News • Hypoxia
Stopping lung damage before it turns deadly
Scientists at the La Jolla Institute for Immunology discover new drug target for severe asthma and fibrosis.
Immune system
News • Histotripsy
Tumors partially destroyed with ultrasound don't come back
Noninvasive sound technology breaks down liver tumors in rats, kills cancer cells and spurs the immune system to prevent further spread.
News • Aspergillosis monitoring
Chip-based model to observe fungal spread in the lung
A chip-based infection model developed by Jena researchers enables live microscopic observation of damage to lung tissue caused by the invasive fungal infection aspergillosis.
News • Mini-livers on a chip
Organoids: step towards hepatitis C vaccine
A platform for studying how the human immune system responds to hepatitis C infection by combining microfluidic technology with liver organoids could speed the hunt for a vaccine.
News • Oncology
Biodegradable hydrogel boosts immune system’s attack on cancers
A new biodegradable gel improves the immune system’s ability to keep cancer at bay after tumors are surgically removed.
News • Inflammatory response
Drug coat on implants reduces "foreign body" reaction
An anti-inflammatory drug incorporated into the coating around an implantable electronic medical device – such as a pacemaker – can reduce the body’s "foreign body" reaction.
News • Cancer research
How the body fights back against leukemia
New research from the University of East Anglia (UEA) and Quadram Institute reveals how our immune system can be triggered to attack cancer cells.
News • New insights into antibody response
How the immune system reacts to coronavirus variants
Researchers from Charité – Universitätsmedizin Berlin and Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) present new findings on the immune response against SARS-CoV-2.
News • Coronavirus research
Why the Omicron variant causes less severe disease
A new study shows that the SARS-CoV-2 Omicron variant is less effective than Delta at blocking a cellular defence mechanism against viruses, the so-called 'interferon response'.
News • Sensitivity and response detection
How long do tests detect SARS-CoV-2 antibodies? New insights
How long can Covid-19 antigen tests reliably tell the antibody status? Researchers at the Paul-Ehrlich-Institut identified several factors that affect the detection duration.
News • Coronavirus research
Why Omicron may be more evasive, but less severe
The Omicron variant of SARS-CoV-2 may be significantly better at evading vaccine-induced antibodies – but preliminary evidence suggests it is less likely to cause severe illness in the lungs.
News • Rare liver disease
New test improves diagnosis of autoimmune hepatitis
Autoimmune hepatitis (AIH) is a chronic liver inflammation that is triggered by an immunological malfunction. In this case, the immune system falsely recognises the patient's own liver cells as "foreign to the body". The symptoms of this rare liver disease are unspecific, and the exact cause is not yet known. If left untreated, AIH can lead to abnormal scarring (fibrosis) of the liver,…
News • Immune response study
Is a "natural" Covid-19 infection better than vaccination? It's complicated
Hope for a future without fear of Covid-19 comes down to circulating antibodies and memory B cells. Unlike circulating antibodies, which peak soon after vaccination or infection only to fade a few months later, memory B cells can stick around to prevent severe disease for decades. And they evolve over time, learning to produce successively more potent “memory antibodies” that are better at…
News • Immunological memory
How our lungs 'remember' a Covid-19 infection
After infection with SARS-CoV-2, where does the immune system store the memory to provide long-term protection against reinfection? Though numerous studies have examined blood to track immune responses to SARS-CoV-2, a new study of Covid survivors shows that the memory of the infection is primarily stored in T and B cells within the lung and the lymph nodes surrounding the lung.
News • Personalised aftercare
Immunosuppression after transplant: as much as necessary, as little as possible
After a liver transplant, patients have to take immune-suppressing drugs for the rest of their lives. These so-called immunosuppressants prevent the organ from being rejected. However, the drugs increase the risk of cancer and serious infections. They can also significantly impair kidney function and even lead to dialysis. In order to be able to give those affected as much immunosuppression as…
News • Promising approach
New nanoparticles suppress resistance to cancer immunotherapy
Hokkaido University scientists and colleagues in Japan have found a way that could help some patients overcome resistance to an immunotherapy treatment for cancer. The approach, proven in mice experiments, was reported in the Journal for Immunotherapy of Cancer.
News • Autoimmune reaction study
Severe Covid-19 linked to increase in self-attacking antibodies
Hospitalized Covid-19 patients are substantially more likely to harbor autoantibodies — antibodies directed at their own tissues or at substances their immune cells secrete into the blood — than people without Covid-19, according to a new study.
News • Immune system research
How the gut microbiome can help prevent brain damage in preemies
Extremely premature infants are at a high risk for brain damage. Researchers at the University of Vienna and the Medical University of Vienna have now found possible targets for the early treatment of such damage outside the brain: Bacteria in the gut of premature infants may play a key role.
News • SARS CoV-2 B.1.621
WHO classifies Coronavirus "Mu" as new 'Variant of Interest'
The World Health Organization (WHO) has taken a closer look at coronavirus variant B.1.621. The strain, first encountered in January 2021 in Colombia, shows traits that could enable the virus to circumvent immune response to vaccination. As a result, the variant, named "Mu", has been classified as "Variant of Interest" (VOI). Despite its prominence in Colombian new infection,…
News • Revealed in CT scans
Lung damage: New cause for breathing troubles in asthmatics found
A novel CT scan-based approach has revealed significant changes in a parameter indicating lung destruction in some asthmatics. This finding could lead to more personalized treatments for asthma accompanied by persistent airflow limitation. Clinicians have long thought that some people with asthma experience declines in their lung function, called fixed airflow obstruction (FAO), due to changes to…
News • Immune response determined
How Covid-19 vaccines prepare our immune system for the virus
In view of the continuing high numbers of infections, vaccination offers important protection against severe Covid-19 disease. Scientists from the Faculty of Medicine – University of Freiburg have now been able to determine in detail at what time point initial immune protection is established after vaccination with an mRNA-based vaccine and how the reactions of the various components of the…
News • Covid-19 detection
New blood test measures immunity against SARS-CoV-2 and its variants
The Lausanne University Hospital (CHUV) and EPFL teamed up to develop a new test that’s sensitive enough to measure the amount of SARS-CoV-2 neutralizing antibodies present in the bloodstream. The scientists’ discovery, published in Science Translational Medicine, opens promising new avenues for tracking immunity acquired by infection or vaccination.
News • Cancer 'avatars'
Predicting immunotherapy outcomes with mini tumours
Miniature tumours in the lab are able to predict whether the corresponding real-life patients will benefit from immunotherapy. “We’ve solved a major problem many scientists had been facing: preserving a tumours original composition and structure outside of the patient in the lab”, says cancer researcher Daniela Thommen.
News • Support for T cells
Improving immune response against severe viral infections
Researchers have identified a way to improve the immune response in the face of severe viral infections. It is widely known that severe viral infections and cancer cause impairments to the immune system, including to T cells, a process called immune ‘exhaustion’. Overcoming immune exhaustion is a major goal for the development of new therapies for cancer or severe viral infections.
News • Immune system
Fundamental advance in understanding T cell immunity
Monash University researchers have provided a fundamental advance regarding how T cells become activated when encountering pathogens such as viruses.