Professor Regina Beets-Tan has been appointed to the mission board of the EU research mission on cancer, part of the European Commission’s research initiative known as Horizon Europe. She has been selected to serve on the 15-member board for the cancer mission, tasked with shaping their mission and further defining what research receives funding within the cancer mission’s mandate, beginning…
Two known gene mutations induce pathways that enhance pancreatic cancer’s ability to invade tissues and evade the immune system. Researchers report the molecular details of this process providing insights into druggable targets for immunotherapies. Mutations in the genes KRAS and TP53 are closely linked to pancreatic ductal adenocarcinoma, by far the most common type of pancreatic cancer.…
A pioneering European research project designed to develop new diagnostic tests to assess patients with Non-Alcoholic Fatty Liver Disease (NAFLD) has expanded giving access to more patients. Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS) funded by the European Innovative Medicines Initiative 2 Joint undertaking, brings together clinical scientists from international…
Researchers at Karolinska Institutet in Sweden have discovered a new sensory receptor organ that is able to detect painful mechanical damage, such as pricks and impacts. The discovery is being published in the scientific journal Science. Pain causes suffering and results in substantial costs for society. Almost one person in every five experiences constant pain and there is a considerable need to…
A new study has begun to test whether broccoli and garlic can help improve prostate health. The Norfolk Accumulation of Dietary Bioactives and Prostate Cancer (ADaPt) study has been launched by researchers at Quadram Institute Bioscience (QIB) and the Norfolk and Norwich University Hospital (NNUH). The study, which will take place at the NNUH-run Clinical Research Facility at the Quadram…
Kiel biochemistry research team proves the existence of a previously unknown alternative cholesterol transport mechanism inside cells. Cholesterol is a vital cell building block in humans and animals, and an integral part of the so-called cell membrane. This boundary layer separates the interior of the cell from the neighbouring cells and the surrounding environment. By means of certain proteins,…
Researchers at ETH Zurich have refined the famous CRISPR-Cas method. Now, for the very first time, it is possible to modify dozens, if not hundreds, of genes in a cell simultaneously. The biotechnological method CRISPR-Cas offers a relatively quick and easy way to manipulate single genes in cells, meaning they can be precisely deleted, replaced or modified. Furthermore, in recent years,…
Neurons of the central nervous system (CNS) shut down their ability to grow when they no longer need it; this is commonly accepted knowledge. This occurs normally after they have found their target cells and established synapses. However, recent findings show that old nerve cells have the potential to regrow and to repair damage similar to young neurons. The underlying mechanisms for this…
Researchers identified how to kill therapy-resistant cells in hypoxic tumors and in cells arising in the von Hippel-Lindau hereditary cancer. In a recent publication in PNAS, the research group identified how to kill therapy-resistant cells in hypoxic tumors and in cells arising in the von Hippel-Lindau (VHL) hereditary cancer.
Blood clotting is one of the most critical, protective processes in human physiology. When something goes wrong with clotting, either because there is too much clotting, leading to a stroke, or not enough, leading to internal bleeding, the outcome can be catastrophic. Now, University at Buffalo researchers have established an in vitro model of this process that will help clinicians improve…
The traditional classification of diabetes, mainly in type 1 and type 2 diabetes, has been challenged by studies from Scandinavia. In the current issue of The Lancet Diabetes & Endocrinology, researchers from DDZ together with colleagues from DZD and University of Lund published a cluster analysis of diabetes allowing for phenotyping into subgroups, which extended the findings by showing that…
A new study harnessed the unique genetic history of the people of Finland to identify variations in DNA that might predispose certain individuals to disease, whether or not they are Finnish themselves.
As the largest organ of the human body, our skin is astounding. It protects us from infection, endures radiation, senses temperature, and is flexible enough to withstand our everyday activities. What holds this all together is the protein we all know and love: collagen. In a paper published in Scientific Reports a team from Japan found for the first time that collagen in the skin is organized in…
Cigarette smoke can make MRSA bacterial strains more resistant to antibiotics, new research from the University of Bath has shown. In addition cigarette smoke exposure can make some strains of Staphylococcus aureus – a microbe present in 30-60% of the global population and responsible for many diseases, some fatal – more invasive and persistent, although the effect is not universal across all…
Women with pre-eclampsia during pregnancy have a five-fold increased risk of end stage kidney disease (ESKD) later in life compared to women who don’t develop pre-eclampsia during pregnancy, according to a new study. Professor Louise Kenny from the University of Liverpool is one of the co-authors of the study, which is published in PLOS Medicine and also involved researchers at University…
Clinical trials are a critical tool for getting new treatments to people who need them, but research shows that difficulty finding the right volunteer subjects can undermine the effectiveness of these studies. Researchers at Cincinnati Children’s Hospital Medical Center designed and tested a new computerized solution that used artificial intelligence (AI) to effectively identify eligible…
Global warming may have played a pivotal role in the emergence of Candida auris. According to a new study published in mBio, an open-access journal of the American Society for Microbiology, C. auris, which is often multi-drug resistant and is a serious public health threat, may be the first example of a new fungal disease emerging from climate change.
A team led by scientists at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI) developed an algorithm that a computer could use to conduct a similar type of search in microbial and metagenomic databases. In this case, the machine “learned” to identify a certain type of bacterial viruses or phages called inoviruses, which are filamentous viruses with small, single-stranded DNA…
Think twice before adding that extra kick of chili sauce or chopped jalapeno to your meal. New research involving the University of South Australia shows a spicy diet could be linked to dementia. A 15-year study of 4582 Chinese adults aged over 55 found evidence of faster cognitive decline in those who consistently ate more than 50 grams of chili a day. Memory decline was even more significant if…
Researchers at Lund University in Sweden have investigated the link between osteoarthritis and mortality in an epidemiological study. It was shown that the risk of dying from cardiovascular disease was higher for people with osteoarthritis than for the rest of the population. Using population registers, the researchers studied approximately 469 000 people living in Skåne, Sweden, who in 2003…
A team of researchers from the SingHealth Duke-NUS Academic Medicine Centre’s Viral Research and Experimental Medicine Centre (ViREMiCS) found that immune cells undergoing stress and an altered metabolism are the reasons why some individuals become sick from viral infections while others do not, when exposed to the same virus. The findings, published in medical journal Nature Medicine, have…
The practice of taking small, regular doses of psychedelic drugs to enhance mood, creativity, or productivity lacks robust scientific evidence, say scientists. The process, called microdosing, has been lauded by some, with high profile proponents in Silicon Valley. But to date, scientific evidence to support or even fully explore claims of the benefits and safety, has been lacking. Now, an…
Researchers at the University of Helsinki have discovered how regenerative capacity of intestinal epithelium declines when we age. Targeting of an enzyme that inhibits stem cell maintaining signaling rejuvenates the regenerative potential of an aged intestine. This finding may open ways to alleviate age-related gastrointestinal problems, reduce side-effects of cancer treatments, and reduce…
In the most comprehensive study of its kind, researchers from the Department of Nutritional Sciences at the University of Surrey investigated if protein intake can impact bone health of adults and children. Examining 127 previous studies published over a 40 year period, which scrutinised the link between protein and bone density, bone mineral content and relative risk of osteoporotic fractures,…
A new study has concluded that psychiatric diagnoses are scientifically worthless as tools to identify discrete mental health disorders. The study, published in Psychiatry Research and led by researchers from the University of Liverpool, involved a detailed analysis of five key chapters of the latest edition of the widely used Diagnostic and Statistical Manual (DSM), on ‘schizophrenia’,…