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News • Coronavirus

Lab-made virus mimics COVID-19 virus

Airborne and potentially deadly, the virus that causes COVID-19 can only be studied safely under high-level biosafety conditions. Scientists handling the infectious virus must wear full-body biohazard suits with pressurized respirators, and work inside laboratories with multiple containment levels and specialized ventilation systems. While necessary to protect laboratory workers, these safety…

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News • Triple-negative breast cancer

Target validation for drug development against aggressive breast cancer

At around 30.5 percent, breast cancer is the most common cancer among women in countries of the industrialized world. The number of cases has doubled since the 1980s: about 69,000 times a year women are diagnosed with breast cancer. Triple-negative breast cancer is a particularly aggressive form of breast cancer. As important receptors are missing here, treatment options and prognosis for such…

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Article • Blood testing for astronauts

Health in space: a mini-lab for zero gravity

Nanoelectronics and digital technologies R&D and innovation hub Imec recently received NASA funding to test a new technology in a gravity-free environment. Eventually, this will enable astronauts to perform blood tests to monitor their health. We discussed the project and technology with Nicolas Vergauwe, CEO of miDiagnostics, the Leuven firm that developed the diagnostic device, and Susana B…

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Article • Spreading quality pathology in Canada

Building a telepathology network

Following success of telepathology in the eastern region of Quebec, the service is set to be further expanded across its remote areas. There are also moves towards a fully digital service at some sites, to introduce tele-autopsy into remote regions and extend the geographical coverage further across the region. The latest developments were outlined at the Digital Pathology and AI Congress in…

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Article • Digital pathology

VIPR: Deep learning for small cohorts

To investigate rare diseases, applying image-based analytics approaches, including the use of deep learning convolutional neural networks (DL-CNNs), can be a major challenge due to great difficulties in acquiring sufficient numbers of cases and associated digital image sets from the small cohorts typically available. To realise algorithms that are both effective and generalisable, conventional…

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News • COVID-19

Four commercial immunoassay tests for detection of antibodies

Public Health England, in partnership with the University of Oxford, recently conducted a head-to-head evaluation of four commercial immunoassay tests available in the UK and used for the detection of SARS-CoV-2 antibodies.

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News • Pathology informatics event

Panel Discussion on the use of digital pathology for remote diagnosis

Hamamatsu Photonics invites you to join us for a panel discussion with pathologist Matthew Hanna, MD and IT Manager Nikolas Stathonikos on Thursday, 9 July at 17:00 CET. In this rapidly evolving healthcare landscape triggered by COVID-19, pathology, and remote diagnosis have been elevated to critical topics. These two experts, representing both the clinical and information technology areas, will…

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News • Review sheds doubt

Major flaws in evidence base for COVID-19 antibody tests found

Major weaknesses exist in the evidence base for COVID-19 antibody tests, finds a review of the latest research published by The BMJ. The evidence is particularly weak for point-of-care tests (performed directly with a patient, outside of a laboratory) and does not support their continued use, say the researchers. Serological tests to detect antibodies against COVID-19 could improve diagnosis and…

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News • COVID-19 diagnostics

SARS-CoV-2 IgG antibody test receives FDA Emergency Use Authorization

Beckman Coulter announced that its Access SARS-CoV-2 IgG assay has received Emergency Use Authorization (EUA) from the U.S. Food & Drug Administration (FDA). Beckman Coulter has already shipped tests to more than 400 hospitals, clinics and diagnostics laboratories in the U.S., and has begun distribution of the new antibody test globally to countries that accept the FDA EUA and CE Mark. The…

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News • UK experts raise concerns

COVID-19 antibody tests: Not a game-changer after all?

A group of senior clinical academics and physicians are concerned about the rapid roll out of COVID-19 antibody testing in England and are publicly questioning how good the tests are - or even what they mean. In a letter to The BMJ, they argue that there is currently no valid clinical reason for large scale testing, test performance has not yet been adequately assessed, and testing risks…

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Sponsored • Corporate responsibility

A reliable partner in a crisis

In many areas of our daily life, plastic is seen in a negative light. However, the ongoing SARS CoV-2 pandemic has profoundly changed our society with intensive efforts being made to find a way out of the crisis.

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News • Viral on­co­logy

Kaposi Sarcoma: Answers to a longstanding enigma

The oncogenic herpesvirus (HHV8 or KSHV) causes a cancer known as Kaposi’s Sarcoma. An international team of scientists led by the University of Helsinki has discovered key factors that control the genome maintenance and replication of a virus responsible for lymphatic vascular cancer. Kaposi Sarcoma (KS) is the most common cancer among Aids patients and it is often seen in sub Saharan and…

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News • Sample analysis

Next-generation analytical lab software strengthens data exploration

Scientists in the life sciences can now benefit from upgrades to a suite of analytical software solutions with new features designed to enhance productivity, confidence and accuracy in numerous fields, including proteomics, food safety and biotherapeutic drug development. The latest suite of software strengthens laboratory workflows across a range of applications through expanded capabilities,…

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News • Predictive proteins

Biomarkers in COVID-19 patients could predict how ill they become

Researchers at the Francis Crick Institute and Charité – Universitätsmedizin Berlin have identified 27 protein biomarkers that could be used to predict whether a patient with COVID-19 is likely to become severely ill with the disease. People infected with SARS-CoV-2, the virus which causes COVID-19, respond differently. Some do not develop any symptoms, some need to be hospitalised and, for…

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News • Cancer research

Lymph node analysis to hunt down metastases

What makes tumor cells turn murderous? The Fraunhofer Institute for Toxicology and Experimental Medicine ITEM is investigating the mechanisms of metastasis formation – and searching for approaches for new treatments in the fight against cancer. Among other things, the research team at Fraunhofer ITEM has developed a method that enables them to analyze entire lymph nodes.

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News • From physical to computational staining

Deep learning accurately stains digital biopsy H&E slides

Tissue biopsy slides stained using hematoxylin and eosin (H&E) dyes are a cornerstone of histopathology, especially for pathologists needing to diagnose and determine the stage of cancers. A research team led by MIT scientists at the Media Lab, in collaboration with clinicians at Stanford University School of Medicine and Harvard Medical School, now shows that digital scans of these biopsy…

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News • COVID-19 detection

New analyzer detects virus antibodies in 20 minutes

Researchers at Hokkaido University have succeeded in detecting anti-avian influenza virus antibody in blood serum within 20 minutes, using a portable analyzer they have developed to conduct rapid on-site bio tests. If a suitable reagent is developed, this technology could be used to detect antibodies against SARS-CoV-2, the causative virus of COVID-19.

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