Dipeptidyl peptidase 4 (DPP4)
Obesity, fatty liver, insulin resistance: Liver enzyme might be to blame
German researches have linked the increased production of a certain enzyme in the liver to fatty liver and insulin resistance.
Liver
Lifestyle-dependent illness
New treatment options for non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent liver diseases worldwide and an estimated 20 million people in Germany are affected.
Biomarkers
Aiming for the earliest diagnosis of hepatocellular carcinoma
For almost three quarters of hepatocellular carcinoma (HCC) patients in Europe it is too late for curative treatment because the disease is often only diagnosed at a very advanced stage. Interviewed Professor Guido Gerken MD, Director of the Department for Gastroenterology and Hepatology at University Hospital Essen, about improved and timelier diagnostic capabilities that have already been…
Interventional Radiology
3-D simulation includes haemodynamics
New 3-D simulation models that include haemodynamics enable better treatment of hepatic tumours via radio-embolisation, according to eminent Spanish radiologist José Ignacio Bilbao Jaureguizar.
MRI & Liver
MRI leading the way in metabolic disease imaging
New MRI techniques are set to offer advances in the earlier detection of liver disease in patients. Radiologists are harnessing the potential of highly-targeted MRI, whilst exploring the imaging modality as a means of delivering non-invasive biomarkers, reducing the need for biopsy to measure treatment response.
Ultrasound
New features complete Philips solution for liver assessment
NEW: Evolution 3.0 EPIQ ultrasound upgrade offers high-res PureWave crystal transducer technology, shear wave elastography, contrast enhanced ultrasound, and image fusion. Could you ask for more?
Award
SIR honors Riad Salem for using radioembolization to treat liver cancer
Riad Salem, MD, MBA, will be honored with the Society of Interventional Radiology (SIR) Foundation Leaders in Innovation Award March 7, during the group's annual scientific meeting in Washington, D.C., for his work in radioembolization.
Oncology
One more piece in the puzzle of liver cancer identified
Researchers at University of Vienna discover unexpected role of signalling protein in hepatocellular carcinoma.
Oncology
Treatment hope would leave liver cancer cells in limbo
Scientists have shown that a mutation in a gene called Arid1b can cause liver cancer. The gene normally protects against cancer by limiting cell growth, but when mutated it allows cells to grow uncontrollably. The researchers have shown that two existing drugs can halt this growth in human cells. This points to a new approach to treating liver cancer.
CEUS
Only convincing with contrast
Contrast enhanced ultrasound is part of clinical routine and makes a substantial contribution towards increasing the significance of tissue and organ diagnosis with ultrasound for difficult cases.
Virology
Tricks of ticking time bomb Hepatitis B virus
Hepatitis B virus (HBV) causes hepatitis B, an infectious disease that afflicts 230 million people worldwide, thereof 440 000 in Germany. Persistence of the virus in liver cells leads to progressive organ damage in the patient and contributes to a high risk of cirrhosis and liver cancer development. Providing a new paradigm to hepatitis B understanding, researchers at the German Cancer Research…
Paediatrics
Elastography is a promising tool in paediatrics
‘Already used in adults for several years, elastography is a promising tool in paediatric imaging,’ according to radiologist Dr Mehrak Anooshiravani-Dumont, from Geneva University Hospital. ‘It allows detection of changes in the mechanical properties of tissues, such as fibrosis, based on viscoelastic characteristics.‘
Oncology
Scientists root out the ‘bad seeds’ of liver cancer
Researchers have found the “bad seeds” of liver cancer and believe they could one day reprogram them to remain responsive to cancer treatment, a new study has found.
When rejection comes from within
A new cellular structure responsible for previously unexplained rejection of organ transplants has been identified by researchers at the University of Montreal Hospital Research Centre (CRCHUM.)
Liver damage in hepatitis C patients significantly underestimated
The number of hepatitis C patients suffering from advanced liver damage may be grossly underestimated and underdiagnosed, according to a study led by researchers at Henry Ford Health System and the U.S. Centers for Disease Control and Prevention.
Research
Malaria’s key to the liver uncovered
Scientists uncover a port of liver entry for malaria parasites in a report published in The Journal of Experimental Medicine. If these results hold up in humans, drugs that target this entry protein might help prevent the spread of disease.
Research
A recipe for long-lasting livers
People waiting for organ transplants may soon have higher hopes of getting the help that they need in time. Researchers at the RIKEN Center for Developmental Biology have developed a new technique that extends the time that donor organs last and can also resuscitate organs obtained after cardiac arrest.
Big data of human biology
A multi-year study led by researchers from the Simons Center for Data Analysis (SCDA) and major universities and medical schools has broken substantial new ground, establishing how genes work together within 144 different human tissues and cell types in carrying out those tissues' functions.
Computer Model
How our livers will store fat?
As part of an effort to understand how an experimental drug for atherosclerosis causes the build-up of fat in the liver, scientists have developed a computer model that can predict how the rate at which liver stores fat in response to various situations.
Organ Transplantation
Innovative technique for liver transplants
Surgeons at the University Hospitals Leuven have used a new technique for two recent liver transplants: in both cases the organ was preserved prior transplantation in a device that mimics the environment of that in the human body, making sure the liver stays ‘healthier’. The device can even assess and improve the quality of the liver.
Diabetes
Biomarker for steatohepatitis
40 percent of people in the EU suffer from non-alcoholic steatohepatitis, a disease which is becoming increasingly more frequent as a result of diabetes and excess weight in an affluent society.
Fast Ultrasound
Ultrasound system sharpens paediatric hepatic imaging
Ask about UltraFast ultrasound and you might expect a technical answer explaining why the ultrasound is faster. However, for Stéphanie Franchi-Abella MD, fast means just fast, an ultra-quick acquisition she can take of a squirming, agitated new-born in the blink of an eye. ‘These babies are small and breathing rapidly, the organs are moving fast in the image and it’s sometimes difficult to…
Liver
Stellate cells control regeneration and fibrosis
Scientists from the German Cancer Research Center (DKFZ) and the Medical Faculty in Mannheim at Heidelberg University are searching for new approaches to prevent liver fibrosis. They have identified a surface molecule on special liver cells called stellate cells as a potential target for interfering with this process. When the researchers turned off the receptor, this led to reduced liver…
Research
New revolutionary culturing technique for liver and pancreas
Researchers at the Hubrecht Institute and the University Medical Center (UMC) Utrecht successfully developed a culturing system for human liver stem cells as well as stem cells from pancreatic cancer. They describe the development of these culturing systems in two articles in this week’s edition of Cell magazine.
Incidental findings
Liver lesions are most often benign
At least 60% of liver lesions can be characterised purely by ultrasound. Screening and examinations of supposedly healthy patients often result in an accidental discovery of liver lesions. According to Dr Antonius Schuster MD MBA, Head of the Department of Radiology at the LKH Bregenz, (Vorarlberg). ‘The prevalence of such changes is around 20% of patients examined’. Depending on a…