Research

News • Human cytomegalovirus in immunocompromised patients

Post-transplant HCMV infection: pre-emptive strike could save many lives

A potential new treatment to protect immunosuppressed patients from human cytomegalovirus (HCMV) has been discovered by scientists at the University of Cambridge. Their study shows that certain epigenetic inhibitors expose and help to destroy dormant HCMV infections, which often reactivate to cause serious illness and death in these vulnerable groups. Subject to clinical trials, their proposed…

News • Peptide research

A 'fake handshake' to trick the coronavirus

Scientists have developed peptides that fit snugly into a groove on the SARS-CoV-2 Spike protein that it would normally use to access a host cell. These protein fragments effectively trick the virus into “shaking hands” with a replica rather than with the actual protein on a cell’s surface that lets the virus in. revious research has determined that the novel coronavirus binds to a receptor…

News • Brain tumour analysis

Glioblastoma '3D maps' help find new therapies

Researchers at the Universitat Autònoma de Barcelona obtained a highly accurate recreation of human glioblastoma’s features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies.

News • After the coma

Prolonged anesthesia 'rewires' the brain

Prolonged anesthesia, also known as medically induced coma, is a life-saving procedure carried out across the globe on millions of patients in intensive medical care units every year. But following prolonged anesthesia--which takes the brain to a state of deep unconsciousness beyond short-term anesthesia for surgical procedures--it is common for family members to report that after hospital…

News • Physics of tumours

How cancer cells shape-shift to squeeze through tissue

Working with colleagues from Germany and the US, researchers at Leipzig University have achieved a breakthrough in research into how cancer cells spread. In experiments, the team of biophysicists led by Professor Josef Alfons Käs, Steffen Grosser and Jürgen Lippoldt demonstrated for the first time how cells deform in order to move in dense tumour tissues and squeeze past neighbouring cells. The…

News • From science fiction to reality

Researchers develop powerful pocket-sized imaging device

Before Wilhelm Röntgen, a mechanical engineer, discovered a new type of electromagnetic radiation in 1895, physicians could only dream of being able to see inside the body. Within a year of Röntgen’s discovery, X-rays were being used to identify tumors. Within 10 years, hospitals were using X-rays to help diagnose and treat patients. In 1972, computed tomography (CT) scans were developed. In…

Video • Regenerative medicine

Lab-grown ‘mini-bile ducts’ to repair human livers

Scientists have used a technique to grow bile duct organoids – often referred to as ‘mini-organs’ – in the lab and shown that these can be used to repair damaged human livers. This is the first time that the technique has been used on human organs. The research paves the way for cell therapies to treat liver disease – in other words, growing ‘mini-bile ducts’ in the lab as…

News • Infection research

Mutations help bacteria resist antibiotic treatment

Bacteria have many ways to evade the antibiotics that we use against them. Each year, at least 2.8 million people in the United States develop an antibiotic-resistant infection, and more than 35,000 people die from such infections, according to the U.S. Centers for Disease Control. Most of the mutations known to confer resistance occur in the genes targeted by a particular antibiotic. Other…

Video • Wearable for blood pressure, heart rate, glucose and more

New patch monitors multiple markers at once

Engineers at the University of California San Diego have developed a soft, stretchy skin patch that can be worn on the neck to continuously track blood pressure and heart rate while measuring the wearer’s levels of glucose as well as lactate, alcohol or caffeine. It is the first wearable device that monitors cardiovascular signals and multiple biochemical levels in the human body at the same…

Article • Implantation of cartilage or stem cells

Remarkable cartilage regeneration

Joint cartilage usually regenerates very poorly. The matrix of cartilage (scaffolding) contains very few cells in deep layers. Moreover, joint cartilage is highly isolated: there are neither regenerative cells in the immediate vicinity that could migrate into the site of the defect and trigger repair, nor vessels that could transport regenerative cells to the cartilage. Unsurprisingly,…

Article • Healthcare facilities analysed

Cutting Coronavirus air contamination in hospitals

Preventing air contamination in healthcare facilities is crucial to minimise the airborne spread of Covid-19 and its new strains. Universal masking, rigorous use of and safe disposal of PPE, plus building ventilation are vital. Twenty-four studies reporting hospital SARS-CoV-2 air contamination are summarised in a meta-analysis by a multi-institutional team of French researchers. These show that,…

News • Inactivation of Coronavirus & Co. via electrochemistry

Antiviral mask offers protection at the push of a button

Researchers at ZHAW Zurich University of Applied Sciences are working with the Swiss company Osmotex AG to develop a self-disinfecting mask that inactivates viruses at the push of a button. The prototype of this mask made of electrochemical textiles shows an antiviral effect of over 99 percent. Further applications such as sterilizable seat covers are being examined.

News • Higher range, lower energy absorption

New high-frequency MRI coil to advance imaging

Anyone needing a tomography gets the clearest possible images of an organ or other body structure slice by slice. But the further inside the potential problem lies, the more difficult it is to obtain high-resolution images in magnetic resonance imaging (MRI). An international team of scientists led by the University of Duisburg-Essen (UDE) has developed a high-frequency coil that allows for much…

News • Research collaboration

'Cells of the future' might cure lung infections

Healing the body with cells – this is the ambitious goal of scientists at Hannover Medical School (MHH). With this in mind, Professor Dr. Nico Lachmann and Dr. Robert Zweigerdt have initiated a research collaboration and license agreement with the pharmaceutical company Novo Nordisk A/S, to combine academic knowhow with the translational power of the industry. The overall aim of the endeavor is…

News • Study on N95, KN95 and FFP2 mask suggests

Covid-19 masks: Why proper fit matters more than material

A team of researchers studying the effectiveness of different types of face masks has found that in order to provide the best protection against Covid-19, the fit of a mask is as important, or more important, than the material it is made of. The researchers, from the University of Cambridge, carried out a series of different fit tests, and found that when a high-performance mask – such as an…

News • Freefrom Reversible Embedding of Suspended Hydrogels

A 'FRESH' way to 3D-print tissues and organs

Research into 3D bioprinting has grown rapidly in recent years as scientists seek to re-create the structure and function of complex biological systems from human tissues to entire organs. The most popular 3D printing approach uses a solution of biological material or bioink that is loaded into a syringe pump extruder and deposited in a layer-by-layer fashion to build the 3D object. Gravity,…

News • Restoring proprioception after amputation

New surgery improves 'phantom limb' sensation, prosthesis control

Researchers at the Massachusetts Institute of Technology (MIT) have invented a new type of amputation surgery that can help amputees to better control their residual muscles and sense where their “phantom limb” is in space. This restored sense of proprioception should translate to better control of prosthetic limbs, as well as a reduction of limb pain, the researchers say. In most…

News • On the go

Improving wearables for medical applications

Cardiovascular diseases are the most common cause of fatalities in Germany. Medical wearables which measure vital parameters such as the blood pressure, heart rate and blood oxygen levels in real time could help detect these diseases early, and treat them on a preventive basis. In daily life and during sports activities, in the form of fitness bracelets or smart watches, these small, portable…

News • From the brain to the joints

Common anti-depressant could also treat osteoarthritis

Osteoarthritis affects more than 30 million adults and is the fifth-leading cause of disability in the United States. In a new study, scientists have discovered the cellular pathway that leads to the joint disease and have identified a commonly used anti-depressant — paroxetine — that inhibits this pathway.

News • Brain cancer research

New approach could stop glioblastoma growth

Inhibiting a key enzyme that controls a large network of proteins important in cell division and growth, paves the way for a new class of drugs that could stop glioblastoma, a deadly brain cancer, from growing. Researchers at Princess Margaret Cancer Centre, the Hospital for Sick Children (SickKids) and University of Toronto (U of T), showed that chemically inhibiting the enzyme PRMT5 can…

News • Spotting viral differences

Finding a better way to search for Covid-19 drugs

Is there a better approach to Covid drug research? Research from the University of Kent, Goethe-University in Frankfurt am Main, and the Philipps-University in Marburg has provided crucial insights into the biological composition of SARS-CoV-2, the cause of Covid-19, revealing vital clues for the discovery of antiviral drugs. Researchers compared SARS-CoV-2 and the closely related virus SARS-CoV,…

News • 53,831 genomes analysed

Rare diseases: huge dataset brings new insights

Researchers at the University of Maryland School of Medicine (UMSOM) and their colleagues published a new analysis from genetic sequencing data of more than 53,000 individuals, primarily from minority populations. The early analysis, part of a large-scale program funded by the National Heart, Lung, and Blood Institute, examines one of the largest and most diverse data sets of high-quality whole…

News • Malignant paediatric cancer

Neuroblastoma: sending tumour cells on a collision course

With two commercially available inhibitors, the cell cycle of the cancer cells in neuroblastomas can be disrupted at a key point causing tumour cell death. Neuroblastomas are malignant solid tumours that occur mainly in early childhood. Inhibiting the MYCN oncogene or its function could be a promising therapeutic opportunity.

News • Target cells, medication effects, evasion methods

4 new facts about early Covid-19 infections

University of Minnesota Medical School researchers studied SARS-CoV-2 infections at individual cellular levels and made four major discoveries about the virus, including one that validates the effectiveness of remdesivir – an FDA-approved antiviral drug – as a form of treatment for severe Covid-19 disease. “Since the start of the Covid-19 pandemic, the way that each individual responds…

News • Anticoagulants vs coronavirus

Preventive blood thinning could reduce risk of Covid-19 death

Patients given preventive blood thinning drugs (prophylactic anticoagulants) within 24 hours of admission to hospital with Covid-19 are less likely to die compared with those who do not receive them, a new study finds. Clinical trials are now underway to see if prophylactic anticoagulants could be an effective treatment for Covid-19. In the meantime, the researchers say these findings provide…

2161 show more articles