Oncology

News • iCAGES

New precision medicine tool helps optimize cancer treatment

Columbia University Medical Center (CUMC) researchers have created a computational tool that can rapidly predict which genes are implicated in an individual’s cancer and recommend treatments. It is among the most comprehensive tools of its kind, and the first that incorporates a user-friendly web interface that requires little knowledge of bioinformatics.

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News • Cancer follow-up

Machine learning to help radiologists

Physicians have long used visual judgment of medical images to determine the course of cancer treatment. A new program package from Fraunhofer researchers reveals changes in images and facilitates this task using deep learning. The experts will demonstrate this software in Chicago from November 27 to December 2 at RSNA, the world’s largest radiology meeting.

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News • Oncology

Treatment hope would leave liver cancer cells in limbo

Scientists have shown that a mutation in a gene called Arid1b can cause liver cancer. The gene normally protects against cancer by limiting cell growth, but when mutated it allows cells to grow uncontrollably. The researchers have shown that two existing drugs can halt this growth in human cells. This points to a new approach to treating liver cancer.

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News • Oncology

Nanoparticle creates ‘wave of destruction’ in cancer cells

Nanoparticles known as Cornell dots, or C dots, have shown great promise as a therapeutic tool in the detection and treatment of cancer. Now, the ultrasmall particles – developed more than a dozen years ago by Ulrich Wiesner, the Spencer T. Olin Professor of Engineering at Cornell University – have shown they can do something even better: kill cancer cells without attaching a cytotoxic drug.

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News • Melanoma treatment

Dermatology develops an effective immunotherapy against solid cancer

Melanomas account among the eight most frequent deadly cancers in Europe and Northern America. Two major clinical criteria separate melanomas from most other cancers: the risk to die from a melanoma is a question of being less or more than 1 mm – and not a question of cm. About 95% of patients with melanomas ≤0.5 mm in thickness are clinically cured by early detection and appropriate melanoma…

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Article • Tomosynthesis

Additional cancer screening for women with dense breasts

Italian-led research has highlighted the value of utilising additional screening technologies to help diagnose breast cancer in some women. Interim analysis from the Adjunct Screening with Tomosynthesis or Ultrasound in Women with Mammography-Negative Dense Breasts (ASTOUND) study has delivered evidence of the potential benefit of adding either ultrasound or tomosynthesis to standard mammograms…

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News • Oncology

Nanovaccine could enhance cancer immunotherapy

NIBIB researchers have created a nanovaccine that could make a current approach to cancer immunotherapy more effective while also reducing side effects. The nanovaccine helps to efficiently deliver a unique DNA sequence to immune cells – a sequence derived from bacterial DNA and used to trigger an immune reaction. The nanovaccine also protects the DNA from being destroyed inside the body, where…

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Overcoming multidrug-resistant cancer with smart nanoparticles

Multidrug resistance (MDR) is the mechanism by which many cancers develop resistance to chemotherapy drugs, resulting in minimal cell death and the expansion of drug-resistant tumors. To address the problem of resistance, researchers at the National Institute of Biomedical Imaging and Bioengineering (NIBIB) at the National Institutes of Health (NIH) have developed nanoparticles that…

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