For the first time, engineered heart muscle (EHM) from human induced pluripotent stem cells (iPSCs) will be used to treat patients with heart failure. After regulatory approval, recruitment of the first patient for the first-in-class, first-in-patient BioVAT-HF early clinical trial has started in Göttingen, Germany.
It is only 120 millionths of a millimetre in size but can bring entire countries to a standstill: the Corona virus. Even if it were to disappear one day, viral infections will still be among the most frequent and difficult-to-treat diseases in humans. Even decades of research have only produced a few standardized vaccines and strategies for treatment to combat just a small number of viruses. Nor…
Scientists have generated accurate replications of human retinas in culture that can be used to pinpoint the specific types of cells affected by genetic eye diseases. The culmination of a six-year effort, this achievement will accelerate progress in developing new therapies and was reported in Cell by a team led by Botond Roska at the Institute for Molecular and Clinical Ophthalmology Basel (IOB)…
Scientists combined induced pluripotent stem cells (iPSC) and their deep knowledge in the bioengineering of human organoids to for the first time bioengineer the human brain at the macroscale level with comprehensive network function
A team of British and American scientists have discovered a way to slow the growth of breast cancer stem cells in the lab. The study led by Dr Bruno Simões and Professor Rob Clarke from The University of Manchester could eventually lead to combination drug therapies on previously untreatable breast cancers. Around three quarters of women who have breast cancer have what are known as oestrogen…
Blood stem cells have a surprising ability. In addition to ensuring the continuous renewal of blood cells, they keep track of past infections so that faster and more effective immune responses can be triggered in the future.
Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury—a first-ever “biomarker” for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve…
Niels-Bjarne Woods, a researcher at Lund University in Sweden, has developed lung-specific mesenchymal stem cells to treat inflammation of the lungs and fibrosis. This research now may be the needed breakthrough for treatment of the severe respiratory issues related to COVID-19. A clinical study may soon be underway contingent on a successful application to the Swedish Medical Products Agency.…
A population of stem cells with the ability to generate new bone has been newly discovered by a group of researchers at the University of Connecticut (UConn) School of Dental Medicine. In the journal Stem Cells, lead investigator Dr. Ivo Kalajzic, professor of reconstructive sciences, postdoctoral fellows Dr. Sierra Root and Dr. Natalie Wee, and collaborators at Harvard, Maine Medical Research…
Scientists suggest a new strategy that uses induced pluripotent stem cells (iPSCs) to regulate immune reaction to transplanted tissues. The team, led by Professor Ken-ichiro Seino of Hokkaido University’s Institute for Genetic Medicine, found that thymic epithelium cells derived from mouse induced pluripotent stem cells (iPSCs) can regulate immune response to skin grafts, extending their…
A study led by scientists from Cornell University provides important new insights into a common and deadly type of gastric cancer. Incidence of this cancer, called gastric squamous-columnar junction (SCJ) cancer, also known as gastroesophageal cancer, rose 2.5 times in the United States between the 1970s and 2000s, while cases of all gastric cancers have decreased by more than 80% since the…
Researchers have created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer’s and Parkinson’s diseases and other neurological disorders.
Researchers have discovered a unique combination of cells grown from stem cells that could prove pivotal in helping a heart regenerate after a patient has suffered a myocardial infarction. The University of Cambridge research team found that transplanting an area of damaged tissue with a combination of heart muscle cells and supportive cells, similar to those that cover the outside of the heart,…
A drug developed by US physician-scientists and chemists speeds up the regeneration of mouse and human blood stem cells after exposure to radiation. If the results can be replicated in humans, the compound could help people recover quicker from chemotherapy, radiation and bone marrow transplants. The study, published in Nature Communications, also sheds light on the basic biology behind blood…
Researchers at the University of Helsinki have discovered how regenerative capacity of intestinal epithelium declines when we age. Targeting of an enzyme that inhibits stem cell maintaining signaling rejuvenates the regenerative potential of an aged intestine. This finding may open ways to alleviate age-related gastrointestinal problems, reduce side-effects of cancer treatments, and reduce…
We all know someone affected by the battle against cancer. And we know that treatments can be quite efficient at shrinking the tumor but too often, they can’t kill all the cells, and so it may come back. With some aggressive types of cancer, the problem is so great that there is very little that can be done for the patients.
A proof-of-principle study shows that gold nanoparticles loaded with CRISPR and other gene-editing tools safely and effectively edited blood stem cells.
Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim University Medical Center have now discovered that a certain group of cancer drugs (MEK Inhibitors) activates the cancer-promoting Wnt signalling pathway in colorectal cancer cells. This can lead to the accumulation of tumor cells with stem cell characteristics that are resistant to many…
A discovery by researchers at Queen’s University Belfast and King’s College London (KCL) could revolutionise treatment for vascular and diabetes related cardiovascular diseases.
Induced pluripotent stem (iPS) cells are among the most important tools in modern biomedical research, leading to new and promising possibilities in precision medicine. To create them requires transforming a cell of one type, such as skin, into something of a blank slate, so it has the potential to become virtually any other kind of cell in the body, useful for regenerative therapies for…
UC San Francisco researchers have for the first time transformed human stem cells into mature insulin-producing cells, a major breakthrough in the effort to develop a cure for type 1 (T1) diabetes. Replacing these cells, which are lost in patients with T1 diabetes, has long been a dream of regenerative medicine, but until now scientists had not been able to figure out how to produce cells in a…
In breast cancer, one of the most common cancers in women, tumors contain a small amount of so-called cancer stem-like cells (CSCs). Being able to eliminate breast-cancer stem-like cells in a targeted way is essential for developing successful therapies — conventional treatments, such as chemotherapy or radiotherapy followed by drug intake, do not target CSCs. A better understanding of the…
People with Duchenne muscular dystrophy (DMD) can develop an otherwise-rare muscle cancer, called rhabdomyosarcoma, due to the muscle cells’ continuous work to rebuild the damaged tissue. However, little is known about how the cancer arises, hindering development of a treatment or test that could predict cancer risk. Now, scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP)…
Scientists from the German Cancer Research Center (DKFZ) and the stem cell institute HI-STEM* have succeeded for the first time in directly reprogramming human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur during the early embryonic development of the central nervous system. They can be modified and multiplied indefinitely…
As mammals age, their sense of smell deteriorates. In a study published in the journal ‘Cell Reports’, an interdisciplinary research team at Helmholtz Zentrum München and the University Medical Centre Mainz investigated why this is the case. For their study, the researchers tracked the development of stem cells in the brains of mice using what are known as confetti reporters. They then…