Scientists are using their increasing knowledge of the complex interaction between cancer and the immune system to engineer increasingly potent anti-cancer vaccines. Now researchers at the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have developed a synergistic nanovaccine packing DNA and RNA sequences that modulate the immune response, along with anti-tumor antigens, into…
‘Lateral flow immunoassays (LFIs) have evolved rapidly in the past 30 years, from the original crude and simple qualitative tests, to more complex multi-analyte and quantitative assays,’ reports BBI Solutions, a firm that has been raising the performance of lateral flow tests with the development of technologies for next generation diagnostics.
Immune cells are normally associated with fighting infection but in a new study, scientists have discovered how they also help the nervous system clear debris, making way for nerve regeneration after injury. In a study published in the Journal of Neuroscience, researchers from Case Western Reserve University School of Medicine showed certain immune cells—neutrophils—can clean up nerve debris,…
Many tumors possess mechanisms to avoid destruction by the immune system. For instance, they misuse the natural “brakes” in the immune defense mechanism, which normally prevent an excessive immune response. Researchers at the University of Bonn have now been able to take off one of these brakes. The study, which involved colleagues from Hamburg and Würzburg, could pave the way for more…
A group of international cancer researchers led by investigators from Mayo Clinic and University of New South Wales Sydney has found that the level of a type of white blood cell, called tumor-infiltrating lymphocytes, present in the tumors of patients with high-grade ovarian cancer may predict a patient’s survival. “We know that a type of tumor-infiltrating lymphocyte called cytotoxic CD8 are…
Every cancer is different and every patient is different. This insight gained in personalised medicine prompted oncology researchers to focus more on the individual patient’s immune system. It is particularly the immune system’s ability to destroy cancer cells that raised hope.
Findings suggest that modifying the cell replication cycle could make combined therapies more successful.
Resident microbes living on the eye are essential for immune responses that protect the eye from infection, new research shows. The study demonstrates the existence of a resident ocular microbiome that trains the developing immune system to fend off pathogens. The research was conducted at the National Eye Institute (NEI), part of the National Institutes of Health. "This is the first…
A certain immune reaction is the key, not to slowing atherosclerosis like cholesterol-lowering drugs do, but instead to reversing a disease that gradually blocks arteries to cause heart attacks and strokes. This is the finding of a study in mice led by researchers at NYU Langone Medical Center.
Scientists from St. Jude Children’s Research Hospital and Fred Hutchinson Cancer Research Center have developed an algorithm that functions like a Rosetta Stone to help decipher how the immune system recognizes and binds antigens. The research should aid development of more personalized cancer immunotherapy and advance diagnosis and treatment of infectious diseases.
With the combination of the basic principle of radioimmunoassay, high sensitive chemiluminescence and high specific immunoassay, the year 1977 saw the emergence of a new technology-Chemiluminescence Immunoassay (CLIA) which provided one of the best solutions for the quantification of specimens from a complex mixture with the non-radioactive nature, making it an advantage to replace RIA in…
Using computer-based simulations and mouse experiments, researchers at the Helmholtz Centre for Infection Research (HZI) in Braunschweig and at the Otto von Guericke University Magdeburg (OVGU), have disentangled the effects of pro-inflammatory signalling molecules on the postinfluenza susceptibility to pneumococcal coinfection.
The era of information systems operating in silos has passed, and this is particularly true in healthcare IT. At SCC Soft Computer, integration is one of our core values.
ELITechGroup Molecular Diagnostics and Precision System Science, Co., Ltd (PSS), a leading global provider of laboratory instruments for nucleic acid extraction, jointly announced the upcoming CE-IVD marking of ELITe InGenius for IVD applications in Europe and the upcoming availability of the instrument as Laboratory Use Equipment in the US.
During the past 15 years, liquid chromatography tandem mass spectrometry (LC-MS/MS) has evolved into a vital technology used to perform routine tests in many clinical laboratories. Historically, LC-MS/MS had been used primarily by research, pharmaceutical, or commercial laboratories; however, advances in the technology, decreasing costs for basic systems, intelligible software, an increased…
This article discusses examples of applications of genetic analyses in coagulation disorders and haematological and oncological diseases. Professor Christine Mannhalter highlights the impact changes have on the occurrence and severity of diseases and their influence on therapy response. Report: Christine Mannhalter
Scientists in the UK have designed a new self-assembling nanoparticle that targets tumours and could lead to quicker diagnosis of cancer. Researchers at Imperial College London report that a new self-assembling nanoparticle can adhere to cancer cells, thus making them visible in MRI scans and possibly eliminate the need for invasive tissue biopsies. Report: Mark Nicholls
Only a single treatment produced what researchers describe as 'rapid, substantial, and durable clinical improvement'.