News • Research
Growing a human esophagus in the lab
Scientists working to bioengineer the entire human gastrointestinal system in a laboratory now report using pluripotent stem cells to grow human esophageal organoids.
Personalised medicine
Article • Precision CV medicine
New biomarkers for cardiovascular disease
A range of new biomarkers and diagnostics for precision cardiovascular medicine were outlined in a session at the British Cardiovascular Society annual conference held recently in Manchester. Speakers from King’s British Heart Foundation Centre looked at how mass spectrometry allows clinicians to measure large numbers of proteins simultaneously, discussed a new biomarker for cardiac ischaemia…
News • Promising research
First steps towards a new, targeted lung cancer treatment
Scientists have identified a key molecular player in a subtype of lung cancer which could lead to a new way to tackle the disease, according to research published in Nature Communications. They found lung squamous cell carcinoma (LUSC) cells contained high amounts of a protein called BCL11A. The study showed that manipulating the gene responsible for the protein stopped the development of LUSC in…
News • Personalised drug treatment
AI approach to help myeloma patients
A multidisciplinary team of researchers from the National University of Singapore (NUS) has developed an artificial intelligence (AI) technology platform that could potentially change the way drug combinations are being designed, hence enabling doctors to determine the most effective drug combination for a patient quickly. Applying the platform towards drug resistant multiple myeloma, a type of…
Article • Gaining ground
MRI advances approach the realm of precision medicine
MRI has developed rapidly over the past decade in Poland, where clinicians are combining MRI with PET and CT to highlight tumour growth or regression and perfusion. ‘The fact that MRI offers new software and programmes means we can diagnose pathologies more precisely and make a diagnosis faster than a few years ago,’ explained Poland’s national advisor on radiology and diagnostic imaging…
News • Deadly brain cancer
Personalized cancer vaccine may increase long-term survival
An international Phase 3 study has found that a personalized glioblastoma vaccine may increase long-term survival in some patients.
Article • Precision medicine
Promising radiomics for breast MRI
‘Breast cancer rates are continuously increasing, and we don’t yet have a means of prevention,’ said Dr Clemens Kaiser, from the Medical Faculty Mannheim, at Heidelberg University, who believes the only way to save more patients from death, after providing the best possible diagnostics procedures, is via precision medicine: the right treatment at the earliest possible time. The radiologist…
News • Innovation
Siemens Healthineers debuts new thermocycler and AI-powered interpretation software
At the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2018), Fast Track Diagnostics, a Siemens Healthineers company, launches a new molecular thermocycler, the Fast Track cycler, and the complementary new FastFinder software. The Fast Track cycler is a compact platform that enables laboratories of all sizes to implement molecular testing with simplicity and speed…
News • New report
Advanced development of primary pancreatic organoid tumor models for high-throughput phenotypic drug screening
A multidisciplinary team of scientists share recent advancements in innovative in-vitro cancer biology methods for screening drug-like molecules in cancer tissue relevant models in a new report published online ahead-of-print at SLAS Discovery. Entitled Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening, the report can be accessed for…
Video • Personalized medication
An edible QR code might be the pill of the future
Researchers at the University of Copenhagen have developed a new method for the production of medicine. They print medical drugs in QR coded patterns onto an edible material. The production can be tailored to fit each patient and has the potential to protect against wrong medication and fake medicine according to the researchers. For the last 100 years, researchers have constantly pushed the…
News • Breast cancer
Pre-treatment with targeted drugs reduces need for radical surgery
Extensive surgery involving mastectomy and removal of several lymph nodes can be safely avoided for more women with some types of breast cancer, if they receive targeted drugs before surgery, according to research presented at the 11th European Breast Cancer Conference. The study focused on women with HER2 positive breast cancer, an aggressive form of the disease, who were given a targeted drug…
Video • Paradigm shift
Diabetes has 5 subtypes, not 2, study suggests
A completely new classification of diabetes which also predicts the risk of serious complications and provides treatment suggestions. The major difference from today’s classification is that type 2 diabetes actually consists of several subgroups, the results indicate. “This is the first step towards personalised treatment of diabetes”, says physician and diabetes expert Leif Groop.
Article • New therapies, new questions
To understand an image is to understand the treatment
Conventional chemotherapy in oncology is increasingly yielding to new procedures such as targeted therapy and immunotherapy. This results in changes for radiologists because new procedures require familiarisation with certain imaging to ensure that the treatment process is interpreted correctly.
News • Replicas from the lab
Growing 'mini tumours' to personalise drug treatment
Testing cancer drugs on miniature replicas of a patient’s tumour could help doctors tell in advance which treatments will work, a major new study reports. The exciting new technique involves growing ‘mini tumours’ from biopsy samples – and could help end reliance on trial and error in selecting cancer treatments for patients where genetic tests are not predictive of response. Researchers…
News • Beyond PSA monitoring
New prostate cancer risk model could better guide treatment
One of the biggest challenges in treating prostate cancer is distinguishing men who have aggressive and potentially lethal disease from men whose cancer is slow-growing and unlikely to metastasize. For years, prostate-specific antigen (PSA) level, cancer grade and tumor stage have been used to sort prostate cancer patients into risk groups established by the National Comprehensive Cancer Network.…
News • A map to the heart
The meaning of heart geometry in surgery
Geometry is often referenced for matters of the heart. Marriage has been described as “two parallel lines,” and others have compared love to an “irrational equation” or as unending as “pi.” But when it comes to the medical matters of the heart, geometry can be a lonely and dangerous affair. “The shape and size of a heart is not the same for every person, and a diseased heart, such…
News • Health IT in sports
Olympic cooperation for precision medicine analytics
The Olympic Games are starting to prove themselves not just as a showcase for the world's elite athletes, but for leading-edge health IT initiatives. The International Olympic Committee and GE Healthcare announced the launch of a new analytics tool meant to enable personalized care at the 2018 Olympic Winter Games in South Korea, as well as at the 2020 Summer Games in Tokyo. GE Healthcare…
News • Microbubbles
Bracco Imaging to innovate ultrasound for new personalized gene therapy
Bracco Imaging S.p.A., a global leader in diagnostic imaging, announced that it has initiated new experimental activities in its R&D Center in Geneva, Switzerland, to explore a new application for gas-filled microbubbles in the development of personalized gene therapy for treatment of chronic dysfunctional diseases related to lipid metabolism. Microbubbles have already revolutionized medical…
Article • Digital Pathology
Deep Blue meets Hematoxilin and Eosin
In the nineties Deep Blue, the famous chess computer, defeated Kasparow. Only a year ago Google’s Deepmind managed to master the ancient Chinese Go, known for its utmost complexity.
News • Gene-based testing
Skewing the aim of targeted cancer therapies
Headlines, of late, have touted the successes of targeted gene-based cancer therapies, such as immunotherapies, but, unfortunately, also their failures.
News • Pediatric leukemia
‘Turbocharged Artificial Intelligence’ could personalize combination therapy
A team of UCLA bioengineers has demonstrated that its technology may go a long way toward overcoming the challenges of treatment for acute lymphoblastic leukemia, among the most common types of cancer in children, and has the potential to help doctors personalize drug doses.
Article • Pathology
Creating a data powerhouse
The ability to digitise results from patient samples has been one of the key enabling technologies that make personalised medicine possible now, says Dr Fiona Carragher, the Deputy Chief Scientific Officer for NHS England.
Article • Personalised medicine
Many issues must be resolved
Hardly any topic has been discussed as broadly as personalised medicine, with countless stakeholders, ministries and organisations involved. That’s good news says Professor Angela Brand, Professorial Fellow at the Maastricht Economic and Social Research Institute on Innovation and Technology (MERIT) and Professor at the Department of Health, Medicine and Life Sciences at Maastricht University.…
Article • Denmark
Successful digital pathology
Advanced computer software underpins a service - coupled with a countrywide database, which enables Denmark’s pathologists to optimise the assessment of patients’ specimens.In turn, the digitisation of the system in recent years has led to significant improvements in pathology services, delivering greater efficiency and advances in patient safety.
Interview • Personalized medicine
“We have to establish a digital health network”
Healthcare and business professionals as well as scientists consider Big Data a promising technology to advance medical research and patient care. “Big Data analysis allows us to better tailor therapies based on the individual patient’s status, that is to implement personalized healthcare,” says Dominik Bertram, Development Manager at SAP and Head of the development field “Personalized…
