A pioneering European research project designed to develop new diagnostic tests to assess patients with Non-Alcoholic Fatty Liver Disease (NAFLD) has expanded giving access to more patients. Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS) funded by the European Innovative Medicines Initiative 2 Joint undertaking, brings together clinical scientists from international…
A new study has begun to test whether broccoli and garlic can help improve prostate health. The Norfolk Accumulation of Dietary Bioactives and Prostate Cancer (ADaPt) study has been launched by researchers at Quadram Institute Bioscience (QIB) and the Norfolk and Norwich University Hospital (NNUH). The study, which will take place at the NNUH-run Clinical Research Facility at the Quadram…
In the wake of an already devastating cancer diagnosis, European cancer patients often grapple with debilitating symptoms and side effects. For these patients, the eSMART (Electronic Symptom Management System Remote Technology) trial provides new hope for improved management of the side effects and symptoms of cancer, and with it, improved quality of life. Now, the eSMART Consortium presented its…
A new study has concluded that psychiatric diagnoses are scientifically worthless as tools to identify discrete mental health disorders. The study, published in Psychiatry Research and led by researchers from the University of Liverpool, involved a detailed analysis of five key chapters of the latest edition of the widely used Diagnostic and Statistical Manual (DSM), on ‘schizophrenia’,…
Is computed tomography suitable for detecting lung cancer at a very early stage and thus still well treatable? Scientists at the German Cancer Research Center have investigated this with the LUSI study started in 2007. The results of the study, which is funded by the Deutsche Forschungsgemeinschaft and the Dietmar Hopp Foundation, are now available.
Half of Ebola outbreaks have gone undetected since the virus was discovered in 1976, scientists at the University of Cambridge estimate. The new findings come amid rising concern about Ebola in the Democratic Republic of Congo, and highlight the need for improved detection and rapid response to avoid future epidemics.
Scientists at the German Centre for Cardiovascular Research (DZHK) have started a study to find out whether a monoclonal antibody restoring vascular integrity is safe and has positive effects on organ functions of patients with cardiogenic shock. The multicenter trial is sponsored by the University of Hamburg, financially supported by the biopharmaceutical company Adrenomed AG, and led by Dr.…
The rate of bowel cancer – also known as colorectal cancer or CRC – is rising among adults aged 20-49 in Europe, suggests new research. Rates rose most steeply among the youngest age group (20-29 years), and the authors warn that if the trend continues, screening guidelines may need to be reconsidered. Rates tend to be lower among people over 50, but the opposite is true among younger adults…
Nearly 90% of all cancer patient deaths are due to metastasis. A study from Uppsala University shows that a process that allows the cells to metastasise is aided by the synthesis of new ribosomes, the cell components in which proteins are produced. The results open the possibility for new treatment strategies for advanced cancers. The study is published in Nature Communications. As tumours…
Induced pluripotent stem (iPS) cells are among the most important tools in modern biomedical research, leading to new and promising possibilities in precision medicine. To create them requires transforming a cell of one type, such as skin, into something of a blank slate, so it has the potential to become virtually any other kind of cell in the body, useful for regenerative therapies for…
Advancing technology is allowing scientists increasingly to search for tiny signs of cancer and other health issues in samples of patients’ blood and urine. These “liquid biopsies” are less invasive than a traditional biopsy, and can provide information about what’s happening throughout the body instead of just at a single site. Now researchers at the University of Michigan Rogel Cancer…
Researchers at Washington University School of Medicine in St. Louis have found, in mice, that treatment with an antibiotic reduces the size of lesions caused by endometriosis. The researchers are planning a large, multicenter clinical trial to test the drug metronidazole in women who have the painful condition. The study is published online April 30 in the journal Human Reproduction.…
For the first time ever, chronic pain will be classified as a diagnosis in line with other diseases when the World Health Organization (WHO) approves the next catalogue of recognised diseases in May. According to Professor Peter Svensson from the Department of Dentistry and Oral Health, this is very significant for the approx. 20% of the population who suffer from chronic pain. Working with top…
A single high dose of radiation that can be delivered directly to the tumour within a few minutes is a safe and effective technique for treating men with low risk prostate cancer, according to a study presented at the ESTRO 38 conference. Radiotherapy traditionally involves a series of lower dose treatments that take place over several days or week. The new treatment is called high dose-rate…
It is the Methusalem among fishkind: The colorful Clownfish lives longer than 20 years in the Aquarium. Researchers of the Scuola Normale Superiore in Pisa, Italy, in collaboration with the Leibniz Institute on Aging (FLI) in Jena, Germany, have investigated the genetics behind the longevity of Clownfish. By sequencing the genome and comparing the sequences with other species, they were able to…
New findings about a fatal form of blood cancer could aid the development of new drugs with significantly less harmful side effects than existing chemotherapy. The discovery could lead to novel treatments that efficiently eliminate blood cancer cells in acute myeloid leukaemia (AML), without harming healthy blood cells. Researchers have discovered how a protein in the body plays a key role in AML…
Women with early, low risk, hormone-driven breast cancer are less likely to have a recurrence of their disease if they have radiotherapy after surgery, as well as anti-hormone treatment, according to results from a trial that has followed 869 women for ten years. New findings from the 8 A trial of the Austrian Breast and Colorectal Cancer Study Group (ABCSG), presented at the ESTRO 38 conference,…
Scientists could help match cancer patients with no other treatment options to clinical trials with experimental medicines, by analysing the genetic faults in a sample of their blood. The researchers, funded by Cancer Research UK, The Christie Charity, AstraZeneca and the NIHR Manchester Biomedical Research Centre (BRC), demonstrated in their feasibility study that a blood test can be carried out…
When the first antibiotics were discovered in the early 20th century, the rate of death from infectious diseases fell dramatically. But the emergence of multidrug-resistant bacteria as a result of antibiotic misuse is raising fears that by 2050, these same diseases will once again become the leading cause of death worldwide. In a bid to boost the arsenal available to tackle this threat,…
Half of patients prescribed statins in primary care fail to reach ‘healthy’ cholesterol levels after two years of treatment with these drugs, reveals research published online in the journal Heart. The findings back up those of previous studies, and highlight the need for personalised medicine to tackle high cholesterol and lower the significantly increased risks of future heart disease and…
BioMérieux and the Laboratory of Medical Microbiology at the University of Antwerp announced at ECCMID (European Congress of Clinical Microbiology & Infectious Diseases) the 2018 results of the Global Point Prevalence Survey (GLOBAL-PPS), a study of antibiotic use and antimicrobial resistance (AMR) in hospitals around the world. Since its launch in 2015, this survey has been conducted in…
Non-alcoholic fatty liver disease (NAFLD) is a condition where fat accumulates in the liver and has become the most common liver disease worldwide. While NAFLD shows few or no symptoms at initial stages, it is a potentially serious disease which can progress to an inflammatory state called steatohepatitis (NASH), which can lead to liver cirrhosis and cancer. Fatty liver disease can be managed by…
A new study provides critical insight into a little-known, yet relatively common, inherited neurological condition called Charcot-Marie-Tooth disease (CMT). The findings point to a pathway to possible treatments for this disease and better understanding of other neurodegenerative disorders, including Alzheimer's disease, that affect millions. The study focused on two related proteins, MFN2 and…
Researchers at Mount Sinai have developed a novel approach to cancer immunotherapy, injecting immune stimulants directly into a tumor to teach the immune system to destroy it and other tumor cells throughout the body. The “in situ vaccination” worked so well in patients with advanced-stage lymphoma that it is also undergoing trials in breast and head and neck cancer patients, according to a…
Scientists have identified key changes in immune cells within cancerous tumours that could help improve the development of treatments. The study, which has been published in the journal Cancer Cell, also found a set of genes that are expressed at high levels in breast cancer tumours and linked to more aggressive cancer types. Researchers say the discoveries offer clues to diagnosis and predicting…