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News • Flow cytometry lab

New ClearLLab IVD Reagents launched

Beckman Coulter is launching the ClearLLab 10C System for the clinical flow cytometry lab. The new system is the first 10-color IVD panel of immunophenotyping reagents cleared by the Food and Drug Administration (FDA) for both lymphoid and myeloid lineages. The four dry pre-mixed antibody tubes use the company’s DURA Innovations technology, eliminating the need to pipette antibodies, improving…

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News • Making the invisible visible

New method opens unexplored realms for liquid biopsies

Advancing technology is allowing scientists increasingly to search for tiny signs of cancer and other health issues in samples of patients’ blood and urine. These “liquid biopsies” are less invasive than a traditional biopsy, and can provide information about what’s happening throughout the body instead of just at a single site. Now researchers at the University of Michigan Rogel Cancer…

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News • Total Laboratory Automation

TLA sets new standard for turnaround time

Beckman Coulter announced that the latest addition to its market-leading automation portfolio, the DxA 5000 total laboratory automation (TLA) solution has achieved European CE Mark and China Food and Drug Administration approval. In today’s healthcare environment, laboratories are highly focused on enhancing patient care by driving faster turnaround time, delivering quality results and…

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News • Post-cancer impairment

'Chemobrain': New biomarkers found

Cognitive impairment associated with cancer, also known as “chemobrain”, has gained recognition as a complication of the disease and its treatment, as it can negatively affect the daily lives of cancer patients and survivors. Chemobrain can be subtle yet persistent, with some cancer patients reporting difficulties related to memory and attention even months after completing their treatment.…

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Article • Digital pathology

Bridging the gap between pathologist and algorithm

Digital pathology can gain huge benefits from rapid image search and the effective extraction of knowledge from large medical archives via artificial intelligence (AI). It facilitates identification of anatomical and pathological similarities, significantly enhances the clinical workflow, and ultimately paves the way for more informed diagnosis and better patient outcome. Effective archive…

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Article • Digital pathology & AI

Unleashing the power of digital pathology for precision medicine

Digital pathology, combined with the power of Artificial Intelligence (AI), is one of the most promising fields for the delivery of precision medicine. In the first keynote address for the 5th Digital Pathology & AI Congress (Europe) held in London last December, Professor of Pathology, Marilyn Bui, focused on how digital pathology is impacting on precision medicine. During her address,…

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Article • Post-analytical interpretive tools

Towards a clearer view of complex lab results

Interpretation of complex profiles of laboratory results can be significantly improved via multivariate pattern recognition software. A multivariate pattern recognition software, developed by a team led by Dr Piero Rinaldo at Mayo Clinic in Rochester, USA, aims to integrate results to diagnose a particular condition in a single score, in an objective evidence-based way that is open to worldwide…

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Article • Heroin, fentanyl, carfentanyl

Mass Spec detects illicit drugs

As a synthetic opioid approved for treating severe pain, fentanyl has shown clear medical benefits. However, in recent years, continuous abuse of fentanyl and its derived analogues substances has become a major public health issue – overdoses and deaths associated with illicitly-manufactured fentanyl rose dramatically.

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Article • Mass spectrometry in patient care

LC-MS/MS: Why qualitatively high-value analysis is cheaper in the end

In the past, we repeatedly focused our attention on developments in the clinical application of mass spectrometry-based methods in patient care. Various aspects became significant. Today, the use of Liquid Chromatography Triple Quad Mass Spectrometry (LC-MS/MS) for therapeutic drug monitoring (TDM) can be considered today’s standard, although classically applied immunoassays continue to be…

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News • Targeted treatment

Cancer: Blood sample to help select the right early phase clinical trials

Scientists could help match cancer patients with no other treatment options to clinical trials with experimental medicines, by analysing the genetic faults in a sample of their blood. The researchers, funded by Cancer Research UK, The Christie Charity, AstraZeneca and the NIHR Manchester Biomedical Research Centre (BRC), demonstrated in their feasibility study that a blood test can be carried out…

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News • New hematologic biomarker

FDA clearance for early sepsis indicator

A major milestone on its strategic mission to lead in sepsis diagnostics, Beckman Coulter announced that its Early Sepsis Indicator has received 510(k) clearance from the U.S. Food and Drug Administration (FDA). Sepsis is a global healthcare crisis that affects more than 30 million people worldwide. The Early Sepsis Indicator is a first-of-its-kind, hematology-based cellular biomarker that is…

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News • Two years earlier

Breast cancer: blood test could detecting relapse earlier

Research has revealed that a new blood test is able to detect disease relapse up to two years earlier than imaging in patients with early-stage breast cancer. The research, carried out by the University of Leicester and Imperial College London and funded by Cancer Research UK, showed that the blood test was able to detect 89 per cent of all relapses, on average 8.9 months quicker than imaging.

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Sponsored • New staining technology

Staining is an art – ColorAX2 will become your favourite artist

ColorAX2 with its new staining technology offers you low staining reagents consumption. The compact, lightweight and autonomous system features 10 independent staining chambers and allows easy and clean procedures. The unique technology of ColorAX2 prevents cross-contamination and significantly reduces the consumption of reagents and waste. Besides it helps you reduce your operation costs. The…

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Article • Infection control

Knowledge is one thing - implementation another

Insufficient knowledge of infection control, resulting in insufficient compliance, increases the risk of hospital acquired infections (HAIs) and multiresistant pathogens that put patients at risk. At the 2019 Annual General Meeting of the German Society for Hygiene and Microbiology e.V. (DGHM) in Göttingen, Professor Frauke Mattner, Senior Consultant at the Institute of Hygiene, Kliniken der…

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Article • Antimicrobial resistance

Apocalypse postponed: upcoming antibiotics bring hope

Antimicrobial resistance is a global issue, with 700,000 deaths per year and 10 million expected deaths by 2050, according to predictions. Appropriate antimicrobial therapy can help to save lives, and a long awaited cure for carbapenemase-producing enterobacteriaceae (CPE) will soon be released, according to eminent Spanish expert Jose Mensa Pueyo, speaking at a Madrid meeting in March. The past…

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Article • Carbapenemase producing enterobacteriaceae

Detecting drug-resistant CPE quickly is still a challenge

Early detection and confirmation of carbapenemase-producing enterobacteriaceae (CPE) are essential when choosing the appropriate antimicrobial therapy and to implement infection control measures. Here, a leading Spanish microbiologist reviews an arsenal of tools currently available to clinicians. Resistance to beta-lactam antibiotics in enterobacteriaceae (EBc) is due to one or more of these…

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Article • Hospital hygiene

Nosocomial infections: a positive trend, but...

Hospital hygiene and how Germany compares in a European survey is somewhat divisive. Some believe Germany does well, whilst others emphasise the need to improve and for a stronger alignment with countries such as the Netherlands. As hygiene specialist Professor Petra Gastmeier, at the Institute of Hygiene and Environmental Medicine in Charité University Medical Centre Berlin, pointed out:…

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Article • Blood transfusions

Donor organs become immunologically invisible

The safety of blood transfusions is questioned again and again by the mass media. Sometimes ‘bad’ blood causes infections; sometimes a transfusion leads to cancer years later. The fact is that transfer blood is subjected to the highest safety standards – there are very clear statutory regulations. Nonetheless, there will be shortages of ‘life’s fluid’ because, given increasing…

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News • Symposium @ ECCMID 2019

How laboratories can help detect AMR and sepsis sooner

Beckman Coulter, a global leader in clinical diagnostics will be demonstrating its latest comprehensive solutions in microbiology, urinalysis and hematology at the 29th European Congress of Clinical Microbiology & Infectious Diseases (ECCMID). During the conference, Beckman Coulter is also hosting a symposium where attendees will learn how the laboratory can help physicians detect…

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News • Rapid diagnostics

T2 Biosystems hosts integrated symposium at ECCMID 2019

T2 Biosystems, maker of rapid diagnostic technology to aid in the detection of blood stream infections to prevent sepsis, will host an integrated symposium titled “Rapid Diagnostics Direct from Whole Blood: A Solution for Fast and Appropriate Antimicrobial Therapy,” at the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Amsterdam, Monday, April 15, 16:00-18:00…

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Article • Meeting of the generations

We need a Senior Laboratory

It’s undeniable: the bulk of our population is growing older. Yet, this demographic change has not altered laboratory medicine: the reference values for many analyses are still based on data of a younger cohort. Inevitably this could lead to serious errors in the interpretation of older patients’ test results.

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News • MRSA

Decolonization protocol can prevent dangerous infections

Antiseptic soap, mouthwash, and nose ointment after hospital discharge reduced infections and infection-associated hospitalizations due to MRSA in high-risk patients. Hospital patients who have methicillin-resistant Staphylococcus aureus (MRSA) can prevent future MRSA infections by following a standard bathing protocol after discharge. The Changing Lives by Eradicating Antibiotic Resistance, or…

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