With two commercially available inhibitors, the cell cycle of the cancer cells in neuroblastomas can be disrupted at a key point causing tumour cell death. Neuroblastomas are malignant solid tumours that occur mainly in early childhood. Inhibiting the MYCN oncogene or its function could be a promising therapeutic opportunity.
University of Minnesota Medical School researchers studied SARS-CoV-2 infections at individual cellular levels and made four major discoveries about the virus, including one that validates the effectiveness of remdesivir – an FDA-approved antiviral drug – as a form of treatment for severe Covid-19 disease. “Since the start of the Covid-19 pandemic, the way that each individual responds…
Patients given preventive blood thinning drugs (prophylactic anticoagulants) within 24 hours of admission to hospital with Covid-19 are less likely to die compared with those who do not receive them, a new study finds. Clinical trials are now underway to see if prophylactic anticoagulants could be an effective treatment for Covid-19. In the meantime, the researchers say these findings provide…
For the first time, engineered heart muscle (EHM) from human induced pluripotent stem cells (iPSCs) will be used to treat patients with heart failure. After regulatory approval, recruitment of the first patient for the first-in-class, first-in-patient BioVAT-HF early clinical trial has started in Göttingen, Germany.
A new type of quantum holography which uses entangled photons to overcome the limitations of conventional holographic approaches could lead to improved medical imaging and speed the advance of quantum information science. A team of physicists from the University of Glasgow are the first in the world to find a way to use quantum-entangled photons to encode information in a hologram. The process…
Wearable devices can identify Covid-19 cases earlier than traditional diagnostic methods and can help track and improve management of the disease, Mount Sinai researchers report in one of the first studies on the topic. The findings were published in the Journal of Medical Internet Research. The Warrior Watch Study found that subtle changes in a participant’s heart rate variability (HRV)…
The first evidence from genetic data that high blood pressure is causally associated with the most common heart rhythm disorder is published in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).
In a recent study, researchers at the Texas A&M University have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
Providing the blind with visual impressions: That is the aim of the I See project, in which neuroscientists from the University of Bremen are involved. The approach: A miniature camera collects visual information and translates it into signal patterns that are transferred to brain implants.
Global greenhouse gas emissions over the last century have made southern China a hotspot for bat-borne coronaviruses, by driving growth of forest habitat favoured by bats. A new study published in the journal Science of the Total Environment provides the first evidence of a mechanism by which climate change could have played a direct role in the emergence of SARS-CoV-2, the virus that caused the…
Researchers from the University of Nottingham have discovered a novel antiviral property of a drug that could have major implications in how future epidemics/pandemics – including Covid-19 – are managed. The study, published in Viruses, shows that thapsigargin is a promising broad‑spectrum antiviral, highly effective against SARS-CoV-2, a common cold coronavirus, respiratory syncytial virus…
USC researchers have developed a new method to counter emergent mutations of the coronavirus and hasten vaccine development to stop the pathogen responsible for killing thousands of people and ruining the economy.
A study reveals that scalp cooling physically protects hair follicles from chemotherapy drugs. It is the world’s first piece of biological evidence that explains how scalp cooling actually works and the mechanism behind its protection of the hair follicle. The data was part of an innovative hair follicle research project carried out by the dedicated Scalp Cooling Research Centre based at the…
Over 23 million people around the world suffer from heart failure. The disease is usually treated with a transplant, but because donated hearts are hard to come by, there is an ongoing need for alternative therapies. With new developments in cardiac assistance systems, we can delay the need for a transplant – or even eliminate it altogether,” says Professor Yves Perriard, head of EPFL’s…
Cancer ranks as a leading cause of death in every country in the world, and, for the first time, female breast cancer is the most commonly diagnosed cancer, overtaking lung cancer, according to a collaborative report, Global Cancer Statistics 2020, from the American Cancer Society (ACS) and the International Agency for Research on Cancer (IARC). Data show that 1 in 5 men and women worldwide…
Covid-19 patients who suffer a cardiac arrest either in or out of hospital are far more likely to die than patients who are not infected with the coronavirus. In particular, women have the highest risk of dying: they are nine times more likely to die after suffering a cardiac arrest in hospital, according to research published in the European Heart Journal.
Engineers at EPFL’s Center for Artificial Muscles have developed a silicone aorta that can reduce how hard patients’ hearts have to pump. Their breakthrough could offer a promising alternative to heart transplants. “Over 23 million people around the world suffer from heart failure. The disease is usually treated with a transplant, but because donated hearts are hard to come by, there is an…
The continuing corona virus epidemic has impacted strongly on cancer care and research, including the delay of treatments and diagnoses as well as on trials of new therapies, and the shift in research to develop a Covid-19 vaccine. However, the session ‘Cancer research and Covid-19’, during the National Cancer Research Institute (NCRI) Virtual Showcase (online 2-3 November) looked at how UK…
A new EU-wide repository for health-related imaging data could boost development and marketing of AI tools for better cancer management. The open-source database will collect and harmonise images acquired from 40,000 patients, spanning different countries, modalities and equipment. This approach could eliminate one of the major bottlenecks in the clinical adoption of AI today: Data bias.
A team of neuroscientists has identified a potential means to address the loss of cognitive function due to Alzheimer’s disease by targeting protein synthesis in mice. Their findings, reported in the journal Science Signaling, reveal that synthetic pharmaceuticals could rescue the activity of brain cells needed for memory formation.
In many ways, our brain and our digestive tract are deeply connected. Feeling nervous may lead to physical pain in the stomach, while hunger signals from the gut make us feel irritable. Recent studies have even suggested that the bacteria living in our gut can influence some neurological diseases. Modeling these complex interactions in animals such as mice is difficult to do, because their…
The most deadly global health crisis in a century has resulted in a substantial decline in overall heart surgery volume and an unexplained increase in deaths after coronary artery bypass grafting, according to late-breaking research presented at the 57th Annual Meeting of The Society of Thoracic Surgeons.
Someone has a stroke every 40 seconds in the US, resulting in death every 4 minutes. Stroke is the leading cause of disability from a medical condition. When it happens, blood clots or bleeds kill a part of the brain – it goes dark – and can no longer control part of the body. People stop being able to walk, see, talk, or control their hand or arm the way they once did. Although treatments…
Evidence is emerging that vitamin D – and possibly vitamins K and A – might help combat Covid-19. A new study from the University of Bristol published in the journal of the German Chemical Society Angewandte Chemie has shown how they – and other antiviral drugs – might work. The research indicates that these dietary supplements and compounds could bind to the viral spike protein and so…
The emergence of SARS-CoV-2 virus variants that are adding twists in the battle against COVID-19 highlight the need for better genomic monitoring of the virus, says Katia Koelle, associate professor of biology at Emory University.