News • Neuropathology
Technology offers new insights into pediatric brain tumors
A new study used new molecular analyses to unravel the biological mechanisms of pediatric brain tumors and refine their classification.
News • Integration of microanalysis chips
Establishing microfluidic control technology for blood testing devices
A research group established a microfluidic control technology that can be applied to small blood testing devices and consequently developed a novel integrated immunoassay device.
Article • Pros and cons of diagnostic techniques
Liquid biopsy vs. tissue biopsy: Getting the best of both worlds
Tissue biopsy and liquid biopsy can increasingly be used as complementary or alternative approaches, with advantages and limitations to each. While speakers at the recent 35th European Congress of Pathology in Dublin were quick to highlight that liquid biopsy was not about to replace tissue biopsy, the focus looked at the benefits and challenges of each through the lens of four expert speakers.
News • Heteroresistance
Researchers discover new mechanisms behind antibiotic resistance
A new study explores the phenomenon of heteroresistance in bacteria, which is a key driver of antibiotic resistance. Two new discoveries could impact the development of future AMR strategies.
News • Axon vulnerability to damage
Male and female brains are different – and so are the effects of concussions
Structural differences in male and female brains might explain why women are more prone to concussions and experience longer recovery from the injury than men, according to a new preclinical study.
News • Three-dimensional tissue processing
Pathology performs leap into 3D with AI
Adding a new dimension to pathology: Researchers explore new, deep learning models that can use 3D pathology datasets to make clinical outcome predictions for curated prostate cancer specimens.
News • Vaccines for future pathogens
“We don’t have to wait for new coronaviruses to emerge”
A new approach to vaccine development could produce vaccines before the disease-causing pathogen – such as a new variant of the coronavirus Sars-CoV-2 – even emerges.
News • Research on autoantibody patterns
The unique and complex origins of rheumatoid arthritis
New research challenges assumptions about the origin of rheumatoid arthritis, which are probably too simple. The findings may point towards improved diagnostics of this painful autoimmune disease.
News • Leukemia MRD after chemo
AML: Residual cancer testing as an important safeguard
Blood cancer cells can remain in the blood of AML patients, even after chemotherapy seemed successful. Testing for these residuals before blood cell donation is a vital precaution, a new study finds.
News • Transfusion medicine
One step closer to universal donor blood
Donor blood is a scarce and valuable resource. Researchers aim to mitigrate this by using enzymes to remove specific sugars that make up the A and B antigens in the human ABO blood groups.
News • Gene-snipping bacterial defenses
CRISPR: a promising tool to fight antibiotic resistance, but...
Could the 'gene scissors' CRISPR be used to make resistant bacteria susceptible to first-line antibiotics again? According to new reseach, yes – but the experts also point out serious caveats.
News • Survey on pathogens of concern
What will cause the next pandemic? Experts agree on a likely culprit
The world has hardly processed Covid-19, so the thought of another pandemic is far from pleasant. Yet, infectious disease experts have picked the most likely candidate in a new survey.
News • Urine-based diagnostics
New prostate cancer test to help avoid unnecessary biopsies
US researchers have developed and validated a new urine-based test for prostate cancer, which was shown to meaningfully reduce unnecessary prostate biopsies while providing highly accurate detection.
News • Immunological improvement
How long is long Covid? New research hints at timeframe
New research provides cause for optimism that long Covid can resolve over time. Following people from the first wave of Covid-19, it monitored the longevity of immune abnormalities after an infection.
News • Research on large foundation models
Reducing bias in pathology AI
A study highlights performance differences in computational pathology systems, depending on demographic profiles associated with histology images. The researchers also propose a way to fix this bias.
News • Presented at ESCMID Global
Immunoassay analyzer extends menu with new hepatitis assays
Beckman Coulter Diagnostics announced ahead of the ESCMID Global congress (formerly ECCMID) that it has extended the menu of DxI 9000 Immunoassay Analyzer* assays.
News • Research on syndrome correlation
Finding the link between Guillain-Barré and Takotsubo
Takotsubo cardiomyopathy (‘broken heart syndrome’) is a known complication of Guillain-Barré, but not much is known about the association between the two. New research aims to change this.
News • Mechanistic subtypes
The telltale traces long Covid leaves in the blood
Findings from the largest UK study of patients hospitalised with Sars-CoV-2 infection show that long Covid leads to ongoing inflammation which can be detected in the blood.
Article • Pharmaceutical research
Boosting biomarker detection with digital pathology
Digital pathology can be used to great effect in pharmaceutical research: it can accelerate analyses, give deeper insights into cellular mechanisms, and enable better understanding of their role into clinical development. This potentially offers clearer predictions on how patients may respond to treatment and lead to personalized therapies.
News • Preventive blood test
Prostate cancer screening: Study advocates 5-year-interval
How often should men get checked for their level of PSA, a marker for prostate cancer? A German study involving over 12,500 men shows that a five-year interval between tests is safe.
News • New-found blood signatures
Multiple sclerosis: subtype discovery opens new ways for personalized therapy
Researchers discovered three distinct immunological endophenotypes of multiple sclerosis, defined by specific blood immune signatures. This opens new avenues for personalized treatment strategies.
News • Osteosarcoma model
Bone cancer prognosis enhanced via deep learning
Osteosarcoma is the most prevalent malignant bone tumor. Now, researchers have developed a machine-learning model to predict the density of viable tumor cells after surgery and chemotherapy treatment.
News • BRCA1 and BRCA2 malfunctions
Targeting 'exhausted' immune cells to prevent breast cancer
A study found immune cells in breast tissue of healthy women carrying BRCA1 or BRCA2 gene mutations show signs of ‘exhaustion’. This opens new possibilities for cancer prevention.
News • Bioinformatics
New tool identifies chromosomal instability in cancer cells
A new detection tool is designed to contribute to improving tumour research and classification by identification and quantification of chromosomal instability in the nuclei of cancer cells.
News • Potential for screening and treatments
Study links bacteria subtype to colorectal cancer growth
A specific subtype of a microbe commonly found in the mouth has been identified that is able to travel to the gut and grow within colorectal cancer tumors, driving cancer progression.
