A team of scientists from the University of Michigan Medical School shows that the genetic material in female (but not male) cells makes tiny amounts of a special genetic material called RNA to make one of the two X chromosomes silent. They call this RNA XistAR.
When a Lake Malawi cichlid loses a tooth, a new one drops neatly into place as a replacement. Why can't humans similarly regrow teeth lost to injury or disease?
Complex life is only possible because proteins bind to each other, forming higher-order structures and signal pathways. Scientists at the Max Planck Institute (MPI) of Biochemistry in Martinsried near Munich and at the MPI of Molecular Cell Biology and Genetics in Dresden have now drawn a detailed map of human protein interactions. Using a novel mass spectrometric quantification method, the…
If you have diabetes, or cancer or even heart problems, maybe you should blame it on your dad’s behaviour or environment. Or even your grandfather’s. That’s because, in recent years, scientists have shown that, before his offspring are even conceived, a father’s life experiences involving food, drugs, exposure to toxic products and even stress can affect the development and health not…
St. Jude Children’s Research Hospital scientists have discovered evidence of a mechanism at the heart of amyotrophic lateral sclerosis (ALS) and related degenerative diseases. The research highlights a possible new treatment strategy for the devastating disorders.
Researchers from the University of Cologne and NEO New Oncology AG today jointly published in Nature* the findings of an extensive genomic analysis of neuroblastoma, a malignant pediatric tumor of the sympathetic nervous system. In the most aggressive forms of this tumor, the researchers identified previously unknown genomic alterations leading to up-regulation of the telomerase reverse…
In a discovery that could lead to more targeted and effective treatments for certain lung and prostate cancers, researchers at the University of Virginia School of Medicine have identified two new cancer-causing gene mutations – mutations that may be particularly susceptible to cancer-fighting drugs already approved by the federal Food and Drug Administration. One of the gene mutations also may…
A team of scientists at the Children’s Research Institute at UT Southwestern (CRI) has become the first to use a tissue-clearing technique to localize a rare stem cell population, in the process cracking open a black box containing detailed information about where blood-forming stem cells are located and how they are maintained. The findings provide a significant advance toward understanding…
A unique molecule developed at Duke Medicine, the University of North Carolina at Chapel Hill and MacroGenics, Inc., is able to bind HIV-infected cells to the immune system’s killer T cells. It could become a key part of a shock-and-kill strategy being developed in the hope of one day clearing HIV infection.
An international team of researchers, led by scientists at the National University of Singapore (NUS), has identified a protein that regulates the growth of neurons by transporting key metabolic enzymes to the tips of neural cells. Their findings open up new avenues for design of drugs for ataxia, a motor coordination disorder.
University of Virginia School of Medicine researchers have discovered a new strategy for attacking cancer cells that could fundamentally alter the way doctors treat and prevent the deadly disease. By more selectively targeting cancer cells, this method offers a strategy to reduce the length of and physical toll associated with current treatments.
People often talk about how important it is to stay in shape, something humans usually can accomplish with exercise and a healthy diet, and other habits. But chances are, few of us ever think about the shape of our individual cells.
Premature births are intimately linked with inflammation of the uterine tissue, a biological response which induces contractions and preterm labor. In their search for a mean to prevent this phenomenon and complications related to deliveries occurring before 37 weeks of gestation, researchers at CHU Sainte-Justine and University of Montreal discovered an agent that shows efficacy in inhibiting…
More than five million Americans are living with Alzheimer's disease (AD). Of them, 400,000 also have Down syndrome. Both groups have similar looking brains with higher levels of the protein beta amyloid.
Every organism—from a seedling to a president—must protect its DNA at all costs, but precisely how a cell distinguishes between damage to its own DNA and the foreign DNA of an invading virus has remained a mystery. Now, scientists at the Salk Institute have discovered critical details of how a cell’s response system tells the difference between these two perpetual threats. The discovery…
Researchers at the Virginia Bioinformatics Institute at Virginia Tech have uncovered key cellular functions that help regulate inflammation -- a discovery that could have important implications for the treatment of allergies, heart disease, and certain forms of cancer.
When our cells copy their DNA to grow and replicate, it’s vital the process runs smoothly. To get this right, cells use a complex “machine”, made from many hundreds of components. This machine is built afresh, moment by moment as it’s needed during the copying process. This assembly–de-assembly is vital to accurate and efficient copying.
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
As new cardiac genetic testing panels become available, cardiologists have been warned not to lose sight of the importance of comprehensive clinical evaluation. While genetic testing is helping to identify more people at risk of inherited conditions, experts stress they are only part of the diagnostic toolkit.
Innovative presentations, ground-breaking science and inspirational lectures underlined the diversity of sessions at the British Cardiovascular Society 2015 conference held in Manchester this June.
A ground-breaking genetic testing programme for an inherited and potentially-deadly high cholesterol condition has been extended to more United Kingdom health trusts.
A new study at the University of Haifa has used “big data” analytical methods to reveal the “social character” of genes – a phenomenon in certain diseases whereby genes operate jointly rather than independently. “The problem is that the possible number of combinations of different genes is enormous, and it is almost impossible to examine them all effectively and reliably,” the…
An LMU team has uncovered a new role for the protein Atrx, which is involved in various aspects of gene expression. The new work shows that the protein is also involved in silencing endogenous retroviral genomes integrated in cellular DNA.
A new technology that will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as stem cell differentiation, inflammation and cancer, is reported in the research journal Nature Methods.
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