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News • COVID-19 medication safety

New traffic light system to prevent coronavirus drug interaction

The University of Liverpool launched a new website featuring a traffic light system to aid the safe prescribing of experimental drugs being trialled against coronavirus (COVID-19). The site, created by the University’s Liverpool Drug Interactions Group, provides vital information on whether or not combinations of an experimental drug and co-medications are safe to prescribe. This is of…

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News • Machine learning in intensive care

AI can predict circulatory failure in ICU

Researchers at ETH Zurich and Inselspital, Bern University Hospital, have developed a method for predicting circulatory failure in patients in intensive care units (ICU) – enabling clinicians to intervene at an early stage. Their approach uses machine learning methods to evaluate an extensive body of patient data. Patients in a hospital’s ICU are kept under close observation: clinicians…

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News • Intestinal distress

Celiac disease: 'Reprogramming' the immune system to tolerate gluten

Celiac disease affects 0.3-2.4% of people in most countries world-wide, and approx. 2% in Finland. Celiac patients suffer from a variety of symptoms, typically intestinal complaints, such as diarrhea, but are often symptom-free. Immunologist Tobias Freitag co-developed and tested nanoparticles containing gliadin for the immunomodulatory treatment of celiac disease in Professor Seppo Meri’s…

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News • Altered chromosomes

Breast cancer: targeted therapy can lead to treatment resistance

If chromosomes are unevenly distributed or otherwise altered during cell division, this normally damages the daughter cells and impairs their viability. Not in cancer cells, however, in which chromosome instability can actually confer a growth advantage under certain circumstances. Moreover, as scientists from the German Cancer Research Center have now demonstrated in mice, changes in the…

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News • Pilot clinical trial

China to test targeted therapy for COVID-19

A University of British Columbia (UBC) researcher is part of an international team working with a biotechnology company on a pilot clinical trial of a potential new treatment for patients with severe coronavirus infections in China. Dr. Josef Penninger, director of UBC’s Life Sciences Institute and Canada 150 Chair in Functional Genetics, is working closely with Vienna-based Apeiron Biologics…

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News • Behind the PICS

Causes for cognitive impairment after intensive care explored

People who have been treated in intensive care commonly suffer from residual cognitive impairment, but the reason for this is unknown. Researchers at Karolinska Institutet now link cognitive impairment with lasting inflammation and a potential treatment target. The results are presented in the scientific journal Intensive Care Medicine.

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News • BCG vs tumour recurrence

Modified tuberculosis vaccine shows promise against bladder cancer

The human immune system can recognize and eliminate not only germs but also cancer cells. This is why treatments with weakened germs can help the immune system in its fight against cancer. Researchers at the Max Planck Institute for Infection Biology in Berlin have genetically modified the tuberculosis vaccine BCG in a way that it stimulates the immune system more specifically. Consequently, the…

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News • COVID-19 infection control

Combatting the novel coronavirus with thorough hand hygiene

WHO Chief Adhanom Ghebreyesus has declared the novel coronavirus (SARS-CoV-2) a global health emergency. He said the decision was reached not because of the situation in China, but because of, “what is happening in other countries.” On Feb. 17, the number of infections totaled around 71,000 globally based on data of the WHO. COVID-19 – the official shorthand name of the novel corona virus…

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News • Cancer radiotherapy monitoring

Novel hydrogel turns pink to indicate radiation dose sweet spot

More than half of all cancer patients undergo radiation therapy and the dose is critical. Too much and the surrounding tissue gets damaged, too little and the cancer cells survive. Subhadeep Dutta and Karthik Pushpavanam, graduate students working in the lab of Kaushal Rege, Professor at Arizona State University in Tempe, and collaborators at Banner-M.D. Anderson in Gilbert, Arizona, developed a…

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News • False appendicitis alarm

Study reveals many unnecessary appendix surgeries in children

Surgery for appendicitis is the most common emergency operation in children. A new study has found that the UK has the highest reported national rate of ‘normal appendicectomy,’ where children undergo surgery for suspected appendicitis but laboratory examination of the removed appendix finds it to be normal. Although most children who are misdiagnosed as having appendicitis improve without…

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News • Assistance in lymphedema treatment

New microsurgery robot shows promise

Supermicrosurgery – operations on vessels ranging from 0.3 to 0.8 millimeters – is limited by the dexterity of the surgeon’s hands. To bypass this limitation, robots can assist in the surgical process. One such robot is MUSA – the world’s first robotic platform for supermicrosurgery, which was co-developed by researchers from Eindhoven University of Technology (TU/e) and the TU/e…

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News • Early detection

Support for lung cancer screening gains momentum in Scotland

The need to consider a formal recommendation on early screening for lung cancer was acknowledged by the Cross Party Group for Cancer, held at the Scottish Parliament in Edinburgh in January. Attended by over 40 people representing patients, the medical community, and the pharmaceutical industry as well as political advisers and Members of the Scottish Parliament, the Group agreed to write to the…

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News • Blood coagulation

Treating hemophilia with gene therapy

Within the framework of an international study, Lund University and Skåne University Hospital have started treating patients with hemophilia with gene therapy, something that began in January this year. The hope is that the new treatment will significantly simplify everyday life for those with severe hemophilia. Hemophilia is a genetic disease where the body does not produce one of the clotting…

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Video • Interventional cardiology

First robotic coronary angioplasties in Germany

Robocath, a company that designs, develops and commercializes cardiovascular robotic systems for the treatment of vascular diseases, announces it has successfully completed its first robotic coronary angioplasties with R-One in Germany. The Percutaneous Coronary Interventions (PCI) were performed by Pr Michael Haude, a recognized and highly experienced interventional cardiologist at Rheinland…

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Video • One-size-fits-all-approach

New T-cell could make ‘universal’ cancer therapy possible

Researchers at Cardiff University have discovered a new type of killer T-cell that offers hope of a “one-size-fits-all” cancer therapy. T-cell therapies for cancer - where immune cells are removed, modified and returned to the patient’s blood to seek and destroy cancer cells - are the latest paradigm in cancer treatments. The most widely-used therapy, known as CAR-T, is personalised to each…

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News • Hyperventilation vs cardiac arrhythmia

Hold your breath – save your heart?

A technique that enables patients suffering from heart conditions to hold their breath safely for over 5 minutes could have potential as part of a new treatment for cardiac arrhythmias, say researchers at the University of Birmingham. In a new study, published in Frontiers in Physiology, researchers initially proposed the technique as a new means for earlier diagnosis of ischaemic heart disease.…

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News • Personalized treatment

Could B cells turn the tide in sarcoma immunotherapy?

How can the treatment of soft tissue sarcomas, these particularly resistant and aggressive forms of cancer, be improved and better personalized? An international team led by Wolf Hervé Fridman with researchers from Inserm, Sorbonne Université and Université de Paris at the Cordeliers Research Center, in collaboration with the French League against cancer and Institut Bergonié, has shown that…

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News • Transplant breakthrough

Machine keeps liver alive for one week outside of the body

Researchers from the University Hospital Zurich, ETH Zurich, Wyss Zurich and the University of Zurich have developed a machine that repairs injured human livers and keeps them alive outside the body for one week. This breakthrough may increase the number of available organs for transplantation, saving many lives of patients with severe liver diseases or cancer. Until now, livers could be stored…

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News • Finding the right hospital

Colon cancer surgery: why experience pays off

Patients with colorectal cancer have a greater chance of survival if they are operated in hospitals with a high case load. This is because complications that can occur after surgery can be better managed there. Tumours of the colon, so-called colorectal carcinomas, are the second to third most frequent tumours in women and men in Germany. The surgical removal of the tumours is a central component…

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News • Woundcare in the age of antibiotic resistance

Next generation wound gel to prevent infections

Researchers at Lund University in Sweden have developed a new hydrogel based on the body’s natural peptide defense. It has been shown to prevent and treat infections in wounds. The formulation kills multi-resistant bacteria, something that is increasing in importance with antibiotic resistance growing globally. “The ability to effectively heal wounds is key for our survival in evolutionary…

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News • Finding the frequency

Ultrasound selectively damages cancer cells (with the right settings)

Doctors have used focused ultrasound to destroy tumors in the body without invasive surgery for some time. However, the therapeutic ultrasound used in clinics today indiscriminately damages cancer and healthy cells alike. Most forms of ultrasound-based therapies either use high-intensity beams to heat and destroy cells or special contrast agents that are injected prior to ultrasound, which can…

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News • Big data vs. neuroblastoma

Smart algorithm finds possible treatment for childhood cancer

Using a computer algorithm, scientists at Uppsala University have identified a promising new treatment for neuroblastoma. This form of cancer in children, which occurs in specialised nerve cells in the sympathetic nervous system, may be life-threatening. In the long term the discovery, described in the latest issue of the scientific journal Nature Communications, may result in a new form of…

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Article • Significant improvement in cleaning, disinfection and sterilisation

Surgical robots must also be hygienic

Modern healthcare without hand hygiene? Inconceivable – particularly in the operating room (OR). But what happens when it is not the surgeon who handles the scalpel, but a robot? Robotic surgery, just like surgery performed by humans, always carries a risk of microbial transmission to the patient, says Professor Johannes K-M Knobloch of University Hospital Hamburg-Eppendorf (UKE). A specialist…

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