Pathology

Supervised learning approach

A new deep learning-based algorithm to predict relapse-free survival in papillary thyroid carcinoma

The tall cell variant (TCV) is an aggressive subtype of papillary thyroid carcinoma (PTC). Sebastian Stenman, researcher from the Institute for Molecular Medicine, and the Department of Pathology at the University of Helsinki, Finland, is developing and training a deep learning algorithm using supervised learning to detect and quantify the proportion of tall cells in PTC.

Article • Patient care

Molecular Tumour Board for better decision-making

As more genomic alterations become targets for therapy, health institutions and hospitals are creating specialist Molecular Tumour Boards to support better decision-making for patient care. This evolving team, and its role, was highlighted in a presentation at the 34th European Congress of Pathology in Basel, Switzerland.

CNN applications in pathology

‘Deep learning can predict survival directly from histology in clear cell renal cell carcinoma’

Renal cell carcinoma is among the fifteen most common cancers worldwide. Dr Titus Brinker, from the German Cancer Research Center (DKFZ), looked at whether a convolutional neural network (CNN) can extract relevant image features from a typical H&E-stained slide to predict 5-year overall survival.

Article • Lab equipment

LABBook - Your guide to laboratory and pathology equipment in Europe

LABBook provides an overview of European laboratory systems. Whether you are about to set up a new lab or want to replace existing equipment, LABBook will help you make smart investment decisions to boost efficiency and productivity in your lab.

Sakura Finetek Europe enables optimal only Advanced Staining results

Imagine a new quality standard that improves the lives of patients and lab professionals in cancer care.

News • Histopathology

Introduction of new advanced staining system

Histopathology company Sakura Finetek Europe announces the launch of its newest solution Tissue-Tek Genie, an advanced staining system, entering a new market.

Advanced staining – Getting the optimal slide

Advanced staining evolved with growing complexity, resulting in many variations and combinations to get the right staining quality. It felt the flexibility brings you total control, but actually what we see is the introduction of multiple variables. This endless tweaking has taken its toll.

News • Liquid biopsy for early detection of brain tumours

Glioblastoma: Mathematical modelling could lead to simple blood test

The development of a simple blood test for glioblastomas could mean earlier diagnosis and more effective and personalised treatment options against the most common type of malignant brain cancer.

News • Rare but dangerous infectious disease

New target to combat Melioidosis

Researchers have identified an enzyme that is a promising new therapeutic target to combat the dangerous bacterial disease melioidosis.

News • Determining aggressiveness

New discovery improves prostate cancer prognosis

Researchers in Sweden have now discovered a faster and easier way to determine who has an aggressive form of prostate cancer, and who has not.

News • Coronavirus research

How the Omicron variant dodges the immune system

By comparing the neutralisation capacity induced by the different variants of SARS-CoV-2, a team from Geneva reveals the exceptional capacity of Omicron to evade our immunity.

News • Lung cancer

A novel AI for digital pathology analysis

Researchers from Boston University School of Medicine have developed a novel artificial intelligence algorithm to assess digital pathology data.

Article • Glioblastoma analysis

Revealing tell-tale signs of deadly brain cancer

A new way of differentiating healthy from diseased cells could pave the way for more personalised treatment for patients diagnosed with glioblastoma multiforme (GBM), a common and aggressive type of brain tumour.

MolGen introduces high quality DNA/RNA extraction kits for efficient high throughput testing

SARS-CoV-2 has heavily impacted global society with high pressure on public health and economics. MolGen is proud to assist in relieving some of the pressure and support the testing framework.

News • cfDNA to assess tumours

Recurrent breast cancer: liquid biopsy improves detection, monitoring

Liquid biopsy performed on serum samples taken from breast cancer patients can provide increasingly accurate information on progression and enable earlier detection of recurrence.

News • Women's health

Breast and ovarian cancer risk assessment from cervical samples

Scientists have discovered a means of identifying the risk of breast and ovarian cancer by measuring epigenetic changes in cervical samples from over a thousand women.

Article • Precision medicine

Liquid biopsy: the ‘next frontier’ for cancer detection?

Mark Nicholls reports from the National Cancer Research Institute (NCRI) virtual Festival, with four expert speakers discussing the role of liquid biopsy in cancer detection.

News • Pathogen analysis

Unlocking epidemic prevention with affordable genome sequencing

A worldwide consortium aims to equip researchers in low- and middle-income countries (LMICs) with cheap and accessible methods for sequencing large collections of bacterial pathogens.

News • New method

3D imaging to determine prostate cancer aggressiveness

A team led by the University of Washington has developed a new, non-destructive method that images entire 3D biopsies instead of a slice. The 3D images provided more information than a 2D image — specifically, details about the tree-like structure of the glands throughout the tissue.

Article • Cancer research

Prostate cancer: Blood tests predict chemotherapy resistance

Researchers have found that regular blood tests can help detect whether prostate cancer patients have resistance to drugs treating the condition. The findings were presented at the National Cancer Research Institute (NCRI) virtual Festival.

Article • An estimated 800,000 deaths in 2030

Warning of looming global liver disease pandemic

Professor Dina Tiniakos, from the National and Kapodistrian University of Athens, predicts that NASH (Non-alcohol related steatohepatitis) cases will soar worldwide by 2030, with 800,000 liver deaths, costing health economies billions of dollars.

Article • WSI, AI and more

New digital frontiers for nephrology

Digital technology solutions create new opportunities in diagnosis and assessment of renal conditions. With whole slide imaging (WSI), improved workflow and better visualization, such technology already yields a ROI for hospitals and laboratories.

Kugel Medical – UCS-2000-D-E

Digitisation offers great opportunities in pathology to work more efficiently and faster. Used correctly, it reduces the workload for both pathologists and laboratory staff.

News • Coronavirus imaging

Brightest ever X-ray shows lung damage from Covid-19

The damage caused by Covid-19 to the lungs’ smallest blood vessels has been intricately captured using high-energy X-rays emitted by a special type of particle accelerator. Scientists used a new imaging technology called Hierarchical Phase-Contrast Tomography (HiP-CT), to scan donated human organs, including lungs from a Covid-19 donor.

Article • Mass spectrometry goes handheld

A pen to pin down the fringes of cancer

Mass spectrometry – a powerful tool for analysing the molecular composition of a tissue sample – is invaluable during cancer surgery. However, mass spectrometers are complex and unwieldy, and certainly a poor fit for an operating room (OR). To create a bridge between the lab and OR, Professor Livia S Eberlin, from Baylor College of Medicine, has developed a very special ‘pen’.

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