists at Calibr, a non-profit drug discovery institute closely affiliated with Scripps Research and TropIQ Health Sciences, a Dutch social enterprise.
Until now ulcers inside the mouth have been treated using creams or mouthwashes for the whole mouth. A new biodegradable patch administers steroids directly to oral ulcers and forms a protective barrier. Scientists from the University of Sheffield’s School of Clinical Dentistry, working in close collaboration with Dermtreat A/S from Copenhagen, have developed a unique patch using special…
Being left-handed apparently means a lot more than gripping things differently than most, researchers find. This sheds a new light on mental health treatment, because current therapies for the most common mental health problems could be ineffective or even detrimental to about 50 percent of the population. For more than 40 years, hundreds of studies suggest that each hemisphere of the brain is…
While treatments for HIV mean that the disease is no longer largely fatal, the world still lacks a true therapy that can eradicate the virus across a globally—and genetically different—population.
Babraham Institute researchers have shown that some tumours use not one but two levels of protection against the immune system. Knocking out one level boosted the protective effects of the second and vice versa. The research demonstrates that a two-pronged approach targeting both cell types simultaneously may offer a promising route for the development of new cancer immunotherapies.
An international Phase 3 study has found that a personalized glioblastoma vaccine may increase long-term survival in some patients.
In an international study, scientists of the University Medical Center Hamburg-Eppendorf (UKE) have discovered a new therapeutic option for a large group of stroke patients. The main results of the European WAKE-UP trial were presented at the European Stroke Organisation Conference (ESOC) in Gothenburg, Sweden. At the same time, the trial results were published in the New England Journal of…
Two major projects feeding on big data and based in Spain have recently come under the spotlight: Mendelian, a tool to expedite rare diseases diagnosis, and Harmony, an EU platform that aims to improve targeted therapy in haematological cancer. Rare diseases affect as many as 6% of the Spanish population. Although this percentage is high, these conditions are individually rare, which complicates…
The first patient in a multicenter pivotal trial using focused ultrasound to address the major motor symptoms of Parkinson’s disease has been treated at Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center in New York. This randomized, double-blind clinical trial is evaluating the safety and efficacy of using Insightec’s Exablate Neuro device in more than 100 patients…
The University of Texas Health Science Center at Houston (UTHealth) has received funding through a public/private partnership for the first-ever clinical trial investigating a stem cell therapy for early treatment and prevention of complications after severe traumatic injury. The proposed Phase 2 trial is underwritten with $2 million from the Medical Technology Consortium (MTEC) and $1.5 million…
Scientists used an experimental targeted molecular therapy to block a matrix-forming protein in heart cells damaged by heart attack, reducing levels of scarred muscle tissue and saving mouse models from heart failure. Researchers at the Cincinnati Children’s Heart Institute report in the journal Circulation testing a manufactured peptide called pUR4 to block the fibronectin protein in human…
A vaccine may successfully turn off peanut allergy in mice, a new study shows. Just three monthly doses of a nasal vaccine protected the mice from allergic reactions upon exposure to peanut, according to research from the Mary H. Weiser Food Allergy Center at the University of Michigan. The study, funded by grants from Food Allergy Research and Education (FARE) and the Department of Defense, was…
Jan Walker, a retired administrative assistant to the superintendent of Boaz City Schools, was getting ready for her regular doctor visit and noticed a lump on her neck. Her primary care physician examined it and determined it was a simple swollen lymph node. Two months later, she began to lose feeling on the right side of her throat and noticed the lump had increased in size. After seeing other…
Healthy women who carry a breast cancer-causing mutation in the BRCA1 gene, not only reduce their risk of developing the disease but also their chances of dying from it if they have both breasts removed, according to new research presented at the 11th European Breast Cancer Conference. However, the study also found that for women with a mutation in the BRCA2 gene, there was no difference in their…
The heart is capable of terminating arrhythmias itself after local gene therapy, potentially avoiding the need for patients to undergo painful electric shocks, according to a proof-of-concept study presented today at EHRA 2018, a European Society of Cardiology congress. Atrial fibrillation is the most common heart rhythm disorder (arrhythmia). Treatment aims to restore the heart’s normal rhythm…
Immunotherapy is taking center stage in imaging, but patient follow-up with CT is no cookie and may fall short in the peripheral limbs, brain and bone marrow. MRI offers specific benefits in these situations, and, combined with PET, it may bring even more results. Research must be carried out on quantitative techniques and tracers developed to fully exploit that potential, Prof. Dow-Mu Koh…
Conventional chemotherapy in oncology is increasingly yielding to new procedures such as targeted therapy and immunotherapy. This results in changes for radiologists because new procedures require familiarisation with certain imaging to ensure that the treatment process is interpreted correctly.
Avoidance of side-effects of chemotherapy is particularly important in the elderly, but finding the balance between reduced toxicity and maximum effectiveness is not always easy. A trial carried out by the European Organisation for Research and Treatment of Cancer, published in The Lancet Oncology, shows that, in older patients with HER2 positive metastatic breast cancer (an aggressive breast…
Loyola Medicine is the first academic medical center in Illinois to use the TCAR system, which reduces stroke risk during carotid artery procedures by temporarily reversing blood flow. Carotid arteries on each side of the neck supply blood to the brain. In patients with carotid artery disease, a build-up of plaque can cause blockages. A common method to open the artery involves a balloon…
Breast cancer patients face complex decisions about their treatment. “Knowledge is a key component of decision making, and yet it’s consistently low even among patients who have received treatment. We need better tools to make these decisions more informed,” says Sarah T. Hawley, Ph.D., MPH, professor of internal medicine at Michigan Medicine. Hawley and colleagues from the Cancer…
Tumor imaging technique has potential as anti-cancer weapon, mouse study shows.